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                  <text>Smallpox</text>
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                  <text>&lt;div class="landing"&gt;
&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with James W. Hicks about his activities in the West
Africa Smallpox Eradication Project. The interview is being conducted at
the Centers for Disease Control and Prevention in Atlanta, Georgia, on July
14, 2006. It is a part of the 40th anniversary reunion of the launching of
the program. The interviewer is Victoria Harden.

Harden:     Mr. Hicks, you were born in Jacksonville, Florida, on January
           17, 1930. Would you describe for me briefly your childhood and
           pre-college education in north Florida, and what it was like in
           the 1930s?
Hicks:           As a child, I grew up in the Depression years, and that
           had some differences when compared to a later period or today.
           We were poor, but we didn't know we were poor because everybody
           around us was no better off. It was a happy time in my life;
           however, at the age of 4, my mother died and that was a very sad
           time. I suppose, during that period when my mother died, the one
           person who was most influential in my life from that time on,
           and into my adult life, was my maternal grandmother. I liked my
           paternal grandmother very much, but I only saw her once for a 2-
           week visit because she lived in Vancouver, Canada, and British
           Columbia was a good ways from Florida in the '30s, so I really
           didn't know her. But my maternal grandmother was as close to a
           saint as you're going to find in this world.
Harden:     What was her name?
Hicks:           Her name was Elmira Fisher Brown, but we called her Big
           Dolly. That was developed out of an affectionate term: my mother
           had called her mother Dolly. It was just a nickname, but when my
           sister was born, the nickname became a name for my sister, and
           she was named Dolly. So now we had Little Dolly and Big Dolly.
           Well, I never looked on Big Dolly as any kind of a size
           associated with the name. It was just said in one swoop-
           Bigdolly. But I'm grateful for the chance to mention her name
           because she is the most influential person in my entire life, up
           until the time I got married.
Harden:     In 1947, you were 17, and you went into the US Navy and served
           in the Pacific until 1952. Would you tell me about your time in
           the navy, and how it might have helped prepare you for your
           later work in the smallpox program and elsewhere?
Hicks:           Well, I enlisted in the navy, and so as a recruit, I had
           to go through one of the naval training camps. My boot camp was
           in Bainbridge, Maryland. I came out of Bainbridge after 12 weeks
           and was selected to go to the Naval Air Technical Training
           Center in Jacksonville, Florida. It was like going back home
           again. It didn't seem like I was going to see the world, you
           know? I went back there, and I completed training in aviation
           fundamentals. Then I was selected to go to Control Tower
           Operators School. The rating was a specialty at that time and
           designated Specialist Y. The work was similar to that of flight
           controllers and control tower operators that control aircraft
           today.
                 I finished that school, and then I went on my first
           assignment, which was in Kodiak, Alaska. I stayed there for
           about a year and a half, came back, and then my next assignment
           was an aiarways flight controller at Moffett Field, California.
           I was there a very short time because I wanted to go abroad and
           see something.
                 I made the choice to accept an assignment to Agana, Guam,
           which is in the Marianas Islands in the Pacific. While on Guam,
           I also went at times to Saipan and Rota Islands, as part of my
           work, but for the most part I remained on Guam as the lead
           Control Tower Operator for the time I was there. When the Korean
           War broke out, I took a contingent of men from Guam, went to
           Sangley Point, Philippines, and opened up the small airport as a
           supply shipping point for the troops in Korea. We used metal
           mats, which had proven to be quite useful in World War II, for
           the single runway. We would later install a concrete runway to
           better serve the support mission..
                 I remained in the Philippines until it was time to return
           to the United States for discharge. During my last months of
           assignment, President Truman extended everybody involuntarily
           because of the war, and so I stayed there another year. When I
           left the Philippines, I went back to North Island, California.
           Again, I was in flight control there until I was discharged in
           January of 1952. I entered the University of Florida that spring
           semester.
Harden:     So, here you are coming back after long military service, and
           having definitely become an adult at this point, and then you
           start back to college. I expect that your approach to studying
           might have been different at this point from the 17- and 18-year-
           olds who were going to the University of Florida. You ended up
           with both a BA and a BS degree and were chosen for the Hall of
           Fame and elected to the Florida Blue Key Honor Society. You must
           have seen this period as an opportunity.
Hicks:           Well, I did realize that I lacked education, and the World
           War IIO and Korean Bill of Rights both offered an opportunity to
           help correct that.  I didn't even have a high school diploma.  I
           realized this early on, when I entered training in Jacksonville
           and I was selected to go to flight training at Pensacola. When I
           was about to leave for Pensacola, I was told by the personnel
           office, "We were pulling together everything for your file, and
           we don't have your high school diploma here." And I said, "Well,
           I can't produce it because I don't have one. But I passed all of
           your entrance tests with high scores." And they said, "Well,
           there's a right way, a wrong way, and a Navy way, and this is
           the Navy way. And we're sorry, but we can't accept you."
                 Well, that bothered me immensely because I wanted very
           much to be a navy pilot. When I got into my next assignment, I
           took some Armed Forces Institute extension courses to get enough
           credits to at least get an equivalency certificate. Duvall High
           School, which was no longer a high school but more of an adult
           vocational school with correspondence courses, literally gave me
           a degree, but I never had a legitimate diploma.
                 When I applied to the University of Florida, I was
           accepted because of what I had, but I was on probation, right
           from the first day I entered classes. Well, that woke me up a
           little bit, too. I've got to do something, or I'm going to lose
           this opportunity. So I took advantage of this opportunity, made
           dean's list the first semester, and after that, the university
           took me off of probation and left me alone.
Harden:     What did you major in?
Hicks:           I was fascinated with the whole liberal arts concept, and
           so my work was 2-pronged. For the Bachelor of Arts degree; my
           major was English, with minor courses in history and economics.
           For the Bachelor of Science portion, I majored in a typical pre-
           med course, with biology, chemistry, and psychology, and I took
           physics and philosophy as electives. So courses on one diploma,
           I could use on the other as electives and vice versa. I had to
           take, I think it was, 30 semester hours over and above the
           requirement for one degree because I was studying for both
           degrees at the same time. It was simply my attempt to catch up
           on a broad education because I had lacked academic achievement
           when I went into the navy.
Harden:     Then, when you graduated, you began to work with the Florida
           State Board of Health. Tell me about being a VD [venereal
           diseases] Representative of the Florida State Board of Health.
           You were in this co-op program with the Public Health Service,
           and I'd like to know more about that too.
Hicks:           The Public Health Service, and specifically CDC as a lead
           point, had an arrangement with some states, not all of them at
           that time, whereby you were an employee of the state but at the
           same time your paychecks came from the federal government.
           Someone in this program was called a Co-op. The understanding
           was that at some point in time, usually about 1 year, you would
           be tested and switched over to what then was called a Program
           Representative or VD Rep.
Harden:     So when you were switched over, then you were an employee of
           the federal government, working for the state, or you were still
           an employee of the state government?
Hicks:           I was a federal employee assigned to the state, with some
           supervision coming from state employees. As soon as we took the
           federal test administered by CDC, we were then promoted to GS-7
           and became an employee of CDC. It was simply a co-op arrangement
           between CDC and state health departments. That relationship of
           being partners in public health programs has existed down
           through the years. There's always been that tie with state
           health departments and CDC. So that's what happened there.
Harden:     What did you do as a VD Officer?
Hicks:           First, I was assigned to a VD clinic. They spent a day or
           2 teaching me how to take bloods from the arm to do serologic
           tests for syphilis and also how to trace contacts who had been
           named during interviews with patients to determine their sexual
           contacts. So that's basically what I did for about 3 or 4 weeks.
           Then I was transferred to a mobile team to take blood tests. We
           used a type of vacuum tube to obtain a blood sample once you got
           into the vein. I remember calling them Kydell or Shepherd tubes.
                 And we would get a great big bullhorn and put 78-rpm
           records on a record player in the front seat of a panel truck.
           We would go park somewhere out under a chinaberry tree, and
           people would come and dance in all that dust and all. And while
           that was going on, we, wearing white coats, would put Shepherd
           tubes in one pocket, the samples in the other pocket, and we
           would just walk through the crowd of people. They'd put out
           their arm, and we'd take their blood. I'm sure it wouldn't be
           allowed today. I got pretty proficient at taking bloods. In
           fact, I sometimes help out now in the hospital when they try for
           a while to take my blood. I say, "You want me to do that?"
           Because we did so many of them. I mean, so many of them. The
           music, which we played loud, would attract the people, and while
           they were there, in a big carnival-like atmosphere, we would get
           all these blood samples from this mass testing.
                 And then we would send them off that night to the State
           Board of Health in Jacksonville, and then they would send the
           reports back and we would do follow-up on those bloods. We were
           trying to find syphilis. We found a lot of latent syphilis, but
           we didn't find as many cases of primary and secondary syphilis
           as we hoped we would because it was through serologic testing
           and not a physical exam.
                 So I did that on that mobile team for 2-4 months,
           something like that, mainly in the Daytona Beach area and in the
           small communities near DeLand, Florida. Then a VD Rep was needed
           in Tampa, covering Pinellas County with St. Petersburg, and
           Tampa, including Hillsborough County. So I was sent to Tampa,
           and I worked there for, well, from '57 for about 3 years. And
           then, besides those 2 counties, I worked on a regular basis for
           3 clinics-one in Pinellas County and St. Petersburg, one in
           Tampa, and one in Plant City, the strawberry capital of the
           world, about 30 miles east of Tampa. So we managed those
           clinics, interviewing for both gonorrhea and syphilis, but our
           primary concern was syphilis. And then if there was an outbreak
           in Naples, or somewhere along the west coast, the so-called Gold
           Coast there, I would go down to Naples or Fort Myers or
           wherever, and do interviews, and then trace people and get them
           into local clinics for treatment.
Harden:     Then after you did this, you moved to Philadelphia. You were
           doing the same sort of thing, I believe, in Philadelphia?
Hicks:           Yes, but it was altered a little bit. When I got there, we
           had city employees as well as federal employees, assignees, in
           the same group in the VD part of it. There was a senior federal
           assignee, fellow by the name of Bill Hamlin, and I went in as
           sort of his assistant. The reason they brought me up there, I
           think, was because I was having pretty good success with the
           interviewing technique. I thought it was kind of fun, you know.
           I went through school in Atlanta to do it, and they test you
           there and I got a perfect score. So I guess based on that and my
           work later (I don't mean to be saying anything other than what
           happened) I think I was selected there to try to rescue some of
           the interviewing failures in Philadelphia. So I spent an awful,
           awful lot of time on reinterviews, to get contacts who weren't
           obtained before. And then, gradually I evolved into other
           activities there.
Harden:     The other important thing about Philadelphia is that you met
           your wife.
Hicks:           I did.
Harden:     And married, and then moved in '63 to Raleigh, North Carolina.
           And by that time you were Chief of the VD Program and
           coordinator of the co-op program, which you had come up through.
Hicks:           Well, North Carolina had always been a heavy co-op
           training state-probably the largest in the country. And there
           were times when we probably had 30, 40-odd people in training
           there. So the assignee in the position in Raleigh, by
           arrangement, primarily on the part of the state, inherited the
           title of Chief of the VD Control Program, or VD Program,
           whatever it was named. And so the state looked at me as head of
           the VD Program. I was an assignee at the GS-13 level, according
           to CDC. So I was one of those federal assignees doing work for
           the state and carrying a state title. And I stayed in that for
           about 3 years, until I got the call from Billy Griggs, offering
           me the job in smallpox.
Harden:     I want to come back to that, but I want to divert for 1 moment
           and say you also adopted 2 children during this time. And you're
           going to tell us a little bit later about the problems you had
           in Africa.
Hicks:           Well, yes, I had a serious problem with one of my sons.
           But now they are both beautiful young men, who have reached that
           age when they have families of their own, and I can't even think
           about them without filling up, I have so much love for my boys.
           And they're both doing extremely well, with families of their
           own.
                 But my concern was, when we had those 2 children, I think
           it was Bill Griggs who said, "You have to let those arranging
           the assignment know they're adopted, that they're not natural
           birth, because you've got to have a birth certificate, all that,
           to get visas, and passports, and this kind of thing" We didn't
           have the final papers for my youngest son, Stewart, and they
           weren't due for another year. So that meant I had to get a
           waiver, and I made it clear to the folks in Atlanta that, if I
           can't get clearance on Stewart, we're back to ground zero. The
           deal is off, you know? But by that time, I was wrapped up in the
           program and the excitement of it, and so fortunately we got a
           waiver that allowed the follow-up to be done in Lagos, Nigeria,
           where we were to live.
Harden:     All right. Now I want to drop back and say, here you are in
           Raleigh. You're the Chief of the VD Program. You've risen
           through the ranks and obviously done very well. So when they
           were looking for someone to be the head of the operations part
           of the smallpox program in the regional office, you were a
           natural choice, I think. Would you tell me who recruited you,
           and what they said?
Hicks:           Well, Billy Griggs was the one who made the call to me. I
           think it was June of '66. And he and D.A. Henderson [Donald A.
           Henderson] apparently had discussed me and my track record up to
           that time. You'll have to get more from them as specifically why
           they chose me. But I was glad they did. Being in North Carolina,
           I had obviously heard about the smallpox/measles control
           program, but most of what was going on I didn't know about.
                 Billy called and asked me about the job, and then when I
           told him about Jimmy and Sewart and that I did need to get a
           waiver, he said he was sure that they would be willing to do all
           they could to help me in that regard. I was grateful for that.
           The leadership in CDC has always been that way-for my family,
           and I've witnessed it for so many other families.
                 I came down to Atlanta in '66, July the 1st, I think, may
           have been the official date. It may have been a few days off
           from that. This was during that period of time, 3 or 4 months,
           when people were being trained to go to West Africa. I spent
           part of my time in French language training because I would be
           covering not only an anglophone country but also French-speaking
           countries. So to get that francophone requirement, I took French
           again. I had studied it earlier in school. I was also preparing
           job descriptions for those who would go to Africa. I
           particularly remember working up Gordon Robbins, our Health
           Educator for the project. He was a very bright, capable guy, and
           helpful in my attempts to get him nailed down for the program.
           It was things like that, and cable traffic overseas, and
           different projects that would have to be done to keep things
           moving. The EIS (Epidemic Intelligence Service) folks were
           putting on training in virology and assessment and things of
           that nature.
Harden:     Were you taking training and also trying to get organized with
           the people you had to help?
Hicks:           I was, but there were a lot of sessions in the training I
           didn't get in on because these other things were felt to be more
           important. We were all very busy. At that time, there were maybe
           40 families holed up around Atlanta in different motels,
           including the Emory Inn, but they were all over the Atlanta
           area. Well, I had this young child who I had just adopted, and
           so my wife, Dorothy, and I decided that we would leave her and
           the 2 children in Raleigh and I would commute home on weekends.
           Eastern Airlines was on a strike in 1966, so you had to resort
           to rail travel, which wasn't bad; there were 2 terminals in
           Atlanta, and if you missed a train going into one station, you
           could usually pick up another in the other terminal. Seaboard,
           Coastline, or whatever.
                 There was one train leaving from downtown Raleigh at about
           10:00 on a Sunday night. I would usually take that train and
           plan to get off at the Emory station near CDC in the morning.
           Emory was a small train station, down at the foot of the hill on
           Clifton Road. It later closed and became a restaurant for
           awhile. I'd ride the train all night, have breakfast on the
           train, and then get off at the Emory station, walk up the hill,
           and go to work. I would arrive in the station about 7:33 or
           something, so by 8:00 I was up the hill, ready to go. That
           worked fine for the summer, when I couldn't use the airlines.
           Dot stayed in Raleigh, where she was more comfortable, and there
           were so many requirements on the part of the new adoption
           procedure that she had to be close by or else she'd be doing a
           lot of traveling. So basically, that's how that worked out for
           us.
Harden:     So, were you the person, then, who was getting the complaints
           from the people who would be in your region, in terms of, get us
           over there, find us housing, help us get settled?
Hicks:           Depending on who initiated them, those primarily went to
           Don Millar [J. Donald Millar] (on technical aspects of the
           vaccine, virology), or they went to Billy Griggs (on equipment
           and program operations). But it didn't matter who got it;
           everybody was together on it. The organization was not nailed
           into place at that time. I had made a quick trip over in the
           early fall to Lagos because we were having some housing problems
           there. Billy Griggs had gone over before me. I don't know how he
           accomplished things so quickly, but he's a gifted guy, when it
           comes to management. I would say, he's a very gifted guy. And so
           a lot of that was done. I was going to manage what was then
           determined to be a line position out to the field, for
           equipment, supplies, money, bodies-this kind of administrative
           operation.
Harden:     So, when did you move to the Lagos office and stay there?
Hicks:           I think it was some time in the early part of November of
           1966. We wanted to get operational by January 1 of '67, and so
           much had to be done. When I first went over there, we were
           operating the regional office out of Muriel Roy's apartment. She
           was the secretary for the regional office and lived nearby.
           Well, that didn't work for very long. My chief concern was
           getting into the building across from her and having a
           legitimate headquarters, not working out of one's back pocket.
Harden:     Were you there ahead of the other folks who were going to come
           and implement the country programs?
Hicks:           Some got there ahead of me and were making do with contact
           with Atlanta and with the USAID [US Agency for International
           Development] representatives because this program was under
           their funding.
Harden:     Did you have to deal with them directly?
Hicks:           Oh, a lot. An awful lot.
Harden:     What kinds of interactions did you have?
Hicks:           All cable traffic concerning any issue came to the
           embassy, so any communications we received came in through the
           embassy and were directed through the USAID people to the
           regional office.
Harden:     And I understand that if you were in an anglophone country and
           wanted to cable a francophone country, or talk to one, you had
           to go through London and back to Paris?
Hicks:           We did it through the embassy, but they had selective ways
           of handling communications. Even though I had a top priority
           clearance, it didn't make any difference when it got to talking
           about how the embassies communicated. I got to be good friends
           with one of the embassy people, and I asked some simple
           questions. He said, "Jim, I can't share anything with you on
           this. That's just privileged information on a need-to-know
           basis." It was difficult, oftentimes, to communicate from one
           country to another. It was easier with the embassy, it seemed,
           to get a cable to Atlanta. Not always, because you'd go through
           the same procedures. And don't forget, for much of the time
           there, a civil war was going on, and there were priorities that
           a lot of people felt were higher than what smallpox was doing.
           But the beautiful part of it, in spite of all that, was the job
           got done.
Harden:     The job got done. My understanding is that the regional office
           was originally conceived to do one thing, but there were some
           difficulties with Atlanta and USAID. Would you talk about those
           problems?
Hicks:           Okay. If you were to look at it in one way,
           professionally, the greatest problem that I, Jim Hicks, saw
           there was communications, followed by transportation. Those were
           the 2 main problems that we faced.
Harden:     Would you explain a little more?
Hicks:           Okay. Communications would lag. Sometimes they wouldn't go
           through. It was very difficult. You had to make reservations for
           long-distance calls if you wanted to reach somebody with the
           normal telephone service, and that was very poor. You'd get cut
           off, and they did a lot of rerouting through Europe and whatnot.
           All of that, I never paid much mind to.
                 I just knew that there was some serious lag time in
           getting through to Atlanta. The regional office, in the
           beginning, was looked on as the headquarters here, as having the
           overall responsibility. So here in Africa is the regional
           office, with almost lateral positions with various disciplines
           in Atlanta. The regional office in the beginning, I think, was
           primarily designed to serve as an in-line focal point. But the
           communication was so bad that people gradually would simply tie
           in to who got them back the quickest answer. And if a guy is
           sitting in-I'll just use this for example-Dakar, Senegal, on the
           furthest western part of West Africa, he could communicate to
           the States a lot easier usually than somebody buried up in
           Dahomey (the country that later became Benin).
                 Communication was a big problem. That was the most serious
           problem to me. And when you have that kind of communication,
           things get misunderstood, and then they get worse. So some out
           in the field, based in Guinea or somewhere, might feel, well,
           you know, who is supposed to give me the information? Regional
           office? I don't get a response. Atlanta? Maybe I'll get a better
           response. So I'll just deal direct with Atlanta. Well, then that
           caused more problems, see? It caused bruised feelings. You know
           what saved all of that?
Harden:     What?
Hicks:           Relationships established in that summer program in
           Atlanta, and among people who came out of Public Health Advisor
           programs, who knew the players. It's hard to stay mad for long
           at somebody you care about. And obviously, the people in Atlanta
           cared about us in Lagos and West and Central Africa, and we
           liked the people who cared about us in Atlanta. So even though
           these things came up, understandably, it wasn't disruptive in a
           serious kind of way. It was just one of the problems you dealt
           with.
Harden:     And this was your most difficult professional problem?
Hicks:           For me, it was communications. Operations Officers in the
           actual countries might come up with something else. But for me,
           the most difficult thing was the communication-and
           transportation.
Harden:     Tell me some more about the transportation problems.
Hicks:           Well, you had a Pan-American flight from the States out, a
           couple of times a week, maybe 3 times a week. The transportation
           throughout Africa was mostly by Mali Airlines, Ghana Airlines,
           Nigerian Airways, Air Niger, and others; and these different
           local country airlines often had other priorities. Their
           concern, when they started flying, was, hey, we've got to get
           tied in with Paris if we're francophone. We've got to get tied
           in with London if we're anglophone; we're going to get tied in
           with Europe, you know? And a lot of the traffic was back and
           forth with expatriate help into these countries. So there was
           more concern to develop the airline system between Africa and
           Europe. At least that's the way it seemed to me.
                 Sometimes you wondered whether they really cared whether
           they got some goats, or tombstones, or something else, from
           Dahomey to Lagos, or from the Cameroons to Gabon. That inter-
           country travel didn't seem to have the attention on developing
           countries as getting tied in with Europe. I remember once George
           Lythcott had to get back for a very important meeting. I don't
           remember whether he was in Ouagadougou, or Bamako, but somewhere
           in the central part of West Africa. And he'd figured out that
           the only way he could get back was to fly to Madrid, and then
           from Madrid to Lagos. He could have come across in the normal
           manner, but it was much, much quicker to fly him to Europe and
           back down again. So, there was occasionally travel like that.
Harden:     And did you have trouble moving supplies for the people in the
           field because of that, too?
Hicks:           I'm sure we did, but so many of these supplies were
           offloaded at the respective country and did not come to Lagos
           for further shipment. There were some that went out from WACS,
           the West Africa Consolidated Service, which was operated with US
           and country agreement. But primarily, things were delivered by
           ship or air direct from the States and offloaded in the country
           of concern.
Harden:     You had a serious personal problem, too, that you had to deal
           with, with your son. Would you tell me about that?
Hicks:           Well, my oldest boy at the time was about 3 years old. He
           had severe asthma. He had been treated in Atlanta, and at Duke
           University, and different places before going to West Africa. I
           had to get a medical waiver on Jimmy, and a legal waiver on
           Stewart. All this did add to my personal problems.
                 Jimmy had bad times of it there. In fact, in 1968, on a
           trip that Dave Sencer [David J. Sencer] made over there, I guess
           because of my feelings, he didn't want to really tell me
           personally. He could do it better writing. So he wrote a
           beautiful letter that just frankly told me, "Jim, I think you're
           too close to the problem. You should think seriously about
           coming back to Atlanta." To illustrate with one related
           incident, one time I was in The Gambia, which is like a dagger
           in the heart, some say, of the surrounding French area of
           Senegal. I was in The Gambia, which is an English-speaking
           country, just a little narrow country, which followed along the
           Gambia River, extending a few miles on either side of the river.
           Well, that's where I was, and I got this cable that said, "Come
           home immediately. Your son is in very serious condition." Well,
           I didn't know what it was, you know. It could have been illness;
           an automobile accident; or it could have been the war. And which
           son? There was no cell phone to pick up; there was no computer
           or Internet. There was none of that. So you just tried to get
           back as soon as you could, which might be a day and a half. I
           was fortunate to be able to do that. But anyway, I got back, and
           it was Jimmy. I had tried on the way home to put 2 and 2
           together and I did think it was probably asthma because Jimmy
           had had many of these attacks. He was very, very seriously ill
           then and a number of other times. So, the greatest problem of
           the West Africa program, are you talking about program-wise?
           Communications. Are you talking about personal problems? My son
           Jimmy's illness.
                 The communications problem got solved, to some extent,
           just with time. You find ways to get around things. Everything
           was working, and progress was being made. So there was a lot of
           forgetting; there was a lot of overlooking. There are people who
           in excitement may say one thing, and you've got to say, "Well,
           wait a minute. I know good-and-well he didn't mean that." So it
           was relationships established that took care of a lot of
           misunderstanding.
                 Ultimately though, the difficulty with communications, I
           think, was a major cause of the demise of the regional office.
           It changed from what it was intended to be and became more of a
           storehouse of knowledge and help in certain areas. Because we
           had a virologist there, a health educator, equipment
           specialists, and so on. As a Medical Officer, Rafe [Ralph H.
           Henderson] was heavy into epidemiology and virology and the
           management of those disciplines. And George Lythcott, bless his
           heart, had to spend so much time, with his enormous gift of
           diplomacy, dealing with people, whether they were foreign
           nationals, expatriates, or our own people. He had a great deal
           of charisma, a great deal of ability to deal with people. So
           that was a great help. You add all those things together, and
           though in the beginning, in 1967, things were troublesome, they
           worked themselves out to a certain degree, but not totally.
           Because the way you got rid of the problem, essentially, was to
           move a lot of the problem-or a lot of the intent of the regional
           office-back to Atlanta.
Harden:     I see. Were there any unique occurrences that you would like to
           talk about?
Hicks:           Oh, there were so many. The whole program was unique. You
           could just pick out almost any of them, but the best
           illustrations of those unique problems would have to come from
           the Operations Officers in the respective countries. Well, we
           did have one unique occurrence in Lagos, during the war, when a
           Fokker aircraft from Benin, in the midwest region, was taken
           over by some mercenaries and Biafran sympathizers. One night, it
           was about 1:00 AM, we heard this awful, awful explosion. The
           Fokker aircraft had been taken away from the Nigerian Airlines,
           flown to Biafra, and 5 white mercenaries and 4 Africans came on
           a bombing run. And they came over Lagos. We pretty much figured
           out they were on the way to Dogon Barracks, where General Yakubu
           Gowan was, who was the head of the federal Nigerian government.
           The Ibos over in the eastern section of the country were the
           ones who were doing the bombing. Their bombs, however, were 55-
           gallon drums, or something in that neighborhood, and they were
           constructing Molotov cocktails of that size, and just pushing
           the barrels out the door of the plane. I think they got 2 off.
           There was some damage done. The drum would break, causing
           primarily explosion and fire. But the plane blew up in midair,
           very, very close to the regional office. It gradually got pieced
           together during the investigation that they had simply tried to
           use a different door, apparently, in the back of the plane, to
           push one of these barrels out, and it was already lit, and it
           wouldn't go through, so the plane blew up in midair. They
           recovered 9 bodies, or the remains of 9, 5 of them white
           mercenaries sympathetic to the Biafran cause, or paid by them.
                 Muriel Roy, our secretary, got hit with flying glass, and
           if she hadn't been wearing a kind of heavy bathrobe, I guess it
           was, she'd have got hurt bad. It blew out most of the windows in
           the regional office across the street and caused some other
           minor damage.
                 Another unusual thing I remember. . .Lagos at that time
           was getting black-and-white television. They had a little
           television station that was not very good for anything, but it
           was there, and it was better than nothing. You saw antennas on
           many rooftops. Well, the explosion twisted Muriel's antenna,
           which had never worked very well, such that she started getting
           pretty darn good reception.
                 I remember an incident that was unique to me. It's not of
           any real importance, but it's something those of us who were
           there when it happened have chuckled over. We were on our way
           back from a regional conference in Yaounde, Cameroon, in early
           '67 for the OCEAC [Organization de Coordination pur la Lutte
           contre Endemies d'Afrique Central] countries. We had had a
           successful time up there and were all heading home. Some of us
           were on our way back to Lagos, and we hit some turbulence just
           outside of Lagos, as we were making a long approach into Ikeja
           Airport. The service personnel had taken all of the meal trays
           and put them on an open rack normally used for luggage, like you
           find in buses and trains. All these trays were stacked up there,
           but what we didn't know at the time was that they weren't tied
           down. Well, I'm in the seat underneath them. So when we
           approached for the landing, the plane made a violent wobble as
           it sometimes does in turbulence, and the trays all came down.
           Well, they didn't come down on the floor; they came down on
           Jim's head. So they hit the top of my head, and out I went.
                 They told me later that a French physician from Senegal
           who was on that aircraft got up to see if he could do something
           to help me. So I later found out he undid my collar (I had a
           suit on with a tie), and he undid the belt on my trousers. Well,
           he went and sat back down because we were coming in for the
           landing. So I didn't know from anything. So when I came to and
           got up, everybody's still seated in the plane because they're
           going to unload us from the front to the back. It was a small
           aircraft. But anyway, I stood up. My pants dropped straight down
           around my ankles, and I stood there in my underwear on that
           plane. Everybody on the plane had a good laugh. Anyway, that was
           unique for me, but it doesn't have any value to the West African
           program.
Harden:     In 1968, you came back to Atlanta, and were named Chief of
           Operations of Area A, which was a 12-country area of West
           Africa. Now, tell me what that job was, and how it was different
           from the regional office.
Hicks:           When we first went into Africa, Medical Officers and
           Operations Officers were assigned to one or more countries.
           Nigeria was divided into 4 regions. A Medical Officer was
           assigned to head up Nigeria and, because of the size and
           population of Nigeria, other Medical Officers were assigned to
           the 4 regions.  Operations Officers were assigned to work with
           the onerous chores of keeping trucks going, Ped-O-Jets and
           refrigerators operational, and other logistical support. The
           Medical Officers had a tremendous schedule of dealing with
           virology, assessment, surveillance, and other things, and a lot
           of the things that the Operations Officer could have helped
           with, he couldn't because he had to train people to help with
           equipment repair and Ped-O-Jet repair. One of the early-on
           problems was axles. They broke all the time in those Dodge
           trucks. Particularly the W-200. A lot of broken axles, and that
           was a real problem.
                 So in the beginning, in early '67, with all the problems
           in communication and that enormous challenge that faced us, I
           remember George Lythcott asking me, "Jim, do you think we're
           going to eradicate smallpox?" And I said "No, but I am grateful
           as grateful can be that you and I both, George, are going to
           have a shot at it. Because," I said, "I think we can reduce the
           morbidity such that we will save many, many lives." You know,
           when we started the program in '66, there were 40-something
           countries endemic with smallpox. Seven of them were in that West
           African program, and at that time, there must have been 3-1/2 to
           4 million people dying every year from smallpox. Well, if you've
           got that kind of problem, and you can reduce the morbidity so
           that 25%, maybe, of the morbidity doesn't become mortality, then
           you've made a big jump. And I was trying to get that point
           across to George, but he already knew what I was talking about.
Harden:     Let me follow up on that. When did you finally feel that
           smallpox would be eradicated?
Hicks:           For me, it was in April, May of  '68. And why do I say
           that? Because in January of 1968-just 13 months after we started
           in January of '68 in Accra, Ghana,-we had a celebration of 25
           million vaccinations. Well, now we're pumping out a lot of
           vaccinations. There's something like 105, 110 million people,
           maybe, in the overall area. The statistics are hard to come by
           with accuracy. But out of all that, 25 million in 13 months,
           something like that, I figured that, yeah, we're getting people
           vaccinated. But that wasn't really it.
                 You see, to me this whole program was a Gordian Knot from
           the beginning. You had smallpox around for 10,000 or 15,000
           years. And people dealt with it, and it would be clean for a
           little while. Then there'd be another outbreak, and it went on
           and on. It was a Gordian Knot. It was unsolvable. You couldn't
           get it answered because you couldn't untie the knot. All right.
           Here's where the big change happened. Alexander the Great may
           have cut with one fell swoop the Gordian Knot that couldn't be
           untied. I think we had 2 fell swoops, backed up by a lot of
           support.
                 I think the first one came from Bill Foege [William H.
           Foege]. Bill Foege was a principal architect of what we called
           "eradication escalation." E-square, we called it. And that was
           presented, as I remember it, about May. It was based on his
           early work in the Ogoja Province, over in eastern Nigeria,
           before he had to leave when the war broke out. And it had to do
           more with identifying cases and then containing those cases,
           rather than just willy-nilly going across the country from one
           side to the other, vaccinating people. When I saw what
           eradication escalation could mean to the total program, that was
           the first cut through the Gordian Knot. The second one, Don
           Millar. Don Millar bought and understood it clearly from the
           very early conversation about it. But Bill's original ideas
           wouldn't have gotten anywhere if Don Millar had not said, "Hey,
           we need to do this as an adjunct of mass vaccination; we need to
           implement this." Well, it all came out in April, May, something
           like that, in '68.
                 Now it was about that time, after I knew about E-square
           and I saw vaccinations going on in the area, that I made up my
           mind. Exactly right then, I did a flip-flop. And George Lythcott
           asked me, "Jim, you know when I asked you this probably a year
           ago, how about if I asked you now? What do you really feel, now
           that we're in the program, been in it a little over a year: are
           we going to be able to eradicate smallpox?" And I said, "I've
           done a complete flip-flop"-those were my words-"I've done a
           complete flip-flop. This disease can be eradicated." And I
           believed it. Now, a year before, I thought we'd bitten off more
           than we could chew, but that it was still very, very important
           to reduce that morbidity. So that's where I was coming from on
           that.
Harden:     Beautifully said. When the West African program ended, you
           continued to work with smallpox eradication in the rest of the
           world. What special expertise did you see coming?
Hicks:           We need to back up a little bit to the summer of '68,
           following the letter from Dave Sencer about Jimmy and his
           asthma, which he wrote to me in Lagos while he was actually
           there. Then I knew I wasn't fooling anybody, and I then began to
           realize seriously, "I may be putting my child at risk" because
           medical care there was not super. I had mentioned to Don Millar
           that I had to come back, and I would much prefer to continue on
           in the smallpox program.
                 Well, up until that time, Henry Gelfand had 12 countries
           in West Africa (Area A) that he was responsible for from
           Atlanta. Bill Foege had primarily Nigeria and, I forget, maybe
           something else; that was Area B. And then Area C was Mike Lane
           [J. Michael Lane], the OCEAC area, over at Cameroon, Gabon,
           Chad, that area. So the long and short of it, I came back to
           play a role in Atlanta with the Area A countries when Henry
           Gelfand left.
                 That pleased me immensely because now I still had direct
           operational opportunity to help these people in so many ways.
           And don't forget that these people now meant something to me.
           They meant a lot to the eradication of smallpox. But one of the
           greatest joys in this thing was working with people who were
           gifted, and who cared about each other. And they cared about
           millions of people they didn't even know. Now, that was
           important to me. So I wanted very much to stay put. And Don
           Millar saw that I could do that job, and so he brought me into
           that, for which I'm very, very grateful. This was one of those
           early examples of an Operations Officer, a Public Health Advisor
           type, being able to step into a role formerly held by a Medical
           Officer. Because it was management, and we could get things done
           through other people in management as effectively in one
           discipline as the other. So that's how I got into that. Then,
           Bob Hogan [Robert C. Hogan], another Operations Officer, came
           back soon after that. And now, Lane and Foege could go on to
           other important things, to directing the program itself.
                 We still had a tremendous amount of money being dumped
           into protecting the country from smallpox. Now we've got no
           deaths from smallpox, but we've got deaths from smallpox
           vaccination complications. So when you add all this together, we
           had to do something from a humane standpoint, from an economic
           standpoint. What were we going to do as our domestic policy? So
           I got involved in some of that. Then the case manual was
           written. We had to go out and talk with State Epidemiologists
           about control activities  in a smallpox emergency, something
           like that. So that's how I stayed on with smallpox. And then
           from that I gradually became Deputy Director of Nutrition, and
           from there Assistant Director of Management for the Center for
           Infectious Diseases, under Walter Dowdle.
Harden:     Coming back then, if you were going to do this program over,
           the smallpox program, what would you change?
Hicks:           Well, this is unfair because if I were in the shoes of any
           of the principal players in 1966, I daresay I would have done it
           the same way. So in hindsight, I'm really doing Monday morning
           quarterbacking, and that's awful easy to do. But you have to
           consider that I lugged around something to compute that probably
           weighed 20 pounds, which was an iron cranking calculator. The
           Dutch made it. If you pushed this lever down, it would multiply
           and divide. But lugging that thing around, and you can buy
           something that'll do a lot more than that for 3 bucks at
           Walgreens, or someplace, and it weighs ounces. But in any event,
           the difficulties we had then, no computers, no cell phones, no
           emails, none of that stuff. So I'd have done it the same way,
           probably.
                 But to do it over again, if I were stepping in now and
           facing the same problem, I would not have put the regional
           office in the plans. I would have had the senior Operations
           Officers and MDs in Atlanta with responsibilities of specified
           countries. They would travel frequently to determine problems
           and help assess the program operations. In this way, they could
           share problems with others in headquarters and do business with
           cable traffic and regular scheduled phone calls-whatever was
           needed.
                 George Lythcott had several years' experience in recent
           work in African when he came to CDC. He would have been
           extremely effective with his diplomatic skills, medical
           knowledge, and high-level contacts in West Africa to service as
           a sort of roving ambassador and personal representative of Don
           Millar. George had demonstrated his exceptional skills at the
           very highest level to settle major problems in Africa with the
           Liberian program before he left fo the regional office.
                 That's what I'd do differently. I would not have the
           regional office.
Harden:     Once smallpox was eradicated in the world, in 1977, you were
           awarded the Order of the Bifurcated Needle. Would you explain
           this for the record?
Hicks:           I wish I could, totally. All I know, it came to me one
           day, but not to me alone. I have seen at this reunion some of
           the guys still wearing the little twisted bifurcated needle. WHO
           [the World Health Organization] was looking for something to let
           those who participated actively in the eradication of smallpox
           receive as an award. I participated, but look at the hundreds
           and hundreds of others. It was not anything unique to me. I'd
           have been way down the line. There are so many others who
           received it with more input than I ever put into the program.
Harden:     No, but I just think this is the neatest thing because people
           give awards for military accomplishment, for various and sundry
           other things, and they may not understand the impact that people
           made with this little bifurcated needle, in terms of
           contributions to humanity.
Hicks:           Well, the bifurcated needle was a turning point in the
           total vaccinating procedure in the countries. You could go train
           somebody in a hurry, with no doubts that you had the right
           amount of vaccine between those forks. And when you put it into
           the arm, it took. That was a great turning point.
                 So it was a thrilling time. I am thankful I had a part in
           it. Time will tell, but I certainly think enough time has passed
           by now to show the world that there's much learned in the
           smallpox program that can be applied to other things. I know
           with me, personally, it helped a great deal. I went on to do
           other things at CDC that required a lot more managerial skills
           than I had before I went into the program. But when you're
           thrown into the fire, so to speak, you learn rapidly. And the
           school I worked in, the people were just so dear to me, even to
           this day.
Harden:     Before we stop, is there anything else you'd like to add?
Hicks:           Well, I've talked way too much. There are lots of people
           who can give you the other things that may be missing, but I
           appreciate the opportunity to share what I have shared, and I
           hope I've done it in a way that might be helpful.
Harden:     I want to thank you very much. It has been just a super
           interview. Thank you for speaking.
Hicks:           Thank you, Victoria.
&lt;/pre&gt;</text>
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                  <text>Smallpox</text>
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                  <text>&lt;div class="landing"&gt;
&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Jean Roy about his experiences in the West
African Smallpox Eradication Program. The interview is being conducted on
July 13, 2006, at the Centers for Disease Control and Prevention. The
interview is a part of the 40th anniversary celebration of the launching of
the project. The interviewer is Victoria Harden.

Harden:     Mr. Roy, would you briefly describe for me your childhood, pre-
           college education, and talk about influential people-friends,
           parents-in your life.
Roy:        Yes. I was born in Maine, in 1941, and grew up there, went to
           primary school there. And then I went off to Pennsylvania for
           high school, at a Catholic school in Scranton. I had read a book
           earlier-oh, I must have been 12 years old-The Keys of the
           Kingdom. I'm Catholic, but it was about Baptist missionaries in
           China. And I was fascinated by life in China, and the Chinese.
           And if you know something about Maine, there aren't many
           opportunities economically, for jobs, and so on. People either
           went into the Foreign Service or became missionaries. Throughout
           my life and career overseas, now, I've run into so many Maine
           natives who were part of the foreign service, working for USIS
           [the US Information Services], or are missionaries.
                 So that was my background. So I wanted to be a missionary
           to China. So I went off to Maryknoll College, a Catholic college
           in Glen Ellyn, Illinois. It was associated with Loyola
           University in Chicago. I was intending, always, to become a
           missionary. By then, China was closed because of the communist
           revolution, so I aimed towards Africa. Now the college campus
           happened to be on a former golf course, which had been taken
           over by the seminary college. And, of course, I was addicted to
           golfing. But I made a tragic mistake one day by going golfing
           with the sister of a colleague. And as a future Catholic priest,
           this was a real no-no. I got called in and disciplined, and
           asked, "Why were you out there? Think of what the public will
           think, a young seminarian out playing golf with this young lady
           on a Sunday afternoon" (which was visitors' day).
                 And that's when I started to rebel. I thought, "Do I
           really want this kind of life?" So I graduated, got a degree in
           philosophy, and then said, "What am I going to do for the rest
           of my life?" And this brings me to the Peace Corps. After being
           in the seminary for 8 years, I still wanted to go overseas. This
           was 1963. John Kennedy had just announced the formation of the
           Peace Corps. So I sent in my application to Washington, thinking
           I would never be accepted, but at the time they liked idealists,
           and they liked the seminary background, and I got accepted. I
           was assigned to West Cameroon, in West Africa.
Harden:     Would you tell me what you did in Cameroon between 1963 and
           1966, when you got into the smallpox program?
Roy:        Several things, and it all has a relationship with the work
           I've done in the last 40 years. 1963, if you recall, was the
           year that measles vaccine was licensed in the United States. And
           that's the year they did trials in Upper Volta, which is now
           Burkina Faso. As a Peace Corps volunteer, I knew nothing about
           public health. I knew all about philosophy. I spoke French-I'm
           of French Canadian background, so that's where the French
           influence came in-and that helped me to get the assignment to
           French West Cameroon. West Cameroon is English-speaking, but
           there's also a larger section of the country that is French-
           speaking. My assignment was actually to start the first Federal
           Bilingual Grammar School in the Cameroons.
                 In 1961, West Cameroon (British Cameroon) was part of
           Nigeria until the U.N. referendum when the citizens voted to
           leave Nigeria and join East Cameroon, which was of French
           colonial descent, French-speaking, and much larger. The Ex-
           British Cameroon tribal groups were much closer to the French ex-
           colonial Cameroon, and it made sense to vote to join together.
                 The French government then poured massive amounts of aid
           into the British Cameroon, to make it French. British Cameroon,
           with 1 million people, was a very small sliver of land between
           Nigeria and the Eastern Cameroon section. The British
           Cameroonians drove on the British side, they used the common law
           code, used the pound sterling. Just a few miles away in the
           French section, the French franc and the Napoleonic code of law
           were used, and they drove on the American side of the road.
                 The referendum changed everything in the former British
           territory. I was there just when all of this was changing, and
           naturally the 3 million francophones dominated the 1 million
           anglophones. But the French started something that was very
           clever. They were going to make all Cameroonians bilingual. 1963
           was the first year of the first bilingual grammar school, a
           pilot effort to merge a French lycee with a British grammar
           school curriculum. I was the first foreign teacher on the campus
           at Man O'War Bay, which is famous for the slaving interceptions.
           The British Man O'War used to anchor in the small bay on the
           coast of Cameroon and intercept the slaving ships after the
           British outlawed slaving. It's a beautiful site, at the foot of
           Mount Cameroon. It's a wild, wild place, very much like Hawaii,
           with volcanic peninsulas into the ocean. Te setting was that of
           a former Outward Bound camp that had been turned into this new
           secondary school campus. So there I was, the only person who had
           a driver's license, so I got to drive the school's only Land
           Rover and serve as Chief Administrator.
                 I actually became the Assistant Principal. This was
           September 23, 1963. Within 6 weeks, 35 students came in from the
           anglophone sector of the country, and a few weeks later, 35
           students from the francophone side. And that was the idea. Every
           year for 7 years (it was a 7-year course), 35 students from each
           sector joined to learn the other sector's colonial tongue, until
           they were well-versed in the other language to be mixed. By
           graduation, the students had reached the equivalent of a second
           year of university-high school plus 2 years.
                 Today, there are many bilingual grammar schools, or
           lycees, and 3 very large bilingual universities in the Cameroon.
           And these young men are now ministers, diplomats, teachers, and
           doctors.
                 The notable thing, though, was that it was September 23,
           1963, when John Kennedy sent us off to Africa, and on November
           22, that fateful day, I still did not have a short-wave radio. I
           was 7 miles from the nearest town and had no bicycle or
           motorcycle and still did not have access to the Land Rover. Late
           Friday afternoon, I believe, on the 22nd, an African came
           running up to me, and he was saying, "Your President, your
           President is dead." I had no idea what he was saying. It didn't
           register. He didn't know very much, but he must have heard it on
           the radio, and all day Saturday I wondered what had happened.
                 On Sunday, still being a good Catholic, I walked my 7
           miles through woods and over 15 bridges to go to the main town
           for church, and at the same time I visited the Peace Corps
           volunteers at the girls' school in town. I walked into their
           house; they were all sitting on the sofa crying, and I said,
           "What is going on?" And someone said, "John Kennedy is dead."
           Immediately the next day, I took my 4,000 or so West Africa
           francs that I had saved and bought a short-wave radio.
                 But that was the beginning of the Peace Corps. I spent 2
           wonderful years, working in an administrative and teaching
           capacity, doing all the things to make a school work. But the
           special thing that I remember was the vaccine trials, the
           measles vaccine trial. Africans were talking about it because
           measles had always been the greatest killer of children in
           Africa. And this vaccine was like a silver bullet, a magic
           bullet.
                 After the Peace Corps, I returned to the States. I sort of
           enjoyed the idea of the bilingualism, and I went off to get a
           master's degree in linguistics at Columbia University. That was
           1965. I was back in New York City, and I said, "Great, I'm back
           in civilization." John Lindsay was the mayor. I was thinking,
           "Gee, that'll be great. I'll have newspapers again, I'll have
           running water again, I'll have electricity again." What happened
           between September '65 and June of '66 in New York City? The
           railways, the metro strike. The huge metro strike against
           Lindsay. Then came the first ever newspaper strike in New York
           City. And for long periods, I said, "This is like Africa." And
           then the blackout occurred. The most famous NYC blackout. I was
           at Columbia University; I had an exam that night, which I didn't
           take. So I said, "Gosh, I came back to the biggest city in the
           United States, and it's more like Africa than Africa."
                 I worked in a halfway house with the Presbyterian Church
           to earn my living. So I started with the Baptist Chinese
           missionaries, and here I was in New York City, working with the
           Presbyterian Church, helping them out. I was just doing their
           Sunday bulletins. I was a great typist, and again, doing
           administrative sort of things.
                 The Peace Corps was excellent about helping us find jobs
           and careers. And every month, we'd get a "Green Sheet," we
           called it. It contained all the job announcements from
           universities, foundations, private corporations. At that time,
           everybody wanted returned Peace Corps volunteers because they
           were thought to be serious, and so on. And 1 month the Green
           Sheet had an announcement for this institution called CDC. And I
           said, "Gee, that's the Cameroon Development Corporation." The
           Cameroon Development Corporation is now called the Commonwealth
           Development Corporation, but it was an old British colonial
           company, which had large plantations: palm oil, bananas,
           pineapples, rubber trees, and many other products in Cameroon.
           So I read that the CDC is looking for somebody for Africa with
           French-speaking ability, some administrative experience, and
           previous experience in Africa. I said, "Boy, this is great." But
           then they had all the public health requirements, and I said,
           "Oh, this will never work."
                 I also had another wonderful job offer, after I' received
           my master's in linguistics. USIS was starting up English
           language schools throughout the world at the time, in 1965.
           USAID [US Agency for International Development] gave the
           contract to a group; it may have been the Academy for
           Educational Development in Washington. But they were hiring a
           director of English language schools, English as a second
           language, for Leopoldville, in the former Belgian Congo,
           Kinshasa. I was accepted to be the director there, so I had a
           choice to make. I decided to apply to CDC, and eventually did
           get recruited, but perhaps that's where we can start talking
           about CDC because it's an incredible saga of how I jumped ship
           from linguistics to public health.
Harden:     This is fascinating. Is it unusual for CDC to recruit from
           outside, and what made them decide to recruit you? What
           qualifications did they want?
Roy:        Excellent question. It was a lot of luck on my part, a lot of
           trust and risk-taking on CDC's part. And I hope it was worth it.
           I. For me, it was. CDC had recruited, I think, something like 60
           staff people to go to the West and Central Africa
           Smallpox/Measles Program, which USAID was funding in 1965. The
           idea was to send epidemiologists and Public Health Advisors
           paired together-the Public Health Advisor as an Operations
           Officer, to make things work-what I used to say (and Public
           Health Advisors didn't like it), the manpower part-and the
           epidemiologist for the brainpower part. However, to be fair to
           my colleagues, we had brainpower as well. But it was a great
           combination of having the epidemiologist and the Public Health
           Advisor.
                 So they'd already recruited the epidemiologist for the
           country that I eventually was assigned to, which was Dahomey,
           now called Benin. It's just west of Nigeria, and east of Togo,
           sandwiched in between Togo and Nigeria. It is just a sliver of a
           country, with, at the time, 1.5 million people. Not very large.
           But the first Public Health Advisor that CDC recruited had a
           heart attack. So he had to decline. So D.A. Henderson [Donald A.
           Henderson] and Leo Morris and Billy Griggs, who were all trying
           to put a staff together for West Africa, went on to their second
           candidate, who accepted the job. He was a traditional, well-
           trained Public Health Advisor, a VD [venereal disease] type, as
           we called them back then. And he was raring to go, but his wife
           says, "Oh, I'm not going to Africa, I can't move the family,"
           and so he declined.
                 At that point, there were very few or no Public Health
           Advisors who had been trained, and who had come up through the
           ranks at CDC from the '50s, available to go to Dahomey, and
           that's when CDC, Leo Morris, and D.A. Henderson reached outside,
           and they eventually hired 3 Public Health Advisors from outside:
           me, Mark LaPointe, and Jay Friedman, all 3, ex-Peace Corps
           volunteers. All 3 of us had French experience. All 3 of us had
           teaching or administrative experience. None of us had public
           health experience. So that was the risk, I think, and the trust.
                  So anyway, they sent Leo Morris out to New York City to
           interview me. He came to the halfway house at the Presbyterian
           Church where I was working, on 36th Street, and we had an
           interview, then we went to the bar and had a beer. I remember
           saying, "Oh, I'll never get this job."
                 Meanwhile, I had heard that CDC had commissioned officers.
           And again, what was happening in 1965? Vietnam. And you saw my
           career path to that date: I had been deferred because of the
           seminary. I'd been deferred from the draft because of the Peace
           Corps. I'd been deferred again because I came back to get a
           master's degree at Columbia. And I had an 81-year-old lady in
           Augusta, Maine, who was my draft board representative, who had
           been after me for about 12 years. And I thought, "How am I going
           to get around this?"
                 While I was in New York, I visited an ex-colleague from
           Peace Corps Cameroon, who was an urban planner living in an
           apartment in Greenwich Village, and he said, "I'm doing my
           Vietnam duty." I said, "What?" He says, "Yes, I'm a commissioned
           officer. I don't wear a uniform. I go to work every day. He was
           a sort of a sanitation engineer, urban planner, and he fit right
           in to the category for the Commissioned Corps." So I said, "Boy,
           that's a fantastic way to do your Vietnam service." And then I
           found out that CDC had this Commissioned Corps, and I thought
           that perhaps I should put my money on CDC rather than the
           Leopoldville, Kinshasa, linguistic directorship. But meanwhile,
           just to protect myself, I took the Army Officer's Candidate
           test, and also qualified. I said, "If I'm going to Vietnam, I'm
           not going as a grunt, I'm going as an officer." Those were my 3
           options at the time: the CDC, the Congo, the army.
                 Leo Morris came, interviewed me, and D.A. Henderson sent a
           letter later saying, "We'd love you to join us, we'd like to
           assign you to Dahomey." I had visited Dahomey in 1964, when I
           was a volunteer, so I knew exactly where I was going, beautiful
           little place. So on July 6, 1966, I came to CDC. I was sworn in,
           along with Jay Friedman and Mark LaPointe. All 3 of us came on
           July 5, started auditing the EIS course, and started doing all
           the training to get ready for the smallpox/measles program.
Harden:     Did you know anything about Dodge trucks when you got here?
Roy:        No, that was great. We learned all about jet injectors, the
           vaccination guns, and Dodge trucks, with training down at the
           Chrysler Corporation down near the airport. We went together
           with Bill Foege [William H. Foege], Rafe Henderson [Ralph H.
           Henderson].
                 It was just amazing. I was 25 years old, and it was my
           first time in the South. I lived in a rooming house across from
           what is now the Rollins School of Public Health. "Ma Moates" had
           a typical clapboard house, a porch, just right out of any novel
           of the South of the '20s, '30s or '40s. Matter of fact, we had
           rocking chairs on the porch where Gordon Robbins and I spent
           many evenings. The Moates chewed tobacco, and each had spittoons
           in their living room; they both chewed tobacco. It had no air-
           conditioning, of course. So it was so humid that the ceiling
           over my bed fell on me while I was sleeping. Here, I was a Maine
           boy who had been to Africa, but arrived in Atlanta and found a
           whole new culture, way of life. I never dreamed that I'd spend
           the rest of my life based out of Atlanta.
Harden:     The summer of 1966, then, when you got here, you were sworn in,
           but were you a commissioned officer yet? What about your lady at
           the draft board in Maine?
Roy:        No, it took quite a while. I was sworn in as a civil servant
           and started the training. About 2 weeks later, July 10 or July
           14, I received another letter from my draft board saying that in
           October I would get my final notice and I would have to report
           to Fort Dix. So I went to D.A. Henderson and said, "D.A., look
           at this. All this work you've done. I'm your number-3 candidate
           for this job. The first one had a heart attack, second one
           didn't want to go, and now I may not be able to go."
                 Then I said, "But I hear you have the Commissioned Corps
           at CDC." And D.A. says, "Yes." And I said, "Well, do you think I
           could, you know, be accepted?" To which he says, "No, it's for
           doctors, dentists, nurses, statisticians, epidemiologists that
           have PhDs. If we do it for you-[Vietnam was getting other boys
           as well, and CDC was filled with Public Health Advisors of draft
           age]-we'd have to do it for everybody at CDC."
                 So I resigned in July at the only time that Delta went on
           a massive 2-week strike, in the summer of '66. No Delta flights
           out of Atlanta. And I was supposed to leave. But then D.A. says,
           "You know, if you get commissioned, that's fine. But we can't do
           it for you. Do you know anybody in Washington?" I said, "Yeah, I
           know Ed." And he says, "Which Ed?" I said, "Ed Muskie [Senator
           Edmund Muskie. He's from my hometown, Waterville, Maine, and he
           knows my mother, knows the family, was a neighbor." And D.A.
           says, "Well, when you go back. . ."
                 I was going back by Greyhound bus, so it took me a day and
           a half back then to get to Washington. I went to Ed Muskie's
           office and saw his secretary, Virginia, and told her the story.
           She said, "Ed's not here; he's meeting with Bill." And I said,
           "Bill who?" And she said, "Bill Stewart [William H. Stewart]. I
           didn't know who Bill Stewart was. And she says, "But let me give
           him a call." So she called, and told him that I was from
           Waterville, who I was, what I'd done, Peace Corps, blah blah,
           and smallpox eradication in Africa, and Ed told Bill, and Bill
           says, "Gee, that sounds good. Tell him to go over to the
           Commissioned Corps office, to fill out the form."
                 So, great. I went over there and started to fill out the
           form. Which medical school did you go to? Doesn't apply. Which
           dental school? Doesn't apply. Which nursing school? Doesn't
           apply. Well, do you have a degree in chemistry? Engineering?
           Nyet, nyet, nyet. I signed it, dated it, and submitted it.
                 Just before leaving Washington, I called D.A.-it was about
           4:00 in the afternoon. I told D.A. that I'd seen Ed Muskie and
           this fellow Bill Stewart. He says, "Who did you say?" And I
           said, "Bill Stewart." He says, "Holy smokes." (D.A. is always
           saying "Holy smokes!") He reminded me "That's the Surgeon
           General." And I said, Oh, I guess, well I knew Ed Muskie was the
           sponsor of the Clean Air bill, the very first Clean Air bill, in
           1965. And Ed was speaking with Bill when his secretary called
           about my situation. So I told D.A. that I filled out the form,
           but, I didn't think it's going to go anywhere.
                 I then took the bus, went up to Maine, another 2 days on
           the bus. And then after about 3 days in Maine, D.A. called me.
           "Jean, do you want to come back to Atlanta? We think it's going
           to work." So I took the bus all the way back, 3 long days,
           because there were no flights. I came back and continued the
           program. I did all the training, the Dodge trucks, the jet
           injector, the French training, the statistics, and listened to
           all of the fantastic speakers from London, people who had been
           to Africa, the public health workers who had been working on
           sleeping sickness, and leprosy, and other diseases. They were
           just the greats of public health. They're all dead now, I'm
           sure. But just inspiring. That whole summer was just like a
           graduate Peace Corps training Program. My Peace Corps training
           had been 3 years before at Ohio University for 3 months, but
           this was just an upscale version of that training, which was
           absolutely fantastic. And here I was, a very timid, shy fellow
           from Maine. Although I'd traveled all over the world, I was
           still very timid and shy, but extremely impressed with CDC and
           what went on that summer.
                 In September, everybody started going off to their
           assignments. The critical thing that everybody needed to have
           was a security clearance. You couldn't move until the whole
           family had security clearance because you were going with the US
           government. And 1 or 2 didn't get security clearance. After all
           the training, they had to pack up their children and then go
           back home and start a life again, where they'd left off before.
           Very disappointing. So we were all very nervous. I'd gotten
           security clearance from the Peace Corps, so I was a little
           optimistic, and I hadn't done anything strange, hadn't been
           burning flags or draft cards, like everybody else was doing. So
           September comes around and everybody went off to Africa.
                 October 1, I got my draft notice. "Please report to Fort
           Dix October 17." And I went up to D.A. again, "D.A., here's my
           draft notice. This is it. And I'm still not commissioned." Three
           or 4 days later I was commissioned. Meanwhile, just for
           protection, Mark LaPointe, who's also from Maine and had a very
           similar background as myself with the same old lady on the draft
           board in Augusta, was commissioned as well. We did it at the
           same time. Jay Friedman was from New York City and he was not
           commissioned. He was not being hounded and did not need the
           commissioning, and so he did not get it. But both Mark LaPointe
           and I stayed 3 years in Africa as commissioned officers,
           fulfilled our military duty. I was sworn in, again, and then
           sent the draft notice back and signed it, Lieutenant JG. And
           that was the end of the story.
                 On December 15, I went off to Dahomey, which had the
           second-highest incidence of smallpox in the world at that time.
Harden:     And you were commissioned at...
Roy:        At CDC for service to the Smallpox Program in Dahomey.
Harden:     So your commission of the Public Health Service was as?
Roy:        As a Public Health Advisor, literally. Or do you mean the
           commission title?
Harden:     Yes. Normally it's Assistant Surgeon, or Sanitary Engineer,
           or...
Roy:        It was Assistant Surgeon, more precisely, Junior Assistant
           Surgeon General.
Harden:     Some title they had made up that would fit. Okay.
Roy:        I don't recall. I was elated to have any title. The pay was not
           great, but the experience and the opportunity were fantastic.
Harden:     Tell me a bit about Dahomey, and what you found in terms of
           smallpox, and describe the people.
Roy:        Dahomey was a very small country, a sliver of a country, maybe
           300 miles long, and 60 miles wide, 1.5 million people. And of
           course, I was 25 years old, and I'm thinking I'm going to have
           to vaccinate, with the Ministry of Health teams, all 1.5 million
           people. I was overwhelmed. Because that was the strategy: start
           at the coast, go up north, and vaccinate all the tribes, all the
           people, the cities, the towns, and villages. At the time, as I
           said, Dahomey had the second-highest incidence of smallpox in
           the world.
Harden:     And why was that?
Roy:        A lot of it was because of the fetisheurs. These are the
           medicine men. The people are of Fon origin. The Fon people are
           connected to the Yoruba people. And Yoruba is a tribe in western
           Nigeria. So the Yoruba Fon people are related. They practice
           voudoun, and the word voudoun comes from the Fon Yoruba
           language. The Haitians and Brazilians use that word because the
           slaves came from that area and brought the language. So the
           voudoun is very big in Benin, even today.
                 In their mythology, there are 2 very important gods. The
           god of earth is one, and his power is called sakpata, which is
           smallpox. The other god is Shango, and the African-Americans
           talk a lot about Shango here in Atlanta, I've heard. Shango is
           the god of the heavens, the sky; its power is lightning. But
           sakpata is the power of the fetisheurs, who are sort of the
           religious representatives of the gods. They were responsible for
           purification and cleansing smallpox-infected people in villages.
           This was how they made their living. So, when smallpox broke
           out, the people normally went to their native medicine men, the
           fetisheurs, to find a solution.
                 Smallpox was the scourge, of course, of the world, and of
           Africa, and Dahomey. During my lifetime, I saw hundreds and
           hundreds and hundreds of cases of smallpox. This horrible
           disfigurement. And the smell. I think everybody will tell you
           when you walked into a house with a smallpox patient, right away
           you knew it was smallpox, and not chickenpox or some other
           disease. The smell was very, very strong. And of course, total
           disfigurement, and pustules, and so on.
                 But the fetisheurs would hide the smallpox patients
           because the villages paid them to heal them. So the only time we
           heard about smallpox is when it totally got out of hand. The
           fetisheurs did not have a vaccine. They did variolation. They
           would take scabs from some of the patients. They would dry them,
           grind them up, and blow them in the air. And so they would
           actually infect people. So they wanted to perpetuate smallpox.
           And we were there to stop it. So you see, we had a common enemy,
           and it was very clear, very, very soon, that this was a major
           cultural barrier to the eradication of smallpox.
                 And that's when we started doing anthropological studies.
           Gordon Robbins, who was a health educator at our regional office
           in Lagos, which was an hour away, came and studied the
           situation. How do we deal with it? Sort of how we dealt with
           chickenpox.
                 When I first arrived in December 1966 in Dahomey, I'd
           heard there was a massive outbreak of smallpox in the prison in
           the town of Ouidah, an old slaving town with a fort, and a big
           prison. So my driver took me there. I said, "Ah, I'm going to
           see my first cases of smallpox." I went into the men's prison,
           and they were all covered with pustules and vesicles. I quickly
           came back and told my epidemiologist, Bernard Challenor, who is
           deceased now, but he was a young, Barbadian-origin doctor-
           epidemiologist. I said, "Bernie, Bernie, there's a tremendous
           outbreak of smallpox in the prison." So he got into his vehicle,
           goes to the prison, comes back smoking a cigar, and says, "Oh,
           Jean, you've got a lot to learn about differential diagnosis.
           That's chickenpox."
                 And that was the answer for the fetisheurs, and that's
           what ultimately happened. To make a long story short, over 2 or
           3 years, as we gradually contained smallpox in Dahomey, in spite
           of and with the fury of the fetisheurs because we were taking
           away their business, they started focusing on chickenpox. And to
           this day, I'm told, chickenpox is what they're now declaring as
           the power, or the anger, of the gods, who punish you by giving
           you, not smallpox now, but chickenpox. And I bet you they still
           call it sakpata. There are still fetisheurs, there is still
           voudoun, highly practiced in Benin today, but I think that's one
           of the reasons why.
                 Our surveillance was very, very bad, and as D.A. said,
           surveillance was the key to any disease eradication scheme. I
           wasn't a real great-I'm not even a good-epidemiologist. Thank
           God, that's why I had Bernie, and Rafe Henderson, and Mike Lane
           [J. Michael Lane], who would come to Dahomey and give the
           support I needed. But even with the French colonial approach to
           public health, which we used, the Service des Grands Endemies-
           very effective health personnel providing curative and
           preventive services throughout French West Africa, and which
           controlled yellow fever, leprosy, and the other major diseases,
           through their roving mobile teams. These ex-French colonial
           teams would go off for 3 months -with tents, cooks, you know,
           all the luxuries of home-with the French Medical Director,
           leading all the African nurses, who were very well supervised.
           They loved it; there was an esprit de corps, teamwork. After 3
           months, they'd come back, rest a month, and go off. And at the
           end of a year or 2, they would have covered the whole country.
           It was a good outreach service.
                 We used the same approach with smallpox, using those same
           teams that had sort of gone defunct because the French stopped
           supporting the colonial public health services when these
           countries gained their independence in 1960 and 1961. When I
           arrived in Dahomey, I found all these nurses, male health
           workers, laboratory technicians, who were ready to go out on
           tour, as they say, for 6 weeks, l month, 3 months. They were
           ready. They loved it. That was their work, and they were helping
           people. But for 2 years previously, they had done nothing.
                 So when I arrived there and set up an office, I found 15
           of these teams. And I had 15 Dodge trucks that arrived at port
           and started setting them up. And at age 25, this was an awesome
           responsibility. But I think all the previous experience in
           Cameroon and the Peace Corps really helped me. Great support
           from the American embassy. USAID was not so supportive, but they
           weren't too keen on the smallpox part, but they were keen on the
           measles part of the campaign. So I just replicated the training
           I had received at CDC in June, July, August, September. Then in
           December, January, February of '66-'67, we trained all these
           nurses, and then organized them so that we did the mobile teams
           again. Again, they would go out for a month, come back and rest
           for 2 weeks.
                 Their mission was to use the jet guns and to vaccinate
           everybody from the coast, to the north, up to the desert. And of
           course, we'd done about a third of the country, so about 400,000
           vaccinations, and we thought that was great. Today (2006), we
           are doing a million vaccinations a week now in Africa; in Kenya
           we did 14 million 2 years ago. But 400,000 back then seemed
           incredible. And everyone was doing that in all the countries in
           West Africa.
                 But Bill Foege noted back then, "How come we still have
           smallpox where we vaccinated everybody?" It's because we weren't
           looking for cases. Our surveillance was not good. Just by
           vaccinating the masses, we were missing the people who didn't
           want to get vaccinated. The fetisheurs were hiding them. The
           fetisheurs were against us, and they were telling the population
           not to get vaccinated. So these were the reservoirs for
           smallpox.
                 So Foege saw this, Rafe Henderson saw this, and that's
           when we started the strategy of search and destroy, using
           Vietnam language. Eradication-escalation. But again, we had this
           esprit de corps. Rafe Henderson came to Dahomey and said, "Let
           us try something." He said he wanted 12 motorbikes, 12
           vaccinators, who he trained to identify smallpox, to go out and
           look at suspected cases. So this was the start of a very intense
           surveillance program. Rafe came and lived for almost 3 months in
           Dahomey. We got him an apartment. And I gave him free rein. I
           said, "Rafe, I don't understand this search and destroy stuff,
           eradication-escalation. Go for it."
                 So I gave him a free hand, and I kept on running the
           regular operation, the systematic, rational, ancient method,
           which I hope is a lesson learned. Malaria eradication failed in
           the 50s because it was too systematic, too military, too rigid,
           not flexible, and every country did the same thing. That's
           stupid. You must be constantly changing, adapting. I think Bill
           Foege and Rafe did.
                 That was the genius of those early days of smallpox:
           figuring out that mass vaccination is not the answer. Sure, for
           some diseases like measles that are highly contagious, you want
           herd immunity, and so on. But in this instance, it was search
           and destroy. So Rafe had his 12 motorbikes, his 12 vaccinator-
           the "dirty dozen," as we called them, and he had a great time.
           He had his Land Rover, and he would follow them, supervise them.
           They went off, and they would probably go to 12 different sites
           and report back whether there was smallpox or not. If it was
           smallpox, they would go right back and start the containment,
           vaccinating everybody in and out of the village, not let people
           out or let people in, and make sure that everybody was
           vaccinated. By doing this strategy, within 3 or 4 months,
           smallpox just started going down tremendously. And then, it was
           a secondary goal to vaccinate everybody. It was good policy to
           give vaccination to everybody because, again, for 4 or 5 years,
           we conducted surveillance, regional surveillance for smallpox to
           be sure that there was no appearance of hidden cases. So it was
           good to have as many people vaccinated. But the key to
           eradication was the search and destroy, the containment, and the
           flexibility to adapt to new diseases, new approaches, and not
           use the old ways.
                 I'm very active in vaccination and public health in Africa
           today. And every time I see young people wanting to do things I
           did, I say, "No. That is totally wrong. Do not. You might have
           learned this as an MPH student, but no. What is the situation?
           Everyone and everything is different; it must be customized."
Harden:     Well, and one of the most important things that I have gleaned
           is that, not only figuring this out, but the importance of the
           logistical support of getting out into the villages, having
           those trucks and having them work, finding housing for these
           people. That it was certainly much more than a medical problem.
           Can you talk about that a bit?
Roy:        Absolutely. These are logistics problems. They're management
           problems. They're operational problems. This is very
           controversial, and not really fair to our medical colleagues,
           but a lot of the problems in public health today are because
           we've used a medicalized approach. Let's take HIV, for instance.
           I give this talk-I give it to old ladies, to governing boards of
           the British Red Cross, Belgian Red Cross, because I'm with the
           Red Cross in Europe, and I shock them. I say, "Do you really
           think that doctors and nurses in hospitals and laboratories can
           stop HIV? They can't." And remember now, I'm with the Red Cross,
           so I'm talking about civil society. I say, "The people in the
           villages are going to stop the HIV. Because to really stop HIV,
           you have to be in the bedroom. Are the doctors, nurses,
           hospitals, medical centers in the bedroom?" And then somebody, a
           Belgian HIV activist said, "No, it's behind the bus stop, too."
           And I said, "Well, are the doctors behind the bus stop, too,
           where you go for a quickie?"
                 Smallpox was eradicated in Bangladesh and India because we
           removed the task from the medical community. We allowed
           thousands and thousands of ordinary people, with the magic of a
           bifurcated needle, to do the vaccinating. And you can learn that
           in 5 minutes. Tens of thousands of ordinary people, using
           bifurcated needles, eradicated smallpox. We must beware that
           what we think is a medical, a public health, problem, is really
           a people problem. You must change behavior. In my talks, I go
           through the helmets, the seat belts, the condoms. Those things
           have nothing to do with doctors and medical schools and
           hospitals. It is people behavior.
Harden:     But it's an awful lot to do with culture, and religion, and
           values.
Roy:        Exactly. Major lesson learned. I use the Kano experience for
           polio. There was a major outbreak of polio in Kano, Nigeria, and
           they've now exported their polio cases all over Africa, to
           countries that had not had polio for 10 years. And what was the
           problem there? I'm told that they perceive the vaccine to be an
           "American vaccine" (but it isn't; it's made in Indonesia) "to
           sterilize the Muslim girls so they wouldn't have babies." But
           actually, the vaccine is made by Muslims, in Indonesia, to
           vaccinate against polio. And of course I agree that in Nigeria
           maybe it was a political problem as well. But, this was not a
           medical public health problem. It was a communication problem.
           And had we spent, in the last 40 years, USAID funding, public
           health funds, on people rather than on consultants and white
           elephants of hospitals, I think we'd be further ahead today. In
           Kano, we should have spent our polio eradication money on
           schools, mosques, churches, people, Boy Scouts, Girl Scouts, and
           the Red Cross. As I say, people. If people know that the vaccine
           is good, they'll get vaccinated. Like measles: they know measles
           kills. But they don't see a lot of polio. Now they are, however,
           because they stopped vaccinating for 3 years, and there's a
           resurgence. And that has cost hundreds of millions of dollars.
                 But just to get back to a point of the importance of
           people in public health, the polio-eradication effort would not
           have occurred if it had been left only to the medical
           institutions and the public health agencies. It was Rotary
           International, the ordinary business people out of Evanston,
           Illinois,  with the help of CDC by assigning a CDCer there,
           because they said, we're not a health agency. They had raised
           $50 million in 1982. I was there at the Evanston headquarters in
           1986, when Rotary was ready to give up. "We can't continue
           raising money for polio eradication because we're not a medical
           health institution." No problem. We'll give you somebody. And
           they went on to raise $600 million.
                 Now, measles elimination is occurring in Africa as we
           speak. Shamefully it is 32 years after measles vaccine was
           introduced in Africa by the measles program. Africa is now
           starting to use measles vaccine in a big way. And that's because
           of the American Red Cross. We started in 2001. And of course,
           the cases have just gone down tremendously, a 60% drop globally
           and a 75% drop in Africa. Because measles was the biggest
           killer. It no longer is today.
                 But it was Rotary, a civil society for polio eradication.
           It was the American Red Cross, a civil society, for measles
           elimination in Africa. Not a health institution. If we do an
           analysis of the really successful public health programs in the
           last 40 years, you will see that the most important common
           denominator was the people who are victims themselves. You must
           involve them, and I think it's a lesson learned for the future.
Harden:     So let's get back to smallpox. One question: if you were going
           to do the program over again, would you change anything?
Roy:        No. We had some assumptions to begin with, but we were very
           flexible. I think it was a brilliant group. I've had 40 years. I
           started with the Bill Foeges, Stan Fosters, Don Millars, D.A.
           Hendersons. I mean, how many people in this world have had that
           privilege? Especially somebody who didn't know any public health
           was not qualified at all for a job like this by standard rules.
           Today, if I tried to get into CDC with the qualifications I had
           back then, I would never get my foot in the door. You'd need an
           MPH and PhD, if not an MD, and so on. But I think they took
           risks; they had a lot of trust. They worked with the African
           governments. While our mission was with smallpox eradication,
           the African governments wanted measles vaccine. And again, ask
           the people what they want, and measles vaccine, which we thought
           was going to destroy the smallpox part of it, actually enhanced
           it because many more people were dying of measles than of
           smallpox. But smallpox was a threat to the Western world, to the
           Soviet Union, and so on. And so the world wanted smallpox
           eradicated, and sure, there were a few countries in Africa that
           had smallpox, so they were a major global threat. But measles
           was killing millions and millions of children under age 5, every
           year in Africa.
                 But listening to the people, taking risks, being flexible,
           constantly changing, and learning, those were the keys. And I
           think the legacies of smallpox are tremendous. You would not
           have had measles control in the United States. We all came back,
           in '69 to '71, to the United States. Even as public health
           advisors, not epidemiologists, we knew a heck of a lot about
           surveillance. We knew about containment, and so we started
           closing down schools with measles in the United States.
                 In '72, '73, I ended up in upstate New York with Alan
           Hinman, who was an EIS Officer then. And we started closing down
           schools, doing search and destroy, containment vaccinations. So
           I think we all brought back to the United States real tools,
           learning lessons that were applied, that helped control measles
           in the United States. Ciro de Quadros, a former smallpox
           eradicator, went on to PAHO [the Pan American Health
           Organization], and became a major player in polio eradication in
           the Americas. PAHO associated measles vaccination with polio
           vaccinations after noting that their surveillance of AFP (acute
           flaccid paralysis) for polio revealed a lot of measles. And then
           the Guinea Worm eradication program, with Don Hopkins [Donald R.
           Hopkins], another former smallpox warrior, who came back to The
           Carter Center. I mean, the legacies, the spinoffs from the
           smallpox/measles program are incredible. Rafe Henderson with the
           global EPI [Expanded Program on Immunization] at WHO in GENEVA
           is a great global contribution. I guess it was 1976 or 1977 when
           Rafe went to the World Health Organization (WHO) in Geneva, and
           he expanded immunization. People in Europe ask, "Why the
           Expanded Program on Immunization?" And I laugh, because I'm the
           only one in Europe that was part of the smallpox group. And I
           say, "Oh, that's the expansion of the smallpox/measles."
                 And this is another lesson, and I'm sure Rafe has talked
           about it. All of it is about management. Good management. And I
           hope D.A. gets interviewed, and he says this, and I'll say it
           for him. D.A. was of course head of smallpox at WHO in Geneva
           for many, many years. And on the day he left, he had a press
           conference, and they asked him, "D.A., now that you've
           eradicated smallpox, what's the next disease to be eradicated?"
           And he said, "Bad management."
Harden:     Let me just say, thank you very much for speaking with me.
Roy:        Good.
&lt;/pre&gt;</text>
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                <text>Jean Roy served as a Public Health Advisor in Dahomey, now known as Benin, which had the second highest incidence of smallpox in the world at that time. Jean describes early lessons learned from his work in the Peace Corps in Cameroon and how it led him to a job with the Smallpox Eradication Program at CDC. Jean talks about the role of fetisheurs and smallpox gods in Benin and getting the program started there, as well as the importance of logistics, management, and local context. "All of it is about management. Good management."</text>
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. David J. Sencer, former Director of CDC,
about the West Africa Smallpox Eradication Program in the 1960s. The
interview was conducted on July 7, 2006, at CDC during the 40th anniversary
of the launch of the program. The interviewer was Victoria Harden.

Harden:     Dr. Sencer, before we get to smallpox, I'd like to establish
           that in 1966 you were the Director of CDC and managed the
           overall direction of the West African Smallpox Eradication
           Program.
                 You were born in Grand Rapids, Michigan, on November 10,
           1924. Would you describe your childhood and your pre-college
           education?
Sencer:          I don't remember very much about the early years. My
           father died when I was 4, in 1929, just at the beginning of the
           Depression, and my mother had to go to work. I was an only child
           in an empty house and had to fend for myself. I went to
           elementary school in Grand Rapids and started high school there
           as well. My mother felt that I needed to be in an environment
           where there were more men, however, rather than living just with
           a lonely widow. So she encouraged me to apply for a scholarship
           to Cranbrook School, a boarding school outside Detroit, and I
           was awarded one. My mother had to pay $32 a month, which in 1936
           was quite a burden on her, but between that money and the
           scholarship, I was able to attend Cranbrook School for 5 years.
           I think I received a very good basic education in an environment
           which was much more masculine than being home with my mother.
Harden:     At that time, did you have any notion of what you wanted to do
           for a career?
Sencer:          When I was in high school, the things that really
           interested me were the sciences: biology, chemistry, geology. I
           was more interested in the sciences than I was in the "softer"
           things.
Harden:     You went to Wesleyan for your college education in the middle
           of the war, in 1942. Tell me about going to college at this
           time, and how this prepared you for medical school.
Sencer:          Actually, that's the beginning of the war, 1942, not the
           middle.
Harden:     Yes, the beginning, you're correct.
Sencer:          My first year was a normal undergraduate year. There was
           no pressure to speed up my education, and the draft was not
           threatening. I took normal liberal arts courses-English, German,
           history, and 1 course in biology.
                 The next year, however, the pressure began to build. The
           military had a variety of programs-the Naval V-12 Program and
           the ASTP[Army Specialized Training Program]-through which
           college students could actually enroll in the military, be paid
           a small stipend as able-bodied seamen or privates, and continue
           their college educations with a commitment to become military
           officers after graduation. I was in the Naval V-12 Program at
           Wesleyan.
                 By that time, assessing my various interests, I had also
           decided that medical school would be the best career route for
           me, and I was thinking of getting into biomedical research. We
           didn't call it biomedical research at that time, but doing
           research in medicine was my goal. Suddenly, however, I found
           that I had to accelerate my program. I took organic chemistry
           first thing in the morning, followed by inorganic chemistry,
           which actually provided the introductory material for organic
           chemistry, plus physics. The only things that I could find to
           fill out my schedule were 2 courses in German literature. That
           year I struggled with a very heavy classroom load and completed
           all of my pre-med credits. Although I had not expected it, the
           Navy officials at Wesleyan informed me that I had to leave the
           undergraduate program because I had completed my pre-med
           credits. There were no openings in medical school, however, so I
           was sent to naval boot camp.
Harden:     Let me interrupt you, just for 1 moment before we go forward.
           You said you had determined that you would go into medicine.
           Would you explain how you came to that decision? Did anybody
           push you in that direction?
Sencer:          No, no. There was no role model. That was the way my own
           thinking just evolved, considering my various interests.
                 I went to boot camp and learned close-order drill, how to
           evacuate a lifeboat, how to climb a rope, and other things like
           that. I became a hospital corpsman, which at that time was known
           as a "pharmacist medic." I was at Mare Island Naval Hospital and
           then at the Naval Hospital, Camp Pendleton, the Marine Corps
           base. My name was on a list to be transferred to the Marine
           Corps. During this period, someone asked me if I wanted to go to
           medical school. I said, "I have a choice between the Marines and
           medical school? I'm a coward. I'll go to medical school."
                 Initially, I went to a 2-year medical school at the
           University of Mississippi, in Oxford. I was in a class of 27
           people. After I finished my 2 years there, I transferred to the
           University of Michigan for the final 2 years of medical school.
           Soon after I got to Ann Arbor, a routine chest x-ray showed that
           I had minimal tuberculosis. For a year, I was hospitalized at
           the university hospital because effective drugs had not yet been
           discovered and so tuberculosis was treated with bed rest. In Ann
           Arbor, when they said bed rest, that is what they meant:
           bedpans, meals in bed, etc. Once a month they would weigh you.
           You would roll out of bed onto a stretcher, and they would weigh
           the stretcher and you. After a year of bed rest, you collapsed
           on the floor when you tried to stand up because your knees
           weren't used to carrying your weight.
Harden:     What did you do all that year? Did you read?
Sencer:          I read and listened to the radio. I read the New York
           Times, Harper's, the Atlantic Monthly, and the Saturday Review
           of Literature. The hospital's 1 rule was that you could read
           anything you wished as long as it had nothing to do with your
           job. I read no medicine, no journals. This was good because it
           opened up a whole new variety of things to me. When you have
           been in the grind of pre-med and medical school, you don't have
           time to think about a world outside of science. I also listened
           to the radio. I had an FM radio, and in those days, that was
           unusual. I could get the political broadcasts, the Town Meeting
           of the Air, and similar things that got me interested in
           politics. That year was a life-changing interlude. I won't say I
           enjoyed it, but it was probably the best thing that happened to
           me. I also learned to knit.
Harden:     And would you say this had a lot to do with your later interest
           in worldwide public health?
Sencer:          I think it planted seeds. I did not immediately become an
           advocate of anything, but the reading, listening, and thinking
           planted seeds and gave me a background in things other than
           science and medicine. I went back to medical school and finished
           on a part-time basis because they were very cautious in those
           days about not over-stressing patients with tuberculosis. I
           finished in January 1952 or December 1951. I have the
           distinction of being both the first and last in my class. I was
           a class of 1, so if I want to brag, I can do it. If I want to
           poor-mouth, I can do that, too. I'd met my wife before I went
           into the hospital, and after I got out, we got engaged and got
           married.
                 I started my internship in Ann Arbor, a rotating
           internship in medicine. I continued with what we called a
           residency in those days and call a fellowship nowadays. I had a
           residency in internal medicine for about a year and a half. One
           day on grand rounds, the Chief of Medicine said to me, "Sencer,
           you know the military's looking for you?" I said, "Well, no. I'm
           4F." He said, "Not anymore. They say you're 1A, and they want
           you. They wrote and asked if you were essential, and I told them
           the department would fall apart for exactly 2 minutes if you
           left." By this time, we were also expecting a baby, and we were
           preparing to move out of our apartment before the baby arrived
           because no pets or children were allowed. Here I was, then,
           faced with 2 decisions: what to do and where to stay. I
           contacted the navy to see if I could re-enlist, but they turned
           me down because of my medical history with tuberculosis. The
           navy did say that if I were drafted, it would be happy to take
           me into its quota. I thought that was a terrible way to do
           business.
                 One night, I was at a concert in Ann Arbor and saw a
           friend who was a professor of public health, Cy Axelrod [S.J.
           Axelrod]. I told him my problems, and he said, "Join the Public
           Health Service (PHS)." I said, "What's that?" He explained and
           said that the PHS had a tuberculosis research program that I
           might be able to join. I wrote the Public Health Service and
           said that I want to join their tuberculosis program. They
           responded with the question "Why?" and I answered, "I know why,
           what I want to know is when." Finally, in January 1955, I became
           a Public Health Service officer in the tuberculosis program.
Harden:     Do you think you would have stayed in internal medicine and
           gone into private practice had you not come into the PHS to
           satisfy your military?
Sencer:          We liked Ann Arbor, and I thought that I might just stay
           on at the university.
Harden:     But instead, you joined the Public Health Service and began to
           work in tuberculosis and migrant health.
Sencer:          At first, I just sat around in Washington. They did not
           seem to know what to do with me. I worked as a code clerk on
           some research projects in tuberculosis. Eventually, I was sent
           to Idaho to run a survey of the health status of migrant
           laborers. When I arrived, I found a little caravan of 2 house
           trailers used as examining rooms, a mobile x-ray truck, and a
           mobile laboratory. To gather data, we had to drive to labor
           camps around the Snake River Valley, so I learned how to drive a
           car with a trailer attached. We would go into a labor camp, hook
           up the water, and talk with them about coming in for
           examinations.
                 Several things about this assignment changed my whole
           attitude about medicine. I began really seeing people who were
           disenfranchised. These were people who claimed to be from Eagle
           Pass or Farr, Texas, but you knew very well they were from the
           other side of the border. They had come to Idaho for 6 months,
           but they could not get citizenship during those 6 months, so
           they had no rights in Idaho. The farmers weren't interested in
           paying them anything more than the minimum wage, and there was
           no health insurance. We didn't see much disease in these camps,
           actually, because the migrants were a fairly healthy group. They
           had to be in order to work in the fields 12 hours a day.
                 One case we did encounter was that of a young man who had
           a tuberculosis of the knee. Idaho had agreed to accept people in
           the hospital if they had infectious tuberculosis, but he didn't
           have infectious tuberculosis. We were faced with the question,
           "How do we get him treatment?" Finally, we decided that the only
           way was to bend the rules a bit. We convinced the young man that
           he was under 18-he was actually 20-because if he was under 18,
           he qualified for Crippled Children's Services, a federally
           funded service. By this subterfuge, we were able to get him
           treated.
                 A few days later, we found a 12-year-old girl who had far-
           advanced tuberculosis in the hospital in a town we visited. The
           hospital administrator called us and said, "Get her out of
           here." He obviously did not want to have to treat her any
           longer. I went to see her parents, and I said, "Don't visit your
           daughter, because if you do, they'll make you take her home."
           Instead, we made arrangements to have her transferred to the
           tuberculosis hospital about 100 miles away.
                 To go to the hospital, however, she had to possess 2 pairs
           of pajamas and a toothbrush. Well, pajamas, what are they?
           Migrant workers did not own them. I said, "Let's see what we can
           do." I went to the TB Association, but they would not provide
           the money to buy the pajamas. Their attitude seemed to be, "She
           doesn't buy Christmas Seals, so we won't help her." I went to
           the Latter-Day Saints, as this was a big Mormon area. "She's not
           one of ours," they said. I went to the Catholic church, and the
           priest said, "They never baptize 'em down there in the valley,"
           but he gave me $10 anyway. I gave it back to him. There was a
           small community of Quakers outside of town, and I went out and
           met with their elders, and they said, come back at 6:00 PM. I
           went back at 6:00, and there was a whole pile of clothes. I
           thought, "Oh boy, this is an opportunity to talk to them about
           problems with the migrants." But they wanted to talk about the
           fact they were playing baseball on Sunday in Boise, not the
           thorny and politically volatile problem of migrant people.
           People were willing to help a little on an individual basis, but
           no one wanted to address the larger problems.
                 Those problems, however, got me interested in public
           health because public health measures provided a way in which
           you could do more for large groups of people than what you could
           do trying to help 1 individual at a time. I had begun thinking
           of a career change into public health when I got a letter
           saying, "You're being transferred to Columbus, Georgia, to run
           the tuberculosis research station there." This seemed like a
           great opportunity to me, so we moved, but it was my wife's first
           experience in the South, and Columbus, Georgia, was really
           "South" at that time. She was not a bit happy. I, on the other
           hand, had a wonderful job.
                 And the PHS then sent me to the School of Public Health at
           Harvard. Getting a Harvard MPH [Master's in Public Health] was
           in my view a necessary "union card" for moving forward in a
           public health career. I learned very little at Harvard, except
           from the other students. What they taught me was much more
           important than many of the courses that I took.
                 After finishing my MPH, I returned to Columbus for a year
           and then transferred to Washington, to a job that I thought was
           just terrible. Finally, however, I realized that it provided an
           excellent opportunity to learn how things really happen in
           Washington. I worked in the Bureau Chief's office essentially as
           a "gofer," but I learned about the budget process, about
           interagency problems, and about how things really transpired at
           this level. Then, in 1960, I was transferred to CDC as the
           Assistant Chief, and I fell in love with an agency.
Harden:     That is what I understand. Elizabeth Etheridge stated in her
           history of CDC that you always thought the best job in the world
           was to be Director of the CDC.
Sencer:          Absolutely.
Harden:     So, obviously, your mind had shifted. Your Washington training
           served you well in learning how the bureaucracy functioned. Now
           walk me through your rise through CDC until we come to the
           beginning of the smallpox program.
Sencer:          For the first 2 years, I was the Assistant Director. Larry
           Smith [Clarence A. Smith] was the Director. To become familiar
           with all of the activities of CDC, I obtained copies of all
           articles published by the print shop at CDC and scanned them.
                 During those 2 years, I was intimately involved with
           decisions relating to how polio vaccine would be licensed. In
           1955, when the Public Health Service licensed the inactivated
           vaccine [Salk vaccine], the PHS bought all of the existing
           vaccine and distributed it to the states but did not give the
           states any money to help organize distribution programs. For the
           states, the easiest way to reach children was to give it through
           the public schools. The result was a shift in polio cases back
           towards what was known as "infantile paralysis." By the 1950s,
           polio had become a disease more of older children and young
           adults, but after school-aged children began receiving routine
           vaccinations, it was the preschool-aged children who became
           vulnerable to infection with polio. These tended to be the
           children of people living in the inner cities with low incomes,
           who could not afford to have pediatricians vaccinate their
           children. There were outbreaks of polio in the late '50s and
           early '60s in Kansas City, Chicago, and other cities, all
           concentrated in the inner cities.
                 When oral polio vaccine came on the horizon, the Surgeon
           General's Public Affairs Officer J. Stuart Hunter suggested
           following the same distribution procedure. We at CDC opposed
           this. We wrote legislation stipulating that the Public Health
           Service would provide vaccines, not just against polio, but also
           against all childhood vaccines, to state and local health
           departments and that this vaccine could be used for children
           under 5 years of age. The legislation also included money for
           the states to organize immunization programs. This shifted
           federal law from a focus solely on polio to a broader emphasis
           on general immunization against childhood diseases, including
           diphtheria, tetanus, and whooping cough. This law stood as basic
           immunization legislation for a long time. Vaccines against
           measles, German measles, and chickenpox were subsequently added
           to the law's coverage.
                 Between 1963 and 1966, I was CDC Deputy Director; Jim
           Goddard [James Goddard] was Director. Jim was a wonderful guy.
           He was gung-ho, do everything. After about 6 months, however,
           Jim decided that he was in the wrong job. He thought he was
           better suited to run a small agency that needed to grow or an
           agency that was in trouble and needed to be fixed. CDC was
           neither. So Jim began looking for another job, and, basically, I
           did the day-to-day management of CDC during those years. In
           1966, Jim was appointed Commissioner of the Food and Drug
           Administration, which was an agency that was in great trouble at
           that time and still is.
                 I became CDC Director in 1966. At the same time, USAID [US
           Agency for International Development] transferred the Malaria
           Eradication Program, which was in great trouble, to CDC. Malaria
           eradication was failing because it was based on premises that
           did not work. Suddenly, CDC had the responsibility for a program
           that was failing. We also inherited staff in 16 different
           countries, and we had to fund them out of the CDC budget. It was
           a huge problem. CDC became the biggest employer of people in
           Haiti through the program. The whole Malaria Eradication Program
           became a direct CDC hire, and we could imagine the staff of the
           Malaria Eradication Program 1 day marching down the streets as
           part of a political uproar in Haiti. But over time-not in 1966,
           but over time-we brought about major changes in the way malaria
           was approached around the world. We worked with WHO [the World
           Health Organization] to get away from the concept of eradication
           and to begin emphasizing control and prevention of deaths in
           children.
                 Later, in 1966, the smallpox program started. Actually, it
           goes back before that. Let me reconstruct the history as well as
           I can remember it. I will talk about CDC's involvement in
           smallpox, not the whole smallpox eradication effort around the
           world. During World War II, Alex Langmuir [Alexander Langmuir],
           the Director of Epidemiology at CDC, had been very interested in
           biological warfare. The Epidemic Intelligence Service (EIS) was
           created, in fact, because of the threat of biological warfare
           during the Korean War. During Congressional testimony, Dr.
           Justin Andrews, who was the Director of CDC at that time, was
           asked about how we planned to address biological warfare. Justin
           thought real quickly on his feet, and said that since military
           draft obligations could be fulfilled through service in the
           Public Health Service, CDC would establish an epidemiology
           service of young people who would be trained to recognize
           abnormal occurrences and thus be able to provide early warning
           against biological warfare. That is how the EIS began.
                 Alex, of course, had been plotting for such a program, and
           he happily seized the opportunity posed by biological warfare to
           implement it. For a long time, he had been interested in
           smallpox, and he got D.A. Henderson [Donald A. Henderson]
           interested as well. In 1962, Don Millar [J. Donald Millar] was
           sent to Indonesia as an EIS Officer as part of a malaria
           assessment program, and while there, he saw smallpox for the
           first time. He became very interested in the disease, and when
           he came back, surreptitiously carrying some scabs of smallpox
           for the lab, he was put in charge of what was called "smallpox
           surveillance" in the Epidemiology Program. He was it. No one
           else was involved.
                 Henderson and Millar began discussing whether smallpox was
           a disease that could be eradicated. In contrast to malaria,
           which has a mosquito vector and animal hosts as well as human
           hosts, smallpox is directly transmitted from person to person
           and has no animal reservoir, which makes it possible to
           eradicate. We had a good vaccine, which made the disease
           susceptible to eradication. The military had invented a jet
           injector, which could be used to give rapid vaccinations to
           large numbers of people. CDC helped the military modify the jet
           injector so that it was possible to give intradermal injections,
           since smallpox injections had to be given intradermally.
                 The intradermal jet injector was tested with smallpox
           vaccine in the friendly islands of Tonga. Everybody made cynical
           jokes about why they picked Tonga-why not choose a lovely
           Pacific island with gorgeous beaches? Our audiovisual group here
           at CDC made a beautiful movie of this, called Miracle at Tonga,
           with the waves crashing up on the scene. But the actual reason
           it was chosen was that Tonga had never had smallpox, and there
           had never been any vaccinations, so it was a virgin territory in
           which to try out vaccinating people with a jet injector, and it
           worked very well.
                 In 1965, after a couple of years in Geneva, the World
           Health Assembly of WHO passed a resolution calling for the
           worldwide eradication of smallpox. President Lyndon Johnson also
           issued a statement saying the United States would support this
           initiative and contribute to the effort.
Harden:     Was CDC involved with getting President Johnson to issue that
           statement?
Sencer:          Yes, but I had nothing to do with it. Alex and D.A.
           Henderson worked with Jim Watt [James Watt], who was the
           Director of International Health for the Public Health Service.
           They also worked the streets of Geneva to get the resolution
           passed, and they deserve a lot of credit for this. It involved a
           lot of hard, political horse-trading. The Indians were against
           it, and representatives from countries that had been burned by
           the failed malaria eradication said, "Oh, no, no, no." But D.A.
           Henderson had become quite familiar with WHO, and WHO had become
           quite familiar with D.A., which I think becomes important as we
           go on.
                 One day in 1965, Jim Goddard was out of town, so I took a
           phone from Dr. A.C. Curtis [Arthur Clayton Curtis], who was in
           the African Bureau of USAID. He asked if CDC would like to take
           on a measles eradication program in West Africa. This call came
           at a propitious time. Dr. Harry Meyer at NIH [National
           Institutes of Health], in the old Division of Biologic
           Standards, was testing out different strains of measles vaccine
           in large populations. Measles was a terrible disease in Africa,
           with high mortality in children. It was a real killer. Many of
           the field trials in which Dr. Meyer was involved were done in
           West Africa, and the measles vaccine proved to be a tremendous
           success. USAID looked at the results of Meyer's efforts and
           decided that it might be a good time for CDC and USAID to expand
           the measles vaccine program in West Africa. I told Dr. Curtis
           that we were not interested in measles eradication, because
           measles eradication was not feasible, but that measles control
           might be feasible if we could couple it with smallpox
           eradication. If we could do that, CDC would be interested. And
           he said, "Sure." It was as simple as that.
                 Then began the hard work of negotiating agreements with
           USAID, writing what they call pro-ags [program agreements or E-
           1s], and all sorts of documents that had to be written about
           each country, and getting each country's agreement with the
           documents. Dr. Henry Gelfand, on CDC staff, spent lots of time
           going from country to country, getting country agreements,
           getting things signed, trying to recruit people to become part
           of the program. All of this was happening in late 1965 and early
           1966. Finally, all of the paperwork was done. USAID had agreed
           to fund the program. We had a 5-year agreement with USAID for a
           program to start on July 1, 1966.
                 D.A. was a good friend of mine, and of the family, and his
           daughter and our oldest daughter were also very close friends.
           They were in the same grade in school. His daughter often told
           my daughter that they were moving to Geneva in November, but
           when I would ask D.A. about this, he would reply, "Oh, no, I'm
           not going. I want to stay here and run the CDC program." His
           daughter Leigh, however, continued to say, "We're getting ready
           to leave in November," and D.A. continued to insist, "Oh, no,
           no." But finally, he said that he was moving to the WHO in
           Geneva, arguing "I was ordered to do it." Well, you know his
           mouth was drooling to take on the WHO program all the time.
                 When D.A. was transferred to Geneva, Don Millar was
           appointed head of the Smallpox Eradication Program. Don had been
           studying at the London School of Tropical Medicine for a year.
           He had gone there because there were people in England who were
           very much interested in smallpox and could provide him with
           additional experience and training. You will be interviewing Dr.
           Millar, I'm sure, and you might want to ask him about his
           dissertation at the London School. I'll let him tell the story.
           By the fall of 1966, Don had come back from England. He was the
           logical one to head up the Smallpox Eradication Program (SEP).
                 In the early part of 1966, the SEP had been run out of
           D.A.'s Epidemiology Program. The people in the Epidemiology
           Program were provincial in some ways. They thought that
           epidemiologists were the only professionals needed to craft a
           solution to any infectious disease problem. A big program like
           this, however, requires logistical experts as well as
           epidemiologists, so I pressed the Epidemiology Program to add
           Public Health Advisors to the staff of the SEP... I pushed hard
           to have Billy Griggs appointed as a deputy to D.A. Henderson, to
           deal with the nitty-gritty of organizing and paperwork and so
           on. As the SEP began staffing up for the West African program,
           Billy made sure that there was a person called an "Operations
           Officer" with each of the epidemiologist "Medical Officers." The
           Operations Officer took care of the logistical things that had
           to be done. You'll be talking to many of those.
Harden:     As CDC Director, what made you buy into that idea? Did the time
           that you had spent with the migrants influence your realization
           of how many "operations" details were involved in such a public
           health effort?
Sencer:          Yes. When I first came to CDC, there was an older man
           (he's 9 days older than I am) by the name of Bill Watson
           [William C. Watson Jr.]. He had been in the Venereal Disease
           (VD) Program for a good number of years, and it had been
           transferred to CDC. Larry Smith was the Director of CDC at that
           time, and he had previously been the Director of the VD Program.
           He knew Bill's capabilities. He had moved Bill out of the VD
           Program and appointed him Assistant Executive Officer at CDC.
                 I got to know Bill very well-he was a close personal
           friend as well as a professional colleague. He often told
           stories about how the VD investigators worked, and through
           listening to him, I began to understand that the logistical
           effort was a key part of disease control programs. People who
           could get out in the field, knock on doors, talk to people, and
           understand how people behaved were essential. The first
           assignments given to VD Public Health Advisors usually were in
           local health departments. They tracked down contacts of cases of
           syphilis and gonorrhea and tried to bring them in for treatment.
           After a couple of years of this work, they would become
           supervisors, with responsibility for several other people.
Harden:     And they weren't physicians.
Sencer:          Oh no. They were a group of people who were recruited at
           the baccalaureate level. They were not disappointed pre-meds,
           but rather people who were interested in people. There were
           certain schools at which the PHS traditionally recruited because
           the PHS knew that these schools would turn out the sorts of
           people that they wanted. The recruits would move up in a
           supervisory managerial chain that stood behind the physician in
           charge. In a state health department, there would always be a
           senior Public Health Advisor behind the physician who was the
           state VD Control Officer. The Public Health Advisor pushed,
           pushed, pushed. He or she never made a medical decision but
           pushed the physician to make the necessary decision and assume
           the leadership role. And they learned quickly that this was how
           you get things done. You don't have to make the decisions
           yourself if you can get somebody else to make the right
           decisions.
Harden:     That's very interesting.
Sencer:          Yes. A history of the Public Health Advisors is being
           written. I think they're looking for a publisher.
Harden:     You were explaining how the SEP was organized-what types of
           people were needed. What did you look for in your staff? What
           did they need to be able to run this program successfully?
Sencer:          I looked for Billy Griggs to make good personnel
           decisions. The physicians had already been pretty much recruited
           by D.A. We lost a few real misfits the first year in training.
           Many of the physicians who were recruited were EIS Officers.
           Stan Foster [Stanley O. Foster], for example, had been an EIS
           Officer. He had left CDC and was back in residency training.
           D.A. called him and said, "You want to go to Africa?" And Stan
           said, "Sure," and he came back to CDC. Rafe Henderson [Ralph H.
           Henderson], who had been appointed to be the regional
           epidemiologist on the ground in West Africa, had been at CDC for
           quite some time. He had been on some of the early trips to West
           Africa. Rafe had very good sense about people, too.
                 I put my trust in the people who were running the program.
           I knew Billy Griggs made good decisions; I knew Don Millar made
           good decisions; I knew D.A. was charismatic and a great
           stimulator. He was not the best manager, but while he was here,
           he developed some excellent management techniques. I knew what
           was going on, but I did not micromanage. My philosophy is to
           hire good people to run something, and then you let them run it.
Harden:     When did you make your first trip to Africa?
Sencer:          In the smallpox program? I think my first trip was for the
           25 millionth vaccination event. They had a big celebration in
           Ghana, in 1968, to mark the 25 millionth vaccination that was
           given. This was a great public relations opportunity for the
           Smallpox Eradication Program. USAID thought it was wonderful.
           Many ambassadors were there. Jim Lewis, who you'll be
           interviewing later, was the Operations Officer in Ghana. He made
           most of the arrangements for this great to-do. It was out in the
           country, about 90 miles north of Accra. There were tribal chiefs
           in uniform, with umbrellas and gold robes and dancing, and so
           on. Events like this were called durbars. I remember that the
           American Ambassador shook his head, saying, "I've been to a 12-
           chief durbar, but this is the first time I've ever been to an 18-
           chief durbar." The Surgeon General was there, and he gave the 25
           millionth vaccination to a screaming little girl.
                 After the event, while we were there, we had more
           meetings. USAID had also recruited a reporter from the New York
           Times,. Fred Friendly's son. They had the military attaché's DC3
           from the embassy in Dakar. The next day we flew for breakfast
           from Dakar to Abidjan, had breakfast at the airport with the
           Minister of Health and the ambassador; flew to Monrovia,
           Liberia, for lunch with the Minister of Health and the
           ambassador; and to Freetown, Sierra Leone, for dinner. We refer
           to that as "breakfast in Abidjan." All of this was good public
           relations. It showed that the Surgeon General of the Public
           Health Service was with us-that is, that we had support from the
           top. It reinforced at USAID, too, the importance that we gave to
           the program because we were able to get the Surgeon General to
           participate.
                 From Sierra Leone, we flew to Bamako, in Mali. The pilot
           had never been there. He flew east until he found the Niger
           River, and then he followed the river up to Bamako. Mali, at
           that time, was a Marxist country, with mostly Chinese activity
           there. It was Chinese construction, Chinese this, Chinese that,
           Chinese all over the place. We spent some time in Bamako, then
           flew out to a market town, and then took the Dodge trucks out to
           the Dogon Territory. This was located at the "end of nowhere,"
           out with cliffs that fall off into the sub-Saharan plateau. The
           Dogons are the people who had the big, big masks. They had
           dancing and thousands and thousands of people getting
           vaccinated. It was very colorful. There was a missionary there,
           with whom we stayed. He had been in the mission field for 40
           years. Ten years out, 2 years back, 10 years out, 2 years back.
           We slept under the stars, where there were no artificial lights.
           It was a wonderful experience. The next day we flew to Timbuktu
           and then went on through Niger, Togo, Dahomey, and back to
           Lagos, and home. That was my first major trip to Africa during
           the Smallpox Eradication Program.
Harden:     Tell me more about how you ran CDC as Director at this time.
Sencer:          Even in those days, I was known for "walking around." I
           wanted to know what was happening, so I walked around to see
           things. I would ask questions, and it scared people sometimes.
           There was 1 person I recall, into whose office I seemed to walk
           every time he was reading his paperback instead of working.
           Finally, he didn't even put it in his desk drawer when I came
           in.
Harden:     Could you say a little more about the bureaucratic relationship
           of the Smallpox Eradication Program to the Department of Health
           and Human Services, to the Public Health Service, to the
           National Institute of Allergy and Infectious Diseases at NIH,
           and any other federal agencies?
Sencer:          The West African program was self-contained as far as
           budget and management were concerned. We had our money from
           USAID. Billy Griggs handled most of the dealings with USAID
           concerning paperwork. At the front office level, we did not have
           too many problems with USAID. The collaboration was something
           that we knew about on a day-to-day basis, but it was not
           something that gave us problems. We had good leadership, and our
           philosophy was to get good people and let them do the work.
Harden:     What was the toughest problem that you faced?
Sencer:          During the African program? You know, most of the
           problems, Billy handled. Ask him about that because the toughest
           problems were paperwork and things like that. Our real problems
           with smallpox began after the African program. The 1 thing that
           the African program did was to demonstrate that mass vaccination
           was not the way to go in smallpox eradication. You'll get Bill
           [William H. Foege] to tell this story himself, but early in the
           program, Bill was working as a medical missionary in eastern
           Nigeria. He was volunteering as the smallpox epidemiologist for
           that area. He did not have enough money to buy enough vaccine
           for the mass vaccination program, so he began looking at spot-
           maps of how smallpox was moving from village to village and how
           long it took to move from village to village. He said, "If we
           could prevent smallpox from moving from 1 village to the next,
           maybe we could break the chain of transmission." He developed a
           scheme of getting village leaders to tell them when there was a
           smallpox case. He and his team would then go in and vaccinate
           the people in that village and around it-the contacts of those
           with smallpox-to contain the disease. And suddenly, smallpox in
           his area began disappearing. He hit it at the low point in
           transmission, so he was able to get to all of the foci of
           smallpox, and smallpox disappeared from his area.
                 This strategy was presented in a variety of ways to others
           in the program. Finally, it became possible to see if it would
           work on a large scale. In Sierra Leone, Don Hopkins [Donald R.
           Hopkins] was the Medical Officer and Jim Thornton was the
           Operations Officer. Sierra Leone had the highest rates of
           smallpox in Africa and was as backward as they come. Don and Jim
           knocked out smallpox in months. This impressive demonstration
           caused Foege's strategy to be adopted for the whole West African
           program.
Harden:     What mechanism did you use to tell everybody, "We're changing
           the way we're doing the Smallpox Eradication Program?" And what
           convinced you that Dr. Foege's approach was the way to go?
Sencer:          This was a scientific study. They needed to show
           convincing data that the strategy worked, and they did. I didn't
           have anything to do with it other than to say, "Yes, you've got
           the data to support your argument. We will do it that way."
Harden:     But I understand the World Health Organization's approach to
           smallpox eradication did not change so rapidly, even in light of
           these data.
Sencer:          Yes. WHO was reluctant to accept this. They had been
           selling the concept of mass vaccination, and they were reluctant
           to begin talking about a new approach. They had sold countries
           on mass vaccination, and to change strategies would require that
           they go back and re-educate them. After the West African Program
           was completed, D.A. finally accepted that this was the way to
           go, and it was after the African program that the hard work in
           smallpox eradication began. That is another story, of India and
           Bangladesh and so on.
Harden:     Once you had achieved zero pox in West Africa and had finished
           the program, CDC no longer received funding from USAID. You did
           not want to let the program completely die, however, because you
           wanted to continue surveillance activities, as I recall. At that
           point, you appointed Bill Foege to be head of the Smallpox
           Eradication Program. Would you talk about the follow-up from CDC
           to the West African program?
Sencer:          When we reached zero pox in West Africa, Bill came back to
           CDC. Don was still in charge of the CDC smallpox program for a
           while. Then the International Red Cross called and said that
           they were concerned about the famine in West Africa, which
           occurred as a result of the Nigerian War. The Red Cross asked if
           Bill Foege-they asked for him by name-would come and do
           surveillance of how bad the famine was. Bill went, even though
           his wife was very reluctant to have him go because she knew if
           he went, he might not come back soon because he would want to
           stay and see things through. He went out and developed a
           surveillance technique for the famine, and we began feeding CDC
           people in, to maintain the surveillance activities and to
           identify where the famine was at its worst, so that relief
           activities could get to those places. This was being done with
           CDC money at this point, but we had little authority to pay for
           famine management in African countries. We were able to do it
           under the guise of protecting the United States from the
           possibility of the recrudescence of smallpox. Some of the travel
           was being paid for by USAID, but CDC was paying all the
           salaries.
                 Then the State Department began getting worried about what
           was happening in Biafra, the secessionist state. State asked if
           we would send somebody in to do a rapid assessment. Karl Western
           [Karl A. Western], who had been at CDC for a good number of
           years, agreed to go. He was taken out to 1 of the islands off of
           Nigeria and flown in at night to Biafra. We had no official
           presence in Biafra. Karl did a magnificent job of showing that
           the famine in Biafra was the worst famine that had occurred
           since the potato famine in Holland after the war, but that it
           was localized. He also showed that 1 organization's relief
           activity would set up in a village, and then other
           organizations' relief activities would come in in competition.
           You'd get the Lutherans, you'd get the Catholics, you'd get the
           Worldfam, Oxfam, and so on. This meant that some villages were
           getting all of the aid, but the major part of the country was
           not getting any. Aid was flowing to places where it was easy to
           get to but not out in the bush.
                 As a result of Western's work, I got a call 1 night from
           Jesse Steinfeld, the Surgeon General. He said, "You and Western
           get to town, right now." On a snowy January night, we went to
           Washington, to the White House. We went into the Situation Room,
           and who should show up but Henry Kissinger. Suddenly, we were
           briefing Henry Kissinger on famine in Biafra. At that time,
           Kissinger was the National Security Advisor. In typical
           Kissinger fashion, he was playing USAID, which was arguing that
           there was no problem in Biafra, against the State Department,
           which was arguing that there was a serious problem in Biafra. He
           was enjoying the bureaucratic struggle. He didn't give a hoot
           about famine. It was the bureaucratic struggle. Kissinger later
           became Secretary of State.
                 We also briefed the State Department person who was going
           to Congress the next day. One of the major signs of malnutrition
           is edema of the legs, which is caused by protein deficiency.
           Assessing edema in a population was a quick way of determining
           how bad the famine was. This Assistant Secretary of State kept
           calling it "endema," and we kept saying, "No sir, it's 'edema.'"
           "Oh, yes," he would say. He got to Congress, however, and in his
           testimony, it was "Endema, endema, endema."
Harden:     I want to drop back into the smallpox program and ask if there
           is any other event of significance that springs to your mind
           like the 25 millionth vaccination event you described?
Sencer:          We went to a village, Ede, in Nigeria, for the observance
           of the 10 millionth vaccination in Nigeria. When we got there,
           there was the Timi, who was the chief of the village. He was
           wearing a leopard-skin cap and robes, and when he went out into
           the town square, everybody gathered around. He stood up and gave
           the most erudite history of smallpox in Nigeria, back into the
           early days of colonialism. It was beautiful.
                 Afterwards, we went in to his house and saw a plaque on the
           wall that said, "Honorary Kentucky Colonel," and another plaque
           that said, "Honorary Alumnus of Western Michigan University."
           Surprised, I asked him to tell me about those plaques. He said,
           "I'm an expert in the talking drums, and the State Department
           takes me to the United States to give lectures on the talking
           drums. In return, Kentucky made me an honorary colonel, and
           Western Michigan made me an honorary alumnus."
                 We asked, "What are talking drums?" He said, "The drums
           talk. They don't talk in code, they talk in Yoruba. Would you
           like a demonstration? I always keep a drummer out in the
           courtyard across from my house in the morning, so he can tell me
           what's going on in the village on the drums." He then asked his
           drummer to demonstrate the drums. One of the USAID people said,
           "Have that man across the way come in and bow to the Timi and
           throw the cat out." So the drummer pounded away, and this guy
           came running across, bowed to the Timi, picked the cat up, and
           threw it out.
                 I said, "Hmm, put-up job." He said, "All right, you tell
           him what to say with the drums." I was smoking in those days. I
           said, "Tell the man to come and take a cigarette out of my
           pocket and light it. He pounded the drums, and this guy came in,
           counted 1, 2, 3, 4, to me, reached into my pocket, took out a
           cigarette, put it in my mouth, reached into his robes, and
           pulled out a lighter. He said, "You know, it's true. We speak in
           syllables. The drum has a head that you can squeeze the side of,
           and it changes the sound, the tone, but it has trouble with
           English words.
                 Don Millar said, "How would it say 'Dr. Millar?'" He said,
           "Oh, that's Yoruba. Do-ki-tar-mil-lar." And that drum began
           going, "Do-ki-tar-mil-lar, do-ki-tar-mil-lar." You could hear
           it. Bill Foege-he was known as the tallest man in Africa-said
           that when he was coming to a village, the drums would pound out,
           "The tallest man in Africa is coming." Learning about the
           talking drums was a wonderful experience.
Harden:     What else did you learn about Africa in the program?
Sencer:          What did I learn about Africa? Oh, my goodness. In those
           days, it was a wonderful, wonderful part of the world. There was
           a lot of concern about improvement, but they were not as highly
           politicized as they are now. You would get outside the capital
           city and find wonderful people who were shaking off colonialism.


                 One of the things about the West African program is that
           there were 2 very distinct parts of Africa in which we worked:
           francophone Africa and anglophone Africa. Each had a very
           different medical system. The French were much better organized
           than the English. When colonial government ended, the English
           just picked up and left. The French left things behind and left
           some Frenchmen behind, too. They pretty much controlled the
           currency, and communications, and so on.
Harden:     Let me change the question slightly. What did Africa learn
           about the United States and CDC?
Sencer:          Thank you for asking. One day in 1969 in the World Health
           Assembly, the Minister of Health of Mali, which had been a
           Chinese-Marxist country, made a speech. This man said, "I want
           to thank the United States for giving us assistance in our
           smallpox eradication program, but not so much for the vaccine or
           the machinery or the Jeeps but for the people that the United
           States sent to help us." That, to me, was the crowning glory of
           the program. The Africans recognized that it was people rather
           than things that the United States gave to Africa. We had sent
           to Africa young guys and gals who had had no experience in
           diplomacy, who had no experience with politics and so on, and
           they went out, altruistic and wanting to get a job done. "We've
           got a job, let's go do it, we can't do it ourselves, and we've
           got to get the people in Africa to do it. We'll be there to
           stand behind them and push. We'll give them the tools, we'll
           give them the know-how, but they've got to do it." And they did
           it.
Harden:     I have just a few more questions. In the middle of the West
           African project, some people recommended that smallpox
           vaccinations be stopped in the United States, and this became a
           hot topic of discussion at CDC. Would you comment on that?
Sencer:          Actually, it was a little after the West African program,
           because it was in 1972 that we really came to the belief that we
           could safely stop smallpox vaccinations. By then, enough
           eradication had been achieved, not only in Africa but in other
           parts of the world, to minimize the threat to the United States.
           The risk of importation was so slight that the risks of
           continuing vaccination with the predictable adverse reactions
           that occur with smallpox vaccine far exceeded it. As usual, we
           had a meeting of our immunization advisory committee to go over
           all of this.
                 We met on a Saturday morning. I had invited the Medical
           Officer of Health of Great Britain, George Godber, with whom I
           had seen recently, to come to our meeting. George was a
           fascinating person. He was the architect of the National Health
           Service in England. Ruddy-faced, white hair, monocle. He had
           lost this eye, and he said, "Why spend money on 2 lenses? I only
           need one." He kept a handkerchief up in his sleeve to pull out
           and wipe his eye. He was a real character but highly articulate.
           He wrote and spoke beautifully. At that meeting, we struggled
           mightily with the wording of our recommendation on smallpox
           vaccination. George finally said, "Dave, excuse me, this is your
           country. But it is my language." He clarified the wording for
           us.
Harden:     If you were going to start the program over again, would you
           change anything about how it was run?
Sencer:          No.
Harden:     Not a thing?
Sencer:          Not a thing-as long as I could have the same people.
Harden:     How did the program change your career at CDC? What impact did
           it have?
Sencer:          It changed CDC, and since I was part of CDC, it changed my
           career. What it did was push CDC into international health, into
           global health. It was the first time that we had responsibility
           for a large international program from its inception. We had
           inherited the malaria program, but the West African Smallpox
           Eradication Program was totally a CDC operation. This was the
           beginning of CDC's global involvement that continues to this
           day, not just of ideas and equipment, but of people. In Dakka,
           at the old cholera lab; we started the field epidemiology
           training programs in different countries. It just goes on and on
           and on. I think that individuals grow with the organization. You
           don't pull the organization. The organization pulls you.
Harden:     Since your role in the smallpox program was here at
           headquarters in Atlanta, did it have any impact on your family?
Sencer:          Not as much as it might have, although I did a lot more
           traveling after the program began. I was not a traveling
           salesman, just home on the weekends, but I did have to travel a
           lot. It became worse with traveling to Washington, but I think
           my family were envious of my going to Geneva for 2 or 3 weeks
           every year for the World Health Assembly meeting, and things
           like that. But I don't think it had any great impact on the
           family.
Harden:     But all 3 of your children are in the field of health in 1 way
           or another. Am I right?
Sencer:          Yes. Our oldest daughter, Susan, is a pediatric
           oncologist. Our middle daughter, Ann, is a nurse practitioner in
           oncology, and our son, Stephen, is Deputy General Council at
           Emory, but he handles a lot of the research and intellectual
           property sorts of things there.
Harden:     Before we stop, is there anything else that you would like to
           add?
Sencer:          I'm tired.
Harden:     Thank you very much for speaking with me. I think this gets us
           off to a wonderful start for these recollections.
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. Ralph H. "Rafe" Henderson, about his role in
the West African Smallpox Eradication Project of the Centers for Disease
Control. Today is July 7, 2006, and this interview is being conducted as a
part of the 40th anniversary reunion of the launching of the Smallpox
Eradication Project. The interviewer is Victoria Harden.

Harden:     Dr. Henderson, I want to begin by setting the stage for who you
           were in the smallpox project, and I'd like to start at the
           beginning. If I am correct, you were born in New York City, on
           March 5, 1937. Would you give me a brief account of your
           childhood and education, who your parents were, and whether any
           of these early experiences nudged you towards medicine or public
           health?
Henderson:  Yes. My father was born in Burma, which is the explanation for
           my nickname, Rafe. The British soldiers in Burma, who were then
           in charge, used Rafe as a nickname for Ralph. My father's name
           was also Ralph, and when he named me Ralph, then they called me
           Rafe as a nickname. So that explains that. But it also explains
           my orientation for international health. My grandparents were
           medical missionaries; their grandparents were also medical
           missionaries in Jamaica. My uncle was a medical missionary in
           China. My father was the black sheep of the family: he went into
           publishing with the Reader's Digest.
                 But my brother and I became physicians. When I was doing
           my internship at Boston City Hospital, I was contacted by
           somebody from CDC, who told me about the Epidemic Intelligence
           Service (EIS). And that, combined with a lot of my other
           interests in the international sphere and missionary work-
           although my father was not religious and I'm not particularly
           either-seemed to be a very good next step for my career in
           public health.
Harden:     Let's drop back a little bit and ask you to talk about your
           years at Harvard. You were at Harvard for both your
           undergraduate education and medical school. Was there anybody on
           the faculty who was particularly important to your career?
Henderson:  Yes, obviously in college, one always has heroes. Mine was a
           psychologist named Jerry Bruner [Jerome S. Bruner], who was
           dealing with cognitive psychology, and I found that very
           interesting. I won't tell you the funny things we did, but in
           any case, it was an interesting time at Harvard. I was there
           only 3 years because I had spent the year before going to
           Harvard as an exchange student for the English-Speaking Union.
           So I was in the U.K. for a year, in what was a public school,
           before coming to Harvard, so I was only at Harvard for 3 years.
           Then I went on to medical school.
                 In medical school, many of us were very, very influenced
           by Professor Thomas Weller, who had worked with Enders [John
           Franklin Enders] and Robbins [Frederick C. Robbins] in
           developing the polio vaccine and later on the measles vaccine.
           Weller was very eloquent about tropical public health and the
           challenges and the needs that were going on. As I say, a whole
           bunch of us came out from under his tutelage very interested
           (well, let's say interested because we were too young to be
           career-committed at that point). I think he was a strong
           influence.
Harden:     You joined CDC immediately after your internship and residency
           in Boston City Hospital. Were you one of the folks joining
           initially to avoid-pardon me, to discharge-your military
           obligation?
Henderson:  Well, I think "avoid" is a very good term because I think for
           many of us, that was 1965, '64, '65, when the Vietnam War, was
           just starting. And how does one want to spend one's military
           career? Well, it was certainly a very easy choicevivid  one for
           us. I would like to think that my own reflexes-both seeing the
           difficulties of practicing in a city hospital, where you're
           seeing end-stage disease and not being able to do very much
           about it, and my interest in international health-made CDC a
           choice whether or not there had been a military draft. But it
           was clear that that served the best of all purposes as far as I
           was concerned. I was not interested in serving in other areas of
           the military. I was very interested in serving in what I knew,
           at that point, CDC was doing.
Harden:     In public health service.
Henderson:  Right.
Harden:     So in 1965 and '66, you were an EIS Officer. Would you talk a
           little bit about your EIS training and assignments?
Henderson:  Well, it was incredible. In those days, they used to call the
           interns "the iron men" because we didn't get salaries, we ate at
           the hospital, we often slept at the hospital, we had 1 set of
           clothes. But we came to Atlanta and we're presented with a slide
           rule; we got a salary; we were treated like important
           individuals. It was incredible. Absolutely incredible. And we
           had a very exciting 6-week EIS course, training us in shoe-
           leather epidemiology. Because of my interest in international
           health, I applied to the smallpox unit. I was lucky enough to be
           selected. And then, lo and behold, I was sent off, very shortly
           after the training, to West Africa as a technical advisor to the
           French public health organization in the western part of West
           Africa, called the OCCGE [Organization de Coordination et de
           Cooperation pour la Lutte contre Grandes Endemies]. That's a
           very long name, but part of it, the Grands Endemies, translates
           into the "great endemic diseases."
                 I have to back up a couple of steps to explain why I was
           going over there. In about 1963, roughly, the NIH [National
           Institutes of Health] conducted a major field trial of measles
           vaccine in West Africa, beginning in Upper Volta, as it was
           called. And it was an astounding success. They covered most of
           Upper Volta in a few months, with mobile teams, and did it very
           well. They had high vaccination coverage, and measles pretty
           well disappeared.
                 Now, that was a self-serving exercise, in that we, the
           United States, wanted to test the measles vaccine on a large
           scale. Here was an area where this could be done, where it was
           desperately needed, where kids were dying of this disease, and
           you would have had to have a very, very bad vaccine indeed, not
           to be ethically justified in doing a combined trial of the
           immunization and of the vaccine itself and seeing what impact
           you would have on public health. Well, the impact was absolutely
           astounding.
                 One of the reasons that USAID [US Agency for International
           Development] was willing to go along with D.A. Henderson [Donald
           A. Henderson] and others at CDC in joining a smallpox
           eradication program, which USAID wasn't interested in, with the
           measles program, which USAID was interested in, was that they
           knew that they couldn't do much with the measles program unless
           they had some good technical support. USAID had some disastrous
           experiences without technical support, before they funded the
           full program in '66.
                 Because the United States had the measles vaccine and no
           other nation did, it was perceived that a measles immunization
           program allowed the United States an entryway into West Africa,
           where the French culture was dominant, one that did not compete
           with the French either on educational or economic grounds. But
           here was a neutral health ground-very popular concept. All the
           countries desperately wanted the measles vaccine because measles
           was such a bad disease.
                 And so I went over as one of the people to help out in the
           stages before the full program got going. I was advising OCCGE
           in running these mass immunization campaigns with measles
           vaccines.
                 Now, the French were very good at doing mass campaigns;
           there was no problem with that. The problem was that they were
           not very good at dealing with this funny, electrical jet
           injector, which we were using to administer the vaccine. And
           they were not very good at dealing with the many, many
           difficulties in supply and logistics posed by our USAID and U.S.
           Government contributions to the programs. And so, when I
           arrived, or at least one of my interviews was with the Ministry
           of Health in Upper Volta and with the Chef des Grands Endemies,
           the French advisor who was running the Grands Endemies. The
           Minister was furious because our 5 Dodge trucks that had been
           given to help administer the vaccines were consuming his entire
           budget of gasoline for his entire Grands Endemies. And the USAID
           deal was, "We give you the trucks, but you run them. You pay for
           the gasoline." And of course, that just wiped out the budget for
           the Ministry of Health for gas. All of these enormous trucks
           were consuming all the gasoline. And so he was not a happy
           person.
Harden:     Was there any solution to this problem?
Henderson:  They did the best they could. They were unhappy, but they did
           not do  a bad job with the things.  One of my problems as
           advisor was firing off cables about getting spare parts for the
           jet injectors. They kept running out of some tiny points-I
           didn't know what they were, but I think that on a regular engine
           they'd be called the points. They relate to the electrical
           system. Forget it. But that's all I knew. And I knew that they
           were burning out, and they couldn't get spare parts. So one of
           my jobs as a technical advisor, very technical, was to send
           cables back saying, "Send more of these things because they
           can't run the injectors." Nor did CDC send enough diluent, so we
           were often using Evian, one of the French bottled waters, as
           diluent for the measles vaccine.
                 I was overseas for about 6 months, traveled widely in
           those countries. I was treated extremely well by the French
           advisors, even though they knew I didn't speak very good French
           and they knew a lot more than I did about anything they cared to
           ask me about. But they were very gracious, very good about
           teaching me and helping me learn about things. I think I saw in
           those 6 months enough problems to last me the rest of my life
           about what can go wrong with an immunization program and with
           other kinds of public health programs that you're running. It
           was extremely valuable.
Harden:     One of the points that has been made over and over here is that
           medical knowledge about smallpox was really only the first step
           to eradicating it. The logistical problems, and the personnel
           problems, and the diplomatic problems, all of these things were
           key to eradicating the disease. So you were seeing this in
           advance of the project.
Henderson:  Yes, I think that's very true. I think the CDC tradition,
           though, is an important one to emphasize. We medical people went
           over with public health advisors, who joined us as nonmedical
           people, who were there exactly for the management issues. CDC
           had had a long tradition of this in the venereal disease control
           program, as it was called in the old days, and the advisors then
           branched out into tuberculosis and many other programs. There
           were always public health advisors who were trying to get the
           logistics and the management right. And so I think the CDC
           position was, "We've got to have some medical expertise to be
           credible, but we really need the management to be sure that we
           can be effective." And I think that was really the key to the
           success of much of what we did.
                 We didn't have such great medical knowledge of smallpox,
           if I can say that. The program was designed to immunize
           everybody in West Africa against smallpox, sort of a 100%
           vaccination coverage. And we didn't find out until a couple of
           years into the program that we didn't need to do that. That was
           one of the really startling breakthroughs in the program-the
           ring vaccination strategy of simply immunizing around active
           smallpox cases, breaking the cycle of transmission, and not
           going all-out to maintain high levels of immunity in all sectors
           of the population. We learned that relatively rapidly, I must
           say, within a year or so of the program. But it was a major
           conceptual breakthrough for us.
Harden:     Would you walk me through setting up the regional office in
           Lagos? You were the Deputy Director and the epidemiologist. I
           know that the Director, Dr. Lythcott [George I. Lythcott], is no
           longer alive. So will you tell me about how it was formed and
           how it functioned?
Henderson:  Well, it's a funny thing. I have very little idea about that. I
           knew that there was to be a regional office and that George was
           the Director. When I was in West Africa, and the full program
           came into being, I was then recruited from my role as an EIS
           Officer to join as the Deputy Chief of the regional office.
           George had worked in Ghana, and was a senior person, very well
           respected. It was perceived that if we were going to have a
           regional office, we should have a good regional office. And in
           the early days, as I understand it, the idea was that this would
           be the first regional office. Then, as the program expanded
           worldwide, as we got rid of smallpox in West Africa and then
           moved to other regions, there would be other regional offices in
           other regions, which were similarly constituted. In any event,
           we never did that. Ours turned out to be the only regional
           office.
                 I was there as an epidemiologist, but I was one of the few
           people who spoke French. So even though I didn't speak French
           very well, my responsibilities were mainly for looking after the
           francophone countries. My role as deputy was sort of doing all-
           hands work. We had an equipment specialist with us, a very good
           health educator, a statistician, and a secretary who was
           knowledgeable about local and embassy issues having worked  in
           West Africa before. And we also had Jim Hicks [James W. Hicks],
           our Senior Administrative Officer, who was very effective.
                 George, as the Director, dealt with all the terrible,
           terrible political problems that were really insolvable, and he
           managed to solve most of them. Jim Hicks dealt with equally
           difficult administrative problems, like who had furniture in
           their houses just in Lagos; could we get transport from the
           embassy in the early days; what was going on with the financing
           of things. He had all sorts of fights  with the embassy and the
           USAID mission, who didn't really have the resources to give the
           support that they were supposed to to our group in the regional
           office.
Harden:     Now you, as I understand, wrote most of the E-1s, the programs
           for each of the countries, in the francophone countries. Is this
           correct?
Henderson:  I don't remember that. At my age, I'm finding that happens more
           and more often. I do know that I spent some time going around
           with George Lythcott and Henry Gelfand trying to finalize and
           write what we called pro-ags, project agreements.
Harden:     Yes, that's what I meant.
Henderson:  That's right. I recently got a communication from a colleague
           who was working with us in West Africa. He sent me some of the
           letters he had sent me then. And he quoted me asking if we could
           give some of the cars that had been assigned to us, as advisors,
           to our national counterparts? And he said in the letter to me,
           "Rafe, you had already anticipated this and put the request in
           for these cars. You knew that they would be needed by the
           ministry, and that you couldn't justify it just for the
           ministry, but you would justify it by giving it to the advisors
           who were there, anticipating that they would then be shifted
           back." I have no recollection of that at all.
Harden:     There was, at this point, however, some tension between CDC
           personnel and USAID as to whom the CDC reported to-whether they
           reported to USAID, or reported to CDC through the regional
           office .  And I think it fell on you to clear the air about
           this, if my reading is correct.
Henderson:  Boy, I don't remember that either, very much. I do remember
           going to a couple of countries; my wife and I were talking about
           that. I remember being in Chad, and I was trying to recall, 40
           years later, why was I in Chad? And then it occurred to me,
           there was something going on with USAID and our staff there that
           I apparently was trying to mediate. Again, I don't remember the
           details of that. I do remember that there was a general problem
           when we from CDC came into the West African countries, and we
           felt we were masters of the universe, and there was nobody about
           to tell us what to do, certainly neither USAID nor the embassy.
            We had a mission. We were going to get our stuff done. And so
           that was a general tension that I do recall. I don't remember my
           role exactly, and what I did about it.
Harden:     You started to tell me about developing the cluster sampling
           system and the instruments we adhered to, to do the sampling.
           Would you explain, for the record, what cluster sampling is, and
           how you developed it?
Henderson:  I can, but I would also like to go back at some stage, to lead
           up as to why I ever got into that.
Harden:     Okay, let's go back. Tell me how you got into cluster sampling.
Henderson:  I had come back from India in the spring of 1967, when there
           was a smallpox outbreak. We had been expected to eradicate
           smallpox in India in a very short period of time. We did not
           succeed in doing that. My wife and I came back to CDC, and found
           that, in the interim, the Biafran War had broken out. She was
           then not allowed to go back to Lagos as a dependent. I would not
           go back to Lagos without her, and we arranged a compromise, as
           my range of responsibilities was the francophone countries
           anyhow. I did a whole series, 6 months or so, of continuous
           consultancies, firefighting, and all sorts of stuff in West
           Africa.
                 And then the Biafran War settled down, and we were able to
           go back to Lagos. I got back to my regular job, as Deputy Chief
           of the regional office. And I promptly got myself into trouble
           with headquarters because I kept feeling that the policies that
           we were being asked to follow by headquarters were not the best
           ones for us in the field and that there was not a very good
           understanding of what was needed in the field.
Harden:     And when you say headquarters, you mean here in Atlanta?
Henderson:  In Atlanta. So I became a very shrill voice, I'm afraid,
           demanding and troublesome. And I don't remember whether I was
           called back, or whether I had to come back on for another
           occasion, but when I did get back here at CDC, I was pretty well
           told, "Enough of this nonsense. We need some assessments done.
           Go do them." Again, my memory is foggy, and it may be that there
           was a lot of help, but I don't remember. What I remember was
           going off and saying, "Oh yeah. Okay. We need to do
           assessments." And it turned out to be 3 major assessments, one
           in northern Nigeria, one in western Nigeria, one in Niger. And I
           brought some reports that I'd been looking at recently, and
           trying to scratch my head, and yeah, the cluster sample survey
           was part of that assessment or evaluation. There were also
           aspects of the assessments where we reviewed records,
           interviewed people, looked at the health centers, inspected
           vaccination teams, and the rest of it. So it was a very
           extensive project.
                 Now on cluster sampling: if you do a random sample, if it
           was the Gallup polls that we do in the United States, you can
           get away with sampling a relatively tiny fraction of the
           population. But you have to do it in a very meticulous, random
           manner, so that the individual that you select is not selected
           with any bias that you can imagine. This is very intensive, very
           expensive, and very difficult to do. A compromise that was
           developed by CDC staff, Serfling and Sherman (Robert Serfling
           and Ida Sherman of CDC), here in the United States, was a
           cluster technique. And that meant that, rather than taking a
           single individual and asking questions, you could take a group
           of individuals. But if you did that, you had to compensate for
           the fact that they were a group and no longer independent. So
           one of the group had more similarities to the other members of
           the group than if you'd taken a totally different person from a
           different area because the cluster was a geographic cluster. So
           you would get households that were all together, or members of a
           household that were all together-that was the "cluster" part of
           the cluster . Rather than sampling as individual people, you
           sampled them in groups. I had learned the Serfling-Sherman
           technique as an EIS Officer. We had done a sample in Atlanta.
           Bill Foege [William H. Foege] did a modification of that in The
           Gambia early on. I knew about that.
                 So when I was asked to run these surveys, run these
           evaluations, and do a cluster survey as part of that, I further
           adapted that survey. To look back on that, it was incredible.
           How am I going to do a survey in a huge area of the country?
           What kind of a sample do I select? How do I get the records
           done? How do I collate them? I taught myself to type; I didn't
           know how to. I realized I was going to have to write these long
           reports, so I was going to have to type.
                 I realized I was going to need some way of recording the
           data. So I had worked on my own files with McBee cards-strange
           animals. I'm just going to hold up one. It's a strange card with
           a lot of holes on the sides of it. And you punch a notch in a
           hole. Each hole corresponds to something you've written on the
           card. So, for example, is this person who you're sampling a male
           or a female? Male, 1; female, 2. If they check 1, I punch 1,
           which is numbered on the edge of the card. At the end of the
           day, I get a hundred cards together, and with a sort of
           knitting needle, I run through the hundred cards, at the number
           1. And lo and behold, all the cards that have this number
           punched fall out, if I shake them vigorously enough. These cards
           were fascinating to use-difficult to use, but a godsend because
           I could then train teams, who would go out with these cards and
           then, while they were in the field, simply mark a number for
           each of the data points I had. Then at the end of the day at
           their leisure, they would take a paper punch and punch out the
           holes that corresponded to what they had found during the
           survey. Then I collected all the cards from all the teams at the
           end of the survey, went home, and spent a long time shaking
           knitting needles and having the cards fall out. And I'm sure
           there were a lot of errors involved with the things. But it was
           absolutely an incredible exercise, and I can't believe, even to
           this day, that I was able to do that, with very short notice, to
           go in, to design the cards, to decide on the sample surveys.
                 But I want to talk a little bit about the actual sample
           survey design because that was fascinating. What are you going
           to do with a population that is as varied as you have in West
           Africa? Yes, you've got some people in cities, but you've got
           people in villages. You've got people that don't particularly go
           to a village; they're nomads; they're all over the place. And,
           again, I'm just impressed with ourselves, myself, in that time.
           We designed the sample surveys to try to get if not a valid
           sample, at least an idea of these various groups.
                 So, for example, we could have a sample survey that said,
           let's take a valid statistical survey of all the villages in a
           catchment area, or a state, or a country, that are under 5,000
           population. Perhaps we thought under 5,000 would be a high-risk
           group for smallpox. We'd get all the villages. So you select,
           say, 30 villages out of those. And then we said, "You get your
           sample from that village but then leaving the village, for the
           next 10 kilometers, you stop every person you see, and you
           interview them-no matter who they are, or what they're doing."
           And then we said, "In addition to that, you go to some of the
           local markets, and you do a market survey and find out who's
           there. And within the market, sometimes you can select
           individual groups." We knew there were nomadic tribes, and we
           could recognize them because they wore distinctive things. So we
           could say, "Survey 10 of the nomads from this area, and 10 from
           that area."
                 In western Nigeria, we had an area of the state that was
           very heavily influenced by fetisheurs, by the traditional
           healers. And we knew that they had a cult, the Shapona or
           smallpox cult, that did not appreciate being vaccinated against
           smallpox. They were against vaccination. And we knew that
           vaccination coverage was lower in that area than in other areas.
           So we did a separate sample of the fetish area and the nonfetish
           area.
                 We did all sorts of tricks to try to probe where we were
           weak. It wasn't so much that the sample was going to give us a
           wonderful average of what was going on in the country, but my
           idea was, let's point the finger at where we think we're doing
           least well. Let's find out what's going on there; that's where
           we need to make the changes. It was just a fascinating
           experience. As I said earlier, the survey was only part of the
           full assessments we did.  We also looked at records, we
           interviewed people, we inspected vaccination teams.
                 We found faults everywhere. There were problems
           everywhere. And that was one of the great lessons that I learned
           in my life-despite all the problems that you find every day, and
           despite the fact that you think nothing's going well, that isn't
           always the case. You can have some success despite it.
                 The other thing that was impressive looking back now on
           this, is that there was no stopping us. I mean, getting a sample
           survey, doing these assessments, that's no problem. We'll just
           do it. And I think it was the attitude of the entire program. We
           had a goal; we were going to do it; nothing was going to stop
           us.
                 I'll tell you 1 other anecdote that illustrates that. We
           got stuck in western Nigeria during one of these assessments. We
           got often stuck in western Nigeria. It was during the rainy
           season, and we spent more times pulling ourselves out of mud
           holes than anything else. But we were in a rubber plantation,
           for reasons I don't understand, but we were doing a survey
           there. And it turned out that the vehicle was running down on
           hydraulic brake fluid. The brake pedal kept getting weaker and
           weaker. And we knew when we left in the morning that we needed
           some extra fluid. We had some, but by the middle of the day, it
           was getting low, and we were running out. And we finally looked
           under the hood and found that the brake line was rubbing against
           the engine, and it had cut a little hole in the hydraulic line.
           And I said, "Right, okay. I know how to do that from an intern
           in Boston City Hospital. Give me some tape, and I'll tape it
           up." I taped it up. But each time I did it, because the brake
           line has a lot of pressure it just blew the tape away. It didn't
           work at all. We were down to our very last little bit of
           hydraulic fluid, and I said, "Right. What am I going to do?" And
           we got some cotton that we had for first aid. I took some sap
           out of a rubber tree, chewed the sap into the cotton to make it
           a solid compress, and tied a whole series of very tight suture
           knots around the hydraulic line. Amazingly, the thing held 'til
           we got back at the end of the day. But that was the attitude:
           "This isn't going to stop us. We can fix this. Nothing is going
           to stop us." And that happened over and over and over again, to
           everybody in the program. It was incredible. And I think it was
           one of the things that made the program just such a success.
           People would not be stopped.
Harden:     Now, do a little analysis here. Was it just because these
           particular people were so special? Was it an American thing? Was
           it inspiration from above? What do you think made this group?
           Obviously, it's a very special group. Do you have any opinions
           on this?
Henderson:  I hesitate to say it, but I'll say it anyhow. It's not a very
           special group. And I think that's the magic of it. Special in
           that the challenge was there, yes. Good leadership. Good
           support. A strong image of what needed to be done. But by God,
           when you do that, and you give people responsibility and things
           that they've never met before, most times, most people will rise
           to that challenge. And I say that because I then had experiences
           later in life, in the World Health Organization (WHO), or other
           programs, where we had the same sort of thing. We had specific
           goals to achieve and people from many cultures, many different
           backgrounds, still rising to that challenge in an extraordinary
           way.
                 And don't forget, as I'm sure that nobody will, that we
           were a tiny fraction of those who did the work. Most were the
           nationals -  the vaccination teams, the staff, the people living
           in the endemic villages. So let's be clear that we were helpers
           in a project that was done largely by national staff.
Harden:     Were there any particular problems in dealing with the national
           staff that you recall or were there good relations from start to
           finish?
Henderson:  I would have to say mixed. I think the relationship got better
           as we all got more familiar with the environment and the
           cultures with which we were dealing. When we arrived, we, the
           CDC people, fresh out of the U.S., were impatient. We didn't
           understand why something couldn't be done yesterday; what was
           the problem? And of course, the folks we were dealing with-
           whether it were the national ministries of health, the French or
           English advisors who were there, the other expatriates-they
           thought we were nuts when we first arrived. They couldn't
           understand why we were having these expectations. Many of the
           French thought that the word "eradication" should be eradicated.
           They had very little little time for this eradication concept.
                 And so, yes, there were a lot of tensions with that. But I
           would have to say, again, that the experience of the public
           health advisors-who had dealt with those kinds of issues in the
           United States with state and local health departments and
           recalcitrant public officials at all levels and learned to find
           ways of getting things done so that everybody went along with it-
           these types of situations are where they really shone. We in the
           medical officer field were often not so good at that, and I
           think we were very well served by having the public health
           advisors with us.
Harden:     In December 1969, there was an observance of the hundred
           millionth vaccination in Niger. Were you involved in that at
           all, and do you have any special memories of that event?
Henderson:  That was in Ghana, and I have some memories of it. I wasn't
           involved with the organization of the event, thank goodness,
           because it was a massive affair. But I do remember going and
           giving an interview to the Ghanaian newspaper about things. The
           report of the interview in the press talked about our work in
           eradicating rabies or malaria, or something totally not having
           anything to do with what I had said or what the program was
           about. One of the reasons I was doing that interview was that, I
           think the Minister of Health and George, the Director of the
           program, were off doing the hundred millionth observance, and
           they needed somebody to satisfy the local news media who could
           speak about the program. So my role was a very minor one. But it
           was a grand affair.
Harden:     If you were going to do the program all over again, would you
           change anything about the way it was run?
Henderson:  Given that it worked, I think not.
Harden:     How did the smallpox eradication program change your life and
           career, or did it?
Henderson:  Oh, very much. When I came to CDC, my idea was to work in
           public health for a while, go back to internal medicine, and
           maybe get a joint accreditation in public health and internal
           medicine, as many of my colleagues were doing. But when I got to
           West Africa and had a little bit of experience there, 2 things
           happened. One, I was addicted to public health. Two, I knew I
           had to go back and get some management training. So I applied to
           the Director of CDC, Dave Sencer, and asked him for a career
           development extension to go back and get a degree in public
           health at Harvard Medical School. And I said, "I know Harvard. I
           will look during that first year at the School of Public Health
           and I will find some management training I can do during the
           second year."   I was sitting in Lagos, so I couldn't tell
           Sencer exactly what that second year was about, but I said it
           would be management. And, in fact, I tried to get into the
           Harvard business school, but they had a very rigid program that
           I thought was very unhelpful. The Kennedy School was just
           starting a program of Master of Public Policy. They wouldn't let
           me into it because they said I was too old. I think I was 28 or
           29. I insisted that I was just the right person and talked my
           way into it. So that was my second year of training.  So it did
           change my life in a radical way.
Harden:     What impact do you think the program had? What impression did
           it leave in Africa about the United States, about CDC? Do you
           think it had an impact on the end?
Henderson:  I think it was good. I mean, it may have been astounding. When
           you're working down in the guts of an organization, one doesn't
           see the perspective of what others have about the whole range of
           things. I don't think we left a bad impression, by any means.
           But that was nothing I was aware of, or got feedback on.
Harden:     You said your wife was traveling with you. What impact did the
           smallpox eradication effort have on your marriage, in terms of
           anything? Traveling?
Henderson:  Well, we were unusual. We had just gotten married. My wife is a
           pharmacist, and we didn't have kids. And I thought that she
           could be extremely helpful in what I was doing. Sample surveys
           are not difficult to do. Keeping the records, drawing maps,
           things of that sort, she does very well, and so we worked as a
           team. And we continued to travel wherever we could as a team,
           together. Now, she wasn't paid by anybody. I paid for whatever
           travel was going on, but we worked together all the time. And in
           fact, when I think about it now, it set an unusual precedent. We
           kept running into problems later in life, when she would sit in
           on staff meetings, or go to meetings with other organizations,
           and they would say, "What's your wife doing here?" Well, there
           would be administrative assistants, other people who would not
           be contributing from a professional perspective but would be
           sitting and listening in.  But the fact that she was a wife
           alienated a lot of people. Eventually, she began introducing
           herself as my personal assistant. That seemed to work a lot
           better. But it had a very strong bonding affect on our marriage
           and lasted throughout our professional lives and through the
           present..
Harden:     Before we stop, is there anything else about the Smallpox
           Eradication Program that you think of, that we should discuss?
Henderson:  I think that one of the extraordinarily important legacies was
           the group of people. Now, I have just told you that the group of
           people was not extraordinary, that they were ordinary people.
           But having gone through that experience, many of them continued
           on working together as colleagues throughout their careers. And
           the smallpox program in West Africa morphed into the larger
           global program, with many of our staff from West Africa joining
           the global smallpox eradication program and having major roles
           in that.
                 After spending some time at Harvard and back at CDC, I
           went back to WHO in 1977. I had left West Africa in '69. So
           almost a decade later, I came back to international health at
           the recommendation of Dave Sencer, to go and replace D.A.
           Henderson at WHO and to run what was then a new program, the
           Expanded Program on Immunization, which was a child of the
           smallpox program.
            Even in the smallpox days, we were looking at how to use other
           vaccines with smallpox vaccine, how to do combined
           immunizations. So a lot of the science had already been done by
           us in West Africa, plus other colleagues elsewhere that were
           working on the same issue. When smallpox success seemed assured
           in 1974, the Expanded Program on Immunization was adopted by
           WHO. The idea was to take what we knew about the smallpox
           experience, providing immunizations for a disease, and do a
           childhood immunization program. The program faltered for a
           couple of years, and I was called in  both because the program
           was faltering and D.A. who everyone assumed would take over the
           program decided to leave WHO.  There was a desire on the part of
           the U.S. to have a CDC US person replace D.A. and I went back to
           do that.
                 Now, when I went back, a lot of the "mafia" I worked with
           were the smallpox mafia-both the smallpox mafia that we had in
           West Africa and the larger mafia that was then created when the
           global program was created because the global smallpox program
           was just phasing out. So suddenly I had a whole large staff of
           people who had that same motivation, who had that same
           perspective, coming into my program now, into the Expanded
           Program on Immunization. They continued on to do polio
           eradication, the diarrheal disease program, a whole slew of
           very, very important public health initiatives. And that came, I
           think, directly from this initiative in West Africa, the
           smallpox group, then going to the larger, international group,
           and then the international group coalescing around several
           extremely important public health programs.
Harden:     Do you think there will be another disease we can eradicate?
Henderson:  Well, we're certainly trying with polio.
Harden:     And having some very difficult problems, I think, and
           discussions about whether it will be done.
Henderson:  Yes. It's a very interesting quandary in public health because
           you don't know, when you're beginning, if you're going to
           succeed. If you knew that, it wouldn't be a problem. You'd just
           get it done. We didn't know when we did smallpox in the
           beginning that we would succeed. In fact, we had to change the
           program radically in order to succeed. The same is happening
           with polio-major, major technical breakthroughs, change your
           philosophy, change of the way we approach things-learning as we
           go, and having a lot of problems on the way. But that's the way
           you make progress in science. That's the way you get better.
           Now, there may come a day when we say, "Okay, enough is enough.
           We've got to call it quits." But until that very end, I think
           it's absolutely well worth giving it the best shot that we can.
            Malaria was a situation where we tried and tried, and then it
           became increasingly apparent that this was not going to work. We
           didn't have the science. We didn't have the technical skills or
           the technical equipment to do the job. We had to change the goal
           of the program. That's not happened with polio, yet. We have a
           lot of good irons in the fire, and I don't think we should be
           anywhere near giving up at this time.
            But there will also be interest in eradicating measles; there
           will be interest in eradicating other diseases. When I did the
           Expanded Program on Immunization, coming in in '77, people in
           WHO said, "OK Rafe, we know who you are. You're one of these
           eradication people. You are just interested in the short term."
           And I said, "Not on your life. I'm not interested in
           eradication. I'm interested in long-term childhood
           immunization."
            But I was interested in eradication. And I came back to that in
           the late 1980s, when our routine immunization had more or less
           done what it could do. It was reaching levels that were not too
           bad but were also not too good. And at that point, we adopted
           polio eradication, not only because we thought we were ready for
           it but also because the polio eradication effort was 1 thing
           that stiffened us up in the other efforts. Because we were
           dealing with a specific disease, that helped us do the rest of
           the things, gave us more enthusiasm for doing those other
           things, as well. And I do think that the occasional disease-
           specific initiative, whether it's eradication or radical control
           of a disease, can help strengthen a larger health initiative, or
           set of initiatives, and will remain a useful public health
           strategy as long as we have both the combination of large,
           integrated services that we're doing and some specific things
           that are within those integrated services. I think that
           combination remains extraordinarily important in public health
           and probably in other enterprises as well.
Harden:     Thank you so much for speaking with me. I think we've got some
           fine footage here. I am delighted about the details on the
           cluster sampling system. Nobody else has provided anything on
           that for me, so I'm very pleased to have that.
Henderson:  Good.
###
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              <text>&lt;pre&gt;&lt;strong&gt; Interview Transcript &lt;/strong&gt;
This is an interview with Diane LaPointe  about her activities in the West
Africa Smallpox Eradication Project. The interview is being conducted at
the Centers for Disease Control and Prevention in Atlanta, Georgia, on July
14, 2006, as a part of the 40th reunion of the West African Smallpox
Eradication Project, to mark the launch of the project. The interviewer is.

NOVA: Would you take a few moments and just describe your early life-where
           you were born and your education?
LaPointe:   I was born in Portland, Maine, and I attended Cathedral High
           School, which is a Catholic girls' high school in Portland,
           Maine.
LaPointe:   I also went to college in Maine, at St. Joseph's College in
           Lake Sebago. After I graduated, I did 1 year of volunteer work
           in Camden, Arkansas, as a teacher for the extension lay
           volunteers and then returned to Portland. My husband, Mark, was
           in the Peace Corps for 2 years before that, and he also returned
           to Maine. We each did a year of teaching in Maine, and after
           that year, we were married and then came to CDC [Centers for
           Disease Control] right after our honeymoon.
NOVA: How did Mark get involved in the Smallpox Eradication Program?
LaPointe:   He was teaching at Mechanic Falls High School in Mechanic
           Falls, Maine, and received a call from someone who was hiring
           for this program at CDC. I believe they were looking for people
           who had African experience and were able to speak French, and so
           his name was suggested by the director of the Peace Corps. Mark
           was hired over the phone. My, how things have changed, to be
           able to get hired over the phone.
NOVA: Absolutely. So, tell me a little bit about what it was like. You're
           living in Africa, you're an expatriate, and it's a different
           country, a different culture. Talk a little bit about that.
LaPointe:   Well, I'd like to, if you don't mind, start with our coming
           here.
NOVA: Okay.
LaPointe:   We married in June of 1966 and took our honeymoon. Mark had
           bought a little Volkswagen bug secondhand; it got 12 cents a
           mile. On the way down to Atlanta, our car broke down in North
           Carolina. So we put all of our belongings in a storage place in
           North Carolina-our belongings were in that Volkswagen bug-and
           took a bus down here. We left the car there to be repaired and
           came and stayed at a hotel in Atlanta.
            Mark would come over here to CDC to do his training, and I'd
           get on the local bus with the newspaper and sit behind the bus
           driver, looking for an apartment and telling him that we were
           going to be at CDC. He would tell me where to get off and point
           in certain directions. So we got a place on Briarcliff and
           started the smallpox training program here, which to me was one
           of the wonderful experiences that we've had, meeting all these
           people.
                 We had intense French training, the [unclear] program,
           where you just saw the pictures and heard the people speak. You
           never saw a written word. That's how we were trained. A group
           came from France, and we did all the training here and met all
           the people who were going to be going to West Africa. We formed
           a real feeling of camaraderie with all of these people.
NOVA: How long was the training?
LaPointe:   I believe it lasted throughout that summer and into the early
           fall. We spent all day with the French-speaking trainers, and
           sometimes in the evening, so we were really not supposed to be
           speaking English at all. It was very intense. It was wonderful.
NOVA: So, how soon after the training did you move to Africa?
LaPointe:   We went back to Maine and got together some household items and
           we flew out probably in October or November of that same year to
           Libreville, Gabon, in West Africa.
            And I do remember an experience there right at the beginning.
           Mark would go off to the embassy and work with his colleagues
           there, with the AID [U.S. Agency for International Development]
           people. We didn't have a place to live yet, so we were at the
           local hotel. And this was my first attempt at using my French.
           So we would get up in the morning. Mark would go off to work,
           and I would go to the restaurant and ask for an orange juice in
           French, jus d'orange [sp.]. And I'd never get orange juice; I'd
           get grapefruit juice. So after a couple of days of that, Mark
           came back from work, and I was in tears. I said, "I can't speak,
           I can't even say orange juice in French. What am I going to do?"
           And so he went to breakfast with me the next morning and he
           asked for orange juice, and they brought him grapefruit juice.
           But he had the foresight to ask, "Why didn't you give me orange
           juice?" and it was because they didn't have any. So that  kind
           of alleviated my concern about speaking French.
NOVA: That's funny, that's funny.
LaPointe:   We had an apartment right on the ocean. I mean, for 2 young
           people, newly married, we had this wonderful apartment,
           completely furnished by the government, overlooking the water.
           It was very, very nice.
                 I was pregnant at the time. I had become pregnant right
           away. So we began thinking about where I was going to have our
           first child. Speaking with the doctor there in Libreville, who
           was a Peace Corps volunteer doctor, we had thought about going
           to Lambaréné, which is Albert Schweitzer's hospital, but we were
           discouraged from doing that. They said they didn't feel there
           were adequate facilities in case of an emergency. So it was
           decided that I would go up to the Cameroons. We knew Arlan and
           Edith Rosenbloom, who were there. So I went up there in my 8th
           month.
                 I flew up and spent my time with them and then went out to
           a hospital in Ebolowa, which was run by an American missionary
           group. I was flown there. It was a very small plane, a 2-seater
           in addition to the pilot. Beside me was an elderly Frenchman.
           Because this was out in the bush, they buzzed the hospital to
           tell them somebody was coming. And I guess I had a look on my
           face that looked as if I was going to pass out. The little
           Frenchman next to me said that he had candy with him and he
           tried to feed it to me so I wouldn't pass out. When the plane
           landed in a field, a nurse from the hospital came, with a cot,
           and I was picked up and taken to the hospital. I spent I'd say a
           week or 10 days there.
                 There was another American woman there, too, who was from
           the Cameroons. We became friends, and we hung out with the
           nurses and the doctors and played Mah Jongg.
                 Mark drove up from Gabon. It took him a while to get
           there, I guess, and he thought the baby would have been born by
           the time he got there. But when he arrived, she had not yet been
           born. So we took a walk around the campus of the hospital that
           day, and that evening our daughter Mary was born.
NOVA: I hope your daughter appreciates the trouble you went through to get
           to a hospital to deliver.
LaPointe:   I think so.
NOVA: What was it like raising your children there?
LaPointe:   Actually, it was very easy. We had help, which was something
           very new to me. We had a woman who would come every day and do
           our laundry and clean our house. I really took care of Mary
           pretty much myself, but that woman was there to help me. It was
           beautiful in Gabon. There were beaches there. So we spent a lot
           of time going to the beach and taking walks.
                 Gabon was very French. It was a former French colony, and
           there was still a large French presence there. So I didn't get
           the feel that I got later, when we went to Mali, of that African
           experience of the marketplace, because it was all French shops.
           We developed a wonderful relationship with a French family that
           lived upstairs from us. The woman took me under her wing. She'd
           take me shopping. And her 2 daughters loved my baby. So we did a
           lot together as family.
                 The thing I remember most is that all of those
           relationships you made took the place of family-although they
           certainly couldn't replace them. But they helped with that
           feeling of loss of family. They became your family.
NOVA: How long were you there?
LaPointe:   We were in Gabon probably about 2 years, and then we were
           assigned to Mali, to Bamako.
NOVA: And there was a big difference between the 2 places?
LaPointe:   Absolutely, yes. Gabon was, as I said, very French, and located
           on the water. Mali was inland, on the Niger. But the culture was
           so rich that I didn't miss the ocean-I had thought I would. But
           I got so engrossed in the culture of the people. That was a real
           experience. That was really going to Africa for me. The people
           were wonderful.
                 Our second daughter was born. I went back to the States to
           have her. We had the Rh-negative/-positive situation, so I went
           back to Maine and then came back with Michelle.
                 In Mali, we lived in a little compound. There were maybe 5
           houses, all young American couples, people with the embassy who
           lived in our area there.
                 And, again, we had help. We had a woman who would come in.
           She liked to take the children and go off. I didn't really like
           that because I wanted to spend my time with them. But she felt
           that was her job. But I enjoyed going to the market; I learned a
           bit of the language, the Bamber [phonetic] language. I liked to
           go and bargain with the women at the market.
                 We had to be careful about boiling our water, and
           filtering it, as well as washing and soaking all our vegetables.
           And if you hung your clothes out to dry, flies would leave their
           eggs on your clothes. They could get into your skin, so
           everything had to be ironed.
                 But I just had a wonderful experience because I was very
           young.
NOVA: What was your toughest problem that you faced while you were there?
LaPointe:   Sometimes Mark would be gone for long periods of time. He
           couldn't stay in the capital all the time; he had to go out and
           do his business out in the villages. Those separations were
           probably the most difficult times.
                 Another incident I remember is that when we were in Mali,
           I traveled with Mark once up into the desert. We left our
           children with some good friends. I can't remember the exact town
           we went to, but this was in the period right after there had
           been a coup in Mali, and the president was imprisoned in this
           town. There were guards around the prison. I wasn't aware that
           you couldn't take pictures. So I was out taking pictures,
           completely unaware of not being able to do that. Later, at our
           hotel, we got a tap on the door, and the local gendarme came and
           confiscated the camera and put us under arrest. We had to stay
           there at the hotel. Mark spoke to the head of the health
           department who he was visiting there, and I believe that man
           must have interceded for us and finally got the camera back. I
           think they took the film. But that was pretty frightening. So
           that's something that has stuck in my memory.
NOVA: Nerve-racking.
LaPointe:   Very much so.
NOVA: And I'm sure you were worried about your children.
LaPointe:   Right, exactly.
NOVA: Earlier, you talked about, shopping and going to the market in Gabon.
           What did you do in your spare time when you were in Mali?
LaPointe:   Much of your day was spent shopping and bargaining. I love to
           sew, so I enjoyed going to the market and buying African
           material. I used to make a lot of dresses and skirts and things
           with the African fabric. I became friends with Peggy Yates, the
           wife of John Yates, a political officer. They had 3 children, so
           we did a lot together. They had a little pool, and we didn't,
           and so a lot of our day was spent over there visiting with them.
           Or we would get in the cars and go off somewhere, find someplace
           to take the children. And then on weekends, groups of us, with
           our husbands, would get together and go out and try to do as
           much as we could around the area.
                 One particular incident I remember is when we all went off
           with the kids on a Sunday to a place near the river. It had
           recently rained, and the cars got stuck in some African lady's
           field, and she was not very happy about it. John Yates was able
           to hail some African guy with a Mobylette. So he went into town
           and got somebody to come out with a truck and chains. We all sat
           out in the field on blankets and waited until they rescued us.
                 But I think most of our day was spent shopping. I like to
           cook, so learning how to cook some of the local foods and just
           raising children and enjoying the friendship of the other people
           that we met filled my days.
NOVA: How do you think participating in the project changed your life?
LaPointe:   Completely. Even to this day, we have a lot of interaction with
           Africans. We went back to Africa again (not with the smallpox
           program), and the children went to French schools. That changed
           their lives. It opened their eyes to a whole different side of
           the world, the poverty, how much we have as Americans, an
           appreciation for what we have. Our daughter Michelle learned to
           speak French. She was younger and she just picked it up; she was
           so fluent in it. So when she went off to college, she majored in
           the romance languages, and that led to things for her.
                 I've done work since we've been back. I taught. I'm a
           retired teacher. But when I retired, I volunteered with teaching
           English as a second language for African women, and, as I said,
           we have a lot of African friends to this day. At our church,
           Corpus Christi, there's a large African community, and we've
           been very involved in things relating to Africa. The experience
           really changed our life completely. I don't know if we'd still
           be in Maine, if I'd still be teaching there. I don't know. I
           can't even think like that.
NOVA: What difference would it have made if families, say the spouse and
           children, could not have joined the CDC employees or the medical
           officers, the folks that were there doing the work? What kind of
           difference do you think it would have made if the families would
           have had to have stayed back home in the United States?
LaPointe:   I can't imagine. I think it would have been very difficult.
           First of all, you wouldn't be able to relate to anything your
           husband was going through. To be there together, you were in it
           together. It would have been a great loss for me, and I think it
           would have been very difficult on our family. I know we have had
           separations like that, and it's very difficult on families, the
           tensions when you get together, and the wife becomes the boss of
           the house, that kind of thing. I don't think I would have
           understood what he had been going through when he'd come back
           and talk about it. I just don't think it would have worked. I'm
           really happy to have been part of that. It was a whole new life
           for us.
NOVA: Is there anything that you would have changed if you had to do this
           all over again?
LaPointe:   I can't think of anything, really. We really enjoyed it. We've
           made lifelong friends, some of them with CDC.
                 A lot of these people [at the reunion] we have not seen
           since back then. But we have 1 friend in particular, Jay
           Friedman [Jay S. Friedman], who lives here, who we've been
           friends with him since we started here. That's 40 years. The
           Roys are another couple that we know. And some of the friends we
           made while we were living in Africa, the people at the embassies
           who had children, we're still friends with a lot of them. Our
           children became friends with their children, and they still stay
           in touch with each other. So we've developed this network of
           friends that will just keep going on.
NOVA: Wonderful. Is there anything else that you'd like to add?
LaPointe:   Just that I'm very happy that we did this. I know it's just
           made a big difference in my life, and, of course, Mark's. We
           came back here to CDC, and that was his career. I'm looking
           forward to seeing a lot of the people who I haven't seen in so
           long today. I'm so glad to have had the opportunity.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Joan Thompson about her activities in the West
Africa Smallpox Eradication Program. The interview is being conducted at
the Centers for Disease Control and Prevention, on July 14, 2006. This is
during the 40th anniversary celebration of the launching of the Smallpox
Eradication Program. The interviewer is Linda Harrar.

Harrar:     Would you describe your early life, where you were born and
           your education through high school and college?
Thompson:   I was born in North Dakota, in a small town. My father was an
           educator, and so I actually lived in 3 different small towns in
           North Dakota, but I spent most of my time in a town of about 600
           from age 8 through high school.
Harrar:     And so you went to high school in North Dakota.
Thompson:   I went to high school in Portland, North Dakota.
Harrar:     I understand that you're married to Dr.  David Thompson.
Thompson:   Right.
Harrar:     So how did the 2of you get involved in the smallpox program?
Thompson:   Well, we were interested in working overseas, both of us,
           before we even met and were married. When he was doing his
           internship, he applied to the Public Health Service; he was
           thinking about maybe working on a reservation in preparation for
           going overseas. It was during the Vietnam War, and there were no
           positions available.
                 Then we applied to the Peace Corps, and there was nothing
           there. And David said, "Well, I guess I'll be going to Vietnam."
           But he didn't want to go to there, and even more than that, we
           were looking already at going overseas and thought that would be
           a good thing.
                 And then totally out of the blue, he got a telegram one
           day that read, "Are you interested in going to Africa?" And we
           didn't know what it was for, not anything. He just responded,
           "Yes." And then he got a phone call, and D. A. Henderson [Donald
           A. Henderson] came to Minneapolis to interview us. There were, I
           think, 3 spots left to fill, and D. A. was interviewing I don't
           remember how many people. Dave was just finishing his
           internship, and we were extremely happy when we were accepted.
Harrar:     Who sent the telegram?
Thompson:   It must have been somebody in the Public Health Service. I
           can't remember. I just remember he came home from work and he
           said, "You'll never believe what I got today."
Harrar:     Wow, amazing.
Thompson:   So it was a very amazing story of how we ended up in this
           program. And it really changed our whole lives.
Harrar:     Oh, I bet.
                 Where were you living at the time that you were accepted?
Thompson:   Indianapolis.
Harrar:     And so you get the telegram and you have the interview, and
           then he's told, "You've got the position." What next?
Thompson:   He was in the internship that finished the end of June.
           Training down here in Atlanta started the beginning of July, so
           there wasn't much time. We just made plans to go. We were very
           excited. Our families were excited for us.
Harrar:     Did you have children at the time?
Thompson:   We had one very young son, newborn practically. He was 6 months
           when we came to Atlanta for training.
Harrar:     So when you were in Africa, where were you stationed?
Thompson:   Initially we were in eastern Nigeria. We flew into Lagos, and
           there was some training there. Probably one of my vivid memories
           is of when we were staying in an apartment. Dave was off from
           early in the morning till probably 5 in the afternoon. I don't
           remember exactly, but all day. And I was really sick. I got
           traveler's diarrhea. Our baby was about 8 or 9 months old by
           then. I just remember lying on the floor in that apartment and
           closing all the doors so he couldn't get into anything, just
           thinking, how am I going to survive? And Dave felt like he
           couldn't stay home. He had to be at this training. That was my
           introduction.
                 Fortunately, I had been in Africa once before, so it
           wasn't like totally new.
Harrar:     So Dave went out every day. So tell me, other than being sick
           when you got there, what did you do every day? How did you spend
           your time?
Thompson:   Well, I was sick for 3 or 4 days, and then I would just take
           the baby and go out walking. It was hard to find time to fill
           the days, during those early days.
Harrar:     So you were living in a small apartment. Is that where you
           stayed the entire time?
Thompson:   No. We were just there a matter of days. And then we went to
           Enugu in eastern Nigeria.
Harrar:     And you were there for how long?
Thompson:   We were there for about 8 months. I can't remember if we
           arrived there in September or October. We were evacuated at the
           end of June.
                 And when we arrived at that airfield and got off the
           plane, the airfield was ringed with men with machine guns that
           were just trained on us like this as we walked in. And that was
           kind of an unnerving feeling.
Harrar:     I can imagine.   So, is this at the time before the Biafran
           War?
Thompson:   Before. But they already had the guns and things, the security.
           There was a lot of unrest. There was a lot of fighting in the
           north, and people were being sent back on trains to the east and
           being pulled off and killed.
Harrar:     So, were you there when the war broke out?
Thompson:   We were there. We have pictures of that Independence Day parade
           where they declared independence, and then the women and
           children were all evacuated.
Harrar:     Including yourself?
Thompson:   Yes.
Harrar:     And what was that like?
Thompson:   Oh, that was a nightmare. We knew it might be coming. They'd
           told us that there was a possibility, and I think we had 2 days'
           notice. We were allowed to take one carry-on, and I packed all
           our pictures and a couple changes of clothes for our son, who by
           then was a year and a half. And I was 8 months' pregnant. And we
           drove to Port Harcourt and loaded the plane. I mean loaded it.
           Every woman had a child on her lap. There were not enough seats
           for every person. We were flown to Lagos. And there we waited.
                 We had thought that we would be flying out immediately,
           but it was during the Six-Day War in Israel, and planes were all
           being diverted over there, so we had to wait for a plane. We
           stayed with a family in the smallpox program in Lagos. They were
           incredibly good to us.
                 And then one night maybe 9, 10 o'clock, came word that a
           plane was on its way, and we went to the airport. We were all
           women with kids, and we were in the airport all night waiting
           for this plane. And early in the morning, the plane arrived. And
           thank and food goodness for Bill Shoemaker [William Shoemaker].
           He carried water and food around all night. I don't know if I
           would have made it otherwise.
                 We got on the plane, and we flew to Monrovia for
           refueling. We were not allowed to disembark. On this plane, I
           think everybody had a seat. But we'd had nothing to eat. When we
           left Monrovia, we sat on the airstrip there for what seemed like
           2 or 3 hours, but my memory might not be right. When we got in
           the air again, they announced that because the pilot would now
           have too many hours to fly to New York, we would be diverted to
           Puerto Rico. So we flew to Puerto Rico, and because it was a US
           port of entry, we all had to disembark and go through customs.
                 Here we were. I'm pregnant; I'm carrying my son, carrying
           a suitcase, and I remember the guy says, "Put it up there. I
           want to look at it. "And I was so tired, and I said, "If you
           want to look at it, you have to put it up there."
                 And then we loaded the plane again and flew to New York.
           We got into New York about midnight. By now it was about 23
           hours' travel time, and we were just dead. Things at the airport
           were closed as far as booking oncoming, ongoing flights. So
           somebody met us, and they took us all to a hotel. When we got to
           the hotel, they had been told that there were refugees coming,
           and they had to put at least 2 families to a room. And I said,
           "You know, I'm not going to do that. I know that USAID [US
           Agency for International Development] is going to pay you for a
           room for every single person, and I want my own room," which I
           got.
                 But then, in the morning, we got up and went back to the
           airport. We spent most of the day in the airport because we had
           to go there to make our ongoing reservations, and we finally got
           into Minneapolis the next night. It was an experience I wouldn't
           want to repeat.
Harrar:     So from the time you boarded the first plane, when you were
           evacuated, until the time you arrived.  .  .
Thompson:   In New York, it was 23 hours.
Harrar:     Twenty-three hours. No food, and with a baby. And 8 months'
           pregnant.
Thompson:   Yes.
Harrar:     Amazing.
Thompson:   I mean, there were other people who had 2 or 3 children, you
           know, maybe an infant or a toddler.
Harrar:     So where was your husband during this time?
Thompson:   The men were not evacuated. They stayed behind. They stayed in
           Enugu, and then they eventually went to a meeting. I don't even
           remember where it was; it might even have been out of Nigeria.
           And when they came back, they did not let them go back to Enugu.
           But Dave didn't come back to the States until August. He got
           back a week before our daughter was born.
Harrar:     So, how long were you actually there in Africa, the 2 of you?
Thompson:   Well, we were in Enugu 8 months, and then we came back here and
           we were down here at CDC from August to January, and then we
           went to Liberia.
Harrar:     Okay.
Thompson:   And then we were in Liberia for 2-1/2 years.
Harrar:     Other than the stories that you just told me about war breaking
           out and everything, were there any other unique occurrences that
           you could tell me about that you went through, either then or
           when you went back to Liberia.
Thompson:   Well, there were a lot of experiences. Of course, we were in
           Liberia much longer.
                 There was a women's medical auxiliary, which I was part
           of, and that was Nigerian expats, so that was a great
           experience. With that auxiliary, we were invited to have tea
           with President Tubman up on the top floor of his palace. That
           was a very unique experience, marvelous.
                 When I was involved with this medical auxiliary, one time
           we were setting up a display of some kind; I don't remember what
           it was for. I left to go home and change clothes to come back
           for whatever the event was. It was very close to the president's
           palace, and I pulled out onto the road, and all of a sudden the
           president's security came zooming by, and I had an accident with
           them. Oh, my goodness. They didn't have sirens or lights or
           anything. They just came zooming by with some dignitary and his
           whole, huge entourage. Wherever he went, it was with a huge
           entourage. But it was like, well, whenever there's an accident
           with that, it's always the expat's fault.
Harrar:     Of course.
Thompson:   But it turned out that that was one advantage of working with
           the government. They took care of everything. But, oh, it was
           very unnerving for me to realize what had happened.
                 One highlight was our involvement with an orphanage there.
           We lived initially in a duplex. A couple lived on the other side
           of us. He was American, and she was Italian. He worked under
           USAID as an advisor to the treasury. They became very good
           friends. And she had some connection somehow. So with her, then,
           we got involved in helping out in an orphanage.
                 I was asking our oldest son, just this week before we
           came, if he had any memories of Liberia, because he was 4 when
           we left. And he said, "I do." And one of the things he mentioned
           was the orphanage. He said, "I remember going there, and the
           kids, and playing with them." It was kind of interesting.
Harrar:     What kind of things did you do there?
Thompson:   It was a small orphanage. It was a lady and her son, and they
           had maybe 6, 8 kids. We would take them to the beach, have a
           picnic. I remember we helped get them a washing machine; they
           did all their wash by hand. We helped out with clothes, had them
           over to the house, just those kinds of things.
                 Her name was Eva Deline [phonetic]. I can't remember her
           son's name.
Harrar:     I'm sure she remembers you.
                 How do you think this participation in the smallpox
           project changed your life?
Thompson:   Oh, as far as our life together, I think it totally changed the
           direction of our lives. We had been interested in going overseas
           to work. I think we had thought in terms of probably working
           with a mission in a hospital. But Dave, after working with this
           program, was just convinced that there was nothing to do but
           public health. So we came back and he got an MPH [Master's in
           Public Health] at Hopkins, and then he did a pediatric
           residency, and then we went back and worked in public health for
           12 years in Chad.
                 One other real highlight of being in Liberia  was that
           every Saturday morning we'd pack a lunch and we'd go to the
           beach. It was just like having a vacation every week. We'd leave
           maybe 10 in the morning and come back around dinnertime. That
           was just marvelous. I said to Dave recently, "I wish we could do
           that now."
                 We had a couple of incidents that happened at the beach.
           Our daughter almost drowned. We were there with a number of
           other people, and there was a lagoon on one side and the ocean.
           Kids were playing in the lagoon, and we were playing cards. And
           all of a sudden one of the women looked over and she said, "I
           [unclear; pls fill in] Christen." And she was just floating. I
           was sure she was dead. I didn't even get up. I was just shell-
           shocked. My friend Ruth is an anesthetist, and she ran and
           grabbed her, and Christen wasn't breathing. And Ruth turned her
           over and hit her on the back, and water came out and she began
           to breathe.
Harrar:     Oh, my goodness, how frightening, how frightening.
Thompson:   Yes. We kept a close eye on the kids after that.
Harrar:     And how fortunate that the woman was there who could do that.
Thompson:   Yes, she just glanced over, ran and got her.   Dave ran too,
           but Ruth got there first.
Harrar:     And how old was your daughter at the time?
Thompson:   I don't think she was a year, but she was walking.
Harrar:     So she doesn't remember.
Thompson:   No, no, no.
Harrar:     I'm sure you've reminded her of that incident.
Thompson:   You know, I don't know that we've talked about it. When I
           realized only the day before yesterday that I was going to be
           interviewed, I said, "Dave, I don't remember anything. I don't
           have anything to say. "He said, "Oh, you remember way more than
           you think." So I don't know that we've actually talked about it
           with her. But I need to write some of these things down so we
           can.
Harrar:     You mentioned that there were a couple of incidents at the
           beach. That was one. Do you remember the other?
Thompson:   Yes. Our son got stung by a Portuguese man-of-war. Often there
           would be many of them-it must have had to do with the weather.
           They would wash up on the beach, and we would be really trying
           to be careful. But one just got all totally wrapped around him.
           But where we went to the beach was at a mission station and they
           had a hospital. We just grabbed him and actually ran up there
           with him. And he remembers that very vividly.
Harrar:     I can imagine that was incredibly painful for him.
                 What was the toughest problem that you faced, and how did
           you resolve it while you were there?
Thompson:   Probably the hardest thing was that Dave was gone all the time,
           especially in Nigeria. When we first got there, we kind of knew
           it was going to be like that, but we didn't know anybody. Paula
           Foege wasn't there yet. Mary Litchfield was there, but she lived
           on the exact opposite side of town from me. That was our team.
           And, yes. They would leave on Monday morning, and they'd come
           back on Friday night. Sometimes they'd leave on Sunday afternoon
           because there was a huge smallpox epidemic.
                 Fortunately, at that particular time, we were living in an
           apartment, and so we got to know the couple upstairs, and that
           helped. And, again, we had a stroller, and I walked and walked
           and walked and walked.
                 One of the things I should mention is that in our
           orientation in Atlanta we had been told that we should hire
           house help, that we were giving somebody a job. But they told
           all of us not to hire anybody without papers. Well, when we were
           in Enugu, this guy showed up at the door one day. His name was
           Patrick, and he wanted a job. He'd been to USAID and they had
           sent him over, actually, to us. He'd worked in the north, and
           he'd had to flee. And so I was very naive, and I asked him for
           his papers, and he said, "I don't have any papers." And I said,
           "Well, I don't know if I can hire you if you don't have papers."
           He said, "Well, I worked for Americans in Kano," but he was Ibo,
           so he'd then had to flee. And he said, "We fled without
           anything." He said, "Just try me, and I will work. And if you
           don't like me, you don't pay me." Of course he was just a
           godsend. He was just incredibly hard-working. He wanted to do
           everything. After we moved into our house, we would wake up in
           the morning and we'd hear him moving furniture. All the floors
           were washed before we got up. And I'd say, "Patrick, you don't
           need to come so early." He'd say [unclear]. "I felt like saying,
           "But I'm not." He was just an incredible guy.
                 And in Liberia, too, we just were so fortunate with house
           help. We got a young guy who actually lived with an American
           missionary family. They had left, and he was looking for work.
                 And our kids, their biggest treat for them, which was kind
           of neat, was if Dave and I wanted to go out in the evening. All
           I had to tell the children was, "You can have rice with Samuel,
           rice and ketchup," and they were thrilled. It was weird.
Harrar:     Did you have to do any of the cooking, the shopping?
Thompson:   I did the cooking and shopping. I loved doing that. I loved
           going to market. I still love going to market. I go to farmers'
           market all the time because it reminds me of Africa.
                 And for Patrick, that was very hard. He wanted to cook.
           And I said, "But what would I do, Patrick, if you cook? You do
           everything else." But he had done it for other people. When we
           were evacuated and he got to cook for Dave, he was delighted.
Harrar:     What kind of impact or what difference do you think it would
           have made if they had said, "Okay, Dr. Thompson, you and the men
           or the CDC employees, whatever, are going to go over, but the
           families have to stay back in the States?"
Thompson:   Oh, it would have been horrible, horrible. I think it's
           important both ways. It's important for the men or the employee,
           whichever spouse that is, to have family there and someone to
           come home to on weekends. But I also think it's very important
           for the family because otherwise that's an entire part of their
           lives that you're not part of.
Harrar:     Right, right.
Thompson:   That would be a big hurdle, I think. There are some broken
           marriages anyway, but I think there would have been more.
Harrar:     Is there anything that you would have changed if you had to do
           it all over again?
Thompson:   I hadn't thought about that. I don't know. I would have to
           think about that.
                 Of course, in our later experience, we lived in a very
           small town, and I was very much more involved with African women
           and really got to know them as friends, just as the African
           women I got to know in Liberia were the lady who had the
           orphanage and then the wives of the African physicians who were
           in the medical auxiliary.
                 And also my neighbor in Liberia. I wouldn't say I got to
           know her well, but she came over almost every day, and she'd be
           in my kitchen while I worked. She said, "I want my kids to play
           here because I want them to be smart." So her kids were at our
           house a lot, and it was great. I wanted my kids to have that
           experience of playing with African kids.
                 So it's funny. Shortly before we were leaving Liberia, she
           threw out her old mortar. I don't know if you've seen them.
           They're about this high and they pound their  grain.
Harrar:     Oh, yes.
Thompson:   She threw it out and got a new one, and she wanted me to come
           and see her new mortar that she'd gotten at the market. And I
           asked her if I could have her old one. It was mended with metal,
           where it had cracked. She said, "You don't want that. You can go
           buy a new one at the market."
                 I said, "No, I want this one because I'll take it home and
           then I'll think of you every time I look at it in my house." And
           she just laughed. She thought it was the craziest thing. She
           said, "I don't understand white people." That's what she said.
                 But I still have it in my house. I have it in my front
           hallway. And I do think of her all the time. I wonder what
           happened to her kids, where they grew up.
Harrar:     So what impact do you think that the experience had on your
           children? I know they were young, but .  .  .
Thompson:   It's hard to separate this from their other African experience,
           but it had a huge impact on them, and they are incredibly
           grateful.
            The son who was born in Liberia is now in the process of
           adopting. And when he and his wife decided to adopt, he said, "I
           wonder if we could adopt from Liberia." So they are going in
           about 3 weeks to get these children. [show's photo]
Harrar:     Oh, how precious!
Thompson:   These are sisters.
Harrar:     Wonderful picture. And the ages are probably .  .  .
Thompson:   Four and 1.
Harrar:     Four and 1. So 2 sisters from Liberia.
Thompson:   Yes.
Harrar:     And they're going to be adopted and come to the States when?
Thompson:   The beginning of August. And I'm sure they would never have
           gone to Liberia if my son hadn't been born there, but he said,
           "If we're going to adopt, and possibly overseas, then let's see
           if there's any possibility of getting somebody from Liberia."
Harrar:     Well, they're just precious. You're going to enjoy them.
Thompson:   Oh, yes. We know that, and we're thrilled. So they're actually
           traveling to Liberia now to get them.
Harrar:     And what about your daughter? Obviously, your son was affected.


Thompson:   Yes. I guess it's hard to separate our experience in Chad from
           our experience with the smallpox program. All the children
           finished high school in Africa. So they just have a different
           world view. They have an incredible interest in international
           things. Living in Africa had a huge impact on them. And they
           have said many times, "I'm so glad we grew up overseas."
                 And our son, David, still maintains contact with an
           American friend, another expat kid, who was his friend there
Harrar:     So, lifetime friendships.
Thompson:   Yes, definitely. And all of them had very close lifetime
           friendships from high school. They went to high school in
           Nigeria even though we lived in Chad; it went to a mission
           school, but it was incredibly international.
                 One of our daughter's classmates in high school, who
           turned out to be a very good friend, was from eastern Nigeria.
           And it turned out that she was born the same week that our
           daughter Christen was born, in the same hospital that Christen
           would have been born in had we not been evacuated.
Harrar:     Wow.
Thompson:   And they ended up classmates 14 years later.
Harrar:     How amazing.
Thompson:   Yes. Isn't that amazing? It is a small world, a very small
           world.
Harrar:     Is there anything else that you would like to add?
Thompson:   Not that I can think of.
                 It was a good experience. We have great expat friends. And
           those friendships have lasted the years.
Harrar:     Well, I want to thank you for your time. This has been very
           helpful for us.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with David Thompson about his activities in the West
Africa Smallpox Eradication Program. The interview is being conducted at
the Centers for Disease Control and Prevention, on July 14, 2006. This is
during the 40th anniversary celebration of the launching of the Smallpox
Eradication Program. The interviewer is Harrar.

Harrar:     Can you tell me where you received your early medical training?
Thompson:   I received my medical training at the University of Minnesota
           and graduated in 1965.
Harrar:     How did that prepare you for your experience with the Smallpox
           Eradication Program?
Thompson:   I had always been interested in international, global health.
           My parents were missionaries in South America. In my senior
           year, I received a Smith-Kline fellowship to work in a mission
           hospital in Cameroon for 3 months, and it was there that I
           became convinced that it was public health that needed the
           emphasis, not curative medicine; that was my primary goal from
           then on.
Harrar:     What was it specifically that led you to that conclusion?
Thompson:   I had the sense of a large population of people, a minority of
           whom ultimately came to the hospital, were treated, would go
           back home, and would keep coming back with the same problems. I
           realized that hospital-based care, as good and necessary as it
           is, didn't make much of a dent in things like mortality rates,
           etc. For me, it was confirmation that I wanted to go back to
           Africa, but I wanted to do public health. I had no idea that I
           would be involved in smallpox.
Harrar:     Can you be specific about the kinds of ailments that people
           might be better served by public health versus curative
           medicine?
Thompson:   Malaria is a big example; all the immunizable diseases;
           measles, whooping cough; malnutrition; TB, you name it. I
           realized then that I could have a much greater impact personally
           by multiplying my few gifts by working through physician
           extenders and by focusing on simple but effective community
           efforts of a preventive nature. Bill Foege [William H. Foege]
           impressed on me the other truth-that when you've got limited
           resources, you just prioritize and use those limited resources
           to serve the needs of an entire, clearly defined
           population/community.
Harrar:     Very interesting.
                 How did you come to be specifically involved with the
           Smallpox Eradication Program?
Thompson:   I was finishing a rotating internship at Hennepin County
           Medical Center in Minneapolis. It was the peak of the Vietnam
           War. I wasn't exactly a pacifist, but I was very, very
           uncomfortable with the war and didn't want to serve in it. So I
           applied to the Public Health Service (PHS). At that time I was
           planning on a medical missionary career, and I thought time as a
           PHS officer in the Indian Health Service would be good
           preparation.
                 I had a long application process. I was in the midst of a
           very busy internship. I had to have a physical exam that
           required going up to the Indian Health Service Hospital on the
           Cass Lake Indian Reservation. They discovered that I had a fair
           amount of dental work that had to be done before my application
           could be finalized. That took some time, and I thought I wasn't
           going to be accepted. I called all the various branches of the
           PHS, and everything seemed to be full. Then all of a sudden one
           day I got an airmail special delivery letter asking, "Would you
           be interested in going to Africa with CDC?" Nothing else. I
           said, "Absolutely," and that was the entree.
                 Dr. D.A. Henderson [Donald A. Henderson] came up to
           Minneapolis and interviewed us at the airport. When he found out
           that we were interested in medical missions, he proceeded to
           spend the rest of the interview talking about how poorly medical
           missions had done in the arena of public health. This was true.
           I left the interview very deflated, thinking, "Well, this won't
           go anywhere." And then, interestingly enough, we received the
           letter of acceptance.
Harrar:     What has been the contribution, do you think, of medical
           missions to the public health of Africa?
Thompson:   Historically, I think they've provided a lot of very good
           person-to-person medical care in terms of building hospitals,
           clinics, etc. Christian missions were pioneers in establishing
           medical and education institutions in the interior parts of many
           of these countries. A lot of these early missionaries died in
           the process of providing these services. But it was a system
           with fixed institutions. People came to these institutions. The
           philosophy was, "I'll take care of you if you cross my
           threshold," but then the people would go back out into the same
           situation, re-contract malaria and all the other diseases that
           you find in Africa, and then come back to the hospital. As time
           went on, studies showed clearly that most people died outside of
           the hospital. Historically Christian missions were slow to enter
           the field of public health.
                 I came at a time in medical mission work when there was
           beginning to be a shift towards thinking about a public health
           approach, and my involvement with CDC just confirmed that for me
           personally. Today, I think they're doing much more in terms of
           public health.
                 Later on I helped to start a totally community-owned and
           -oriented public health program in southern Chad, but I also
           provided regular medical care in the local government hospital
           and in our home.
Harrar:     What drew you, in your early life, to think that you might want
           to become a medical missionary?
Thompson:   I came from the rural Midwest, miniature Scandinavia. My
           parents were missionaries; they spent most of their lives in
           Bolivia and Ecuador. My father was a minister and a farmer, but
           he met all sorts of needs. I remember very well going with him
           up to the local village, taking care of people who had been
           severely burned. That instilled in me an interest in medicine
           that increased with time. I've always had an interest in issues
           of justice.
Harrar:     And what kinds of injustice have you seen that are most
           compelling to you that you wanted to fight?
Thompson:   Well, living in this time, injustice is such a huge issue. I
           have always been sensitive to the inequities, the imbalances,
           the increasing self-centeredness, and isolation that
           characterize our Western world, particularly the United States.
           My parents always allowed me to see and share in the suffering
           of others. They didn't hide this. As a matter of fact, they made
           me participate in it.
                 I remember very well when I was in early grade school. It
           was after the war, and my father insisted that we all sit up and
           listen to a radio program put on by the Lutheran World
           Federation, which then was focusing on the refugee situation in
           Germany. These were all very sad stories, and I remember wanting
           to go upstairs and hide.
Harrar:     And your parents wouldn't allow it?
Thompson:   No, no, they wouldn't.
Harrar:     I believe that Martin Luther King said that, of all the
           inequities there are in the world, the worst inequities are in
           health. Could you comment on health inequities?
Thompson:   Health inequities. I've spent 16 years of my life working in
           Africa, 12 of those in Chad, which is one of the poorest nations
           in the world. I had a child die on my dining room table from
           pneumonia. He'd been treated in the hospital, and he wasn't
           making it, so we took him into our house. My intervention with
           the limited resources we had did not work either. I watched so
           many children and adults die who didn't need to die.
                 And then we live in this very affluent country and culture
           with slums, a large homeless population, and millions of people
           without medical insurance let alone consider the utterly poor of
           the "two thirds world'. The United States is way down the list
           of industrial countries in terms of its giving to overcome
           global poverty. What our government does in this regard is
           pitiful.
                 These inequities can be overwhelming, but they don't need
           to be; we simply need to find a place where we can make a
           difference. And in my case, very fortunately, I had the
           marvelous opportunity to spend 4 years with CDC and the Smallpox
           Eradication Program. The 12 years in Chad were a wonderful time,
           when I was able to share and to learn, to participate. And,
           actually, I wanted to continue on in that work and spend the
           rest of my life working in Africa. But other things intervened
           and didn't make that possible.
                 So I struggle with the inequities even here right now. I
           work in an inner city, safety-net hospital, taking care of
           recent immigrant kids. So inequities are a part of my life.
Harrar:     Would you say that the inequities are greater in the developing
           world than they are here, or could you just comment on that?
Thompson:   They're of a different nature. It's interesting when you work
           in the inner city. There are certain strengths in African
           culture that aren't there in the inner city. There are ways in
           which a culture and the strengths that hold people together-the
           collective forces that make people help one another, that give
           people cohesiveness and commitment to a group-aren't as present
           in the inner city, but in Africa they're very strong. In Africa,
           excess of this commitment to community results in tribalism, but
           the very positive part of it is this tremendous allegiance to
           your clan, to your family, to your extended family. So the
           inequities are certainly bigger in Africa and in the
           underdeveloped world, but they are mitigated by the cohesiveness
           of the community and the concept of the extended family.
           Although the levels of poverty etc. in this country are
           certainly less, the inequities here are almost harsher and
           harder to tolerate because we could do something about it and we
           don't. So I think our failings or our guilt-if I can talk about
           guilt-is bigger here because it's our own country and our own
           people and we could do so much more. That does not take anything
           away from the responsibility we need to take to address global
           inequities and poverty.
Harrar:     I'm working on a series about health disparities right now in
           the United States so I'm just curious whether you see those as
           being directly involved with race or with socioeconomic status?
           Which is bigger in your own experience?
Thompson:   Our history of racism has had a very negative effect on our
           society. The result of that has contributed to a loss of
           identity and culture that has been very disruptive to family and
           community life. There are obvious and severe economic effects as
           well. There is a tendency to become callused towards this, to
           live in affluence with blinders on so we don't see the sadness
           and turmoil that are there. The solution-or at least an
           approach, if there is one-is to share, in some tangible way, the
           suffering of someone, somewhere (preferably close by) so that we
           don't lose sensitivity and become callused, isolated, thinking
           only about acquisition, protection, insurance against all
           suffering, and the need to live looking eternally young.
Harrar:     When you wake up in the morning and think, what's the meaning
           of my life, have you found some comfort that you . . .
Thompson:   Yes, I do. I wake up in the morning looking forward to the day.
           I come from a conservative religious community, Lutheran
           background, and right now I'm concerned about reawakening in the
           church a sense of biblical justice. The Bible is full of a
           prophetic kind of advice and wisdom that is concerned about
           taking care of the poor, the widow, the elderly, and the
           refugee. I wake up with hope, and I've got a good job that
           allows me to do this. We have a large extended family that
           reaches around the world. A wonderful part of this has been
           having a wife and a family who have been very supportive; they
           have been a very key part of this all along. I wouldn't have
           been able to do it without Joan.
Harrar:     Did you take your family abroad when you worked?
Thompson:   Oh, yes. When we went to Nigeria, the Biafran War was brewing,
           and our families were evacuated before the first year actually
           came to an end. Joan was 8 months' pregnant with our second
           child, who was born later in the United States. Then we were
           reassigned to Liberia, and our last child was born there. When
           we went back to Africa to work with the church, they were all in
           grade school; they all graduated from high school in Nigeria
           before returning to the United States for college. We raised our
           family in Africa. I'm very, very thankful for that.
Harrar:     How would you say that has changed their worldview?
Thompson:   Their worldview is such that they tend not to see color.
           They're similarly interested in living justly, if I can put it
           that way, in sharing.
                 Our daughter has 2 daughters; they live in Billings,
           Montana. One of the neatest things they did, when the girls were
           probably about 8 and 6 years old, was to get a list from United
           Way of families that needed specific things at Christmastime.
           They went out and the girls helped shop for all of these things.
           Then they actually delivered these things to United Way; that
           made a lasting impression.
Harrar:     So you have a sense that you were able to pass on to your
           children what your parents taught you.
Thompson:   Yes. I'm very thankful for what my parents gave me, and I'm
           thankful for the lessons we learned together as a family in
           Africa. One of the things we did was have our children
           participate in our life and activities, even though that
           involved interruptions, doing without things, and some degree of
           hardship. One night our children, who were in the latter grade
           school years at the time and home on vacation from their
           boarding school, were chatting. They were talking about parents
           who weren't available and weren't around. I kind of got the
           sense that they might be talking about me, so I said, "Well,
           look, I'm here every day; I'm here at night." And they replied,
           "But, Dad, you fall asleep." My work frequently took me out into
           the villages on motorbike and that sort of thing. I loved the
           work, but it was taxing and our children experienced a father
           who was often pulled in many directions and sometimes over-
           extended. But I think my children were able to accept and adjust
           to that and ultimately were able to share some of the sense of
           accomplishment that came from it.
            They're all doing similar things in very different arenas
           today. Our son and wife are actually going to Liberia to adopt 2
           Liberian girls this summer, we hope.
Harrar:     How exciting, that's great.
                 Can you tell me, on a day-to-day basis, what kinds of
           things did you do for the smallpox eradication effort? And tell
           me about Dr. Foege, too.
Thompson:   Yes, I had the good fortune of being assigned to the Eastern
           Region of Nigeria with Bill Foege and Paul Litchfield. I don't
           know why we were assigned together, but I suspect it might be
           the fact that Bill was a missionary at the time on contract to
           the smallpox program, and I was interested in medical missions.
           Paul Litchfield, our Operations Officer, had also been a Mormon
           missionary. I considered myself extremely fortunate to be part
           of this team!
                 We arrived in Enugu in the fall of that year, and very
           soon there was a major smallpox epidemic that produced over a
           thousand cases. The epidemic was centered in the area where Bill
           had worked before with the mission; consequently, he knew key
           people and understood the area. One of the missionaries was
           particularly helpful; he supplied us with motorbikes and we went
           hunting smallpox. For weeks, we (Paul Lichfield [Paul R.
           Lichfield], Bill, and I) spent most of the week out in the
           countryside trying to track down smallpox and organizing an
           official vaccination campaign. Then we'd come back on weekends
           and crash. It was tough on our families, specifically my wife
           and Paul's wife, who had never been overseas. For me, it was
           kind of a lark. I was having fun.


                 While the smallpox epidemic was raging in Ogoja Province,
           pressure was being applied to conduct a vaccination campaign in
           Enugu, the capital city. We temporarily moved our activities to
           Enugu. One day, Bill, Paul, and I were going around Enugu with a
           big map, looking for logical gathering sites to vaccinate
           people.
                 People started gathering around, and pretty soon policemen
           appeared; we were arrested and brought to the police station. In
           the context of all the fears and stories circulating about the
           atrocities etc. that preceded the war, our maps and activities
           looked suspicious. The police called the Ministry of Health, and
           Dr. Anazonwu, our counterpart, came down and said, "Fine, no
           problem." We were immediately released.
                 Towards the end of the Ogoja epidemic, we began hearing
           about hidden smallpox cases among people in a big town who
           belonged to a group called the Faith Tabernacle. This religious
           group refused immunization and vaccination. They were hiding
           these cases because they feared having vaccination forced on
           them and because the patients themselves would be sent to the
           huge isolation camp that the Ministry of Health had set up out
           in the bush. With the help of one of the health inspectors, I
           was able to investigate the epidemic and identified 4 distinct
           generations of smallpox that were being transmitted in this
           submerged and interrelated community without spreading to the
           rest of the community. Unfortunately, the conditions leading up
           to the Biafran War started heating up and we had to be
           evacuated. So, really, my memories of smallpox and the program
           in Nigeria are limited to the above
Harrar:     And your own faith, experience with faith, was that helpful to
           you in getting this group to open up to . . .
Thompson:   No.
Harrar:     No?
Thompson:   No, no, no.
Harrar:     That did not apply?
Thompson:   That didn't apply.
Harrar:     What other cultural obstacles did you encounter?
Thompson:   Fear of vaccination was the biggest thing along with the fear
           of being sent to the isolation camp if you were diagnosed with
           smallpox.
                 For the most part, the obstacles weren't all that great.
           The obstacles were more mechanical, just getting teams into the
           field, keeping them going, keeping them supplied. I think
           ultimately the people appreciated and cooperated.
                 The Ministries of Health weren't all that excited
           initially about smallpox eradication. They wanted measles
           immunization, and we had to combine measles immunization with
           smallpox to get to the smallpox program accepted.
                 I encountered a lot more cultural issues in my later work
           than I did in smallpox.
Harrar:     How about politics, either here in the United States or in the
           countries where you were working? Any comment on that?
Thompson:   I can't comment very much on politics.
                 Our time in Nigeria was so brief that our relationships
           were limited to one small sector of the Ministry of Health. Of
           course the fears of genocide and the tensions that led up to the
           Eastern Region's withdrawal from the federal government and the
           civil war were increasingly occupying people's attention and
           those did get in the way.
                 In Liberia the times were stable; the physician in charge
           of infectious disease and our immediate supervisor was a very
           wise and gracious ex-Haitian who did all the political
           interference. So we didn't have any political issues that I can
           recall.
Harrar:     Okay. You were starting to say that there were more cultural
           and political things when you worked in other places (in Chad
           more than in Liberia).
Thompson:   Generally speaking, working cross-culturally in Sub-Saharan
           Africa is difficult. There were often old historical distrusts
           and animosities. However, the area we were working in Chad had
           primarily one ethnic group; they had a long tradition of strong
           leadership and that was very helpful in organizing a community
           program. They had, in effect, a king; they were used to working
           together and that contributed significantly to the ultimate
           success of the program. In Chad, my work involved setting up a
           very simple healthcare system using lay volunteers, young
           farmers, whom we trained. They were able to treat malaria,
           prevent dehydration with oral rehydration, take care of simple
           wounds, and give a treatment for intestinal parasites as well as
           educate by example. An immunization program in participating
           villages was carried out with the cooperation of the local
           government hospital. We were there 12 years. After about 6
           years, I turned responsibility over to a Chadian nurse and
           worked as his advisor for an additional 6 years before leaving
           permanently. We chose the leadership carefully.That and the
           cultural cohesiveness helped them not only to continue on their
           own, but also to thrive.
                 There were relatively few cultural barriers with the Chad
           program. It was the cultural strengths of the community itself
           that made our work possible. I think we would have encountered a
           lot more barriers if we had started to expand this program
           beyond this limited population, to work interculturally.
Harrar:     How important do you think a primary healthcare system is to
           solving a global problem like smallpox or polio eradication?
Thompson:   It's part of the answer. The eradication of smallpox was a
           special case; it was basically achieved by applying massive,
           regional programs of a vertical nature. These regions of the
           world had minimal primary care resources, but that did not
           prevent them from mounting special mobile campaigns with the
           help of well-targeted and effective outside technical and
           financial assistance. The eradication of polio would prove to be
           much more difficult and more dependent on primary care
           resources. Even when I was with smallpox, I started thinking
           about how the eradication effort could be used to build primary
           healthcare at the local level. One thing the smallpox
           eradication effort did accomplish in respect to primary
           healthcare was the practical epidemiologic and managerial
           expertise it left behind in each country. The development of
           successful primary healthcare systems is highly dependent on
           operating from a firm public health/epidemiologic base! However,
           I didn't get a chance to apply what I learned in the smallpox
           program until I returned to Africa in 1975 under the auspices of
           our church. The goal then became to create a simple, self-
           sustaining, primary healthcare system with immunization as a
           core feature.
                 There are several unique healthcare systems operating in
           countries like Chad. The primary and most obvious is the
           government system, which is very centralized, poorly managed,
           and poorly supplied, for obvious reasons. Chad is one of the
           poorest countries in the world with very little infrastructure.
           (The main clinic building in Léré dated from the pre-World War I
           German colony era.) Another system, which I call the emerging or
           chaotic system, is the sale of almost anything in the
           marketplace. In addition, many families have a little box of
           medicines they received from their city relatives. And finally
           you've got the traditional healthcare system that includes
           herbalists, bonesetters, diviners, etc.
                 Unfortunately, with the passage of time and the
           availability of miracle medicines (antimalarials and
           antibiotics), an attitude arose in the popular mind that the
           individual is not really capable or responsible for his/her
           healthcare; an expert/outside agent provides that. The people
           lost their ability or confidence to care for themselves that
           they had, even though much of that care may have been
           problematic. So the long-term answer is to build a primary
           healthcare system that restores self-confidence along with local
           responsibility and control.
                 Large vertical programs have their place, and smallpox was
           probably the best example of a successful one. But I think as we
           move on from that, there has to be more emphasis on creating
           locally owned, locally driven, primary healthcare systems that
           nonetheless work within the system, subject to the local
           authorities. Good technical expertise and public health
           principles need to be coupled with local decision making as part
           of a more global national effort. This is what our program in
           Chad was all about, but we accomplished only the first step by
           establishing a program in a single cultural community. The next
           and harder step will be to grow related programs in other areas
           and cultures.
Harrar:     You mentioned that the local people you trained were
           volunteers, and I know there's a long history of community-based
           volunteers in many parts of Africa.
Thompson:   Right.
Harrar:     At the same time, I hear people like Jim Kim and Paul Farmer
           saying they think healthcare workers should be paid. You know,
           why should we ask the poorest people in the world to volunteer?
           Could you comment on that for a moment?
Thompson:   How are you going to pay for primary healthcare, and where do
           you start? One way is to pay them. Well, where are you going to
           get the money? These are subsistence farmers. The system that
           the villages agreed upon was that they would give each volunteer
           2 sacks of corn and I think 4 liters of cooking oil a year, plus
           some work in their fields. They didn't receive any money for the
           care they rendered. The medicines given to patients were sold at
           cost. This way they established a revolving fund that enabled
           them to buy new medicines. The reimbursement of the health
           workers, however, was always a problem, and it was tempting to
           dip into the health post funds. But how else are you going to
           start? In this case, most of the health workers were motivated
           by their Christian faith to be of service to their community
           without expecting anything in return. (The villagers, the great
           majority of whom were animist, selected the workers. There were
           absolutely no requirements as to church membership or religion.)
                 The other way is to pay for them from abroad, and then
           you're creating dependency. One of the rules we started out with
           was that we were going to use available technologies and
           available resources so that when I, as the white physician left,
           people couldn't say, "Well, I can't do this because he had
           this." So I limited my work resources. For instance, I rode a
           mobylette or a 100-cc motorbike, rather than a car. In similar
           ways I attempted to do my work in such a way so that the Chadian
           nurse who I trained and mentored could follow in my footsteps.
                 Ultimately, primary healthcare is linked to economic
           development. I always foresaw the next stage as not more
           healthcare, but economic development and local industry, doing
           something with agriculture so that people had more money. More
           resources would then be available to invest in the next stage of
           health development. Government is always a wasteful, albeit
           necessary, manager of resources. We need to foster development
           in a progressive, step-by-step manner with recurring cycles of
           very simple primary healthcare as we did in Léré, then economic
           development, then another level of healthcare, and so on, all
           based on developing sustainable local economies. The healthcare
           and economic cycles could of course go on simultaneously, but it
           is important that they be coordinated and go at a speed that is
           manageable by the local community. Unfortunately, we weren't
           able to see the next stage of economic development, but from
           reports, that seems to be happening currently. The program that
           I began is still going and actually expanding. But I wonder
           whether it can survive in the long term because of the economics
           and because they're just one local organization. They're limited
           to a sub-prefecture, 100,000 people. My dream was to take this
           model, build in adjacent areas, and then let it spread by
           itself. Hopefully, this may take place someday. I don't know.
Harrar:     What you said sounded very much like the Tau leadership. Have
           you read about that, that I go into the village and I talk to
           the people about what they need?
Thompson:   Yes.
Harrar:     I knew that I had succeeded if, when I left, the people said,
           "We can do this ourselves." It's a very powerful idea.
Thompson:   Yes. There's a story that I believe came out of Guatemala. A
           hospital in a rural area had difficulty in expanding their very
           good public health programs to villages in the near by
           mountains; the hospital wasn't having any effect on this group.
           Finally, in desperation, they sent someone up there with the
           question: "What are your problems?"
                 "Oh," they said, "our chickens are dying."
                 So they sent staff up to find out what the problem was
           with the chickens, solved it, and that was the entrée. If I had
           to do this all over again, I would have done a lot more of that.
                 I came in with good ideas and said, "This is the primary
           healthcare model we're going to start with," and as time would
           tell, the better way would have been to simply to come and say,
           "Okay, how do we do this, and what are your needs?" So I made
           mistakes.
Harrar:     But that's how you learn. Right?
Thompson:   That's how you learn. That's right.
Harrar:     So were you trained by the West Africans, or the East Africans?
Thompson:   West Africans.
Harrar:     Do you see lessons from the Smallpox Eradication Program that
           can be applied today to public health, other public health
           problems?
Thompson:   The model of the smallpox program was really simple, had very
           clear goals and objectives, and it used non-physicians
           extensively. I think the physicians were a necessary element,
           but the role of the Operations Officers was equally important.
           It was the people behind the scenes and the PHS Operations
           Officers who kept the vehicles running, who made sure there were
           adequate vaccine supplies, who kept the cold chains intact, who
           did a lot of the team teaching, supervision and mentoring. That
           was the real secret.
                 All of the countries were coming out of the colonial
           period with a certain legacy of hierarchy and beaurocracy. For
           instance, when it was proposed that I go to Liberia, there was a
           reluctance to accept me as an epidemiologist because I was just
           a recent graduate. I'd just finished an internship; I didn't
           have a public health degree at the time. There were a number of
           people like this. There was a tendency to believe you needed
           degrees and experience. One thing this program showed was that
           if you had professional staff with the basic medical background
           who were adaptable, teachable, creative, hardworking, and well
           supported, you could do almost anything. (The brief training
           provided by CDC before we left for Africa, that included the
           summer EIS course, was superb.) A good understanding of basic
           epidemiology was also critical. The proof of this is in the
           results of the program.
Harrar:     Can you elaborate on the epidemiology aspect of it? What were
           the challenges and the keys to that?
Thompson:   The epidemiologic keys pretty much came from Bill Foege and the
           principles behind his notion of eradication-escalation. First of
           all there are almost no cases of smallpox infection that are not
           quickly and easily recognizable. So the first step was to
           achieve a high level of herd immunity and a low incidence of
           smallpox by means of mass vaccination campaigns. Random sample
           vaccination scar surveys were then carried out to insure that
           the vaccination take-rates or immunity (as measured by a recent
           vaccination scar) were indeed adequate. The next step was to
           have a good surveillance system in place so that any suspected
           case of smallpox was reported and aggressively investigated.
           When cases were identified, the final tactic was to do ring
           immunization in the community around the case and look even more
           aggressively for other cases. It was simple and brilliant.
                 I think CDC did a marvelous job of putting resources
           behind this program so that we didn't run into mechanical
           roadblocks like lack of well-functioning equipment. One of the
           major problems was that the 4-wheel-drive vehicles were breaking
           down, but the needed axles were going to Vietnam, and so they
           had to scrounge and make do. But they always came up with
           solutions. The administrative backstopping by the Atlanta and
           Lagos staffs, and their ability to work things out with USAID
           [US Agency for International Development] and WHO [the World
           Health Organization], for instance, were extremely important.
           Finally the CDC staff on the ground in the individual countries
           and their partners were resourceful and became adept at finding
           local solutions.
Harrar:     So, how did you personally feel about being part of this
           program? In your own life and career, would you rate it right up
           there, or . . .
Thompson:   Oh, man. My involvement in the smallpox program was a mountain
           peak that I, in many respects, felt I didn't deserve; I consider
           myself extremely fortunate to have been a part of this. The
           opportunity to work with Bill Foege and to keep up that
           friendship down through the years has been stimulating and
           wonderful. All you have to do in public health circles is drop
           the word, "I was with smallpox," and you've got recognition.
Harrar:     Are there any funny, heartwarming, or terribly important
           stories to you that you'd like to lay down on tape?
Thompson:   Everybody knows Bill Foege; he's great! He has a fabulous
           memory and is one of the best story tellers around. He is
           extremely competitive, and once had a contest with an office
           mate as to how early they could get to work. Bill won that hands
           down!
            A secretary found him reading an airline schedule book and
           asked, "What are you doing?" Bill responded in all seriousness
           that he was memorizing the schedule. A bit suspicious, she asked
           him what the connections were between 2 specific cities. As luck
           would have it, he had been looking at exactly that specific
           connection and rapidly gave her the correct data. She was very
           impressed. Bill remained silent.
            Later Bill told a story of when he was in India with the
           smallpox program. He traveled frequently on the trains and made
           friends, as he was wont to do, with the conductors and staff. A
           staff member was leaving the country and Bill volunteered to
           take a large crate of personal effects with him to the coast. He
           got the train officials to agree to carry the crate without
           charge or papers. Arriving at the destination, the crate was
           unloaded, and Bill was heading out of the station. Some customs
           officials stopped him and asked for the papers on the crate.
           Realizing he was in a jam, he acted as if he couldn't understand
           and began talking in German. I believe he even began reciting
           the Lord's Prayer when his limited German ran out. His ruse was
           at the point of being discovered when the officials were
           interrupted by more serious problems and disappeared.
            Our counterpart in eastern Nigeria, Dr. Anazonwou, could never
           pronounce Dr. Foege's name, and he always called him Dr. Fog,
           which is kind of humorous considering who he is.
                 But I had other goals and after 4 years with smallpox, it
           was time to move on. We wanted to return to Africa as medical
           missionaries, but for some reason, those doors didn't open up
           right away. We went to Baltimore, where I received an MPH
           [Masters in Public Health] in international health. Since
           pediatrics seemed be the best clinical preparation, we returned
           to Minnesota, where I finished a residency in pediatrics at the
           University of Minnesota. By that time things were ready, and we
           returned to Africa.
Harrar:     And what do you see now as the biggest challenge in pediatric
           health for the children of the world and the children here in
           the United States?
Thompson:   It's interesting. The challenges for pediatrics in the United
           States are to provide access for all, to decrease the cost of
           medical care, to recognize the fact that a lot of the services
           we as physicians provide are not truly effective in terms of
           improving health and that a number of these services can be
           better provided by non-physicians. Our well-child checks (WCCs)
           are an example. There are good data to show that WCCs are a very
           ineffective use of resources. One of the things that I try to
           encourage our trainees to do is to think: how can we live and
           work in this environment in such a way that we use fewer
           resources so that we can devote more resources to kids in the
           underdeveloped part of the world?
Harrar:     And what do those children need?
Thompson:   Oh, boy. Well, the children in the rest of the world need
           peace, first of all, and that's a major failure on our part.
           They need local resources. They need training. They need
           opportunities for training. Probably one the hardest experiences
           for us was to see bright young kids who would have to take their
           exams multiple times or bribe an instructor in order to get
           their baccalaureate and graduate from the lycée. The corruption
           in the system was such that passing marks were frequently not
           enough to get a diploma. And then there was so little
           appropriate employment available once they did graduate. Not too
           surprisingly, we need education, job opportunities, and local
           development, so we don't have brain drain or brain loss (from
           lack of opportunity and use).
                 I always liked the bumper sticker that says, "Think
           globally; act locally." Right now, probably the biggest
           hindrance is our tremendous affluence and this political climate
           that we've created today, which is not only getting in the way
           today, but also will for decades.
Harrar:     What do you see to be the problems the way people are today?
 Thompson:  9/11 created an attitude of paranoia. As Americans, we weren't
           used to being attacked on our home ground. We've always been
           very cocky and self-assured. We could live in an isolated
           fashion without really suffering too much. But 9/11 kind of blew
           that all away. Unfortunately the reaction was to become even
           more insulated, self-protective, and defensive.
                 There is a glaring gap between the "haves" and the "have-
           nots" in the United States. An example from the healthcare field-
           and this has gotten a lot of press in Minnesota, the home of the
           whole HMO [health maintenance organization] idea-the CEO of
           United Health Group, a large HMO, received a total compensation
           of $124.8 million in 2004. Then look at the poverty rates and
           the rates of the uninsured! We live increasingly in an
           environment where we are repeatedly being invited to become more
           self-interested, self-protected, suspicious, and reactive to
           anything that looks contrary to our interests wherever that
           might be. Then we get involved in this war in Iraq. It is going
           to be very hard to recover from this and to move on.
Harrar:     Do you see some hope in other sorts of small things that are
           going on?
Thompson:   Oh, yes. There's lots of hope. The smallpox program created
           tremendous hope. And I think the program that we started in Chad
           does too. They've not only continued but have grown under total
           local leadership and financing. And we've seen our children grow
           up and do good things. Then you come back to a place like CDC
           and run into all these people and see what people are doing.
           Yes, there are a lot of good things going on.  There is plenty
           of hope
!Harrar:    Okay. Well, we thank you so much. That was really interesting.

                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Deane Hutchins about his activities in the West
Africa Smallpox Eradication Project. The interview is being conducted at
the Centers for Disease Control and Prevention in Atlanta, Georgia, on July
14, 2006, as a part of the 40th reunion of the West African Smallpox
Eradication Project, to mark the launch of the project. The interviewer is
Laura Harrar.

Harrar:     I noted in reading your bio that you were involved in private
           practice in Boothbay Harbor and then taught at the University of
           Maine. So how did you even begin to think about taking a leave
           of absence to join the Smallpox Eradication Program?
Hutchins:   While at the University of Maine, I was the Director of
           Clinical Services at the Student Health Center, and I what I
           thought was influenza. I knew D. A. Henderson [Donald A.
           Henderson] because he was my classmate in medical school, and I
           knew he'd been on the surveillance program for influenza. So I
           called him up and said, "D. A., are you interested in some
           throat washings of influenza?" And D. A. said, "No, not really,"
           he said, "but would you like to go to Africa?"
                 My wife and I had never talked about this. I went home
           that noon and talked with her and said I'd seen D. A. She said,
           "What did you talk about?" and I said, "Nothing in particular.
           He asked me if I wanted to go to Africa," and she said, "What
           did you tell him?"
                 I said, "I told him I would call him back."
                 My daughter was home from school, and she went to school
           and told her teacher we were going to Africa. Within 2 days, I
           had called D. A. back and said, "Yes, we'd like to go."
                 I got a leave of absence from the university for 2 years.
           Now, universities don't like to give a 2-year release, but the
           president of the university had been overseas himself and knew
           that it was a 2-year assignment. So I got the leave of absence,
           and we made up our mind and, in July, we came down to CDC and
           were on our way.
Harrar:     I noted that you had a major in zoology in your earlier years.
Hutchins:   Yes. Zoology was just part of the premedical course that we
           took.
Harrar:     And why do you think D. A. tapped you to do this? Had you ever
           imagined that you would be working abroad in public health?
Hutchins:   No. I'd done a few surveys at the university when they had
           their usual food outbreaks and tracked that down, but nothing
           really formal about epidemiology. As I mentioned, I worked with
           D.A. in the same room with the dissecting tables in medical
           school, so I knew him well.
Harrar:     Had you ever imagined that you would work abroad?
Hutchins:   Not in particular. I'd been overseas during World War II, but
           nothing beyond that.
Harrar:     Okay. So you can blame all of this on D.A.
Hutchins:   Blame it on D.A.
Harrar:     Okay, all right. Tell me a little bit about your family at the
           time. Were they excited about this? Was there just the one
           daughter?
Hutchins:   We'd never considered going overseas. My wife was excited about
           it; all 4 daughters were excited about it. And had there been
           one dissent, I'm sure we'd have thought that we shouldn't do it.
           But we decided to go and never regretted it at all.
Harrar:     Would you call your family adventurous and outgoing and
           curious?
Hutchins:   I guess the family probably was curious and was moderately
           outgoing. They had a good time.
Harrar:     What was the range of your daughters' ages at this point?
Hutchins:   The oldest one was 14; the youngest was probably 7.
Harrar:     So, start with the phone call from D. A. Henderson, and tell me
           what happened then, how you got yourself and your family to
           Africa.
Hutchins:   Well, we started preparing to go to Africa, and come June, we
           packed up our Volkswagen, packed up the car, and drove to
           Atlanta.
                 Ion the humorous side of things, we sent our Volkswagen
           bus in June to Nigeria, and we received it the next February,
           which was par for the course.
Harrar:     And so, did you need to send an enormous boatload of goods?
Hutchins:   Yes. We took a lot of things. We had 2 shipments. We had an air
           shipment of limited pounds, and then we had sea freight, in
           which you could take most anything you wanted. We read books to
           find out what we should take.
                 Air freight got there just before Christmas, and we left
           in October. Sea freight didn't get there until sometime in the
           spring.
Harrar:     Was it a pretty big culture shock for you and your family? Talk
           to me about the language issues and some of the cultural changes
           that they had to get used to.
Hutchins:   The cultural shock hit us, I think, the worst right in Lagos,
           which is a capital city. From the airport into the center of the
           city, it's pretty raw. The smells are terrible, as you may well
           remember. It wasn't unusual to see a dead body on the street,
           and it would stay there for a day or 2.
                 Most of the people we dealt with could speak English, so
           that wasn't a big problem. When we got up to Kaduna in northern
           Nigeria, we did try to pick up the local language, Hausa, enough
           so that we could say good morning, how are you, where's the
           bathroom, how do I get home, what time is it, and that type of
           thing.
Harrar:     Would you say that you were welcomed by the local people?
Hutchins:   Definitely. The local people were very nice. I never felt
           uncomfortable. And this was right before the Biafran War had
           started. But about 2 weeks before we went to Kaduna, they'd
           killed about 30,000 Ibo people who were living up there. So
           you'd go by these houses that were strictly empty and burned
           out, and we didn't realize the significance of it at the time,
           but, in retrospect, it was a little bit scary.
Harrar:     How did you and your wife feel about this once you got there
           and you realized what you had brought your family into?
Hutchins:   It was an adventure. I don't think we ever felt uncomfortable.
           There were problems like communications. We were there for 2
           years, and to call the United States, you had to book the call
           ahead of time. Then they would call London, London would call
           New York, then New York would call where you were calling. One
           time I did get through on the telephone. You were limited to 3
           minutes, but my 3 minutes were used up by the time they got
           through, and I could just barely hear my father say, "Hello."
           Then the operator said, "Your time is up." And I said, "Would
           you at least tell him that we're all right?" That was quite an
           experience.
                 We had a telephone in our house all the time we were
           there. It worked just 3 months. The military government took
           over the country. We lived right beside the military governor,
           and I know our telephone number was given to him. But that
           wasn't too bad because no one else had telephones either, so you
           couldn't call anybody.
Harrar:     So, did your family feel isolated at all, do you think?
Hutchins:   I don't think they felt isolated. All of my daughters went to
           school in Kaduna. The second semester, my oldest daughter went
           to an international school down in Ibadan, 400 miles from
           Kaduna. The problem there was that there was just one bridge
           across the Niger River, and this was after fighting had started;
           if they'd blown that bridge, it would have been difficult to get
           to my daughter.
                 Two other daughters went to a missionary school in Joss,
           which was an American school 150 miles from Kaduna. During the
           rainy season, you couldn't drive, so it was a mixed situation.
Harrar:     Transport, yes. And what was your exact role on the Smallpox
           Eradication Program?
Hutchins:   I was the Medical Officer in the Northern Region of Nigeria.
           Two Operations Officers worked with us.
Harrar:     So on a day-to-day basis, describe for me your activities and
           the range of challenges that you had.
Hutchins:   Well, let me tell you a little bit about our office. We lived
           in an ex-Minister of Finance house. This is a Muslim country,
           90% Muslims. So they had a long tunnel that went from the house
           out to the wives' quarters. There were 7 apartments out there, 4
           for wives and 3 for the concubines. Well, since the Minister had
           been kicked out of his house, the Ministry gave it to us to live
           in. We had our offices out in the old wives' quarters, which was
           crude but convenient. It wasn't very nice, but at least it was a
           place where we could sit down.
Harrar:     I thought you were going to say you installed your daughters.
Hutchins:   Well, I did have a kid come up to me and want to buy my
           daughter, but I told him she wasn't for sale. He was serious, I
           think.
Harrar:     On a day-to-day basis, what kinds of things were you involved
           in as a Medical Officer?
Hutchins:   I was concerned about the quality of the organization of the
           eradication program, smallpox reporting, and the vaccinating
           teams. As the reports of smallpox came in, we would investigate
           the outbreak and visit the various smallpox hospitals. That's
           about it, I guess.
Harrar:     Was there a strong sense of collegiality among the people
           working on the effort?
Hutchins:   Yes. We had 3 groups of teams, and each group had about 10
           teams; there were 7 people in each team. So we had well over 100
           Nigerians who were taught to give smallpox vaccinations. Now,
           most of them had not gone beyond 7th grade, but they were
           classified as health workers. We would teach them how to give
           smallpox vaccine with the jet injector and how to take care of
           the vaccine.
                 We stressed very strongly that the vaccine should be kept
           cold at all times. We told the drivers of the trucks to turn
           their refrigerators off-these were kerosene refrigerators-while
           moving along, and when they got to the destination, the first
           thing they should do is turn the refrigerator back on.
                 Well, I came across one truck one day, and it was probably
           100°F or so in the sun. He'd broken down. My first reaction was
           to put my hand down in the freezer to see if it was cold. It was
           hot. So I started giving him a bad time. "But, master," he says,
           "you said to turn it on when I got to my destination," and, of
           course, he was a long way from his destination.
                 But you could tell stories like this end on end.
Harrar:     What do you think were the biggest obstacles that you faced,
           that you had to find a way around?
Hutchins:   Communications, there's no question. For me to get in touch
           with my boss, Stan Foster [Stanley O. Foster], in Lagos was
           almost impossible. And to do it by courier took a long time,
           maybe another week or so, before you'd get an answer back. But
           communication, by all means, was difficult.
                 Transportation of vaccine-getting it from Lagos to Kaduna-
           was also difficult. I remember one time we were having problems
           with this, so we had one of the Americans put it on the plane in
           Lagos. We got to Kaduna, and the vaccine was not there.
           Unbelievable. To this day I don't know where it was. And we're
           talking about several thousand dollars' worth of vaccine.
Harrar:     When you were training the Nigerians, did you also learn things
           from them?
Hutchins:   Oh, yes.
Harrar:     Can you elaborate on that 2-way process?
Hutchins:   I guess, overall, the biggest thing you learn from all
           developing countries is that you're not going to change them a
           whole lot. They've been doing something one way, and they're
           going to continue doing it about the same way.
                 The first morning that we officially vaccinated, I had a
           schedule all made out. At 7:00, the driver is to be there; 8:00,
           we'd move out; at 9:00, we'd start vaccinating. Well, to begin
           with, the drivers didn't show up till after 9:00, and this was
           probably typical of where we worked.
Harrar:     Were there comical things that happened along the way?
Hutchins:   Oh, yes.
                 Well, thievery in developing countries is always a
           problem. We had these kerosene refrigerators, and kerosene was
           worth good money. So I went out one morning, and here's this
           fellow with a 5-gallon can of kerosene in his hand. "Oh," he
           says, "I'm not stealing, I'm putting it back."
                 I guess one of the funniest things that I remember
           concerned Dr. Foege [William H. Foege]. He had been in eastern
           Nigeria, and then the Biafran War broken out, and so they asked
           him to leave. He came up to northern Nigeria, where I was, and
           he said he would like to see some of my teams operating. So I
           gave him a truck and a driver, and he went out. About 3:00 in
           the afternoon, the Minister of Health called me and says,
           "Where's that Dr. Foege? You know, he came up from the east,"
           where, of course, there was fighting. And I said, "He's up-
           country."
                 And so they got the army out and picked him up that
           evening-they wouldn't let him break down his tent-and, under
           armed guard, brought him back to my house. Well, Dr. Foege is a
           very tall person to put in the back of a Land Rover, especially
           with an armed guard on both sides of him. And to hear Bill tell
           the story, he says, "I nudged one of these soldiers and said,
           'Would you mind moving that rifle over? It's hurting my leg.'"
Harrar:     Can't you just hear him saying that?
Hutchins:   Yeah.
Harrar:     Oh, boy. Okay.
                 I understand that you were involved in tracing monkeypox
           to humans in the 1970s.
Hutchins:   Yes. That was in Sierra Leone. I got a call about a case of
           smallpox in a small village. Well, this was after we thought
           smallpox had been eradicated from Sierra Leone. So I went out to
           this village and finally found the case. Clinically, it
           resembled smallpox; you couldn't tell that it wasn't smallpox.
           So I took a brief history and checked to see who had been
           vaccinated against smallpox, and this patient had not been
           vaccinated. I got some samples and sent them back to CDC. Well,
           again, communications. Two or 3 weeks later, I got a cable back
           saying, "This is smallpox. Look for other cases" because you
           can't have one case of smallpox without having another case.
                 So I started looking. After a few days, I got another
           cable from CDC saying, "This is not smallpox. It's monkeypox."
           If you grow it out on the allantoic membrane of chick embryos,
           you can differentiate the 2 viruses.
                 So I went back to the village again and took a better
           history, and, sure enough, this fellow had prepared a monkey to
           eat about 12 days before onset of his illness. This was a tribe
           that ate monkeys. He was the only one who had not been
           vaccinated against smallpox; the rest of the village had been
           vaccinated. This was good evidence that the smallpox vaccination
           also protected him against monkeypox.
Harrar:     Can you tell me a little bit more about the experience in
           Sierra Leone? How did it differ from the experience in Nigeria?
Hutchins:   Well, the day before we left the United States to go to Sierra
           Leone, WHO [World Health Organization] had reported cholera in
           West Africa for the first time, and so I called up CDC to get
           some information on it. I think I talked with Gene Gangarosa or
           one of the fellows in the enteric group, and they gave me what
           information they had on it off the top of their head.
                 I arrived at the airport in Freetown, and reporters were
           there asking how we were going to eradicate cholera; like we had
           eradicated smallpox? Of course, I didn't have any answers for
           them. It's a different disease, and you can't eradicate it like
           that. So I spent most of my time with the cholera program that
           we developed while we were there.
Harrar:     Were there things that you learned about public health in West
           Africa that you have been able to apply in your career since,
           either in some of these international places you worked or back
           in Maine?
Hutchins:   Well, if you see an outbreak of something, you take a different
           approach to it. Most practicing MDs aren't really interested in
           epidemiology, although you became interested in it once you'd
           seen how it can really help.
Harrar:     Is there anything that you wish you could have done differently
           in the way the program was run?
Hutchins:   Well, getting back to the communications, there wasn't too much
           that you could do to improve communications in those days.
           Today, of course, it's so much different.
Harrar:     And how would you say that this experience had an impact on
           your wife and children?
Hutchins:   Well, having lived with a different culture, especially a black
           culture, my kids have no racial bias at all. I don't know if I
           mentioned this before, but my oldest daughter went to school
           with 500 Nigerian schoolgirls, and I think there were 3 other
           expatriates in that school. My daughter has long blonde hair.
           The Nigerian girls were fascinated with this, and they'd come up
           and they'd feel her hair. She learned a lot. And the other kids
           went to various and sundry schools.
Harrar:     So your wife wasn't one who said, "How dare you make a decision
           like that?"
Hutchins:   Well, we had a good time the first 2 years in Nigeria. We went
           back to the States and swore we'd never go overseas again. We
           were back about 3 months, and we decided, "Well, gee, we really
           had a good time," so we went back to Sierra Leone. After Sierra
           Leone, I went with the State Department, taking care of the
           American Embassy personnel in these other countries.
Harrar:     So it turned you into adventurers for the rest of your life.
Hutchins:   Yes. And 2 of my daughters lived overseas after they were
           married.
Harrar:     Did any of them go into health?
Hutchins:   Two are nurses, and one married a doctor.
Harrar:     So, could you comment on the problems of health workers and how
           you could see that getting solved today, I mean from your
           experience seeing the need for trained health personnel?
Hutchins:   I realized that you could train uneducated people to do a
           health program. For example, these vaccinators that we had had
           very little education. Sterile technique was still unheard of,
           and we didn't really use much sterile technique. We did not
           clean off arms before people were vaccinated. We told the
           vaccinators that if they dropped the nozzle of the jet injector
           on the ground, clean it off with some alcohol or something. They
           would just brush it off and put it back on.
                 We did studies to see if there were any adverse effects,
           and there was no significant increase in infections from this
           lack of sterile technique.
Harrar:     And do you think that people can be trained who maybe haven't
           had an advanced education to do many of the tasks of public
           health?
Hutchins:   Yes. Especially something that's repetitive can be taught to
           most anyone. Matter of fact, there are places in West Africa now
           where they teach local people to do eye surgery. You know, it's
           one simple procedure, but they do it, and they have very good
           success with it.
Harrar:     I've heard it said, too, that if one wanted to really solve the
           problem of maternal mortality, if you could get some basic
           anesthesia capacity and some basic cesarean-section capacity,
           you could do an awful lot in field hospitals to save women's
           lives.
Hutchins:   Yes. I think there are places where they've taught the local
           technician to do cesarean sections. It's not that difficult.
           Now, if they run into problems, well, that is a problem, and
           they probably couldn't solve it. But 9 out of 10 go along as
           planned.
Harrar:     Better than obstructed labor?
Hutchins:   Yes.
Harrar:     Is there anything I can ask you that you haven't had a chance
           to speak about that you would like to?
Hutchins:   Well, it was a great experience. I would not recommend it to
           anyone if one member of the family didn't want to go overseas.
           As I said, I worked for the State Department Medical Program
           overseas afterwards. I saw some families that were sent over
           there and there'd be one dissenting family, and invariably that
           whole family was unhappy. They either had to be shipped out or
           would quit.
Harrar:     But, fortunately, you had a family full of adventurous people
           and curious people.
Hutchins:   Yes. Our kids were great, and my wife was great, and we had a
           good time.
Harrar:     Well, thank you so much. I really appreciate it.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dorothy F. Hicks. The interview is being
conducted at the Centers for Disease Control and Prevention in Atlanta,
Georgia, on July 14, 2006. It is a part of the 40th anniversary reunion of
the launching of the West Africa Smallpox Eradication Program. The
interviewer is Linda Harrar.
HARRAR:     There's no such thing as a wrong answer here. If you don't like
           the way you said something, just say, "Let me pick that up
           again," and you can start your thought again. So don't worry;
           it's not a high-pressure situation by any stretch of the
           imagination.
                 May I call you Dot? Is that okay?
Hicks:      Please do; all my friends do.
HARRAR:     Okay, great. How did you and your husband came to be involved
           with the smallpox eradication campaign?
Hicks:      My husband was here as an employee of the Centers for Disease
           Control but had been transferred to Raleigh, North Carolina. He
           was Chief of Venereal Disease Control as a federal assignee to
           the state of North Carolina.
                 We lived in the Raleigh area and didn't have children
           after being married for quite a few years and decided we would
           like to have a family. We progressed in adopting a little boy,
           and Jimmy came to live with us at 8 months. And we had our order
           in for a little girl, but Jimmy had to be 2 years of age before
           we could adopt again, under the law in North Carolina.
                 Jim didn't come home for lunch each day. He stayed at the
           office and went out with different people for lunch. And 1 day
           he came home, and he walked in the house at lunchtime and I
           said, "Are you feeling all right?"
                 And he said, "Yeah, I'm fine, but I think you'd better sit
           down."
                 I said, "Why? Are we being transferred to New York or
           Chicago?" because he knew those were 2 places where I had worked
           at 1 time and did not want to go back to live.
                 And he said, "No." He said, "I've been asked to take a job
           in West Africa."
                 And I said, "What are we going to do about the second
           child? When do you have to go?"
                 He said, "Yesterday they wanted me there."
                 And I said, "Let me call Josephine Kirk," who was the
           director, at that time, of the agency.
                 I said, "Josephine, we're supposed to get a little girl,
           and Jim's being sent over to West Africa."
                 And she said, "Well, Dot, if you would take a boy, we've
           got a precious little boy you could take."
                 And I said, "But we don't even have birth certificates yet
           for Jimmy because he's not 2 yet."
                 And she said, "Well, we'll work something out."
                 And I said, "Well, Jimmy has asthma, and I don't know how
           that's going to affect things."
                 And, of course, Jim told Dave Sencer [David J. Sencer],
           who at the time was the Director of CDC, and he said that CDC
           would get a waiver on it from Washington, which they did.
                 Jim left, and I was there until the house was sold, and
           then he came back to go over with us. So that was how we wound
           up in Lagos, Nigeria.
HARRAR:     Okay. And what were your first impressions when you arrived in
           Lagos with 2 children in . . .
Hicks:      In diapers. We came in from Switzerland, where it was snowing.
           When we arrived at the airport, they actually told us on the
           plane that it was very hot, and we, of course, had winter
           clothes on. When we deplaned, it wasn't like any airport here.
           It was like airports used to be in this country, where you had
           to deplane out on the tarmac and walk in. And as we walked in,
           there were guards with guns, and you had to walk through them to
           go into their security, and I wasn't used to that, of course. It
           wasn't 9/11 yet, so we weren't used to this kind of security.
                 And we got through security, and they had a car waiting to
           take us to a residence, which I had never seen. I had no idea
           where we would be going. And I was amazed, as we left the
           airport to head to Lagos. There were no streetlights, very few
           paved roads. But along the roads there were little stands that
           people obviously had made, and the only light was candlelight to
           sell their wares. So that was my first impression.
                 I was a bit apprehensive about where we were going to be
           living. What are we going to be living in? I didn't know whether
           it was a thatched hut or what it was going to be. But when we
           drove in, it was a compound. The housing had been provided by
           the government, and it turned out to be a very nice home.
                 Our only concern when we arrived is that we had been told
           by 1 of the physicians here who had been over there that they
           were concerned about having the 2 boys because the stairs were
           different than any stairs that we have here. They didn't have
           backing to the stairs, and with the children that small, they
           were concerned about when they started to crawl and get around.
           But we never worried, never had any problem with it. We were
           there when they were going up and down the stairs. And just
           things like that.
                 But it was a very nice compound, the housing that was
           provided, and the furniture was provided. By the guidelines, you
           had to hire locals to work for you while you were there. They
           had secured a nanny for us, a cook, and since cooks do not clean
           the house, we had a houseboy to clean.
                 And then, like dumb Americans going into that kind of an
           environment, we, in our sea freight, sent over a lawnmower. But
           we found out, when it arrived, that that's not what they use
           over there. They use machetes to cut the grass. It was little
           things like this.
                 But I thank God that we had a chance to see another
           culture.
HARRAR:     I imagine you learned some things and had some experiences that
           you will just never, ever forget.
                 How did you find the people of Nigeria? Were they
           welcoming to you?
Hicks:      Very friendly.
                 They had guards. You know, we were there during the
           Biafran War with the Eastern Region, the oil region of Nigeria,
           and the military capital was in Lagos. The American wives and
           children were given the opportunity to evacuate, but we could
           not come back. And we chose, as a family, to be together, even
           though Jim was traveling throughout the entire 19 countries, I
           believe it was. It may have been 20; I don't remember. And it
           was an experience then that I hadn't expected.
HARRAR:     What would you say the impact of this experience was on your
           family, on the boys growing up, and on your own view of the
           world?
Hicks:      My view of the world is that we don't know how fortunate we
           are. I wish I could convey that to people. And when people are
           poor in this country, I haven't seen anything in this country,
           as many places as we've lived, that would be anything like
           living in an environment like that. When you see children that
           are sold from 1 client to another to work, and they'd come to
           our backdoor in the morning carrying loaves of bread, little
           tiny loaves, to sell. Precious children. And children with
           swollen bellies, that you thought, "Boy, that child had too much
           to eat," and then you'd find out that it wasn't that they had
           too much to eat, they weren't getting enough to eat. It's hard
           to convey to somebody.
HARRAR:     It kind of breaks your heart, I'm sure.
Hicks:      It does.
HARRAR:     Especially when you're raising children of the same age.
Hicks:      Yes. But both of our sons now really don't remember anything
           because Jimmy became very ill with his asthma overseas, after we
           were there for 2 years, and had been hospitalized over there
           around 20 or 22 times. Jim was out of Nigeria, in 1 of the other
           countries, and they sent a cable and told him to come back
           because they didn't think Jimmy was going to make it, and they
           decided to send us home.
HARRAR:     It must have taken a lot of courage for you to be the mother
           and try to hold down the fort at home while this was happening
           and your husband was traveling.
Hicks:      So we were there about 2 years, going on 3 years, before we
           left. And we couldn't come straight home by plane. They wanted
           us to stop in major cities in case Jimmy had an attack.
                 He's now 42 years of age and is a chemical engineer with
           Solvay. And why he chose to take chemical engineering, I don't
           know, but he's in polymers. So he says, "Mom, we develop it on
           the computer, and if it explodes, we don't do it." But it's
           things like this.
HARRAR:     Do you remember how you felt when it was announced that
           smallpox had been eradicated?
Hicks:      Elated, absolutely! Jim continued to work in smallpox from here
           and would leave and go over for 6 weeks at a time and that sort
           of thing. But it was an experience that I'm thankful we were
           able to have.
HARRAR:     And did you see values in Nigeria maybe that you thought were
           powerful, whether it's family . . .
Hicks:      Absolutely family. The mothers, if they can afford to do it,
           keep their children, and they try to take care of them. They
           would feed the children before feeding themselves. You see
           little children laughing, and they don't realize what the
           situation is. They're not used to having a plate full of food.
           And I can remember my dad telling me, when I was growing up,
           that "you have to clean that plate now. There are a lot of poor
           people in the world." Well, we were poor, but I didn't know it
           until I grew up. You know, when you get to be in your 70s, you
           remember those days.
HARRAR:     And do you think that this experience really shaped your
           husband's career and his work that he did thereafter?
Hicks:      Oh, yes, absolutely. He'd been with CDC, was hired from Tampa
           Health Department after graduating from-am I allowed to say he's
           a Gator?
HARRAR:     Sure, go Gators!
                 And you yourself, did you ever work outside the home?
Hicks:      I was teaching the Nigerian police, equestrian arts. For years,
           I showed hunters and jumpers and 3- and 5-gaited saddle horses.
                 I was going to market 1 day with the boys, and I saw this
           Nigerian police officer-this is one of the things you may want
           to edit out-he had dismounted from his horse, had urinated, and
           couldn't get back on the horse again.
                 So I stopped the car and went over to him, and I said, "I
           could make that easy for you."
                 And he said, "How?"
                 And I said, "You lower the stirrup." And so I showed him
           how to lower the stirrup and how to put his foot in it, and gave
           him a boost up. I was a lot smaller than him, but he got up. And
           so the police asked me if I would help them with training, and I
           was doing that. They have a polo ground in Lagos.,
                 We actually lived on the island of Akoya, which is
           connected by a very small bridge. You don't even realize that
           it's an island until you go over the little bridge and wonder
           what it's doing there. You think it's a drainage ditch.
                 I was amazed at the fact that the sewage consists of open
           sewers. Before you could go into your own home, as a precaution,
           you would take your shoes off and wash your feet at the door.
           You just didn't go in and out when you were down in that area.
                 There was water there, and we wound up with a boat. We
           used to take the boys out to this little island that the embassy
           had. We'd take them to a hotel that they had, and it had a
           little pond. The children would push their little sailboats
           around that. And we'd have high tea in the afternoon on Sunday.
                 We were Christians, and we were fortunate enough, when we
           went over, to go to the First Baptist Church of Lagos with our
           sons. The first Sunday we were there, the service was in the
           Yorba tongue, and we knew the music, but it was sung in Yorba. I
           said to Jim as we were leaving, "Gosh, our sons will never
           understand the language, and we certainly don't understand it."
                 Having said that, a couple walked up to us. Quite
           honestly, I thought we were the only white people in there, but
           there was another couple, an older couple, who came over and
           introduced themselves. They had been sent over by the Southern
           Baptist Convention as missionaries and had been in Africa for
           many years. And we found out that their residence was just
           around the corner from our house. So they became grandparents to
           our children while they were there.
                 We mentioned to them that our children would never
           understand the sermon or the Bible. We read the Bible to them,
           but they needed to do something.
                 And she said, "Well, do you think you-all would be
           interested in trying to help to formulate an English-speaking
           church here?"
                 And we said, "Yes, of course."
                 And, to make a long story short, we were able to do that.
           We didn't have a preacher every Sunday, so Jim would take 1
           Sunday, and then there was another couple from Gulf Arabian
           American Oil who were Baptists, and they came, and he would
           preach 1 Sunday. And then there was a Nigerian man who was part
           of the Southern Baptist Convention but African, and he traveled
           in Nigeria from 1 place to another to do services, so he wasn't
           always there. Before we left, they had received enough money
           that we were in a school on Sunday mornings. A lot of the
           Nigerian young men who were in university chose to come to the
           English-speaking church because most of them had learned English
           when they were out of country, in the U.K. or in the United
           States, and they wanted to continue the language.
HARRAR:     Did you feel isolated when you were there? I mean, I know it
           was very tough in those years to-you couldn't call home easily.
Hicks:      No. You had to make an appointment to call home. As a matter of
           fact, when I was there, I received a wire through the embassy
           that my grandfather had passed away. It was during the Biafran
           situation. If I had left the country, I could not come back. And
           by the time I got the message, he was already buried, but I
           found that out only because I had made an appointment to make a
           long-distance call. And when I finally got through to my
           parents, he was already buried. So that was one of the factors.
                 The children reached the point that, when we came back to
           the States, they were speaking some of the Yorba tongue. The
           worst part of it was our help were not all of the same tribe,
           and there were 3 different dialects spoken in our house, not
           including English.
HARRAR:     Were you concerned that the children, aside from the asthma,
           would be affected by illnesses over there? Did your family, you
           or your husband, ever become ill?
Hicks:      No, not at all. We had a physician at the embassy. I couldn't
           find him at the time that Jimmy went code blue, but one of our
           own physicians, Dr. Stan Foster, I called his residence, and the
           help said that he was out playing tennis. And I said, "Can you
           get a message to him that I need help?" Jim was out of country
           at the time. And Stan was a lifesaver to us to get us over. He
           tried to work with Jimmy at home for a short time and saw that
           it wasn't going to work, so he drove. And, of course, because of
           the war, we were stopped by soldiers for security who wanted to
           go through the car and all that, and Stan was able to get
           through to them that this was an emergency and we had to get
           Jimmy to the hospital. So I'm thankful for that.
HARRAR:     Well, that was quite an experience.
                 I think we're all set. Thank you so much. It's really a
           great honor to meet you.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

D.A. Henderson with Paul O'Grady
Transcribed: February 2009



Paul O'Grady:    This is an interview with D. A. Henderson on July 12,  2008
           at the Center for Disease Control  and  Prevention  in  Atlanta,
           Georgia about his  involvement  with  the  smallpox  eradication
           program. The interview is being conducted as a part of a reunion
           marking the 40th anniversary of the program  in  Asia  and  East
           Africa. The interviewer is Paul  O'Grady.  Can  you  state  your
           name?

D.A. Henderson:  D. A. Henderson

Paul O'Grady:     And  you  understand  that  this  oral  history  is  being
           recorded?

D.A. Henderson:  Yes, I do.

Paul O'Grady:    Thank you. I would like to start off by having you give  us
           a little bit about your background, what lead you to a career in
           public health and how you started working for the CDC?

D.A. Henderson:  Well, I was born and brought  up  in  Lakewood,  Ohio  near
           Cleveland. Went to Oberlin College and then to the University of
           Rochester School of  Medicine.  After  internship  at  the  Mary
           Imogene Bassett Hospital in Cooperstown,  I  was  told  that  my
           deferment from the draft was at an  end  and  I  had  my  choice
           either to voluntarily enlist in which case I would  be  a  first
           lieutenant, or be drafted in which case I would  be  a  private.
           So, like many of my colleagues who had been deferred  since,  in
           my case 1946, and this is 1955, I decided I could  volunteer.  I
           was having difficulty making up my mind  whether  it  was  army,
           navy or air force. I figured I am just an intern, all I am going
           to do are boring draft and do physical of new recruits. So about
           this  time  somebody  shows  up  from   something   called   the
           Communicable Disease Center, which I had never  heard  of.  They
           are from the public health service which I knew  nothing  about,
           but they talked about working on  infectious  diseases  which  I
           didn't really much care for. As I  thought  about  it,  well  it
           might be two years and I'd learn something, and as they  pointed
           out we don't wear uniforms, we don't salute, you don't do  basic
           training. I  go,  well,  okay,  doesn't  sound  too  bad.  So  I
           enlisted, in the public health service.

      Now, this was the Epidemic Intelligence Service  which  at  that  time
           was only four years old. That created by Alex  Langmere  at  the
           CDC. There were, however, quite a  number  of  applicants  every
           year who were anxious to do their required time and  service  at
           CDC  would  be  challenging,  interesting,   so   forth.   Well,
           fortunately I had done a history of medicine paper  in  my  last
           year of medical school. Why had a done the history  of  medicine
           paper? Because  they  offered  $200  and  a  handy  subject  was
           something about cholera in upstate New York in  1834  and  there
           was material available in the newspapers and so forth.

      So I spent time creating this paper,  going  through  the  newspapers,
           plotting cases, doing curves. I didn't know what I was doing  in
           terms of training but it really was epidemiology and in fact  it
           turned out to be rather fun. I had to see what the responses  of
           the health department were, to the  various  challenges.  Seeing
           how it spread through the city and so forth. So  in  advertently
           I'd become interested in a subject which we had no courses in at
           all and I got drafted to the public health service. That's where
           I got into public health and I had no interest in public  health
           either at that time. I was going to be in my mind a cardiologist
           and this would be two years  out  and  then  I  go  back  to  my
           residency in cardiology.

Paul O'Grady:    What were the major public health concerns at that time?

D.A. Henderson:  There was one dominant major public health problem at  that
           time or challenge and that was polio myelitis.  There  had  been
           significant cases, significant outbreaks of polio  myelitis.  In
           the 1950s, there was a great deal of fear  at  that  time  about
           polio. In the summers there was - they  closed  swimming  pools,
           parents kept their children away from other children.  If  there
           were outbreaks  there  was  a  great  deal  of  anxiety  in  the
           community. The National Foundation for Infantile Paralysis was a
           very major foundation. It was the only categorical foundation at
           all  that  time.  It  had  been  started  because  of  President
           Roosevelt's, Franklin D. Roosevelt's polio myelitis and they had
           raised for Warm Springs, Georgia rehabilitation center. They had
           been extremely successful and they took some of this  money  and
           they put it into some basic research of very  good  quality  and
           development of the vaccine. There was great anticipation in 1954
           because they began the first major study of the Salk vaccine and
           there was school children across the country. I forget how  many
           were involved. As I recall it's 100,000 plus.

      The results were coming up in April of that year that I was  doing  my
           internship. Very soon thereafter they  began  to,  in  April,  I
           guess they announced the  results  and  they  began  vaccination
           around the country with the vaccine. About this time they  found
           that some of the lots of vaccine were not quite - the virus  was
           not quite as dead as it should be. They began to  get  cases  of
           polio myelitis, paralytic disease caused by the  vaccine.  So  I
           was being inducted into the Center for Disease Control.

      The epidemic intelligence service Alex  Langmere's  group  were  doing
           the work of compiling information on the cases in trying to find
           out which lots of vaccine were involved and trying to  determine
           the magnitude of the problem and then what to do about it. So we
           were totally immersed, as I came into the service on the 1st  of
           July with what was an ongoing investigation into what really was
           the end of the largest field trial ever conducted on  a  vaccine
           and the introduction of the polio myelitis vaccine which  was  -
           had been awaited for so long. At the same time we had  what  was
           amounted to a vaccine incident which was serious with  a  number
           of paralytic cases associated with  the  vaccine.  The  question
           was, was it the vaccine of all companies or  was  it  maybe  one
           company and only some lots of the vaccine or  what  was  it.  So
           this was all absorbing for many of those who came aboard at that
           time.

Paul O'Grady:    And how many years were you at CDC after your - so you  got
           a two year government required service and then you stayed on?

D.A. Henderson:  Well it turned out be  rather  more  exciting  than  I  had
           thought. They had a matching program. So,  that  those  who  are
           recruited you then submitted  your  preferences  on  a  list  of
           different positions you could have. They in turn would  look  at
           the people who are coming in, about 30-35 of us and decide which
           ones they wanted and they would list their priorities  and  then
           they match them up. I matched  up  with  a  position  which  was
           called assistant chief  of  the  epidemic  intelligence  service
           which would be as they called it a go-for job  kind  of  putting
           things together, helping organize a course and doing  things  of
           this sort.

      Well, we would have a course to a one month at that  time  where  they
           taught us epidemiology and  bio  statistics.  Basically  how  to
           investigate an outbreak and at the end of the one month you  are
           then a qualified epidemiologist in our terms and at the  end  of
           that course I had to go off the  epidemic  intelligence  service
           did to an epidemic. We were constantly being called for  various
           epidemics. There was a big epidemic  of  diphtheria  in  Phoenix
           City, Alabama. I went down, I spent three weeks down  there  and
           giving vaccine, taking cultures. The patients were housed  in  a
           big Red Cross tent. I came back and here was the chief  epidemic
           intelligence service officer packing his bags.  I  said,  "Where
           are you going?" He said, "I have another job. I am going to be a
           state health commissioner." I said, "Well, what  do  I  do?"  He
           said, "I guess you are the Chief EIS officer." I said,  "I  have
           no idea what to do?" He said, "You will learn."

      Sure enough, then I began working in a job that certainly  I  was  not
           qualified for but plunged in. With the mentorship of  this  Alex
           Langmere who was a legendary epidemiologist, a rather  difficult
           person but demanding and  just  a  wonderful  teacher,  just  an
           extraordinary teacher. At the  end  of  two  years  of  this,  I
           finished my duty. I proposed  to  him,  you  know,  we  are  not
           keeping many people on. The people were getting, so many  people
           apply. They are  well  qualified.  All  of  them  wanted  to  do
           academic medicine or pediatrics. Just about nobody wants  public
           health.

      Now, if we offered a 5-year training  program  in  which  you  do  two
           years of training, like a residency in  cardiology  that  I  was
           thinking for myself, and maybe then three years with the  public
           health service. Maybe that would be a  way  to  attract  people,
           then by then you will have, say then, seven years and  we  might
           get people staying longer. Well, he  liked  the  idea  and  then
           well, he submitted it up-line to the surgeon general.  He  liked
           the idea. So, I applied for a five  year  training  program  and
           went back to get my residency.

      At the end of the - well, during the course of the residency, I  found
           this to be frankly rather boring. I was seeing patients and some
           of them had some heart  disease  and  heart  failure,  a  little
           diabetes, a little gastroenteritis. A  little  constipation  and
           sort of the end of the day I felt, you know, if I really  hadn't
           been there, I wonder if it would have made  any  difference  and
           was I making any difference. Am I going to be doing this for  my
           next 40 years?

      Well, meanwhile I had been two  years  in  the  epidemic  intelligence
           service which some exciting outbreaks here and  there  including
           one which was an interesting one in Argentina. There was  a  big
           outbreak  of  food  borne  disease.  They   were   stoning   the
           restaurant, the Argentine government was upset. They thought  it
           was a type of food poisoning due to the  Botulinum  toxin.  They
           wanted our, what we had in the way of antitoxin to  treat  them.
           So I took off for Argentina with such supplies as we had.

Paul O'Grady:    When was this?

D.A. Henderson:  That was 1957. At the end of this I saw  the  secretary  of
           health. He sort of offered "Well, let's go on a hunting trip  or
           a shooting trip with me at my lodge." I said, "You know, I  hear
           you have got an outbreak of smallpox." He said, "Yes."  I  said,
           "I would like to go see it." So he said, "Fine." We took off  on
           an old Pan-Am clipper off the waters and the river on La  Plata.
           On up to another place and we got in a two passenger  piper  cub
           and flew into a smallpox - the area where they had the  smallpox
           and they had an outbreak of smallpox. The people were  in  tents
           in the field and so, about 30 different patients. We  looked  at
           the patients one by one, it was fascinating. And at that  point,
           I had never seen a case of smallpox, really didn't know what  it
           looked like. But it was my first contact with smallpox.

Paul O'Grady:    Was there at  that  point  any  national  or  international
           interest in trying to organize the fight for smallpox?

D.A. Henderson:  The international concerns about smallpox were there  very,
           very strongly  because  all  travelers  were  obliged  to  carry
           certificates indicating  they've  been  successfully  vaccinated
           within the preceding  three  years.  Just  about  every  country
           including our own enforced this. If you weren't  vaccinated  you
           wouldn't get admitted or they might vaccinate you on  the  spot.
           There was a great concern about importations of smallpox.

      It was in 1958, just about a year later after I  had  seen  the  cases
           that the vice-minister of the Soviet Union proposed to the World
           Health Assembly that  they  undertake  a  program  to  eradicate
           smallpox. That was the year the Soviets came back in to  the  UN
           family. They'd withdrawn because of the Korean War and they were
           - they just come back. So the proposal,  they  looked  at  this,
           delegates at the assembly looked at this and they really  wanted
           to be helpful and encouraged the Soviets this time.  So  a  year
           later they approved a program to eradicate smallpox.

      The only thing  was  that  at  -  that  same  time  the  World  Health
           Organization was deeply  involved  in  a  program  to  eradicate
           malaria. And fully a third of all staff were  involved  in  that
           and all the spare money they could get together because  it  was
           very expensive, very costly. The  idea  of  undertaking  another
           eradication program was really not the intent  of  the  director
           general. In fact the only thing he could do is say,  "Fine."  He
           really gave it very little money and a few  countries  then  did
           some vaccinating and tried to get rid of smallpox. They did make
           some progress in this but it basically was going anywhere.  That
           was the beginning. It was 1959 when they decided that they would
           undertake a global program but it really was not  anything  that
           was happening. It was seriously, it was not until 1966 that they
           really took it seriously.

Paul O'Grady:    What was the  attitude  of  the  United  States  government
           towards this program that it seemed to have gotten some  impetus
           from the Soviet Union? Was  there  any  political  peculiarities
           about that?

D.A. Henderson:  There, clearly was an element of Cold War competition.  The
           US was heavily supporting the malaria eradication program,  both
           through  the  organization  very  heavily  and  through   direct
           bilateral donations to the  countries.  So  the  US,  you  could
           almost say, owned the malaria eradication program. The  Russians
           had no program at that point that they could say the same  thing
           about. So, in a way they came in with  this  smallpox  and  said
           look, we got rid of it in the Soviet Union  back  in  the  1930s
           when our vaccine wasn't so good,  when  health  conditions  were
           poor, where personnel were not well trained and we  got  rid  of
           it. So, why can't the rest of the world get rid of it?

      So that's where they came in and then put after 1959,  every  year  at
           the World Health Assembly they would really  give  the  director
           general a very hard time. Why aren't you putting more money into
           the smallpox program? Why do you favor the malaria program?  And
           so that went on as a continuing piece. The  US  really  took  no
           notice of it. It's really what it amounted to  until  really  it
           came up to 1965 when a change came for the US.

Paul O'Grady:    Which was?

D.A. Henderson:  Well, in 1965 - I'll go back  a  little  bit,  1961,  Merck
           Sharp &amp;amp; Dome, at  that  time,  was  introducing  a  new  measles
           vaccine. It caused a lot of fever in children.  So  in  the  US,
           they were using it giving the measles vaccine and they gave them
           some immune globulin at the same time so that they wouldn't have
           so many reactions to the measles vaccine illness, if  you  will.
           This made little practical sense if you went to Africa. The idea
           of  doing  these  two  together  and  made  life  a   lot   more
           complicated. You really could not do large scale vaccination and
           try to preserve the immune globulin and deal with two  shots  to
           get this. So they undertook studies in Upper Volta, Benin. I  am
           sorry Upper Volta  is  the  place  where  they  were  doing  the
           country.

      They did x number of children, 150 -200, kids reacted very well.  They
           were no complications. Then they asked -  the  country  minister
           said, could you give - do it for all kids  under  six  years  of
           age. So they gave them a vaccine enough for that. Then there was
           an organization,  French  organization  that  had  a  number  of
           countries and he said, could we do it  for  six  countries  now.
           USAID said, "Okay, we will  do  it  for  six  countries."  Well,
           things couldn't go very well with six. I won't go  into  all  of
           the complications but we got drawn in at that time to evaluating
           it. I sent one person over to evaluate. It was a disaster.

      Well, not to be deterred they decided  we  are  now  going  to  do  11
           countries. We need from you, 11 people for six  months  each  to
           help get the program started in  each  country.  I  thought,  we
           can't do that. Really, it's - a good segment  of  my  staff  and
           signing people over for  6  months  at  a  stretch  is,  without
           families and what have you, this is tough.  So  I  thought,  you
           know, I really have to work  with  AID,  we  really  got  to  be
           responsive to them. I didn't know what to do. So I decided,  all
           right, let's put together a proposal that we would say is  sound
           from this public health standpoint.

      Why was the measles proposal bad? Well, they were  going  to  give  it
           for just four years and then stop.  In  other  words  AID  would
           support it for four years and they  expected  the  countries  to
           continue. It cost a $1.75 a dose. The countries couldn't  afford
           $0.10 a dose for yellow fever  vaccine.  So  this  is  not  good
           public health practice. To start a program, get the hopes of the
           public up and then drop it. This  is  terrible  way  to  do  it.
           Smallpox had vaccine however, cost  a  penny  a  dose.  So  they
           proposed the idea, well, suppose you take this  whole  block  of
           countries, 18  countries  and  suppose  you  give,  do  smallpox
           vaccination -

Paul O'Grady:    And you talk about West Africa?

D.A. Henderson:  This is west, West and Central Africa as  well  called  it.
           And so we do 18 countries.  You  give  smallpox  and  develop  a
           smallpox program there. We could get rid  of  smallpox  in  that
           whole area, they could then  -  would  have  as  an  established
           program for vaccination. They could continue it easily when that
           only cost them a cent a dose  in  vaccinating  newborns  and  so
           forth. Then if they want to have measles vaccine added  and  the
           ministers think this is a good idea, we would be happy  to  give
           measles vaccine at the same time,  but  we  can't  eradicate  it
           because measles spreads too easily. We couldn't get rid  of  it,
           but at least the countries would have to think through was  this
           a good idea to do this with measles vaccine as well.

      Well, I think the cost - what USAID expected to spend was  about  five
           or $6 million. The proposal we submitted was about $35  million.
           So, I knew it can be turned  down.  But  on  the  other  hand  I
           thought it was going to be a point of departure for  discussion.
           I didn't know where we were going to find any sort of compromise
           on this. They just, their demands were  so  great  that  it  was
           impossible. So I set it up through channels, through the surgeon
           general and very shortly USAID turned  it  down.  We  were  just
           debating along about autumn what we  would  do  subsequently  on
           this.

Paul O'Grady:    And we are still in 1965?

D.A. Henderson:  This is 1965, when all of a sudden we got information  that
           the president had decided to  approve  the  program,  the  whole
           program.  This  shook  everybody.  My  boss  Alex  Langmere  was
           absolutely beside of himself.  As  I  told  him  they  were  not
           supposed to accept it, that was - but the president was  looking
           for an  initiative  which  would  be  something  that  he  could
           publicize that the US was contributing  to  a  UN  International
           Cooperation  Year.  There  were  several  proposals  that   went
           forward. This I had  no  idea  was  even  being  considered  and
           suddenly AID was told by the White House,  fund  it.  All  of  a
           sudden, we are told, all of a sudden we have got 18 programs  to
           set up in the West and  Central  Africa.  We  had  never  run  a
           program outside the United States at all.

Paul O'Grady:    So you guys have been  faced  with  a  tremendous  manpower
           problem?

D.A. Henderson:  Well, we would need about 54 people. That we are  going  to
           have to recruit. AID said that it probably would be - you  can't
           do this under three years. They agreed finally to fund  it  then
           on November. They felt we could get it in three years.  I  said,
           no. This is wrong. It's just got too much of a delay. How  about
           13 months? We will have the people  over  there  in  January  of
           1967.

       They  thought  it  was  almost  impossible.  You've  got   individual
           agreements what  every  country.  You  have  got  to  order  the
           vaccine, you have got to put on training programs, you've got to
           recruit all the people. We did. Recruited the people, we got the
           vaccine ordered. We got vehicles. We  had  to  use  US  American
           vehicles. There weren't  any  in  all  of  these  countries.  No
           maintenance, no repair, so  we  had  to  set  up  workshops  and
           everything else, to train our people to be mechanics. We had  to
           lay out plans for all of the countries to get everything  signed
           and we did.

Paul O'Grady:    Let's talk of, just for a second, about  the  attitudes  of
           the countries  involved.  What  was  the  interaction  with  the
           governments like?

D.A. Henderson:  Well, in November as soon as  this  was  approved,  I  went
           over with a consultant that I had who, Warren  Winkelstein,  who
           was a good epidemiologist and spoke French,  another  person  by
           the name of Dr. Henry Gelfand. The three of us went and  visited
           each of the different countries. Fortunately a  number  of  them
           were having a meeting, so we could present it to all of them  at
           one time.

      They were enthusiastic. Why were they enthusiastic?  More  -  most  of
           them, more because of the measles vaccine because this is a very
           - in Africa, this is a very deadly disease.  It's  10-15%  death
           rate. The French speaking countries by and large had  done  some
           pretty good vaccination with pretty good  vaccine.  The  English
           speaking countries  had  a  lot  of  smallpox.  They  were  more
           enthusiastic about the smallpox. But they were getting both  and
           they were really very  enthusiastic.  We  were  coming  up  with
           vehicles. We were coming up with vaccines  and  consultant  help
           but not a lot of people. It was by and large one or  two  people
           or advisors to be assigned to most of the countries with  a  few
           more in Nigeria.

Paul O'Grady:    And how about the Americans that  were  going  to  go  over
           there as part of this program? Let's talk  a  little  bit  about
           their attitude?

D.A. Henderson:  Well, the Americans who were going over there, a number  of
           the people I - some of them I had known. Basically called up and
           said, we have got this coming up, are you free, or would you  be
           interested, people, contemporaries and so forth. I had a  couple
           of people  who  are  already  serving  in  CDC  and  took  them.
           Basically it was almost word of mouth advertising because  there
           just wasn't very much time, and contact with people  at  schools
           of medicine and other places,  infectious  disease  people  that
           might know of people interested in this. People -  the  word  of
           mouth, by word of mouth they learned about this and my goodness,
           we were able to recruit enough, so that we were  able  to  begin
           the training program in July of 1966.

Paul O'Grady:    And people were on the ground?

D.A. Henderson:  Well, they had to finish up the training.  We  had  to  get
           all the agreements signed. I think we got all of them in  to  16
           of the 18 countries. We managed to put two, postpone two, but we
           had 16 of them by January of 1967. Meanwhile, there is a  little
           problem. There was a debate coming up in the Assembly in May  of
           1966. So this is only like about 6-7 months after this  approval
           for the whole West African program had come through.

Paul O'Grady:    Debate in the United Nations Assembly?

D.A. Henderson:  Debate in the World Health Assembly?

Paul O'Grady:    Okay.

D.A. Henderson:  Every year the ministers  of  health  convene  in  May,  in
           Geneva to look at issues of health. So they  were  debating  the
           question of  going  with  an  intensified  program  of  smallpox
           eradication with  a  budget  of  $2.4  million  a  year  and  an
           objective to complete that within 10 years. The director general
           Marcelino Candau, a very capable  Brazilian  knew  that  it  was
           impossible to  eradicate  it.  He  felt  you  had  to  vaccinate
           everybody in the world and he was a Brazilian and he  knew  that
           there were tribes in the Amazon that hadn't been found. Or  were
           just recently found or  that  sort  of  thing.  So  he  knew  it
           couldn't be done.

      There were a number of  countries  that  were  very  doubtful  of  the
           concept of eradication at all because they were having  so  much
           trouble in malaria eradication. There were  others  who  thought
           this was far too ambitious for an organization  like  WHO  which
           is, where it's not, except for the malaria really it hadn't  run
           programs or really coordinated  that  way  operationally  health
           programs. So it came to a debate in the assembly. The US had, as
           I said, been very quiet before this really in taking a  position
           but at this assembly they were going  to  take  a  vote  finally
           because it was very controversial, whether they  went  ahead  or
           didn't go ahead. One of the strong arguments was well, the US is
           already committed, funds and personnel for - to take care of  18
           countries.

      So that's a big start on this whole thing and after two o three  days,
           three days debate, they did vote. They had  about  58  votes  to
           start the program and it passed by just two votes.  It  was  the
           closest vote they have ever had in the  World  Health  Assembly.
           The director general was furious and felt that the assembly  had
           committed the World Health Organization to a  program  which  is
           going to fail. It would bring the  organization  into  disrepute
           and question the credibility of  public  health  and  the  World
           Health Organization. He blamed the US for this.

      Well, in a way, it was true. If the US had not done this  crazy  thing
           in West and Central Africa  that  almost  certainly  the  voting
           would not have gone as it did. So he was  blaming  the  US.  He,
           then, called the surgeon general in the US and said  I  want  an
           American to run the program because when it goes down,  when  it
           fails, I want it to be seen that there is an American there  and
           the US is really responsible for this dreadful  thing  that  you
           have launched the World Health Organization into and the  person
           I want is Henderson. Well, I was associated, of course, with the
           West African program of having gotten involved with starting  it
           and so forth.

      So I got called to Washington and I was told I was being  assigned  to
           be head of  the  World  Health  Organization's  Global  Smallpox
           Program. I declined. I said, we  are  just  starting  this  West
           African program. We have just - there is a huge amount  of  work
           and we have just barely started. The $2.4 million we got to  go,
           we had programs in 50  countries.  We  don't  even  have  enough
           money, $2.4 million won't even buy the vaccine we need.  Trying,
           I  had  some  experience  in  working  with  the  World   Health
           Organization and they really were  not  working  well  together.
           Each of the six regional offices were sort of wholly independent
           and trying to coordinate them was a terribly job. So I  said,  I
           really can't do it.  I,  you  know,  I  think  this  is  a  very
           difficult task. I really, I think if we do a good  job  in  West
           Africa, we are going to show what can be done. Maybe  that  will
           encourage the other countries but that's, I think, where I ought
           to stay.

Paul O'Grady:    Was this conversation going on between you and the  surgeon
           general?

D.A. Henderson:  Yes. So I declined. He said - I  said,  you  do  not  -  we
           don't order people in the public health service to go from place
           to place. That we - we talk about career opportunities,  and  so
           forth and so on. It's not like the military services.  He  said,
           "Well, this is your career opportunity." I said, "And suppose  I
           decline." He said, "You are fired." I said, "You  are  serious."
           He said, "I am very serious. I will tell you what, make a  deal.
           You go for 18 months and if at any time during  that  18  months
           you really feel it won't go, just send me a telegram,  just  put
           now and I will pull you out." So, I headed for Geneva to head up
           the Global Program.

      We left in October to go to Geneva, get a house. Wife and three  kids,
           plus left half of our household goods in the storage because  we
           knew we would be back pretty soon. Took over  a  program,  which
           was a  global  program.  This  provided  for  headquarter  staff
           eventually of nine of us. It never  got  bigger  than  that.  So
           there were five medical  officers,  two  admin  officers  and  a
           couple of secretaries. That was our total staff.

Paul O'Grady:    Let me ask you about your own mindset at  this  point.  You
           had mentioned the problems with the  measles  program  and  that
           malaria eradication had been problematic. Were you optimistic at
           this point about - at least with respect  to  the  West  African
           piece of the puzzle? You  were  optimistic  about  eradication's
           success?

D.A.  Henderson:   This  is  a  good  question  as  to  whether  you   would
           characterize what I felt is optimistic. My feeling  was  it  was
           doable but without a full appreciation of  everything,  all  the
           problems we would encounter. I must say  because  as  I  thought
           back on it, had I any idea of all the  problems  that  we  would
           face, I would have not been  optimistic.  You  can't  anticipate
           civil wars, floods, masses of refugees, one thing after  another
           and bureaucratic  blockage  of  things,  countries  refusing  to
           participate. All of the difficulties you can have with this, but
           fortunately I was innocent of the problems, these problems  that
           you would encounter or we couldn't anticipate,  obviously,  most
           of these.

      It was the fact we had a good vaccine and the vaccine we knew and  I'd
           worked, we had done some studies at CDC while I was in charge of
           the surveillance program, showing the vaccine was very good. You
           could  get  virtually  a  100  percent  takes,  using  a  proper
           technique. We had jet injectors that  we  had  worked  with  and
           perfected these with the inventor in the  US  Army  so  that  we
           could add jet injectors that could vaccinate a  1000  people  an
           hour. They looked - we looked optimistic that we could do a  lot
           of vaccination with them. So that, we had  a  good  vaccine,  we
           knew something about smallpox. You know  that  -  we  knew  that
           there were a  number  of  countries,  developing  countries  who
           didn't seem to have any cases but the reporting was so bad that,
           little did we know that many of them just weren't reporting it.

      But we just - we really didn't have an idea but we thought there  were
           large countries, free of the disease, certainly the US  was  and
           Canada was. Certainly there must be others  that  were  involved
           too. So it was a feeling of  technically  this  was  doable  but
           without an appreciation that experience would provide as to just
           how difficult the problem would be.

Paul O'Grady:    Let's take you to - take  you  back  to  Geneva.  You  have
           arrived, you had your family there and when  did  you  start  to
           realize that these challenges were going to present themselves?

D.A. Henderson:  We quickly found that we  had  problems.  Within  just  the
           first couple of years, we ran into a number of problems.

Paul O'Grady:    Can you - ?

D.A. Henderson:  The West African program basically,  Don  Millar  who  took
           over from me, who had been my chief of my smallpox unit  before.
           He was running it and he had a good administrative  officer  and
           he had some very good people in the field. My feeling  was  that
           they had to run that themselves and the only thing we could help
           them with, which they needed was some local costs.  I  think  we
           gave them a  couple  of  $100,000  a  year  to  permit  in  some
           countries, purchase a vaccine, gasoline and a few other  things,
           they couldn't get it, legally with their USAID funds. Other than
           that, they were on their own.

      So we worked at the world and saw well,  we  got,  two  countries  are
           sitting rather at the far end. One is Indonesia,  the  other  is
           Brazil. Now at that time, South America appeared to be  free  of
           smallpox except for Brazil. They had done  vaccination  programs
           in the other countries  and  one  way  or  another,  with  their
           infrastructure, not perfect but  they  managed  to  get  rid  of
           smallpox. That of course was encouraging. But if we got  rid  of
           it in Brazil then they would be far away from endemic areas  and
           indeed they could be basically the funds  that  we  are  putting
           into a Brazilian program could be withdrawn and  we  put  it  in
           other areas like Asia or Africa.

      Similarly with Indonesia, Indonesia sitting off where we are here  and
           the countries nearby are free of smallpox.  So  the  chances  of
           smallpox being imported into Indonesia,  if  we  got  that  free
           would be small and therefore the  limited  amount  of  funds  we
           could use have, we could then transfer that to  other  countries
           and at least make a start in trying to get rid of  the  smallpox
           with the limited funds we had. So, that was the strategy.

      We almost immediately found we had a  vaccine  problem.  The  Russians
           had pledged 25 million doses a year and we had no idea how  much
           vaccine we would really need. Most of the countries  were  doing
           some vaccination. The disease was  so  severe,  it  was  such  a
           problem that at least they had to vaccinate in  the  big  cities
           simply because of civil disorder, with too much of this epidemic
           smallpox, it is destabilizing. So in all countries we are  doing
           some vaccination and what we had - we made the  assumption  that
           most of them, already have vaccine and we have  got  25  million
           from the Soviet Union. US is covering all the vaccine  needs  in
           their 18 countries, later 20 countries. So we got to be alright,
           but we - I thought we need to have some way to determine whether
           the vaccine is really, really potent, really good.

      So, I went to the Netherlands and asked if they would  help  in  doing
           testing the vaccine, vaccine quality of the production that  was
           there and then we went to Connaught Laboratories in  Canada  and
           they agreed to do that as well. So we began getting  samples  of
           vaccine from the different countries and they began testing  it.
           Five percent of it was potent and stable. Five percent  met  the
           international standards.

      So we had a problem almost immediately. We couldn't afford to buy  the
           vaccine. So I made a decision, we won't buy any vaccine. We  are
           going to have  to  develop  -  improve  the  vaccine  production
           facilities that are out  there.  We  called  a  meeting  of  the
           vaccine producers from several major  laboratories.  From  Wyeth
           Laboratories in the US, they were the producer  here,  they  had
           one Lister Institute in London, where  Netherlands  were  there,
           Soviet Union were there. I think that was it.  We  brought  them
           together and  we  talked  about  vaccination  and  developing  a
           standard manual. Every country was using where they were  making
           a vaccine they were using all sorts of different techniques.

      So let's get what we think is the best  way  to  do  it  in  a  simple
           manual that I can  understand.  Then  let  us  then  help  these
           countries improve their vaccine. We will, then work with  UNICEF
           to try to get them to provide some machines so that  they  could
           freeze dry the vaccine and we would use some of the people  from
           these consultant laboratories that we had brought together to go
           out and train and help develop the vaccine. That's what we did.

      The vaccine quality began to pickup. It was  by  about  1972,  we  had
           more than 80 percent of the vaccine was being  produced  in  the
           endemic countries themselves and it was good quality. So we were
           immediately  involved  in  trying  to  solve  just  the  vaccine
           problem. How to administer the vaccine was the second problem.

      The problem was this. You have a vaccine which is a very, has a  vial,
           it's in a vial with about 0.25 milliliters  of  fluid.  That  is
           reconstituted. You have one vial that has dried  powder  of  the
           vaccine, another which has a quarter of a  milliliter  of  fluid
           which is a very small amount. To use a vaccine, you have to  put
           the liquid into the dry powder and mix it up. Then  you  had  to
           put it on the arm.  The  way  they  did  this  in  most  of  the
           developing countries was take like a glass rod, dip  it  in  and
           then put it on the - dip the rod against the arm, tip it against
           the arm and a little drop would be there. Then by and large what
           they did was scratch through the vaccine. They had a  number  of
           scratches through the vaccine, it was  an  old  technique  which
           goes back more than a 100 years.

      In the US we did  a  little  bit  differently  but  it  was  the  same
           principle but it was important that the US did it this way. They
           took and took a needle and they put the drop back on the arm and
           then they gently pushed the virus through the skin and the  idea
           was that if you got it just through the skin it  will  grow  and
           produce something. If you push too hard you will  get  bleeding.
           If the bleeding occurs then it washes out the virus.  You  don't
           push hard enough, it doesn't  go  into  the  skin,  and  so  the
           vaccination fails.


      Wyeth laboratories was developing a new device which I  visited  Wyeth
           laboratories because  it  was  the  question  of  improving  our
           vaccine production capabilities in the other countries and  they
           showed me this wonderful device which they developed.  A  little
           needle about - well, tube about so long. There  are  two  little
           prongs on the end. They called it a bifurcated or  sort  of  two
           fork needle. The idea was you put the needle  into  the  vaccine
           and you just withdrew it. Between those two  prong,  the  little
           bit of vaccine would be held and then they thought you press  it
           through the skin.

      In this way the amount of vaccine you could get from a  vial  was  100
           doses rather than 25 doses. Well, I looked at it and I know  how
           much trouble we had had in  trying  to  teach  them  to  medical
           students how to vaccinate because they were forever not  getting
           it quite - not enough pressure to break the skin. So  it  wasn't
           growing and then a number of them are getting a  little  bit  of
           drop of blood and that was thought to be bad. So  I  raised  the
           question of well, suppose that we take a needle and just hold it
           like this and poke it like this, we called it multiple puncture.
           Instead of  scratching  or  pressing  it  through,  do  multiple
           puncture. You are going to  get  bleeding.  So  let's  see  what
           happens.

      So we tried a few of these, they all got  very  successful  takes.  We
           took it to the field into Kenya and Egypt and  did  several  100
           children and we did it very vigorously. There was a little  drop
           of blood on everyone. Every single one of them  was  successful.
           So this was incredible. All of a sudden we were  going  to  have
           four times as much vaccine than we thought  we  had  or  we  are
           getting, with these wonderful needles. The needles cost  us,  we
           shortened them up a little bit and make  them  cheaper  than  we
           made them out of a stainless steel virtually.  We  could  get  a
           thousand of them for $5. You could boil them and reuse them  and
           we ran through about a 120 vaccinations perfectly  good.  So  we
           had needles very inexpensively.

      We had a vaccine and suddenly we had four times as much vaccine as  we
           thought we had. Then it was a matter of bringing those into play
           in the different countries and this went very rapidly. So it was
           another development, right at the beginning which  made  a  huge
           difference. It was a  crazy  little  thing.  Now  the  important
           thing, I think was is that the - the inventor of this, a man  by
           the name of Ben Rubin received a one time, to tell  you,  what's
           called the John Scott Medal of the City of Philadelphia for  the
           best, most important invention of a particular year. Here he was
           getting this and it had gone back - the award goes back  to  the
           1700s. Marconi has received it, Edison has received it so forth.
           He said, "This is the most insignificant patent or  invention  I
           have ever made," and he said, "And here I am receiving the  John
           Scott medal." And it was - it just was like inventing the safety
           pin. It was so incredible.

      So we began using that, we had - introduced the jet injector for  West
           Africa but very soon we said,  for  this  price  we  don't  have
           problems in mechanic to repair  or  what  have  you.  It's  very
           inexpensive, much less expensive than a bio - than jet injector.
           So pretty soon the bifurcated needles took over the whole of the
           world in terms of vaccination. Well, we had a couple of the very
           early problems that we had. There were many more.

Paul O'Grady:    So tell me how the smallpox program  moved  into  Asia  and
           East Africa?

D.A. Henderson:  Well, West Africa, I want to go back to  the  West  African
           program which began in '67 and they managed to record their last
           case in 1971. Well, ahead of schedule and under budget. Not  too
           many programs come through like that. Meanwhile, I had a man  in
           East Africa and he was working with the people in the  different
           countries and helping them  and  strengthening  what  they  were
           doing, a Russian, Ivan Ladnyi and they began to make  very  good
           progress. We, from WHO, began  supporting  Central  Africa,  not
           Central Africa, but Sudan  and  Zaire  are  two  huge  countries
           across the middle. This was frightfully  difficult  but  we  had
           some very good people, incredible people.  Some  national,  some
           internationals and they began to make a good deal of progress.

      Brazil, I got  back  to  say  Brazil  became  free  in  '71.  We  had,
           Indonesia was a bit of struggle but they became free by 1972. In
           fact the whole of  Africa,  was  free  of  smallpox  except  for
           Ethiopia. The whole of Africa was free of smallpox by the summer
           of 1973. We were only six years into the  program  and  here  we
           were with a good piece of the world free now of smallpox. So, in
           the summer of 1973, we were down to - just five  countries  that
           had  smallpox,  just  five.  It  was  India,  Pakistan,   Nepal,
           Bangladesh in Asia and Ethiopia.

      When you looked at India and that group - that bunch of  countries,  I
           think the population then was maybe about 700  million.  So  you
           look at it and you say, only four  countries  in  Asia  but  700
           million people is, at that time, almost three times the size  of
           United States. So it was not a small undertaking  to  deal  with
           that. Meanwhile in Ethiopia, they were doing a malaria  program.
           They did not want to see a smallpox program. So, the Minister of
           Health refused to even have  me  go  and  talk  with  him  about
           starting a program. So nothing had happened in Ethiopia  at  all
           on smallpox, up until late 1970 before I  managed  to  get  into
           Ethiopia and lay out a  plan  and  by  various  devices  working
           through the emperor to get approval to get started in Ethiopia.

      So we came in the summer of '73. We had programs in all the  countries
           and we were very optimistic that now we are on our way. The  big
           problem, frankly, at that time was India. Huge country, a number
           of people talked about India being like the native, like we talk
           about cholera being the home or India being the home of cholera.
           There are some who said, well, India with very dense population,
           particular climate  and  so  forth.  They  must  have  something
           special  here  that  maybe  is  the  home  for  smallpox.   Very
           difficult, you will never get rid of  it  there.  That  was  the
           general discussion that was going on.  We  weren't  making  much
           progress.

      India had started a program back in 1962, not so long after the  first
           World Health Assembly heads said, well, let's do an  eradication
           program. By the time they got to 1973  it  really,  they'd  made
           progress some of the southern states of India but most of India,
           they were still recording as much smallpox  as  they've  had  11
           years before. They were discouraged and really,  not  sure  they
           would continue. There was a lot of discussion about it. It was a
           problem saying we really have to keep going. They agreed  to  do
           so and this was the earlier 70s. They agreed to  keep  on  going
           but then we met and sort of the late spring of '73 and we  said,
           we have got to do something different.

Paul O'Grady:    Who's meeting?

D.A. Henderson:  In India, well  the  strategy  that  we  had  had  was  not
           working. They had done a lot of  vaccinating.  They  were  doing
           mass vaccination all the time, they were then  beginning  to  do
           what we called surveillance and containment. Really getting much
           better reporting and when a report came  from  a  village,  they
           would go out, send a team out. Try to vaccinate and control  the
           outbreak. It didn't seem to be working and there was a  still  a
           lot of cases and we were - they were  not  making  progress.  So
           that spring we decided what we needed to do was find  the  cases
           more quickly. Find them before they became outbreaks.

      So the decision was made  that  we  try  to  undertake  a  village  by
           village search throughout the whole of India in  10  days  time.
           Mobilize the health services for an  intensive  10  day  search.
           With this we were - would employ about a 120,000 people. And the
           idea initially was to go to selected parts of the village  in  a
           particular pattern to try and find cases and see what you  could
           turn up. There was a lot of planning. A lot of organization went
           on. We got Bill Foege from CDC, was sent over. I had  asked  for
           more help. They sent over a couple of people but India is a  big
           place and we have a very  cracked  team  of  international  from
           France, from Czechoslovakia, from Soviet Union, but not  a  lot,
           we were very few.

      So the first search was completed in October  in  this  one  state  of
           India. We were normally getting about 500  cases  a  week.  That
           first search was completed and they  recorded  10000  new  cases
           found, 10000 new cases. This wasn't even the high point  of  the
           season. This was really at the - almost the  beginning  of  when
           the seasonal increase occurred. Oh my gosh!  This  is  far,  far
           worse than we had ever imagined. Well, it was  even  worse  than
           that, because it wasn't several weeks later  I  found  that  the
           search teams had not done a great job and  they  really  reached
           only half of the villages. So it was probably twice  as  bad  as
           bad as I thought it was.

      They repeated the search in another two months and  they  got  better.
           By about the third search they got into  the  point  where  they
           would do house to house. We actually had a  team  following  and
           doing a sample number of the villages to make sure that they had
           really reached at least 80 percent of the houses.  So  we  began
           gradually to mobilize this tremendous force. It took 8  tons  of
           paper for one search. We began getting  more  cases.  The  cases
           were increasing. The problems were that of mobilizing the staff,
           of supervision, quality control. It was a really tough  job.  We
           went on and through the summer of 1974, when at  that  time  the
           smallpox goes down to its low as  points.  Some  of  -  smallpox
           transmits best like measles in the winter. Measles is  a  winter
           disease, smallpox is the same.

      Whatever it is, whether it's being dryer air and cooler air that  does
           it we don't really know  all  the  answers.  But  certainly  the
           summer months are where it gets to  the  lowest  point.  So  the
           summers and the states, northern states where  this  almost  all
           the smallpox was, the summers are terrible, 120  degrees.  There
           is not - limited amount of electricity and there is certainly no
           air conditioning. We were bringing in a lot of people who are on
           3-month volunteer stints  with  their  Indian  colleagues.  That
           summer it was murder. We brought them together,  once  a  month,
           looked at what they had done. Reports, we viewed all  of  these.
           We had no cell phones, we  had  no  telephones.  There  were  no
           computers. I mean, this was all done by hand. They'd come in for
           a weekend. We'd come in for work for a day and then they had one
           day of rest.

Paul O'Grady:    Can you identify a turning point in the Indian experience?

D.A. Henderson:  Yeah, I will come to that.  At  the  moment,  there  was  a
           turning point but a strange one. We worked through  '74  but  we
           got started going into late '74. The seasonal  pick  up,  picked
           up. There were more cases than ever, it was really a  going  and
           there were several longer term trends in the  disease  in  India
           and this was a little [1:03:18 inaudible]  with  a  longer  term
           trend. It was on its way up and we were not having that much  of
           an effect.

      However, by the time we got to around February, we realized  that  the
           search system was in place. That we had some  very  good  people
           supervising this and in fact I even remember  the  time  it  was
           with, Bill Foege, the  two  of  us  were  looking  at  this  and
           wondering now, where were we at this point in time  and  that  -
           but as Bill said, I am not sure I am going to put out a weekly -
           putting out, I guess a bi-weekly report and the curve was  going
           up and he said, the only thing I can  do  that's  optimistic  is
           turn it upside down. But we felt at that time, secretly that  we
           are on our way and they got worse.

      It got worse for the bad time in a way and  a  good  time  in  others.
           India detonated a nuclear device. They had people, press  coming
           from all over. The theme of all of the coverage,  news  coverage
           was India detonates nuclear  device,  smallpox  -  their  health
           system is so bad that they are the world's primary  country  for
           smallpox. So here is this advanced country with  such  primitive
           health facilities that it's epidemic for smallpox.  This  got  a
           lot of interest. The Indian government  was  not  pleased.  They
           were very upset and they began making more resources  available.
           Higher levels in government began paying  attention  to  it  and
           they assigned to the program, from  the  Indian  side,  four  of
           their very best people to work with four of our central  people.
           We call it the central appraisal team.

      Well, we got over that and for India at least, when  we  came  to  the
           end of the last cases in May of 1975, we thought we had the last
           case. There was a beggar woman out on a railway platform in  the
           far eastern part of India going into a whole area  and  she  had
           infected a bunch of people going after. We had no idea what  was
           going on.

      By that time  by  October,  the  Minister  of  Health  and  the  Prime
           Minister were very excited about this.  We  were  not  confident
           that we got rid of smallpox. October 5 - August 15th is  India's
           Independence Day. They were determined to announce that this was
           India's Independence Day and it's freedom from smallpox for  its
           first time in history. I would say we were chewing nails at that
           time, thinking, oh my gosh! If they have more cases,  you  know,
           the press coverage and these people don't  know  what  they  are
           doing, oh god. It would have been awful, that was the last case.

      Meanwhile, Bangladesh was  going  through  tragedy  after  tragedy  of
           flood and famine  and  we  had  an  exhausted  group  of  really
           fighting to get rid of it in Bangladesh which is  a  story  unto
           itself. So, on August 15th, the Director General and  I,  headed
           for Bangladesh. They only had I don't know, something like maybe
           80 villages infected at that point. It was  just  really  coming
           way down and we felt, my gosh! I think we are going to have - be
           rid of this bad disease for all the world. It was a very  severe
           time for smallpox. That would have been in.

      So we are on our way to the airport and got the word, all flights  are
           canceled. The President of the country, the really the  founding
           father of the country, Mujibur  Rahman,  had  been  assassinated
           along with his entire family. Martial  law  had  been  declared.
           Troops were moving  to  the  border.  Floods  of  refugees  were
           expected. We thought, oh my god, once more, but for some reason,
           the international group, was laid low. They worked locally, they
           kept out of the way and the expected civil war that was expected
           to erupt immediately did not. They went back to work and finally
           in October of '75 it was all done in Asia.

      Then we were left with Ethiopia  and  Somalia,  subsequently  Somalia.
           Well, if you like to hear the rest of the  story  I  can  go  on
           Ethiopia but Ethiopia is a huge country. People look at the  map
           and they say oh, it's about the same size as  Georgia,  but  not
           so. It's equivalent to all of the states on the eastern seaboard
           of the United States in area. It's  huge.  There  are  very  few
           roads or where there are roads or even roads you can  drive  on.
           It's estimated I think that, two-thirds of the population  lived
           more than one day's walk from any accessible road, at least  one
           day.

      We had just - the government had only, I think,  2000  health  workers
           in the whole country. For  a  while  we  were  working  with  20
           Ethiopian sanitarians, 14 US peace  corps,  about  six  Japanese
           peace corps and some Austrian peace corps  and  some  volunteers
           who kind of wandered in. Anybody who wanted to work, we put them
           to work and paid them the Ethiopian per diem which if you didn't
           [1:09:59 inaudible] high on the hog on that one, I can tell you.
           Then as they were making progress, slowly but it was  difficult.
           Some of the - first time we ran  into  a  huge  area  where  the
           people fought against vaccination. They didn't want it.

      Trying to solve that problem, took us  some  doing  but  finally  they
           wanted malaria drugs and we could give them  malaria  drugs.  We
           got malaria drugs to give them,  provided  they  got  vaccinated
           first. So they got vaccinated first and then got the drugs.  Not
           the way you like to run a program but that was the only  way  we
           were going to stop the disease. It was a  less  severe  decision
           than let's say in  Asia.  So  there  is  less  motivation,  less
           concern on the part of government.

      Well, we got all of a sudden the emperor Haile Selassie was in  charge
           and had been there you know, as emperor for a  long  time.  They
           had a coup, military coup. Marxist  military  group  took  over.
           Civil war broke out, so there was fighting in different parts of
           the country. The emperor was, I don't really know what  happened
           to him. I think he was killed. Then it was the  US  Peace  Corps
           had to pull out as did the other groups. A number of the embassy
           people pulled out and for a quite a  period  of  time  the  only
           people allowed by the military to go outside of Addis Ababa were
           the smallpox group.

      We had some pretty very good people, particularly our person  who  was
           the real leader of the program, he was a Brazilian fellow by the
           name of Ciro de Quadros. He  had  a  charm  and  an  ability  to
           persuade that was legendary. That's why we had permission to  go
           outside the country but that wasn't much fun because they were -
           we had to go to many  of  the  provinces  with  military  escort
           because it was too dangerous. So  they  fought  through  all  of
           that. It was really horrendous and then they came to a point.

      Finally we got additional people in,  and  then  finally  the  surgeon
           general of the United States came up with a  contribution  of  a
           million dollars for us to get  three  helicopters  to  transport
           people. It was so big. That made a huge difference. Well, one of
           them was shot down, one of them getting up there - I don't know,
           we don't know what reason went into like Kenya. Another one  was
           hit with - they threw a hand grenade at it. They were a pair  of
           those, of those and they took one for the - we had to get at one
           of them with a hostage and they were captured and we had  ransom
           notes which I've still got a copy of the request for ransom from
           the people dictated by the rebels,  written  by  the  helicopter
           pilot. While he was captured took the vaccine and  got  all  the
           rebels vaccinated, so took care of that, he was thinking all the
           time.

      Finally we got to this place in Dimo, a little  village  way  down  in
           the desert, last  case.  I  flew  down.  We  thought  we  got  a
           television crew down there, film this and we did and got  a  lot
           of footage of Dimo, crazy little village sitting in  the  middle
           of a desert. We had a hard time even finding it with  the  -  by
           helicopter, you couldn't spot at great distance.  We  went  back
           and we waited and they searched. Nothing, nothing.  It  went  on
           for eight weeks. We were about ready to make a statement at  the
           press, we are done. There was a report came in of two  cases  in
           Somalia right next door.

      Well to make a long story short, the Somali government, even  for  the
           all the discussions we had had with them, had been hiding cases.
           They knew they had smallpox.  They  were  admitting  them  to  a
           hospital in a sort of secret ward, nobody knew about. They  were
           trying to stop it but because they were  embarrassed,  the  only
           country with smallpox. They hated the Ethiopians and they  hated
           the thought that Ethiopia was free of smallpox. They refused  to
           believe that they were free.

      This went on and as they would let our people come in but  they  would
           let them go out beyond the main city  of  Mogadishu.  The  cases
           kept occurring but they are having  trouble  finding  out  where
           were they coming from, in other words, who was  infecting  them.
           Finally, there was a great discussion  about  this  and  one  of
           them, the turning points, I  think  it  was  that  a  couple  of
           turning points had happened. One being  they  captured  a  Dutch
           adviser who we had working with Ethiopians. He was kidnapped, if
           you will, with his team and vehicle and taken  to  Mogadishu.  I
           think we had eight or nine of these and then the UN commissioner
           would intervene and talk to president and minister.

      This fellow Bert van Ramshorst, finally they took him. He has  to  see
           the minister. So he spent, sat down with the minister and pretty
           well, persuaded him that Ethiopia was free of smallpox and  that
           there was a problem and that the - WHO would be willing to  help
           and so forth and so on. He made a quite a persuasive pitch here.
           Meanwhile, Assistant Director General, Ivon Lodney indicated  he
           would want to come down and visit the city of Mogadishu  at  the
           capital and meet with the Minister.  The  Director  General  was
           threatening to do the same and I think the pressure was on.

      Then they began to loosen up. So from then until this was about  March
           of '77 and the number of cases, I recall are  about  3000  cases
           finally that they had troubles because  they  had  nomad  groups
           moving all over the desert area, couldn't  find  them.  Smallpox
           kept spreading and you couldn't vaccinate them. It  wasn't  that
           they would resist vaccination, you couldn't find them. Then  the
           great problem was, come November, was the Hajj. Somalia is right
           near Saudi Arabia. Many people come from Somalia to  Mecca.  All
           we could imagine were people and they would  come  from  through
           Somalia from other countries, all we could imagine  was  can  we
           possibly have at this time, one of these groups  infected  going
           into Mecca and spreading  it  among  hundreds  of  thousands  of
           people and watching smallpox go like this.

      So there was a frantic effort in terms of - they flew in vehicles,  so
           we had more mobility and flew in all sorts  of  people  and  the
           government declared a national emergency and it went all out. On
           October 26, 1977, Ali Maow Maalin, a cook  23-year-old  was  the
           last case of smallpox. That was the end of the smallpox. We  had
           to spend two more years working in the countries to make sure it
           was really the last one.

Paul O'Grady:    How  did  you  find  out  about  that  last  case,  do  you
           remember?

D.A. Henderson:  Oh, yeah. They had brought in some people at this point  in
           time. They were moving people to an isolation camp to make  sure
           that they would be held. There was two kids who were brought  in
           by a vehicle from outside one of the program vehicles  and  they
           brought them in and they stopped  at  the  hospital  to  inquire
           about where the camp was. Ali Maalin was a cook at the hospital.
           He was supposed to have been vaccinated but he  wasn't.  He  had
           been a vaccinator, in fact but he hadn't been vaccinated. How we
           went wrong, - he got in the vehicle, rode for about  10  minutes
           till they got to the isolation camp. He got out and he came down
           with smallpox.

      Well, he came down with a rash, and as often the case the last is  the
           worst. He was admitted in a hospital and  diagnosed  as  chicken
           pox. Finally, they had  discharged  him  with  a  mild  case  of
           chicken pox and it was one of the other people, friends of  his,
           who said,  I  don't  think  this  is  chicken  pox.  It  wasn't,
           smallpox. He was a very popular guy and he had contact with  all
           sorts of people. So, there were everything  from  roadblocks  to
           all night searches throughout Mogadishu to goodness knows  what,
           trying to find possible other cases, but it was the last.

Paul O'Grady:    So do you have any final thoughts,  anything  you  want  to
           share about your experience with over the course of the years in
           the program?

D.A. Henderson:  Well, I think there were several things about  the  program
           that were very special and that is that we came together, people
           from across the world worked together very well. I  worked  very
           closely with the Russians. It was during the darkest days of the
           Cold War. Totally cooperative, we shared all  sort  of  problems
           and they had some things that needed to be corrected and I  flew
           to Moscow. We talked it over, they corrected them. We had people
           working across borders from one country to another. We  had  mix
           of nationalities out there. What was perfectly clear was that if
           we had a goal, we had leadership at all  these  levels  that  it
           became a very unique situation. Bridges were built such  as  you
           can't imagine. It formed the basis for going  on  from  smallpox
           and we really convened a meeting  and  before  the  program  was
           over, to say, the vaccination has been so  inexpensive.  We  can
           vaccinate  so  many  people  in  a  day,   so   effectively   so
           efficiently. We should be doing more of the smallpox vaccine.

      This  was  an  international  meeting  we  held  and  from  that  came
           recommendations for an expanded program for immunization,  which
           was finally accepted by the World Health Assembly in 1974,  even
           before the end of smallpox. The idea was to add other  vaccines,
           diphtheria, whooping cough, tetanus, the  DPT  vaccine,  measles
           and polio and add this to smallpox. That was  adopted  and  then
           UNICEF got behind it and rotary got behind the  polio  side  and
           the goal was at that time to reach 80  percent  of  the  world's
           children by 1990 with these six vaccines. At the  beginning,  we
           estimated that at best about 10  percent  were  receiving  these
           vaccines. So we had cases of  tetanus  and  diphtheria.  Totally
           preventable diseases, whole wards full of whooping cough and  so
           forth and good vaccines out there, well, made it. So by 1990, 80
           percent of the world's  children  had  been  vaccinated  against
           these  six  diseases.  So  this  was  the  expanded  program  in
           immunization which  is  going  on,  became  in  due  course  the
           eradication of polio. It served to eradicate measles  throughout
           the western hemisphere. Measles was gone.

      We had so few cases of tetanus and diphtheria that it was  a  amazing,
           they were  exceptionally,  just  throughout  the  whole  of  the
           Americas, they developed reporting system which I think, at  the
           beginning we had 500 hospitals reporting once a month. The  last
           count I looked at the reporting, they had weekly reporting  from
           42000  sites  in  Latin  America.  People  just  -  it's  better
           reporting for these diseases than it is in the United States  of
           America. This is going on to develop the group that has convened
           here, have done all sorts of marvelous things and  out  of  this
           came a feeling  of  we've  done  this,  why  can't  we  take  on
           something else. They have done that with great success.

      So, if there is a real need for  an  international  organization  WHO,
           even though there is some of those like our President  Bush  who
           have not felt the need to work with other countries, this  could
           never have been done in the United States, it could  never  have
           done by a  few  countries,  it  had  to  have  an  international
           organization. It showed also how much you  can  do  if  we  have
           preventive medicine and public health vaccines. We were  dealing
           with 10 to 15 million cases of smallpox a year, 2 million deaths
           a year and 10 years later we have zero cases, and  zero  deaths.
           This is pretty dramatic.

      Now you  are  seeing  similar  things  happening  with  measles.  Very
           dramatic changes and now we are talking  about  with  the  Gates
           Foundation supporting a lot of  things,  why  can't  we  go  and
           tackle malaria in a different way. Why aren't we doing  research
           to get better vaccine for tuberculosis,  why  don't  we  have  a
           vaccine against malaria? It's opened  up,  it's  begun  a  whole
           revolution in prevention which is really something to see. Today
           or last couple of days, we have been hearing  reports  of,  now,
           how many different fronts it's moving on very rapidly and really
           rethinking all of this.

      It has, I think, built bridges in the  international  field  that  you
           can't build in agriculture or education.  Those  are  political.
           Agriculture, for obvious reasons,  even  education,  it  becomes
           quite political. With the health side, you really just don't get
           into political issues. It's amazing, you don't and thus  it  has
           built relationships in ways that are really quite unique  across
           the Americas which I have spent more time with  recently.  There
           have been in other areas as well. They had days  of  tranquility
           in the  Americas,  where  in  the  fighting  in  Nicaragua.  The
           agreement was they would stop fighting for  two  days  and  they
           would and the vaccination team to go out. This has  happened  in
           Afghanistan, days of tranquility. So that even the rebel  groups
           could be approached and could be helpful.

      So we got to Peru in the end of polio in the Americas, the last  cases
           were in the area called the Shining Path, where the Shining Path
           was. They destroyed hospitals, they destroyed schools what  have
           you. What the people really behind the scenes, Ciro  de  Quadros
           who was the head of immunization for the Americas had  met  with
           the commanders of the Shining Path and talked it through and got
           commitments from them, not to harm  the  health  workers.  Well,
           they went through and this is what the health workers are doing.
           Guess  what,  they  searched  this  whole  area  which  was   so
           dangerous, it was a problem for the military to go into.

      So there, it's something that I think is unique about health here  and
           something which gives you great encouragement  for  the  future.
           Thus, I really feel  quite,  I  feel  like  we  have  a  made  a
           difference well  beyond  smallpox  eradication.  I  think,  well
           smallpox eradication, I think has been the first  step.  We  are
           now moving on well beyond that into many more exciting things.

Paul  O'Grady:     Great.  DA  Henderson,  thank  you  very  much  for  this
           interview.

D.A. Henderson:  Yeah, you are very welcome.

[End of audio 1:29:16]
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