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                  <text>Smallpox</text>
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                  <text>&lt;div class="landing"&gt;
&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
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Interview

Dr. David Pratt with Interviewer Elisa Koski
Transcribed: January 2009 | Duration: 0:31:56




Elisa Koski:     This an interview with David Pratt on July 11, 2008 at  the
      Centers for Disease Control and Prevention in Atlanta,  Georgia  about
      his role in the Smallpox Eradication Project. The interviewer is Elisa
      Koski.

      With this interview, we are hoping to capture for future  generations,
      the  memories  of  participants  and  their   families   involved   in
      eradicating smallpox. This is an  incredibly  important  and  historic
      achievement and we want to hear about your  experience.  I  have  some
      questions to guide you, but please feel free to  recount  any  special
      stories or anecdotes that you remember about  events  or  people.  The
      legal agreement you signed says that you are donating the oral history
      to the U.S. Federal Government and that  it  will  be  in  the  public
      domain. For the record, could you please state your full name and that
      you know you are being recorded.

David Pratt:     Sure. My name is David Pratt and I am  aware  of  the  fact
that I am being recorded.

Elisa Koski:     Thank you so much. Thank  you  for  being  here  today  and
      being willing to share your experiences. I'm going  to  start  with  a
      question about your childhood and how you grew up. Could  you  briefly
      describe for me your childhood and your pre-college education and  how
      you became interested in Public Health?

David Pratt:      Sure. I grew up in a small town in Massachusetts,  Newbury
      Port, Massachusetts and did my primary grades in Newbury Port and  had
      nobody really - I shouldn't say nobody,  I  had  two  aunts  who  were
      nurses and I think they perhaps had influences. Nobody  in  my  direct
      family though, neither my parents, nor my grandparents  were  involved
      in healthcare in any way. So perhaps it was my aunts'  influence  that
      got me interested.

Elisa Koski:     How did you become involved with CDC, and particularly  the
      Smallpox Eradication Program?

David Pratt:     Very interesting question. I  went  to  medical  school  at
      Tufts in Boston and while I was a medical student at Tufts there  were
      people  in  infectious  disease  who  were  Fellows  in  training   in
      infectious disease and one Kenny  Ratson  had  actually  been  an  EIS
      Officer; and I was a medical student while Ken was  a  Fellow  and  in
      discussions  back  and  forth  about  a  variety  of   questions   and
      interesting topics he shared  with  me  and  with  the  other  medical
      students what it was like to be an EIS Officer.  So  I  became  really
      quite interested in that. At the same time at  Tufts  Medical  School,
      Jack Geiger and Count Gibson were running a  family  medicine  program
      and they were doing some very interesting things with Social  Medicine
      in Bolivar County,  Mississippi  and  in  Housing  Projects  in  South
      Boston. So the complete picture of what Public Health  could  be  like
      from the social, economic  and  cultural  aspects  to  the  infectious
      disease aspects, really increasingly got me interested.  So  following
      my medical school experience with Ken Ratson and Community Medicine, I
      applied to become an EIS  Officer.  Now  at  that  time,  we  have  to
      remember that the Vietnam conflict was ongoing and choosing  a  career
      in Public Health was also ethically more comfortable for  me  at  that
      point in my life. So it was a wonderful way to serve the  country,  it
      was an exciting area to learn and be a health professional, and it was
      an exciting time.

Elisa Koski:     Thank you. How did you specifically end up  in  India,  you
      mentioned a little bit, prior to  this  interview  as  we  were  being
      introduced, that you actually had an option?

David Pratt:     Right. When EIS Officers in my cohort came to CDC we had  a
      choice of what kind of assignment to take. There were assignments here
      in Atlanta and there were assignments in the field with  State  Health
      Departments; and I chose to  actually  take  an  assignment  with  the
      Hawaii Department of Public Health. That group was doing routine State-
      based Public Health, but in  addition,  we  were  doing  some  vaccine
      development, specifically an intranasal vaccine with measles.  It  was
      clear for the group of people who came in when I  came  into  the  EIS
      that   there   were   going   to   be   opportunities,   international
      opportunities. One was an opportunity in Nigeria, the  Biafran  famine
      was ongoing and huge amounts  of  migration  of  Nigerians  ethnically
      diverse moving across the country and a great  deal  of  hardship  and
      despair over that, and EIS officers were given an  opportunity  to  go
      and actually do  assessments,  surveillance,  measurement  around  the
      famine. The alternative option was Smallpox Eradication. When we  came
      to CDC the West Africa campaign was  largely  victorious  and  a  very
      clear strategy had been laid out by Henderson and others and so  those
      two options were available. Ultimately I chose to turn down  an  offer
      to go to Nigeria and accept the offer to go to India in 1974.

Elisa Koski:     What influenced that decision, why would  you  have  rather
been in India?

David Pratt:     I think two things really. One was the - I think even  then
      I understood the magnitude of what we were going to try to do. I  also
      thought that the work in  Biafra,  though  important,  and  doing  the
      assessment of the famine, and the impact of famine on  the  health  of
      those children was important, I thought it was also  desperately  sad,
      probably tougher going and I  thought  that  the  chance  to  have  an
      opportunity to play a role in the eradication of a  disease  was  very
      significant and exciting and India also interested me a great deal. As
      a resident at the University of Michigan, I had a medical student  who
      talked in very interesting terms about work that he had done in  India
      and so I was intrigued by his descriptions, I  was  intrigued  by  the
      challenge and the opportunity and decided that when the call came from
      Lyle Conrad here at CDC that it was a good thing to do.

Elisa Koski:     Can you tell me a little  bit  about  your  role  when  you
arrived in India?

David Pratt:     I think as a slight - to step back just a bit - it  took  a
      fair bit of convincing in my own life  circumstance,  I  just  had  an
      infant son born way away from family, so my wife -  and  this  is  our
      first child, so she was there to take care of a child by herself  when
      I trotted  off  to  India.  We  knew  communications  was  very  poor,
      telephonic communication was virtually non-existent in the areas  that
      we were going to be in and telegrams were iffy. So  I  had  to  really
      convince my wife that this was of great enough significance  to  allow
      me to leave her and my son to go and  do  this.  So  the  context  was
      socially challenging for me personally, but I thought very  important.
      So the routing that I took was  basically  from  Hawaii  over  through
      Thailand, from Thailand up to Delhi and then when we got to  Delhi  we
      were met by the WHO people at the regional office in Delhi and began a
      briefing. I think it's important to explain, or  share,  how  dramatic
      the arrival in India was  for  us  in  1974.  The  gulf  in  terms  of
      economics and in terms of the way the place looked from where  we  had
      come from, that is Hawaii and mainland United States,  was  incredibly
      different. The smells, the sounds, the beggars at every stoplight, the
      crush and the throng of millions of people  it  felt  like,  was  very
      different and for a while the truth  is,  I  think  we  were  stunned,
      literally stunned and it took us a while to kind of catch up with  the
      fact that we were in a brand new environment, very different than  the
      West. So there were going to  be  lessons  to  be  learned  about  the
      economics, about the sociology,  about  the  psychology  of  this  new
      terrain that we were entering. So  those  first  few  days  were  very
      challenging I think for all of us.

Elisa Koski:     Of course, there was the challenge with your wife and  son.
      Did you  encounter  any  other  challenges  when  you  first  arrived,
      housing, food and water, anything that you can recall like that?

David Pratt:     The WHO team in New Delhi arranged to pick  us  up  at  the
      airport which is always interesting and hasn't  changed  too  much  in
      India, getting through the  airports;  and  they  brought  us  to  our
      hotels. They had things pretty well arranged,  the  logistics,  pretty
      well arranged for us.  The  hotels  were  certainly  comfortable,  not
      lavish, it wasn't anything we expected and I think they built  a  very
      nice routine, a briefing routine for us in Delhi before we went to the
      field. The food of course was very different than what I was  used  to
      in Hawaii, but I always have been sort of an omnivore  and  interested
      in different cuisine, exotic cuisine, so that was fine with me. I  was
      good with that. I think where it got interesting is when  we  went  by
      train across the North of India, a group of us all together, to go  to
      our duty station which was in Bihar. Now at the time I  really  didn't
      realize that Bihar was among the poorest States of India and that  the
      poverty that we'd witnessed in Delhi was going to be compounded by the
      kind of misery that we would see when we got  to  the  Bihari  regions
      across the Ganges River to the  North.  So  it  got  more  interesting
      rather than less interesting as we went further  and  further  to  our
      duty stations.

Elisa Koski:     Can you describe to me a little  bit  about  what  happened
      when you arrived in your duty station?

David Pratt:     Okay.

Elisa Koski:     What was your role? How did you interact with your team?

David Pratt:     I was assigned to two areas,  two  States  or  two  regions
      inside Bihar. One was called Sarn; (S-a-r-n), and the other was  Siwan
      (S-i-w-a-n). The stepping off point for those assignments was in Patna
      and you may remember from Lord Jim, the name of the boat in  Lord  Jim
      is the Patna, ill fated boat-Anyway we went to a hotel in Patna, where
      we had a further briefing on Bihar and our duty station and then  very
      interestingly took ferries across the Ganges River.  There  were  some
      wonderful lessons about the ferries. It turned out that moving  a  WHO
      jeep across the Ganges River was not as easy as simply pulling up  and
      buying a ticket. It turned out that if you  pulled  up  and  bought  a
      ticket, everybody went around you and the reason everybody went around
      you was  because  there  was  another  payment  being  made  that  was
      invisible beyond the ticket, so  it's  called  baksheesh.  So  if  you
      didn't understand that if you really wanted to get  that  ride  across
      the river, it would be the ticket plus some baksheesh, you would  wait
      a long time at the ferry dock. So cross the river by  ferry  and  then
      got to Chapra which was the area that was my  headquarters  for  those
      months that I served in that region.

Elisa Koski:     Can you tell me  about  the  smallpox  situation  when  you
arrived?

David Pratt:     There were lots of outbreaks going on. I think at the  time
      in my region, there were 18 or 20 outbreaks that were in the midst  of
      being dealt with, controlled; contained. A wonderful experience for me
      as I reflect on it; was the first day in my region. We went by jeep to
      an outbreak at a village, we went into a mud hut in the village and  a
      woman presented me with her infant covered with  smallpox  lesions.  I
      picked the child up as you would to  examine  anyone;  the  child  was
      pretty miserable and had still persistent fever in spite of  a  fairly
      well developed rash, and the thing that really struck me was  at  that
      moment I was betting that my immunization was sufficient  to  keep  me
      healthy as I  went  forward  in  the  program.  So  it  really  was  a
      challenge; you know, how deeply do you believe  in  immunization,  how
      profound is your faith, and so it was  obviously  pretty  profound.  I
      examined the child and on we went. I mean, I am recognizing  that  the
      case fatality rates are 25%. So it  was  a  huge  gamble  really  that
      things were going to work. I mean, we all  knew  the  history  of  the
      immunization, that it was robust and successful, but  when  it's  you,
      with a child  at  home,  and  so  forth,  and  you  are  beginning  an
      assignment, you'd rather not get a dreadful illness in the  middle  of
      India.

Elisa Koski:     Of Course. Can you describe to me a little  bit  about  the
      progression of your assignment there, from your first day onward;  how
      did things move forward?

David Pratt:     From that day, seeing that outbreak that  very  first  day,
      it was right at the tail end of the monsoon, humidity was  very  high,
      day time temperatures were routinely 40  degree  Celsius,  104  -  105
      degrees, and taking notes, which I tend to be a compulsive note taker;
      was very challenging because perspiration would run down your arm onto
      a pencil right on to your notepad or onto your notebook. So I  had  to
      find clever ways to do note taking that wouldn't  saturate  my  books,
      and so on and so forth. So it was very, very warm,  very  dusty;  when
      the monsoon ended the dust began. But it was still raining during  the
      time that we first arrived. The Indian Public Health people said  that
      searching, trying to search through the monsoon was nuts and  yet  the
      people we relieved had done it and had done it successfully. So we had
      in some ways bucked the standard wisdom about it and had gotten off on
      a really good foot.

      So I was turned over to a region that was well done, well  maintained.
      I stayed in a place that was called the  Circuit  House.  The  Circuit
      House - they were they were  also  called  Dak  Bungalows.  They  were
      locations where the British mail people went when they  delivered  the
      mail around the country. It was basically a squat toilet, there was  a
      shower that was heated by a tank on the ceiling,  a  little  desk,  no
      screens on the doors, we had bed nets that we used and I  had  monkeys
      as my neighbors who would come in on my porch and actually come in  my
      room if I wasn't very  careful.  So  I  had  good  neighbors  and  the
      accommodations were decent, in the day it got very hot, but  at  night
      it cooled successfully; and I didn't realize, but  my  colleagues,  my
      Indian colleagues assured me that the  mosquito  nets  served  a  dual
      purpose, not only would it keep the malarial mosquitoes from biting me
      at night, but it was also good as a preventive measure against  Cobras
      and Kraits and Russell's Vipers which  were  snakes  that  potentially
      could bite you in the night because you were warm. So they would sense
      your warmth and come up on your bed. So I had no  problem  with  that,
      but my Indian colleagues frequently slept on the cement floor  in  our
      building covered with their dhotis and  mosquitoes  would  bite  right
      through the cotton. It was extraordinary to  see  the  situation  that
      they were in at night.

      So the living situation was in the Circuit House or Dak  Bungalow.  In
      the morning I had a chowkidar, the servant of the bungalow;  he  would
      bring tea to me from a tea stall down the road and one morning  I  had
      my tea delivered by this  little  man  and  my  Indian  Epidemiologist
      counterpart saw this occur and was horrified, because  it  turned  out
      that the man who delivered the tea to me was an untouchable and that's
      unacceptable. They were unclean so  to  bring  me  food  was  sort  of
      revolting[indiscernible0:17:11] and being  outside  the  caste  system
      there was no issue for me but there was like a little confab and  they
      discussed it and explained  that  really  you  shouldn't  do  that.  I
      continued to have tea from the chowkidar the day after that,  it  just
      wasn't an issue with me, but it was my first banging  into  the  whole
      issue of caste was right there in the Circuit House that day.

Elisa Koski:     Okay. How close were your field assignments to the  Circuit
      House? Were you were working right in the surrounding villages or  did
      you have to travel a lot?

David Pratt:     No, there was a fair amount of travel.  We  had  jeeps  and
      drivers and on an average day, we would probably work 8  or  10  hours
      driving and you would go from outbreak to  outbreak,  District  Health
      Officer - you would visit with the District Magistrate, you would meet
      with the various people who were critical to you being able to get the
      project done. So there was a great deal of traveling  around.  We  all
      had drivers and I have to say that the Indian, Dr. Chakravarty who was
      my counterpart in Chapra was an extraordinary  guy,  very  bright  and
      could accomplish things that clearly I could not accomplish. He  spoke
      the language; he knew how to influence in very effective ways,  so  he
      was critical. I would begin the morning by going to his home  and  his
      wife would serve me another cup of tea, we would lay out the  day  and
      then we would just simply start going; and routinely  we'd  leave  his
      house probably at 10:00 o'clock and not  return  until  8:00  or  9:00
      o'clock at night - that evening. He never stopped for lunch,  I  don't
      know what the guy ate, but he never stopped for lunch, so we just kept
      going. Sometimes we'd stop actually on the road and our  driver  would
      buy in the market cow dung, these dried patties  of  cow  dung,  light
      them on fire and then buy cucumbers and cook cucumbers in  their  skin
      and we would eat those as kind of a snack, a break on  the  road  with
      tea. So extraordinary things, and cow dung was routinely used as fuel.
      In the mornings in the villages you could smell the cow  dung  burning
      as people began to make tea and food for breakfast.

Elisa Koski:     Very, very interesting. How  were  you  received  when  you
      arrived in these villages?

David Pratt:     Interesting. I am 5'6" tall and  they  would  say  the  big
      saab. "The big saab is here," which I always thought was hysterical or
      they would say, "The American saab is here in the village." So it  was
      a respectful term - the fact that an American would come that  far  to
      Bihar to work on this issue  was  felt  to  be  extraordinary  by  the
      Indians. So in many ways there was a great deal  of  respect.  It  was
      beneficial as well that I was outside the caste system because  I  was
      allowed to make mistakes and gaffes that an Indian couldn't make,  and
      I could perhaps ask for things that an Indian couldn't ask for and get
      away with it. So I was well received,  respectfully  received,  and  I
      tried  to  work  carefully  with  the  people,   the   Indian   health
      professionals that were with us-it was intriguing, when we were  there
      - when my  group  was  in  India,  Daniel  Patrick  Moynihan  was  the
      Ambassador to India and he indirectly told the American  EIS  Officers
      who were deployed in the field never to speak to the press. Only allow
      the Indians to speak to  the  press  and  don't  make  any  derogatory
      comments at all. So we were well schooled and well prepped about  what
      not to do, what not to say in the country. So we really counted on our
      Indian colleagues and counterparts to do a great deal of  the  PR  and
      the outreach  and  the  commentary  that  Ambassador  Moynihan  really
      prohibited us from doing.

Elisa Koski:     You mentioned earlier that you were perhaps  more  socially
      free to have some indiscretions or  make  some  mistakes  that  Indian
      people would not have been allowed. Can you  describe  any  particular
      instances where you ran into a problem or where those mistakes weren't
      accepted?

David Pratt:     Yeah. There were times when people would flatly refuse  you
      because you didn't quite look right and I  remember  specifically  one
      outbreak, a woman became very upset when I personally asked to be able
      to immunize her, and I think I was bucking  probably  the  male-female
      divide, Eastern-Western divide, so that was an instance where  it  was
      very clear that I was not welcome in that circumstance. But  that  was
      the minority. The thing that was interesting, another key learning for
      me in the villages, is the villages were  frequently  broken  up  into
      tolas [0:22:07] or sections. There was often a  Hindu  section,  there
      would be a Muslim section and  then  there  would  be  a  section  for
      tribals [0:22:12]; and it was always humorous  to  me  that  when  you
      spoke to the different leaders of the different tolas, they would make
      derogatory comments about their counterparts, and it  frequently  went
      something like this. "Oh, you will never get  them  to  be  immunized,
      they  don't  know  anything.  They  are  sort  of  ignorant."  It  was
      intriguing how each of them made similar commentary of the others, but
      at the end of the day they all allowed us to immunize  them;  and  the
      strategy was frankly to invite the village headman  to  be  the  first
      recipient of vaccine when we were doing containment. So if the opinion
      leader in the village would allow you to immunize him, then all things
      seemed to flow from that. So if he got it done, well  everybody  would
      line up behind him and we would be able to do a good job.

Elisa Koski:     Of course. I would like to talk a  little  about  how  your
      entire experience in India really influenced your  life  and  impacted
      your career in public health subsequently?

David Pratt:     You have to realize that this was sort of like winning  the
      grand slam in tennis at 29 years of age. Where do you  go  from  here?
      You know, it was an extraordinary event and as the years went  on  and
      the true eradication was proclaimed, and so on and so forth, it became
      even more spectacular in my career. So what do you do?  What  is  your
      follow on act? It's like a first novel, if it's a success, it's a huge
      challenge. I think that I took a lot of  important  lessons  from  the
      Smallpox Eradication Program. The first one is that sometimes  naiveté
      is  a  wonderful  asset.  You  know,  we  really   didn't   know   how
      extraordinary what we were going to do was, and we went at  it  anyway
      assuming that it could be done. So I think that was of importance, the
      naiveté; and the other thing that goes with it is a comment that Colin
      Powell makes and he says that -  General  Powell's  comment  is  that,
      "Optimism is the most important  force  multiplier"  and  I  tried  to
      remain - the optimism that I  brought  to  the  table  I  thought  was
      powerful in allowing us to get my region - and by way by  the  time  I
      left my region we were smallpox  free.  All  the  outbreaks  had  been
      contained and I left an absolute  pristine  area,  I  should  say  the
      Indians and I as their assistant, left a  pristine  area,  and  I  was
      always outwardly very optimistic although as I read my diaries, I read
      that there were times when I was very pessimistic that  we  would  get
      the job done. But ultimately when I spoke to our searchers  and  spoke
      to students and spoke to people in the villages,  I  was  always  kept
      that very optimistic view. That's one.

      I think a second big one is the  fact  that  it  is  sometimes  really
      simple  stuff  that  makes  a  huge  difference.  For  instance,   the
      logistics, knowing where to get gasoline, knowing  how  to  keep  your
      jeep serviced so when you had to go to  an  outbreak  you  could  keep
      going. Having sufficient Rupees to pay the  people  who  search,  just
      really nuts and bolts of good management were critical  to  succeeding
      in India and in the rest of my career they have been critical elements
      as well.  Simplicity too; I think part of our success in the  Smallpox
      Eradication Program had to do with the fact that we were using  proven
      technology for the vaccine, we were using a strategy and  the  tactics
      to deploy that strategy that  had  been  proven  in  West  Africa  and
      basically what we did was execute, execute, execute. Just this kind of
      diligence of doing it every  day,  following  the  book,  compulsively
      filling in all the things that we needed to get  the  job  done.  Atul
      Gawande who was a writer, an American health writer, talks  about  the
      power of diligence and improving quality in care.


      Well, it was sure true with smallpox, diligence really paid off. Which
      reminds me of a point where things were not looking so good, in  early
      October in fact, it was October 5, 1974, I  know  from  my  diaries-we
      went to meet with Bill Foege  -  Dr.  Foege  in  Patna,  and  we  were
      explaining how it was going and the answer was: "Not so great" and  we
      were really working hard. I mean: we were doing 10 and  12-hour  days,
      lots of driving around and very bumpy  roads,  the  infrastructure  in
      India was tricky, and we met with Bill and he said, "Not good  enough,
      you are going to  have  to  do  more."  So  we  were  saying  -  Jason
      Weisenfeld[inaudible name0:26:57] and l were  working  in  the  region
      together, and we'd say, "Phew, okay we can do it Bill, but we are  not
      sure how much more." So we went back and tried to think; how do we  do
      this in a fashion that is more efficient, more effective  as  well  as
      putting in more hours. That was extraordinary. So I think  those  were
      the real key takeaways,  simple  things  logistics,  good  management,
      proven  technology  and  diligence.  Just  doing  it,  recording   it,
      measuring the heck out of it and continuing to execute every day.

Elisa Koski:     How about in your personal life, I mean you mentioned  that
      prior to going you were quite torn of leaving your  wife  and  son  at
      such a critical time and those obviously had to play into some of your
      future decisions as well? How did this experience  in  India  indicate
      your personal decision to continue on in Public Health?

David Pratt:     Yeah. That's a great question. Actually I  didn't  continue
      in Public Health until much later. Well, I'll explain. I  was  invited
      to move from India to Bangladesh and then ultimately  it  would  be  a
      move from Bangladesh to East Africa where  the  smallpox  was  finally
      eradicated, Jason Weisenfeld and so forth, his team; and it was pretty
      clear that I was not going to be able to  continue  with  the  effort.
      Several reasons: I had an infant son at home; I had  a  commitment  to
      continue my training in internal medicine. My father had had  a  heart
      attack, my mother-in-law died while I was deployed in India. I mean it
      was social catastrophe. So it really probably took me 24 months before
      everything was kind of right in the world, in  my  little  world  back
      home after I got back. So I made a conscious decision at that point to
      do  something  that  was  going  to  be  less  travel  and  more  like
      traditional clinical medicine. I continued  to  drift  towards  Public
      Health in spite of that and ultimately did a number of  activities  in
      clinical care that drew upon the public health model to  allow  me  to
      get the good vibrations back  again  about  public  health,  and  then
      ultimately when I retired from being a medical director with  a  large
      Fortune 500 company, now I have gone back - actually go back  fulltime
      into Public Health, which is a wonderful place to be.

Elisa Koski:     Excellent. In conclusion, I'd just like to  offer  you  the
      opportunity to share anything that we perhaps  didn't  cover,  that  I
      didn't touch on, anything very poignant  about  your  time  in  India,
      people, places that you would like to add.

David Pratt:     Yeah. A couple of things: Number one is that I was a  grunt
      in a huge campaign and it was my wonderful opportunity to  be  at  the
      right place at the  right  time  with  wonderful  leadership,  Indian,
      International, American-It was a tremendous experience for me to  work
      with D.A. Henderson and with Bill Foege, Mike Lane, Nicole Grasse, and
      a gentleman named Yallaporka[inaudible 0:30:02],  who  was  an  Indian
      expert, a smallpox expert. So it was a privilege, first of all, to  do
      that work. I played a minor role in a great pageant  of  strategy  and
      tactics and so forth, and I am grateful for that. Another  thing  that
      was very clear is that it was the Indians who did the job in India. We
      frequently, I think, perhaps take more credit - the EIS types, but  at
      the end of the day; the day by day, grind them out,  hard,  hard  work
      was  done  by  the  Indians  and  we  need  to  salute  them  for  the
      extraordinary job that they  did.  Bright,  bright  people  very  hard
      working, deeply committed and it was an honor to work beside them  and
      with them. I think that the Public Health model that I learnt  in  the
      Smallpox Eradication Program  of  assessing  a  situation,  trying  to
      decide how do you do the greatest good with  the  smallest  number  of
      resources, in the shortest period of time, served me again  and  again
      and again, whether it was organizing programs for farmers  in  Upstate
      New York or whether it was thinking about field engineers deployed  by
      General Electric in Nigeria, the same thinking that I learned and  was
      underscored in the India Smallpox Campaign served me again and  again.
      So it was a wonderful learning experience for a young man, it  laid  a
      foundation,  an  infrastructure  for  a  career  that  has  been  very
      rewarding, and I  look  back  on  it  fondly  as  both  formative  and
      instructive for the rest of my life.

Elisa Koski:     Excellent. Thank you so much for  being  willing  to  share
      your experiences with us and for speaking with me today.  I  wish  you
      the best in your future endeavors and as you  continue  on  with  your
      medical training.

David Pratt:     Thank you, it was my pleasure.


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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

David Bourne with Elisa Koski Elisa Koski
Transcribed: January 24 2009 | Duration: 0:31:00



Elisa Koski:     This is an interview with David Bourne on July 11, 2008  at
           the Centers for  Disease  Control  and  Prevention  in  Atlanta,
           Georgia about his role in the Smallpox Eradication Project.  The
           interviewer is Elisa Koski.

           With  this  interview,  we're  hoping  to  capture  for   future
           generations the memories  of  participants  and  their  families
           involved  in  eradicating  smallpox.  This  is   an   incredibly
           important and historic achievement and we  want  to  hear  about
           your experience. I have some questions to guide you, but  please
           feel free to recount any special stories or anecdotes  that  you
           remember about events or people. The legal  agreement  that  you
           signed says that you're donating the oral history  to  the  U.S.
           Federal Government and it will be in the public domain. For  the
           record, could you please state your full name and that you  know
           you are being recorded?

David Bourne:    Yes, my name is David  Bourne  and  I  understand  this  is
      being recorded.

Elisa Koski:     Thank you so much, and thanks again for being  here  today.
           Now David, we just want to start with a brief  background  about
           you, how you  grew  up,  your  pre-college  education  and  your
           college education, and how you came to be interested  in  public
           health?

David Bourne:    You bet. I was raised in New Mexico and I moved there  when
           I was about five. My dad was a Public  Health  Officer  for  the
           State of New Mexico for most of his career while I  was  growing
           up. So I became interested in  public  health  and  in  medicine
           generally through him and I graduated from high school  in  1967
           from Robertson High School  in  Las  Vegas,  New  Mexico  and  I
           attended a couple of years at New  Mexico  Highlands  University
           there in Las Vegas and then I graduated from the  University  of
           Utah in Salt Lake City in 1971. During the  course  of  my  last
           year or so, I applied  to  the  Peace  Corps  and  was  accepted
           approximately a year later. So I was accepted  around  March  of
           1972 having graduated in August  of  1971.  So  my  interest  in
           general in the Peace Corps was to help with the health  programs
           and they offered me the Smallpox Eradication Program in Ethiopia
           and I accepted that and became a volunteer in  April  1972  with
           the intention  of  coming  to  Ethiopia  and  working  with  the
           Smallpox Eradication Program.

David Bourne:    Okay. So that's a unique way to  get  involved  with  CDC's
           Smallpox Program.

David Bourne:    Right.

Elisa Koski:           So what was your role when you arrived?

David Bourne:    I'm sorry?

Elisa Koski:           What was your role in the program when you arrived?

David Bourne:    Okay. In the smallpox program, I was  called  the  Smallpox
           Surveillance Officer.  So  what  they  did,  they  had  us  have
           orientation here for a day or two in Atlanta with Dr.  Foege  on
           smallpox generally and after orientation we went to Ethiopia for
           approximately eight weeks of language and cultural training, and
           then we went to our various provinces where we were to  work.  I
           was a Smallpox Surveillance Officer, as they were called. So  in
           Ethiopia, the way it was setup, it was run jointly by the  World
           Health Organization (WHO) and the Ethiopian Ministry  of  Health
           and the Peace Corps Volunteers worked  in  concert  with  people
           from the Ministry of Health and the WHO to do  the  eradication.
           So our job or role was to go village to village  from  where  we
           were assigned and look for smallpox. When we found it, we  would
           in effect, evacuate - vaccinate the  affected  village  and  the
           surrounding villages. Functionally, I think the goal  was  a  2-
           hour walk around the village, but the villages were sufficiently
           spread out, so it worked out that the affected village  and  the
           surrounding villages - the adjacent villages, vaccinate them and
           move on to the next area where there was smallpox. I  worked  in
           two areas of North Central Ethiopia primarily.

           The first problem area I've worked in  was  Gojam,  and  then  I
           worked in that province along the Western edge of the Blue  Nile
           and then I transferred - they transferred us out of Gojam and  I
           went to Wollo which was essentially on the  other  side  of  the
           Blue Nile, and I worked in Eastern Wollo. So I spent most of  my
           career on each side of the Blue Nile, the Blue  Nile  Gorge  and
           there was an awful lot of smallpox. By that time, '72 into  '73,
           a large part of the remaining smallpox was in the North  Central
           Highlands of Ethiopia and that's where I  was;  and  during  the
           course of the year, during the rainy  season  which  is  in  the
           summer, all of us in Wollo, of which  there  were  four  or  six
           volunteers, we would move to the desert because the  rain  would
           make the - we didn't have roads or vehicles but the  paths  were
           impassable due to the mud, so during the summer we would move to
           the desert in Western Wollo  and  then  we  would  deal  with  a
           totally different type of people, these were  the  Nomads,  they
           were subject to a Sultan, and we would work with the Sultan  and
           his people to find out where the Nomads were at that  particular
           time; they always knew where they were and  we  would  vaccinate
           them, so that's essentially - I spent most of  my  time  in  the
           Highlands, probably about 9,000 feet elevation. The weather - it
           was near the equator, the weather  was  beautiful  most  of  the
           time, and then in the summertime I would go to the dessert.

Elisa Koski:     It sounds like you were quite a young man  when  you  first
           arrive there, coming out of college and then  the  Peace  Corps.
           Can you describe to me a little bit  of  what  it  was  like  to
           arrive in such a foreign place and begin  to  work  on  such  an
           important program?

David Bourne:    It was to me very exciting, initially certainly, to what  I
           found - I was probably 23 when I arrived there and it was  very,
           very new and very exciting. No one spoke English. What  we  did,
           we lived in a provincial capital. There were probably  three  of
           four of us in the Peace Corps that had a house together, and  we
           would  go  to  different  parts  of  the  provinces  -  of  that
           particular province. So I, for 30 days at a time would  not  see
           any Americans or any white people for that matter or anyone  who
           spoke English, with the exception of a translator that I had the
           first year, and I would fly to, in effect, the county seat of  -
           fly commercially to the county seat of the district where I  was
           working. In that particular area there was very little smallpox;
           the smallpox was focused in the Northern part  of  that  county,
           so we would walk approximately 50 miles the next day, leaving at
           dawn and getting there at dark to  get  to  the  center  of  the
           Northern part of the county where most of the smallpox was.  For
           the next 30 days, I would go village to village or  to  markets,
           trying to find smallpox which was relatively easy to find. There
           was a lot of it.

           One of the most interesting things, and far the most interesting
           ultimately was that the second year I didn't have  a  translator
           so I never heard English or spoke English during those entire 30-
           day segments, I had a guide, but no translator. So that  made  a
           very enriching experience; and then it got quite  mundane  after
           the initial excitement; months after months,  year  after  year,
           going village to village vaccinating. The people were not - they
           were very, very - always very hospitable. They were  not  always
           very enthusiastic to see me. They had other diseases  that  they
           were worried more about than smallpox, but they were always very
           hospitable even though they were very poor. I'd  live  with  the
           people; there was nowhere else to live. They gave me  what  food
           they had, they share that with me. That was the most  incredible
           thing and it was very interesting to live in a place where  they
           had not seen white men. Certainly the children never had, and it
           was very good and to deal with; and from time to time the people
           at WHO in Addis Ababa, Dr.  Henderson,  came  there  once  in  a
           while, so  I  did  meet  him  once.  So  it  was  very  exciting
           initially, then it became quite mundane and difficult throughout
           the course of the two years and a half.

Elisa Koski:     Thank you. You  mentioned  that  you  lived  with  families
           while you were staying in these villages?

David Bourne:    Right.

Elisa Koski:     Are there any specific memories or stories you can tell  me
           about that experience? That must've been interesting.

David Bourne:    The interesting - there's a tremendous - I understand  that
           those guys that worked in  Southern  Ethiopia  had  a  different
           experience than those of us  that  worked  in  the  North.  Even
           though the people in the North were always very hospitable, as I
           mentioned, they weren't particularly enthusiastic, but each  day
           it was assumed that you would be able to spend  the  night  with
           someone, and it would be only for one  night  typically  because
           you would be moving on and the people would talk to the Governor
           and the Governor would - usually have him yourself,  but  if  he
           weren't  available,  occasionally,  there'd  be  a  -  I   could
           understand everything they could say even though sometimes  they
           didn't realize it. Sometimes they'd say, "You  take  him."  "No.
           You take him." "No. I don't -" But it was fun for us  to  batter
           with our Southern colleagues when people would fight over  them,
           "I want him." "I want him." They would  kill  a  sheep  for  the
           people in Southern Ethiopia quite often. Nobody  ever  killed  a
           sheep for us. They killed a few chickens, which was always  very
           welcome and very good. But now I don't think they had as much up
           in the North and they were certainly a different tribe, but they
           were always very friendly. One night, I  was  sleeping  outside,
           even though I was in the company of a family -  because  it  was
           very hot. I remember waking up to a dog barking very close to me
           and very scary because the dogs there, they're not exactly  pets
           and not all that friendly, so that was one  particular  case  at
           that point where I was pretty scared to be  out  there.  But  in
           general they were so friendly and I felt no danger whatsoever.

Elisa Koski:     You did say they weren't  always  enthusiastic  about  what
           your purpose was in the village. Oftentimes maybe  because  they
           had other diseases that they were a little  bit  worried  about.
           Did you ever run into any problems or difficulties accomplishing
           what you came to do?

David Bourne:    Yes. From time to time, they absolutely  would  refuse.  In
           general, the way it worked is that the decision makers  had  had
           smallpox before, so these  were  the  adults  and  it  was  very
           [inaudible0:13:26] minor  in  Ethiopia  so  the  mortality  rate
           wasn't very high. So they would often be  able  to  survive  and
           they knew they  couldn't  get  it  again,  so  the  people,  the
           governors,  the  decision  makers,  the  adults,  they   weren't
           enthusiastic, but they would almost always let their children be
           vaccinated. But you had to go seek them out, generally speaking.
           They might come in small groups. I  understand  many  times  our
           colleagues in the South, they would  have  to  have  the  police
           control the crowds too because they wanted to be vaccinated.  So
           it was  a  little  different.  But  occasionally,  people  would
           absolutely refuse. "No. Get  out.  We  don't  want  you  in  our
           village. Leave." In that  case,  I  would  ignore  the  affected
           village, but vaccinate the surrounding villages.  Thereby,  they
           would be unwittingly protected to a large extent because I would
           be able to vaccinate those surrounding villages.

            Now during the course of our tenure there,  the  Emperor,  Haile
           Selassie, was overthrown in a coup but I  assume  they  are  the
           people who are still in power today. It was a Military Junta and
           the types of people at least - if they were still in power today
           - and that created a situation of anarchy to a large  extent  in
           the countryside because the Government had  been  overthrown,  I
           think in general, the Government did not affect the people, they
           were farmers, kind of under a feudal system, but everyone had  a
           gun in Ethiopia. There was one situation, where right after that
           revolution, in the county seat in the effect I flew  into,  some
           students  had  surrounded  a  judge's  house   who   was   being
           transferred and they were in the spirit of  the  revolution  and
           they said,  "No.  This  judge  expropriated  property  from  the
           people. He's unjust and he's not leaving." So  the  judge  hired
           some robbers, in effect, highway men, they  were  fairly  common
           there, "Shift" as they called them; and these robbers were  well
           armed and he hired them to escort him and  his  family  and  his
           stuff. They were planning to go by mule or whatever to the  next
           town, but when these shifters came, these highway  men  came  to
           his house, the students and the people in the town, they  had  a
           gun battle.

            The judge's wife was killed certainly and  most  of  his  family
           and about half of the highway men were killed. This is  the  gun
           battle that occurred the day before - the day of the  evening  I
           was walking back there. So the guy I was  staying  with  was  in
           effect the Public Health Officer who was a doctor,  and  he  was
           treating the wounded - the remaining wounded who were very badly
           wounded, and the people in the house, they  threatened  to  burn
           down our house, his house, the one I was staying in  because  he
           had done that, but they fortunately didn't do that. But  talking
           about refusal, the next day I was scheduled to go back North and
           no one would go with me because the people that got killed  were
           from the Northern part of that county; and they were rumored  to
           be coming down to burn down the town. Kind of like the Old West.
           Then the next day, the judge's  family  arrived  by  plane  from
           Addis Ababa, the capital, armed with machine guns and whatnot to
           exact revenge on the people and I left on that  very  plane.  It
           was time for me to go. In fact, that was the last time I was  in
           that part of the country.

Elisa Koski:           It seems like that would've been  quite  a  dangerous
      situation.

David Bourne:    It had appeared to be. Everybody  else  really  thought  so
           and I was ready to go, and I was pretty - I guess I  was  24  by
           that time, 25. But I could  understand  that  the  guide  I  had
           usually: he said, "What good would that do me if I got killed up
           there-I'm from the South;" and there was going to be a big  feud
           between the North and the South. During that whole period  there
           were a lot of situations  like  that  where  the  citizens  took
           advantage of the roles of the anarchy in the country,  and  then
           soon after that, Peace Corps offered people to leave voluntarily
           because of the deteriorating situation. Most  of  us  stayed,  I
           stayed through my tenure and a couple of months beyond, but  the
           next year, I'd say,  I  think  it  was  probably  in  '75,  they
           actually kicked the Peace Corps out of Ethiopia,  and  everybody
           left.

Elisa Koski:           How far along into your time  with  the  Peace  Corps
           did this occur; and after it occurred, did that change  how  you
           played your role in the Smallpox Program?

David Bourne:    I was pretty well - I was there a total of about two and  a
           half years and this was probably about two years into it.  So  I
           had about three months to go and I think  if  memory  serves  me
           right, it was time to go to the desert anyway which was  totally
           different. Their political situation was -  there  weren't  that
           much people, there wasn't much Government and the Nomads that we
           dealt with went back and forth between what was called then  the
           territory of [inaudible 0:19:42] in Ethiopia;  I  think  it  was
           Somalia Land or  -  So  the  political  considerations  and  the
           security situations were far  different  in  the  desert.  So  I
           finished out my tenure in the desert and then I agreed to remain
           a couple  more  months  to  train  the  new  group  of  smallpox
           volunteers, about nine or 12 of them that came, and I stayed for
           about  two  months  or  three  months  helping   the   Ethiopian
           contractors train this new group.

Elisa Koski:           Now you mentioned a little bit earlier that  you  did
           have some contact with WHO and  CDC  counterparts  such  as  Dr.
           Henderson. Can  you  tell  me  a  little  bit  more  about  that
           relationship?

David Bourne:    I remember meeting him only once, but we had - with  regard
           to CDC, I only met only one CDC person. I don't recall his name.
           He was an EIS Officer that came from Atlanta  for  a  period  of
           time, three months or so, and he actually worked in a  different
           - in a neighboring province but I did meet him.  So  there  were
           very few CDC people in Ethiopia and there were a few WHO people,
           Dr. Vitello[inaudible name0:21:09] was the head of  the  program
           there  in  Ethiopia  for  WHO.  I   dealt   with   a   Brazilian
           Epidemiologist  Dr.  Ciro   de   Quadros   and   an   Indonesian
           Epidemiologist, Dr. Peter Kaswar[inaudible  name0:21:25].  There
           was actually also a Russian Epidemiologist I know who came  down
           there; so they had an office there in the capital city in  Addis
           Ababa. I dealt mainly with Dr. Kaswar, to some extent  with  Dr.
           De Quadros. So we would occasionally meet with Dr. Hen - I would
           happen to be in the office one day-It might have been literally,
           right after I'd left the troubled area, the plane was  going  to
           Addis, so I went there to Addis Ababa and I  may  have  met  him
           there. I remember the conversation, I was talking to  him  about
           my - the success with those jet guns, the people seemed to  like
           them on the one hand, but on the other hand, they so often broke
           down especially in the desert. So in effect that turned out -  I
           thought it was a good idea and told him so; and he thought  that
           was interesting, but in the end, they didn't work  for  me  very
           well. But I did have a brief conversation; he wanted to know the
           status, where I'd  come  from,  that  kind  of  thing,  and  the
           country. It was an honor to meet him there because at that time,
           he was the Director of the  global  program.  So  that  was  the
           extent of my dealing with WHO From time to time I  would  go  to
           the office, not very often: the day to day efforts would be just
           me and a guide and we're out for 30 days at a time and  then  go
           back to the provincial capital of the town of about 60,000;  and
           we had an office within the  Ethiopia  Ministry  of  Health,  in
           effect the Health Department. So we had a smallpox office  there
           that - even though there were four of us, we were gone so  much,
           we rarely saw each other.

Elisa Koski:            Were  there  any  specific  challenges  or  positive
           aspects to working with the Ministry of Health?

David Bourne:    With working with the Ministry of Health?

Elisa Koski:           Yes.

David Bourne:    They were very - actually I don't recall if we were in  any
           challenges  particularly,  they  were  very  enthusiastic,  very
           dedicated; and there  weren't  that  many  of  them  either.  We
           probably outnumbered them. They would have -  maybe  within  the
           province, they would probably have a staff  of  maybe  four  and
           there were four to six of us, so it  was  pretty  equal  and  in
           general we wouldn't have a lot of interaction with them  because
           like we did, they would go to different parts of  the  province.
           So when we did come together  they  were  very  dedicated,  good
           friends of ours and so forth. Then I had nothing but praise  for
           them and their dedication and their competence.

Elisa Koski:           Great. You mentioned early  in  your  interview  that
           you had about four to six team members who were also Peace Corps
           volunteers, but that you didn't see them incredibly  often.  You
           were on your own most of the time.

David Bourne:    Right.

Elisa Koski:           Were they doing the same sort of thing and how  often
           did you get to share your experiences together?

David Bourne:    They're doing exactly the same thing. Now this was just  in
           that particular province. So I think  we  might  have  had  four
           people there. Throughout the country, there might have  been  at
           any one time, 20 Peace Corps volunteers in the Smallpox Program,
           or 25, in different parts of the country. But  each  of  us  did
           exactly the same job. We would go to different provinces because
           they were - in our province, Wollo, that was  probably  -  if  I
           remember right it almost led the nation in a number of  smallpox
           cases by that time and I think they were among the last cases in
           Ethiopia after I left Wollo province or near there.  So  we  had
           plenty to do. I would say, my area and other people's might have
           been similar, but I in effect, I think was  responsible  for  an
           area maybe 40 miles wide  and  120  miles  long,  maybe  250,000
           people, the way I remember it,  but  there  were  no  roads,  no
           electricity, no towns. Well, there were some  towns,  but  there
           were no roads with the exception of an old  road  built  in  the
           '40s that was impassable, or mostly so. I would walk up and down
           that area for  two  years  and  mainly  in  the  North,  and  my
           colleagues would do the same. They would go to other  areas  and
           they did a lot of walking as well.

Elisa Koski:           I'd like to talk a little bit about  how  this  whole
           experience in Ethiopia really influenced your  life  after;  and
           how it impacted your career in Public Health?

David Bourne:    Great. Right after I came back, I came back around  October
           of 1974; and actually, as a result of my conversation with  this
           EIS Officer in Ethiopia, he told me about working for CDC, about
           the process, and that's what I wanted to do. That was the single
           purpose I had. At the time before  I  met  him,  earlier  in  my
           career in Ethiopia, I was thinking about coming back  and  going
           to Pharmacy School, but I decided I would try to work  for  CDC.
           So I immediately, probably the next day, applied to CDC there in
           October of '74 and I had an interview and I was hired  to  start
           in Los Angeles in January of '75 with the VD Program as everyone
           in CDC virtually then, and maybe today I'm not sure, I think  it
           may have changed now; but that was the path. You started out  as
           a VD Investigator for CDC, and I started out in Los Angeles.  So
           I went from Los Angeles to CDC; to  Anchorage,  Alaska,  and  to
           Gallup in New Mexico. So New Mexico happened  to  be  where  I'm
           from, so when the time came  to  be  transferred,  I  decided  I
           didn't want to be transferred and wanted to remain in New Mexico
           so I resigned from CDC after about eight years and then I  -  So
           the Peace Corps was directly responsible  for  my  remaining  in
           Public Health and remaining in and being at CDC, and I did  that
           for about eight years and then for other reasons I  didn't  -  I
           remained with CDC. From there I  worked  for  the  U.S.  General
           Accounting Office for similar number of years, maybe  10  years,
           and I currently work with the U.S. Department of Energy. So I've
           stayed with the Federal Government from the time I  started  the
           Peace Corps in several different agencies including CDC, and  it
           was directly responsible for my decision and my ability to  work
           for CDC.

Elisa Koski:           Thanks. Just in closing,  I  would  like  to  ask  if
           there is anything else, any other particularly poignant memories
           or stories you would like to share about your time  in  Ethiopia
           that we haven't covered so far?

David Bourne:    It was basically a - it was a very hard job.  At  first  it
           was  very  exciting,  it  relatively  quickly  became  hard  and
           mundane, but it was very rewarding because  you  could  and  you
           would leave a village and know that they've had - that area  had
           smallpox for maybe 2000 years and  will  never  have  small  pox
           again. At the time, I think  that  feeling  and  perspective  is
           growing with time especially when you view the global program in
           perspective of disease control  programs  that  they're  seeking
           now. So it was very, very rewarding. I did have the  opportunity
           - also there was a massive cholera outbreak in the desert during
           one of the summers there, and that was  a  situation  where  far
           more people were dying and it was far more serious, but we  were
           able to - myself and a  colleague,  particularly  another  Peace
           Corps volunteer, were able to maybe vaccinate  several  thousand
           people and even start a couple of  IVs  which  we'd  never  done
           before and haven't done since. But that was rewarding  as  well.
           So on balance, it was really quite  difficult,  but  very,  very
           rewarding and I appreciate the chance talking about it.

Elisa Koski:           Thank you so  much  for  talking  to  me  about  your
           experience. It sounds like it was very rewarding and had a great
           impact  on  your  life.  We  really  appreciate   sharing   your
           experiences.

David Bourne:    Great. Thank you.

Elisa Koski:           Thanks.


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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

Dr. Davida Coady with Interviewer Chris Vaniser
Transcribed: January 2009 | Duration: 0:33:21



Chris Vaniser:   This is an interview with Davida Coady on July 11, 2008  at
           the Centers for  Disease  Control  and  Prevention  in  Atlanta,
           Georgia about her role in the Smallpox Eradication Project.  The
           interviewer is Chris Vaniser.

           With this  interview  we  are  helping  to  capture  for  future
           generations the memories  of  participants  and  their  families
           involved  in  eradicating  smallpox.  This  is   an   incredibly
           important and historic achievement and we  want  to  hear  about
           your experience. I have some questions to guide you, but  please
           feel free to recount any special stories or anecdotes  that  you
           remember about events or people. The legal agreement you  signed
           says that you are donating the oral history to the U.S.  Federal
           Government and it will be in the public domain. For the  record,
           could you please state your full name and that you know you  are
           being recorded.

Davida Coady:    Davida Coady, and yes I realize I am being recorded.

Chris Vaniser:   Thank you again for coming and sharing your memories  about
           the Smallpox Eradication Project or Program. I guess  to  start,
           if you could talk a little bit  about  your  early  days  before
           going on to college and if you knew what you wanted to  do  with
           your life, or what you wanted to be when you grew up; and  share
           a little bit of that information with us.

Davida Coady:    I grew up in Berkeley, California  in  a  family,  none  of
           whom had graduated from High School previously. I was  fortunate
           enough though to be living in Berkeley, it had  some  good  role
           models and decided that I wanted to something worthwhile with my
           life. I met two women doctors, pediatricians, running a camp for
           diabetic children and I decided  that  I  would  try  to  go  to
           medical school and I did so. I read about Dr. Tom Dooley and his
           work in Southeast Asia, and I decided I wanted to spend part  of
           my life in the Third World and went to medical school with  that
           idea.

Chris Vaniser:   Were you thinking of being more of a clinician?

Davida Coady:    I was thinking more about being  a  clinician.  I  went  to
           Columbia Medical School and of the acceptances I  got,  I  chose
           that school because they  had  an  elected[inaudible0:02:49]  in
           Liberia in the fourth year, and  I  went  there  and  I  made  a
           decision that I would definitely  go  into  pediatrics.  I  also
           realized that I really loved working in a third world country. I
           think up until that point I had kind of a  moderate  complex.  I
           thought I was going to die young of malaria or something, but it
           hadn't occurred to me really that I would  enjoy  being  in  the
           third world and working in places where you could be  innovative
           and where people really needed  you,  where  the  young  people;
           people who were being trained as nurses would  be  so  eager  to
           learn, and any time that you would spend with them,  they  would
           pick your brain about everything you knew, and  I  saw  lots  of
           people getting well. I also became aware of the need for  Public
           Health. So during my Pediatric Internship and Residency at  UCLA
           I found time to go to Mexico and then to Guatemala where  I  met
           Dr. Thomas Weller from the Harvard School of Public Health and I
           talked to him about career development and he persuaded me  that
           I needed an MPH if I really wanted to work in Prevention which I
           certainly did by that point. So I went to the Harvard School  of
           Public Health and then jumped into Third World work from there.

Chris Vaniser:   So where did you go then after Harvard?

Davida Coady:    I went first to Nigeria, only I was in the  part  that  was
           then called Biafra. I was there obviously  during  the  Nigerian
           civil war. I worked with a small relief  agency  run  by  Normal
           Cousins inside of Biafra and got out the night that the  country
           collapsed. I was sent back to Nigeria on a Government assignment
           shortly thereafter as part of the relief efforts  for  what  had
           been the former Biafran enclave and it was there  I  got  really
           acquainted with Bill Foege and Stan Foster and people who became
           my heroes, my mentors, my gurus; and I became so  interested  in
           smallpox campaign. I then went to work at the Peace Corps, first
           as their Acting Medical Director and then as a Health Programmer
           and it was during that time that I met  D.A.  Henderson  and  he
           became one of my big heroes in life and I was  involved  in  the
           Peace Corps involvement in smallpox at that point. Then later on
           I left the Peace Corps, I went to UCLA to teach and  I  went  to
           Bangladesh after their revolution and was working there  when  I
           ran into Dr. Henderson in the airport in Dhaka. Actually he  was
           getting off a plane and I was getting on a plane. He  said  "Hey
           Bill Foege is in India and he is looking for people to  work  on
           smallpox on three-month assignments;" and I said "Oh wow,  I  am
           interested!" and the next day I got a telegram from  Bill  Foege
           asking me to come to Delhi and talk about it which I did and -

Chris Vaniser:   Where were you based with at the time? You  were  with  the
           Peace Corps at that time?

Davida Coady:    No, I was still - I had gone to UCLA at that  point  to  be
           an academic, but I am not an academic, I don't like it.  I  like
           teaching, but I didn't like the rest of it, and by that  time  I
           was a part time academic, but mainly  working  on  my  own.  For
           years then I taught one or two Quarters a year at UCLA  and  did
           international work the rest of the time.

Chris Vaniser:   So you got this telegram from  Bill  Foege  asking  you  to
           come and talk to him in Delhi?

Davida Coady:    In Delhi-and I was actually on my way home and I  did;  and
           I arranged to go back a few weeks later. I was  getting  married
           at that point and my husband - I thought it would be much easier
           to work out in the Boonies in India with a partner, and  he  was
           interested and we went back to India; Bill sent us to Gorakhpur.
           So I was the first woman field epidemiologist and there  were  a
           number who followed me. They were watching me very closely and -
           you know, it was a real highlight of my life, it was just such a
           wonderful thing to be  part  of.  I've  been  part  of  lots  of
           different Public Health initiatives of one kind or another,  but
           this was something that was so clear  that  you  could  see  the
           results. So we put a 1000 miles a week on our Land Rover, a  lot
           of it on dirt roads going around to the villages  in  India  and
           many villages there, in those Northern districts  of  the  Uttar
           Pradesh, they had never seen a white woman.  In  fact  they  had
           really never had any women visitors and all kind of rumors would
           go around the villages about who I was. The one I liked best was
           that occasionally the rumor would go round  that  I  was  Indira
           Gandhi and so I - that was kind of fun; and I  would  tell  them
           that I was not, but I -

Chris Vaniser:   How long did you go over for? What was your - ?

Davida Coady:    I think we were there for  a  three  month  assignment  and
           then we were extended for several months after that and then  we
           went back to Los Angeles for a couple of months, and  then  went
           back for a second assignment, and the second assignment  was  in
           West Bengal. I had asked particularly to go to Calcutta, I  love
           Calcutta, and so we were based in Calcutta in charge of the four
           districts to the North and the East, East - No I  am  sorry,  it
           was actually the North and the West of Calcutta  and  then  when
           Calcutta - when  West  Bengal  was  free  of  smallpox  we  were
           transferred to Bangladesh.

Chris Vaniser:   Going  back  to  Gorakhpur  again,  which  was  your  first
           assignment in India and your first smallpox assignment, can  you
           tell me a little bit about your team that you worked with?

Davida Coady:    We had an Indian doctor,  Dr.  Rao[inaudible  name0:10:14],
           who was from South India who worked with us, and he kind of took
           two of the districts and I took two of the districts. We  had  a
           wonderful paramedical assistant and a driver who we became  very
           close to; and we went touring around the  countryside.  I  think
           one of the things that I did was  I  realized  that  the  people
           working on it in the villages, the doctors, the health  workers;
           they had no idea when I got there  that  this  was  part  of  an
           international effort. So I managed to get a map of the State  of
           Uttar Pradesh, and another map of India, and another map of  the
           world. These were not easy to come by in Gorakhpur,  but  I  got
           them. Now we would take them around to the districts and we'd go
           through and I'd show them what they were part of,  and  hundreds
           of people would gather around and listen to this and they  would
           get so excited and then when I'd go back weeks later  or  months
           later, they'd say what is happening  now  in  Ethiopia.  Are  we
           going to beat Bihar, are we gong to beat Bangladesh  or  are  we
           going to beat Ethiopia in eradicating smallpox; and  they'd  get
           so excited and the quality of work would improve tremendously.

Chris Vaniser:   How were you received as a Caucasian woman working in  that
           area of India, which I am sure that most of the  physicians  you
           were dealing with, I assume, were male?

Davida Coady:    Right.

Chris Vaniser:   At least most of the other people.

Davida Coady:    I think fairly well-very well in fact.  I  think  in  India
           there were no problems really. You know, I dressed appropriately
           and all, and got my legs covered and all those  things,  and  in
           Bangladesh it was a little harder. If I went  somewhere  without
           my husband, people would say well bring your husband next  time,
           and they didn't my traveling without him, and we'd  often  split
           up and did different parts of the work. But in India  there  was
           none of that. There was  a  village  character  in  one  of  the
           villages who wrote a song about me and evidently the chorus - he
           was a man suffering from tertiary syphilis and was quite crazy -
           the chorus was translated to me saying: "Dr. and Mrs. Coady is a
           wonderful doctor, she's the  best  doctor  in  the  whole  world
           because she carries herself like a doctor and she  acts  like  a
           doctor." So I thought that was very, very nice.

Chris Vaniser:    Very  nice-Yeah  respectful.  Did  you  have  any  special
           challenges or  events  that  happened  when  you  were  in  that
           Northern part of India that kind of stand out as very  memorable
           events during the smallpox?

Davida Coady:    Just that it was terribly, terribly hot. We were  there  in
           the pre-monsoon season and  I  don't  remember  anything  really
           frightening. Our driver and medical assistant,  and  many  other
           people were very kind of cautious when we first  got  there  and
           they - the person before us had  made  an  error  in  trying  to
           vaccinate a woman - this is a male epidemiologist - without  her
           permission and the villagers had come very close to throwing him
           down the well. So they told me,  they  lectured  me,  but  after
           about a week they said, "It is fine. We know you are  not  going
           to cause any problems like that." But that always made me just a
           little bit wary.

           One thing we noticed was a - my having worked in  Africa  before
           where people  loved  to  get  immunizations  and  loved  to  get
           vaccinated; was that the Indians, they wanted some  conversation
           before they were vaccinated.  They  wanted  an  explanation  and
           their views of the goddess and  her  role  in  all  this  varied
           really from village to village, and sometimes - in  one  village
           they wanted us to come back next Tuesday because that's what the
           goddess wanted us to do instead of vaccinating  people  then.  I
           think we finally agreed to do that, it was just easier, but many
           times  they  would  say,  "No,  the  goddess  doesn't  want   us
           vaccinated;"  and  we'd  sit  down  and  go  through   all   the
           explanations and just at the point when we were  convinced  they
           were never going to let us vaccinate anyone,  they'd  say,  okay
           now we understand that it's a disease and it's not a goddess and
           please vaccinate us." I remember one elderly man, he said,  "No,
           I don't want to be vaccinated because I'm getting ready to go to
           God;" and my husband looked him right in the eye  and  said,  "I
           really think God would like you better vaccinated;"  and  I  was
           just thinking "Oh my!" And the man said "Oh, alright fine,"  and
           he said, "Please, please vaccinate me." So a lot of it was  just
           listening and realizing that nothing worked fast in India.

Chris Vaniser:   Now did you speak Hindi or did you have a  translator  with
you?

Davida Coady:    We had a translator.  Our  paramedical  assistant  was  our
           translator. I learnt a little bit of Hindi and  just  enough  to
           get around, just a little to ask where ask directions and  where
           people  were,  and  of  course  the  word   for   smallpox   was
           Bashanto[0:16:56] which is also the word for springtime;  and  I
           relied a little bit less on my Hindi after  one  of  our  fellow
           epidemiologists, a man from France whose name I forget;  he  got
           very good at Hindi, but he spent a long time, he had a  sprained
           ankle at the time, walking to a village looking for - he'd asked
           if there was any Bashanto and everybody said: yes,  yes.  "Where
           is the person with smallpox?" And after he walked a  long,  long
           distance he finally found this man out on the field.  It  turned
           out   that   the   man's   name   was   Bashanto.   So   I   was
           [crosstalk0:17:57]

Chris Vaniser:   A little bit more  [crosstalk  0:17:56]  after  that  about
           your Hindi. Was your husband a physician  as  well,  or  in  the
           health field?

Davida Coady:    No, my husband at that time was not, he was not a -

Chris Vaniser:   But he was - he sounds like part of the team?

Davida Coady:    Yeah, he helped.

Chris Vaniser:   In terms of going out and-

Davida Coady:    He liked to write and he  was  collecting  information  and
stories.

Chris Vaniser:   Interesting. So then it sounds like  soon  after  that  you
           went to Calcutta? Was that the same trip?

Davida Coady:    Right, we came back to the United States for  a  couple  of
           months and then we went back and went to Calcutta.

Chris Vaniser:   How did that differ from Gorakhpur?

Davida Coady:    Well, we  were  in  the  city  and  Bengal  was  much  more
           sophisticated, and there was much less smallpox. I saw  hundreds
           and hundreds of cases of smallpox in  Uttar  Pradesh  and  many,
           many ...[inaudible0:18:58]. We were doing the last of it and the
           reward was being offered by that time  and  the  amount  of  the
           reward was going up, and we  went  around  to  different  groups
           asking them to help us. One of the interesting  things  was,  we
           went to see Mother Teresa to see if she would have her nuns help
           us in looking for and reporting any smallpox; and Mother  Teresa
           like she always did - I went  back  and  worked  for  her  later
           actually - she turned it around on us and she got us to agree to
           bring our staff on our day off and vaccinate  everybody  in  her
           feeding lines; and our driver and our paramedical assistant were
           just so thrilled to meet her and to be part of that,  they  took
           their day off too, and we did that, so that was kind of fun.

Chris Vaniser:   Did she also agree to have her nuns help  with  identifying
           any cases and reporting them?

Davida Coady:    Yes, yes they did. I can remember that they did.  But  then
           in those times we spent a lot of our time with people coming  to
           us, being brought to us with everything from scabies to  chicken
           pox to hives, with people trying to tell us it was smallpox  and
           they wanted the reward. So I spent  an  awful  lot  of  my  time
           saying no that was not smallpox; and it was interesting, one man
           particularly who came  to  us;  and  I  still  have  his  little
           advertisement. He was an Ayurvedic Doctor of some  kind  and  he
           had a little advertisement which I have still,  with  a  picture
           that he'd drawn of somebody  with  smallpox  and  he  introduced
           himself as a specialist in smallpox from a part of our district,
           North of Calcutta, and he  had  a  man  whose  scabs  were  just
           falling off, or just forming I guess; and we said,  "Why  didn't
           you bring him sooner," and he said, "Because he just ran out  of
           money," and we said, "Well, explain this." He said, "You  see  I
           charge people when they come with the fever, I charge  them  and
           they pay, I have a medicine to make the rash break out, I have a
           medicine to make the macules..." - He knew the terms  -  "...the
           macules form into papules, and the papules form  into  pustules,
           and then for the scabs to form, and then for the scabs  to  fall
           off and for the scars to go away. They come back and I sell them
           each of these medicines. But he has run out of money, so I  came
           to get the reward." Then we talked with him further and  he  was
           able to tell us every case of smallpox, maybe then 25, 30  cases
           in that district, in that outbreak over the past  two  or  three
           months, and he was able to tell us everyone of them and who  got
           it from who and it corresponded exactly to the reports  that  we
           had gotten from the health workers. So he knew the whole thing.

Chris Vaniser:   But of course, he didn't have the vaccine. He  was  missing
           that part he had medicine to make -

Davida Coady:    He had no interest in the vaccine.

Chris Vaniser:   That's right; it destroyed his business I guess.

Davida Coady:    Right.

Chris Vaniser:   How did you find the conditions?

Davida Coady:    They were difficult. Gorakhpur: it was hard to eat; we  ate
           at the hotel where we stayed which was - and then later we found
           a Chinese restaurant, but we didn't find that for about a month,
           and we ate at the hotel and everything was so terribly, terribly
           hot. I am used to hot food, but this was really, really hot.  So
           we would just try things. Of course, we couldn't read  the  menu
           so we would point to things on other people's  plates  and  they
           would get those for us, and it  was  challenging,  but  we  were
           young. Life was easier in Calcutta, there  was  indoor  plumbing
           and -

Chris Vaniser:   When you traveled up in Gorakhpur, were you  out  overnight
           sometimes in the neighboring districts?

Davida Coady:    No, we were always  able  to  get  back  when  we  were  in
           Gorakhpur. In Calcutta we did, we had these four districts; we'd
           stay in the districts, we found places to stay. In Gorakhpur  we
           never - [crosstalk 0:24:17].

Chris Vaniser:   It was always maybe a long day trip, but you  would  always
           get back. How about any problems with getting  safe  food,  safe
           water?

Davida Coady:    We would find that we'd buy bottled water  and  Coca  Cola,
           and I think there was one time when we bought some cokes and  it
           was adulterated and we all got very sick.

Chris Vaniser:   Any other events that stand out from your  time  in  India?
           Now you came back to the States before going  back  to  Calcutta
           and then [crosstalk0:25:01] from Bangladesh also?

Davida Coady:    Then we went directly from Calcutta to Bangladesh.  I  know
           it  was  before  Christmas  because  we   spent   Christmas   in
           Bangladesh.

 Chris Vaniser:  Then, how was that in comparison to India?

Davida Coady:     It was very different. In Bangladesh they didn't have  the
           structure. In India they had the structure, these Health Centers
           and there was always somebody who was in charge that  you  could
           work with and some of them were wonderful and some of them  were
           not at all interested; but at least there was  a  structure.  In
           Bangladesh we were in the North in Saidpur, which  is  a  larger
           Bihari City and which was good because they spoke Urdu  which  I
           could understand;  I  never  really  got  hold  of  the  Bengali
           language at all, and the Urdu I could understand from the  Hindi
           that I knew. There was no structure, we just had to do the  work
           and hire the vaccinators and find the epidemics and it was  much
           harder and you had the feeling that you  weren't  teaching  that
           much. You were just trying to get the cases  and  get  the  work
           done.

Chris Vaniser:   When you say you had do the work, it was actually  you  and
           your team that was more - not the Bengalis that  were  there  as
           counterparts?

Davida  Coady:     Right.  We  didn't  really  have  counterparts,  we   had
           vaccinators that we trained and hired to work for us.

Chris Vaniser:   What year was that, when you were in Bangladesh?

Davida Coady:    That would have been '75; in late  December  '74  and  then
into '75.

Chris Vaniser:   So  I  guess  -  it  sounds  like  you  also  had  just  an
           incredible time as part of the  Smallpox  Program  and  you  had
           brought to  it  lot  of  experience,  international  experience,
           specially from Africa and  other  places,  Guatemala  and  other
           international locations that you had  worked  in.  How  did  the
           smallpox  experience  affect  your  future   career   and   your
           involvement in Public Health?

Davida Coady:    I became very, very convinced that the idea of  eradicating
           infectious diseases was very doable and feasible and helpful and
           everything right about it; and I  have  been  very  disappointed
           that other diseases have not been eradicated. I  thought  surely
           the lessons would be learned. We had this wonderful seminar this
           morning that I thought surely guinea worm and polio and  measles
           and some of the others would be gone by now with the lessons  we
           learned, and I think people made such valiant efforts to promote
           the principles. Dr. Henderson and Dr. Foege, Dr. Foster; and all
           of them; they had such a wonderful plan to really use all  these
           principles to  eradicate  other  diseases  and  it's  been  very
           disappointing that there  wasn't  the  political  will  and  the
           finances - the political will to do it.

Chris Vaniser:         [cosstalk0:29:05] the difference perhaps?

Davida Coady:    Yeah; and I think the idea  that  an  international  effort
           like that could work, has kept me going through some hard  times
           and some of the battles I fought are harder than  that  and  you
           have more foes, there weren't too many people  against  smallpox
           eradication.  There  were  a  few  people  who  made  money  off
           smallpox. I remember one very  overweight  politician  in  India
           railing at me one day,  when  we  drove  up  with  the  smallpox
           vaccines - with the smallpox van; and he said then: Why don't we
           foreigners and smallpox people go home and let our people die of
           smallpox before they starve to death  from  overpopulation;  and
           this man was fat and he was eating a plate of food, and  he  was
           one of the few people I  ever  met  that  said:  eradication  of
           smallpox is not a good thing to do.  It just  seemed  so  clear;
           one of the  battles  that  I  fight  today  in  my  hometown  in
           Berkeley, is we are fighting the tobacco industry very hard  and
           the pharmaceutical industry and the illegal drug industry; and I
           work in the addiction field now and you have these  giants,  the
           Alcoholic Beverage Industry and the Tobacco  Industry,  and  all
           the rest, are such hard foes that I look longingly at  the  time
           when I  was  fighting  smallpox  which  didn't  have  those  big
           interests against you.

Chris Vaniser:   [crosstalk 0:31:01] with lots of money to -

Davida Coady:    But it has given me - I had training in  epidemiology,  but
           the smallpox work gave me  the  field  experience  to  see  what
           epidemiology  could  really  do,  and  it  of   course   greatly
           influenced my teaching at UCLA - but really the way  I  look  at
           everything. I am in the addiction field  now  because  I  looked
           around  my  own  community  with  the  tools  I  learned  as  an
           epidemiologist and said: The biggest cause of  homelessness  and
           crime and misery and violence and child abuse in my community is
           the substance abuse, which is not being treated. So that's why I
           made that decision.

Chris Vaniser:   That's a pretty big decision to have ended up -  it  sounds
           like you had spent time in international health and trained as a
           pediatrician. Correct?

Davida Coady:    Right.

Chris Vaniser:   And now you are working in smoking  and  addiction  control
           because of lessons learned through the smallpox eradication.

Davida Coady:    Right.

Chris Vaniser:   Well, thank you very much again for sharing  your  stories.
           This sounds like it must have just been -  again  an  incredible
           experience.

Davida Coady:    It was a peak experience;  it  is  something  that  I  just
           wouldn't trade for anything. I am just so happy I  was  part  of
           that.
Chris Vaniser:   And it sounds like you made quite a few friends  along  the
           way that are legends in their own right in the  area  of  Public
           Health and -

Davida Coady:    I did.

Chris Vaniser:   Not just smallpox, but Public Health in general.

Davida  Coady:     Right;  and  I  just  loved  India  and  Bangladesh,  but
           particularly India. I loved working there. I loved the people. I
           love to look now at pictures of  Indians  and  see  that  nobody
           under 30 has got smallpox scars. That just chokes me up.

Chris Vaniser:   There's nothing else that you can really say  that  of-that
           has been so eradicated and know that you had a part  in  all  of
           that. It was just a huge accomplishment. Thank you again.

Davida Coady:    Thank you.



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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
Interview

D.A. Henderson with Paul O'Grady
Transcribed: February 2009



Paul O'Grady:    This is an interview with D. A. Henderson on July 12,  2008
           at the Center for Disease Control  and  Prevention  in  Atlanta,
           Georgia about his  involvement  with  the  smallpox  eradication
           program. The interview is being conducted as a part of a reunion
           marking the 40th anniversary of the program  in  Asia  and  East
           Africa. The interviewer is Paul  O'Grady.  Can  you  state  your
           name?

D.A. Henderson:  D. A. Henderson

Paul O'Grady:     And  you  understand  that  this  oral  history  is  being
           recorded?

D.A. Henderson:  Yes, I do.

Paul O'Grady:    Thank you. I would like to start off by having you give  us
           a little bit about your background, what lead you to a career in
           public health and how you started working for the CDC?

D.A. Henderson:  Well, I was born and brought  up  in  Lakewood,  Ohio  near
           Cleveland. Went to Oberlin College and then to the University of
           Rochester School of  Medicine.  After  internship  at  the  Mary
           Imogene Bassett Hospital in Cooperstown,  I  was  told  that  my
           deferment from the draft was at an  end  and  I  had  my  choice
           either to voluntarily enlist in which case I would  be  a  first
           lieutenant, or be drafted in which case I would  be  a  private.
           So, like many of my colleagues who had been deferred  since,  in
           my case 1946, and this is 1955, I decided I could  volunteer.  I
           was having difficulty making up my mind  whether  it  was  army,
           navy or air force. I figured I am just an intern, all I am going
           to do are boring draft and do physical of new recruits. So about
           this  time  somebody  shows  up  from   something   called   the
           Communicable Disease Center, which I had never  heard  of.  They
           are from the public health service which I knew  nothing  about,
           but they talked about working on  infectious  diseases  which  I
           didn't really much care for. As I  thought  about  it,  well  it
           might be two years and I'd learn something, and as they  pointed
           out we don't wear uniforms, we don't salute, you don't do  basic
           training. I  go,  well,  okay,  doesn't  sound  too  bad.  So  I
           enlisted, in the public health service.

      Now, this was the Epidemic Intelligence Service  which  at  that  time
           was only four years old. That created by Alex  Langmere  at  the
           CDC. There were, however, quite a  number  of  applicants  every
           year who were anxious to do their required time and  service  at
           CDC  would  be  challenging,  interesting,   so   forth.   Well,
           fortunately I had done a history of medicine paper  in  my  last
           year of medical school. Why had a done the history  of  medicine
           paper? Because  they  offered  $200  and  a  handy  subject  was
           something about cholera in upstate New York in  1834  and  there
           was material available in the newspapers and so forth.

      So I spent time creating this paper,  going  through  the  newspapers,
           plotting cases, doing curves. I didn't know what I was doing  in
           terms of training but it really was epidemiology and in fact  it
           turned out to be rather fun. I had to see what the responses  of
           the health department were, to the  various  challenges.  Seeing
           how it spread through the city and so forth. So  in  advertently
           I'd become interested in a subject which we had no courses in at
           all and I got drafted to the public health service. That's where
           I got into public health and I had no interest in public  health
           either at that time. I was going to be in my mind a cardiologist
           and this would be two years  out  and  then  I  go  back  to  my
           residency in cardiology.

Paul O'Grady:    What were the major public health concerns at that time?

D.A. Henderson:  There was one dominant major public health problem at  that
           time or challenge and that was polio myelitis.  There  had  been
           significant cases, significant outbreaks of polio  myelitis.  In
           the 1950s, there was a great deal of fear  at  that  time  about
           polio. In the summers there was - they  closed  swimming  pools,
           parents kept their children away from other children.  If  there
           were outbreaks  there  was  a  great  deal  of  anxiety  in  the
           community. The National Foundation for Infantile Paralysis was a
           very major foundation. It was the only categorical foundation at
           all  that  time.  It  had  been  started  because  of  President
           Roosevelt's, Franklin D. Roosevelt's polio myelitis and they had
           raised for Warm Springs, Georgia rehabilitation center. They had
           been extremely successful and they took some of this  money  and
           they put it into some basic research of very  good  quality  and
           development of the vaccine. There was great anticipation in 1954
           because they began the first major study of the Salk vaccine and
           there was school children across the country. I forget how  many
           were involved. As I recall it's 100,000 plus.

      The results were coming up in April of that year that I was  doing  my
           internship. Very soon thereafter they  began  to,  in  April,  I
           guess they announced the  results  and  they  began  vaccination
           around the country with the vaccine. About this time they  found
           that some of the lots of vaccine were not quite - the virus  was
           not quite as dead as it should be. They began to  get  cases  of
           polio myelitis, paralytic disease caused by the  vaccine.  So  I
           was being inducted into the Center for Disease Control.

      The epidemic intelligence service Alex  Langmere's  group  were  doing
           the work of compiling information on the cases in trying to find
           out which lots of vaccine were involved and trying to  determine
           the magnitude of the problem and then what to do about it. So we
           were totally immersed, as I came into the service on the 1st  of
           July with what was an ongoing investigation into what really was
           the end of the largest field trial ever conducted on  a  vaccine
           and the introduction of the polio myelitis vaccine which  was  -
           had been awaited for so long. At the same time we had  what  was
           amounted to a vaccine incident which was serious with  a  number
           of paralytic cases associated with  the  vaccine.  The  question
           was, was it the vaccine of all companies or  was  it  maybe  one
           company and only some lots of the vaccine or  what  was  it.  So
           this was all absorbing for many of those who came aboard at that
           time.

Paul O'Grady:    And how many years were you at CDC after your - so you  got
           a two year government required service and then you stayed on?

D.A. Henderson:  Well it turned out be  rather  more  exciting  than  I  had
           thought. They had a matching program. So,  that  those  who  are
           recruited you then submitted  your  preferences  on  a  list  of
           different positions you could have. They in turn would  look  at
           the people who are coming in, about 30-35 of us and decide which
           ones they wanted and they would list their priorities  and  then
           they match them up. I matched  up  with  a  position  which  was
           called assistant chief  of  the  epidemic  intelligence  service
           which would be as they called it a go-for job  kind  of  putting
           things together, helping organize a course and doing  things  of
           this sort.

      Well, we would have a course to a one month at that  time  where  they
           taught us epidemiology and  bio  statistics.  Basically  how  to
           investigate an outbreak and at the end of the one month you  are
           then a qualified epidemiologist in our terms and at the  end  of
           that course I had to go off the  epidemic  intelligence  service
           did to an epidemic. We were constantly being called for  various
           epidemics. There was a big epidemic  of  diphtheria  in  Phoenix
           City, Alabama. I went down, I spent three weeks down  there  and
           giving vaccine, taking cultures. The patients were housed  in  a
           big Red Cross tent. I came back and here was the chief  epidemic
           intelligence service officer packing his bags.  I  said,  "Where
           are you going?" He said, "I have another job. I am going to be a
           state health commissioner." I said, "Well, what  do  I  do?"  He
           said, "I guess you are the Chief EIS officer." I said,  "I  have
           no idea what to do?" He said, "You will learn."

      Sure enough, then I began working in a job that certainly  I  was  not
           qualified for but plunged in. With the mentorship of  this  Alex
           Langmere who was a legendary epidemiologist, a rather  difficult
           person but demanding and  just  a  wonderful  teacher,  just  an
           extraordinary teacher. At the  end  of  two  years  of  this,  I
           finished my duty. I proposed  to  him,  you  know,  we  are  not
           keeping many people on. The people were getting, so many  people
           apply. They are  well  qualified.  All  of  them  wanted  to  do
           academic medicine or pediatrics. Just about nobody wants  public
           health.

      Now, if we offered a 5-year training  program  in  which  you  do  two
           years of training, like a residency in  cardiology  that  I  was
           thinking for myself, and maybe then three years with the  public
           health service. Maybe that would be a  way  to  attract  people,
           then by then you will have, say then, seven years and  we  might
           get people staying longer. Well, he  liked  the  idea  and  then
           well, he submitted it up-line to the surgeon general.  He  liked
           the idea. So, I applied for a five  year  training  program  and
           went back to get my residency.

      At the end of the - well, during the course of the residency, I  found
           this to be frankly rather boring. I was seeing patients and some
           of them had some heart  disease  and  heart  failure,  a  little
           diabetes, a little gastroenteritis. A  little  constipation  and
           sort of the end of the day I felt, you know, if I really  hadn't
           been there, I wonder if it would have made  any  difference  and
           was I making any difference. Am I going to be doing this for  my
           next 40 years?

      Well, meanwhile I had been two  years  in  the  epidemic  intelligence
           service which some exciting outbreaks here and  there  including
           one which was an interesting one in Argentina. There was  a  big
           outbreak  of  food  borne  disease.  They   were   stoning   the
           restaurant, the Argentine government was upset. They thought  it
           was a type of food poisoning due to the  Botulinum  toxin.  They
           wanted our, what we had in the way of antitoxin to  treat  them.
           So I took off for Argentina with such supplies as we had.

Paul O'Grady:    When was this?

D.A. Henderson:  That was 1957. At the end of this I saw  the  secretary  of
           health. He sort of offered "Well, let's go on a hunting trip  or
           a shooting trip with me at my lodge." I said, "You know, I  hear
           you have got an outbreak of smallpox." He said, "Yes."  I  said,
           "I would like to go see it." So he said, "Fine." We took off  on
           an old Pan-Am clipper off the waters and the river on La  Plata.
           On up to another place and we got in a two passenger  piper  cub
           and flew into a smallpox - the area where they had the  smallpox
           and they had an outbreak of smallpox. The people were  in  tents
           in the field and so, about 30 different patients. We  looked  at
           the patients one by one, it was fascinating. And at that  point,
           I had never seen a case of smallpox, really didn't know what  it
           looked like. But it was my first contact with smallpox.

Paul O'Grady:    Was there at  that  point  any  national  or  international
           interest in trying to organize the fight for smallpox?

D.A. Henderson:  The international concerns about smallpox were there  very,
           very strongly  because  all  travelers  were  obliged  to  carry
           certificates indicating  they've  been  successfully  vaccinated
           within the preceding  three  years.  Just  about  every  country
           including our own enforced this. If you weren't  vaccinated  you
           wouldn't get admitted or they might vaccinate you on  the  spot.
           There was a great concern about importations of smallpox.

      It was in 1958, just about a year later after I  had  seen  the  cases
           that the vice-minister of the Soviet Union proposed to the World
           Health Assembly that  they  undertake  a  program  to  eradicate
           smallpox. That was the year the Soviets came back in to  the  UN
           family. They'd withdrawn because of the Korean War and they were
           - they just come back. So the proposal,  they  looked  at  this,
           delegates at the assembly looked at this and they really  wanted
           to be helpful and encouraged the Soviets this time.  So  a  year
           later they approved a program to eradicate smallpox.

      The only thing  was  that  at  -  that  same  time  the  World  Health
           Organization was deeply  involved  in  a  program  to  eradicate
           malaria. And fully a third of all staff were  involved  in  that
           and all the spare money they could get together because  it  was
           very expensive, very costly. The  idea  of  undertaking  another
           eradication program was really not the intent  of  the  director
           general. In fact the only thing he could do is say,  "Fine."  He
           really gave it very little money and a few  countries  then  did
           some vaccinating and tried to get rid of smallpox. They did make
           some progress in this but it basically was going anywhere.  That
           was the beginning. It was 1959 when they decided that they would
           undertake a global program but it really was not  anything  that
           was happening. It was seriously, it was not until 1966 that they
           really took it seriously.

Paul O'Grady:    What was the  attitude  of  the  United  States  government
           towards this program that it seemed to have gotten some  impetus
           from the Soviet Union? Was  there  any  political  peculiarities
           about that?

D.A. Henderson:  There, clearly was an element of Cold War competition.  The
           US was heavily supporting the malaria eradication program,  both
           through  the  organization  very  heavily  and  through   direct
           bilateral donations to the  countries.  So  the  US,  you  could
           almost say, owned the malaria eradication program. The  Russians
           had no program at that point that they could say the same  thing
           about. So, in a way they came in with  this  smallpox  and  said
           look, we got rid of it in the Soviet Union  back  in  the  1930s
           when our vaccine wasn't so good,  when  health  conditions  were
           poor, where personnel were not well trained and we  got  rid  of
           it. So, why can't the rest of the world get rid of it?

      So that's where they came in and then put after 1959,  every  year  at
           the World Health Assembly they would really  give  the  director
           general a very hard time. Why aren't you putting more money into
           the smallpox program? Why do you favor the malaria program?  And
           so that went on as a continuing piece. The  US  really  took  no
           notice of it. It's really what it amounted to  until  really  it
           came up to 1965 when a change came for the US.

Paul O'Grady:    Which was?

D.A. Henderson:  Well, in 1965 - I'll go back  a  little  bit,  1961,  Merck
           Sharp &amp;amp; Dome, at  that  time,  was  introducing  a  new  measles
           vaccine. It caused a lot of fever in children.  So  in  the  US,
           they were using it giving the measles vaccine and they gave them
           some immune globulin at the same time so that they wouldn't have
           so many reactions to the measles vaccine illness, if  you  will.
           This made little practical sense if you went to Africa. The idea
           of  doing  these  two  together  and  made  life  a   lot   more
           complicated. You really could not do large scale vaccination and
           try to preserve the immune globulin and deal with two  shots  to
           get this. So they undertook studies in Upper Volta, Benin. I  am
           sorry Upper Volta  is  the  place  where  they  were  doing  the
           country.

      They did x number of children, 150 -200, kids reacted very well.  They
           were no complications. Then they asked -  the  country  minister
           said, could you give - do it for all kids  under  six  years  of
           age. So they gave them a vaccine enough for that. Then there was
           an organization,  French  organization  that  had  a  number  of
           countries and he said, could we do it  for  six  countries  now.
           USAID said, "Okay, we will  do  it  for  six  countries."  Well,
           things couldn't go very well with six. I won't go  into  all  of
           the complications but we got drawn in at that time to evaluating
           it. I sent one person over to evaluate. It was a disaster.

      Well, not to be deterred they decided  we  are  now  going  to  do  11
           countries. We need from you, 11 people for six  months  each  to
           help get the program started in  each  country.  I  thought,  we
           can't do that. Really, it's - a good segment  of  my  staff  and
           signing people over for  6  months  at  a  stretch  is,  without
           families and what have you, this is tough.  So  I  thought,  you
           know, I really have to work  with  AID,  we  really  got  to  be
           responsive to them. I didn't know what to do. So I decided,  all
           right, let's put together a proposal that we would say is  sound
           from this public health standpoint.

      Why was the measles proposal bad? Well, they were  going  to  give  it
           for just four years and then stop.  In  other  words  AID  would
           support it for four years and they  expected  the  countries  to
           continue. It cost a $1.75 a dose. The countries couldn't  afford
           $0.10 a dose for yellow fever  vaccine.  So  this  is  not  good
           public health practice. To start a program, get the hopes of the
           public up and then drop it. This  is  terrible  way  to  do  it.
           Smallpox had vaccine however, cost  a  penny  a  dose.  So  they
           proposed the idea, well, suppose you take this  whole  block  of
           countries, 18  countries  and  suppose  you  give,  do  smallpox
           vaccination -

Paul O'Grady:    And you talk about West Africa?

D.A. Henderson:  This is west, West and Central Africa as  well  called  it.
           And so we do 18 countries.  You  give  smallpox  and  develop  a
           smallpox program there. We could get rid  of  smallpox  in  that
           whole area, they could then  -  would  have  as  an  established
           program for vaccination. They could continue it easily when that
           only cost them a cent a dose  in  vaccinating  newborns  and  so
           forth. Then if they want to have measles vaccine added  and  the
           ministers think this is a good idea, we would be happy  to  give
           measles vaccine at the same time,  but  we  can't  eradicate  it
           because measles spreads too easily. We couldn't get rid  of  it,
           but at least the countries would have to think through was  this
           a good idea to do this with measles vaccine as well.

      Well, I think the cost - what USAID expected to spend was  about  five
           or $6 million. The proposal we submitted was about $35  million.
           So, I knew it can be turned  down.  But  on  the  other  hand  I
           thought it was going to be a point of departure for  discussion.
           I didn't know where we were going to find any sort of compromise
           on this. They just, their demands were  so  great  that  it  was
           impossible. So I set it up through channels, through the surgeon
           general and very shortly USAID turned  it  down.  We  were  just
           debating along about autumn what we  would  do  subsequently  on
           this.

Paul O'Grady:    And we are still in 1965?

D.A. Henderson:  This is 1965, when all of a sudden we got information  that
           the president had decided to  approve  the  program,  the  whole
           program.  This  shook  everybody.  My  boss  Alex  Langmere  was
           absolutely beside of himself.  As  I  told  him  they  were  not
           supposed to accept it, that was - but the president was  looking
           for an  initiative  which  would  be  something  that  he  could
           publicize that the US was contributing  to  a  UN  International
           Cooperation  Year.  There  were  several  proposals  that   went
           forward. This I had  no  idea  was  even  being  considered  and
           suddenly AID was told by the White House,  fund  it.  All  of  a
           sudden, we are told, all of a sudden we have got 18 programs  to
           set up in the West and  Central  Africa.  We  had  never  run  a
           program outside the United States at all.

Paul O'Grady:    So you guys have been  faced  with  a  tremendous  manpower
           problem?

D.A. Henderson:  Well, we would need about 54 people. That we are  going  to
           have to recruit. AID said that it probably would be - you  can't
           do this under three years. They agreed finally to fund  it  then
           on November. They felt we could get it in three years.  I  said,
           no. This is wrong. It's just got too much of a delay. How  about
           13 months? We will have the people  over  there  in  January  of
           1967.

       They  thought  it  was  almost  impossible.  You've  got   individual
           agreements what  every  country.  You  have  got  to  order  the
           vaccine, you have got to put on training programs, you've got to
           recruit all the people. We did. Recruited the people, we got the
           vaccine ordered. We got vehicles. We  had  to  use  US  American
           vehicles. There weren't  any  in  all  of  these  countries.  No
           maintenance, no repair, so  we  had  to  set  up  workshops  and
           everything else, to train our people to be mechanics. We had  to
           lay out plans for all of the countries to get everything  signed
           and we did.

Paul O'Grady:    Let's talk of, just for a second, about  the  attitudes  of
           the countries  involved.  What  was  the  interaction  with  the
           governments like?

D.A. Henderson:  Well, in November as soon as  this  was  approved,  I  went
           over with a consultant that I had who, Warren  Winkelstein,  who
           was a good epidemiologist and spoke French,  another  person  by
           the name of Dr. Henry Gelfand. The three of us went and  visited
           each of the different countries. Fortunately a  number  of  them
           were having a meeting, so we could present it to all of them  at
           one time.

      They were enthusiastic. Why were they enthusiastic?  More  -  most  of
           them, more because of the measles vaccine because this is a very
           - in Africa, this is a very deadly disease.  It's  10-15%  death
           rate. The French speaking countries by and large had  done  some
           pretty good vaccination with pretty good  vaccine.  The  English
           speaking countries  had  a  lot  of  smallpox.  They  were  more
           enthusiastic about the smallpox. But they were getting both  and
           they were really very  enthusiastic.  We  were  coming  up  with
           vehicles. We were coming up with vaccines  and  consultant  help
           but not a lot of people. It was by and large one or  two  people
           or advisors to be assigned to most of the countries with  a  few
           more in Nigeria.

Paul O'Grady:    And how about the Americans that  were  going  to  go  over
           there as part of this program? Let's talk  a  little  bit  about
           their attitude?

D.A. Henderson:  Well, the Americans who were going over there, a number  of
           the people I - some of them I had known. Basically called up and
           said, we have got this coming up, are you free, or would you  be
           interested, people, contemporaries and so forth. I had a  couple
           of people  who  are  already  serving  in  CDC  and  took  them.
           Basically it was almost word of mouth advertising because  there
           just wasn't very much time, and contact with people  at  schools
           of medicine and other places,  infectious  disease  people  that
           might know of people interested in this. People -  the  word  of
           mouth, by word of mouth they learned about this and my goodness,
           we were able to recruit enough, so that we were  able  to  begin
           the training program in July of 1966.

Paul O'Grady:    And people were on the ground?

D.A. Henderson:  Well, they had to finish up the training.  We  had  to  get
           all the agreements signed. I think we got all of them in  to  16
           of the 18 countries. We managed to put two, postpone two, but we
           had 16 of them by January of 1967. Meanwhile, there is a  little
           problem. There was a debate coming up in the Assembly in May  of
           1966. So this is only like about 6-7 months after this  approval
           for the whole West African program had come through.

Paul O'Grady:    Debate in the United Nations Assembly?

D.A. Henderson:  Debate in the World Health Assembly?

Paul O'Grady:    Okay.

D.A. Henderson:  Every year the ministers  of  health  convene  in  May,  in
           Geneva to look at issues of health. So they  were  debating  the
           question of  going  with  an  intensified  program  of  smallpox
           eradication with  a  budget  of  $2.4  million  a  year  and  an
           objective to complete that within 10 years. The director general
           Marcelino Candau, a very capable  Brazilian  knew  that  it  was
           impossible to  eradicate  it.  He  felt  you  had  to  vaccinate
           everybody in the world and he was a Brazilian and he  knew  that
           there were tribes in the Amazon that hadn't been found. Or  were
           just recently found or  that  sort  of  thing.  So  he  knew  it
           couldn't be done.

      There were a number of  countries  that  were  very  doubtful  of  the
           concept of eradication at all because they were having  so  much
           trouble in malaria eradication. There were  others  who  thought
           this was far too ambitious for an organization  like  WHO  which
           is, where it's not, except for the malaria really it hadn't  run
           programs or really coordinated  that  way  operationally  health
           programs. So it came to a debate in the assembly. The US had, as
           I said, been very quiet before this really in taking a  position
           but at this assembly they were going  to  take  a  vote  finally
           because it was very controversial, whether they  went  ahead  or
           didn't go ahead. One of the strong arguments was well, the US is
           already committed, funds and personnel for - to take care of  18
           countries.

      So that's a big start on this whole thing and after two o three  days,
           three days debate, they did vote. They had  about  58  votes  to
           start the program and it passed by just two votes.  It  was  the
           closest vote they have ever had in the  World  Health  Assembly.
           The director general was furious and felt that the assembly  had
           committed the World Health Organization to a  program  which  is
           going to fail. It would bring the  organization  into  disrepute
           and question the credibility of  public  health  and  the  World
           Health Organization. He blamed the US for this.

      Well, in a way, it was true. If the US had not done this  crazy  thing
           in West and Central Africa  that  almost  certainly  the  voting
           would not have gone as it did. So he was  blaming  the  US.  He,
           then, called the surgeon general in the US and said  I  want  an
           American to run the program because when it goes down,  when  it
           fails, I want it to be seen that there is an American there  and
           the US is really responsible for this dreadful  thing  that  you
           have launched the World Health Organization into and the  person
           I want is Henderson. Well, I was associated, of course, with the
           West African program of having gotten involved with starting  it
           and so forth.

      So I got called to Washington and I was told I was being  assigned  to
           be head of  the  World  Health  Organization's  Global  Smallpox
           Program. I declined. I said, we  are  just  starting  this  West
           African program. We have just - there is a huge amount  of  work
           and we have just barely started. The $2.4 million we got to  go,
           we had programs in 50  countries.  We  don't  even  have  enough
           money, $2.4 million won't even buy the vaccine we need.  Trying,
           I  had  some  experience  in  working  with  the  World   Health
           Organization and they really were  not  working  well  together.
           Each of the six regional offices were sort of wholly independent
           and trying to coordinate them was a terribly job. So I  said,  I
           really can't do it.  I,  you  know,  I  think  this  is  a  very
           difficult task. I really, I think if we do a good  job  in  West
           Africa, we are going to show what can be done. Maybe  that  will
           encourage the other countries but that's, I think, where I ought
           to stay.

Paul O'Grady:    Was this conversation going on between you and the  surgeon
           general?

D.A. Henderson:  Yes. So I declined. He said - I  said,  you  do  not  -  we
           don't order people in the public health service to go from place
           to place. That we - we talk about career opportunities,  and  so
           forth and so on. It's not like the military services.  He  said,
           "Well, this is your career opportunity." I said, "And suppose  I
           decline." He said, "You are fired." I said, "You  are  serious."
           He said, "I am very serious. I will tell you what, make a  deal.
           You go for 18 months and if at any time during  that  18  months
           you really feel it won't go, just send me a telegram,  just  put
           now and I will pull you out." So, I headed for Geneva to head up
           the Global Program.

      We left in October to go to Geneva, get a house. Wife and three  kids,
           plus left half of our household goods in the storage because  we
           knew we would be back pretty soon. Took over  a  program,  which
           was a  global  program.  This  provided  for  headquarter  staff
           eventually of nine of us. It never  got  bigger  than  that.  So
           there were five medical  officers,  two  admin  officers  and  a
           couple of secretaries. That was our total staff.

Paul O'Grady:    Let me ask you about your own mindset at  this  point.  You
           had mentioned the problems with the  measles  program  and  that
           malaria eradication had been problematic. Were you optimistic at
           this point about - at least with respect  to  the  West  African
           piece of the puzzle? You  were  optimistic  about  eradication's
           success?

D.A.  Henderson:   This  is  a  good  question  as  to  whether  you   would
           characterize what I felt is optimistic. My feeling  was  it  was
           doable but without a full appreciation of  everything,  all  the
           problems we would encounter. I must say  because  as  I  thought
           back on it, had I any idea of all the  problems  that  we  would
           face, I would have not been  optimistic.  You  can't  anticipate
           civil wars, floods, masses of refugees, one thing after  another
           and bureaucratic  blockage  of  things,  countries  refusing  to
           participate. All of the difficulties you can have with this, but
           fortunately I was innocent of the problems, these problems  that
           you would encounter or we couldn't anticipate,  obviously,  most
           of these.

      It was the fact we had a good vaccine and the vaccine we knew and  I'd
           worked, we had done some studies at CDC while I was in charge of
           the surveillance program, showing the vaccine was very good. You
           could  get  virtually  a  100  percent  takes,  using  a  proper
           technique. We had jet injectors that  we  had  worked  with  and
           perfected these with the inventor in the  US  Army  so  that  we
           could add jet injectors that could vaccinate a  1000  people  an
           hour. They looked - we looked optimistic that we could do a  lot
           of vaccination with them. So that, we had  a  good  vaccine,  we
           knew something about smallpox. You know  that  -  we  knew  that
           there were a  number  of  countries,  developing  countries  who
           didn't seem to have any cases but the reporting was so bad that,
           little did we know that many of them just weren't reporting it.

      But we just - we really didn't have an idea but we thought there  were
           large countries, free of the disease, certainly the US  was  and
           Canada was. Certainly there must be others  that  were  involved
           too. So it was a feeling of  technically  this  was  doable  but
           without an appreciation that experience would provide as to just
           how difficult the problem would be.

Paul O'Grady:    Let's take you to - take  you  back  to  Geneva.  You  have
           arrived, you had your family there and when  did  you  start  to
           realize that these challenges were going to present themselves?

D.A. Henderson:  We quickly found that we  had  problems.  Within  just  the
           first couple of years, we ran into a number of problems.

Paul O'Grady:    Can you - ?

D.A. Henderson:  The West African program basically,  Don  Millar  who  took
           over from me, who had been my chief of my smallpox unit  before.
           He was running it and he had a good administrative  officer  and
           he had some very good people in the field. My feeling  was  that
           they had to run that themselves and the only thing we could help
           them with, which they needed was some local costs.  I  think  we
           gave them a  couple  of  $100,000  a  year  to  permit  in  some
           countries, purchase a vaccine, gasoline and a few other  things,
           they couldn't get it, legally with their USAID funds. Other than
           that, they were on their own.

      So we worked at the world and saw well,  we  got,  two  countries  are
           sitting rather at the far end. One is Indonesia,  the  other  is
           Brazil. Now at that time, South America appeared to be  free  of
           smallpox except for Brazil. They had done  vaccination  programs
           in the other countries  and  one  way  or  another,  with  their
           infrastructure, not perfect but  they  managed  to  get  rid  of
           smallpox. That of course was encouraging. But if we got  rid  of
           it in Brazil then they would be far away from endemic areas  and
           indeed they could be basically the funds  that  we  are  putting
           into a Brazilian program could be withdrawn and  we  put  it  in
           other areas like Asia or Africa.

      Similarly with Indonesia, Indonesia sitting off where we are here  and
           the countries nearby are free of smallpox.  So  the  chances  of
           smallpox being imported into Indonesia,  if  we  got  that  free
           would be small and therefore the  limited  amount  of  funds  we
           could use have, we could then transfer that to  other  countries
           and at least make a start in trying to get rid of  the  smallpox
           with the limited funds we had. So, that was the strategy.

      We almost immediately found we had a  vaccine  problem.  The  Russians
           had pledged 25 million doses a year and we had no idea how  much
           vaccine we would really need. Most of the countries  were  doing
           some vaccination. The disease was  so  severe,  it  was  such  a
           problem that at least they had to vaccinate in  the  big  cities
           simply because of civil disorder, with too much of this epidemic
           smallpox, it is destabilizing. So in all countries we are  doing
           some vaccination and what we had - we made the  assumption  that
           most of them, already have vaccine and we have  got  25  million
           from the Soviet Union. US is covering all the vaccine  needs  in
           their 18 countries, later 20 countries. So we got to be alright,
           but we - I thought we need to have some way to determine whether
           the vaccine is really, really potent, really good.

      So, I went to the Netherlands and asked if they would  help  in  doing
           testing the vaccine, vaccine quality of the production that  was
           there and then we went to Connaught Laboratories in  Canada  and
           they agreed to do that as well. So we began getting  samples  of
           vaccine from the different countries and they began testing  it.
           Five percent of it was potent and stable. Five percent  met  the
           international standards.

      So we had a problem almost immediately. We couldn't afford to buy  the
           vaccine. So I made a decision, we won't buy any vaccine. We  are
           going to have  to  develop  -  improve  the  vaccine  production
           facilities that are out  there.  We  called  a  meeting  of  the
           vaccine producers from several major  laboratories.  From  Wyeth
           Laboratories in the US, they were the producer  here,  they  had
           one Lister Institute in London, where  Netherlands  were  there,
           Soviet Union were there. I think that was it.  We  brought  them
           together and  we  talked  about  vaccination  and  developing  a
           standard manual. Every country was using where they were  making
           a vaccine they were using all sorts of different techniques.

      So let's get what we think is the best  way  to  do  it  in  a  simple
           manual that I can  understand.  Then  let  us  then  help  these
           countries improve their vaccine. We will, then work with  UNICEF
           to try to get them to provide some machines so that  they  could
           freeze dry the vaccine and we would use some of the people  from
           these consultant laboratories that we had brought together to go
           out and train and help develop the vaccine. That's what we did.

      The vaccine quality began to pickup. It was  by  about  1972,  we  had
           more than 80 percent of the vaccine was being  produced  in  the
           endemic countries themselves and it was good quality. So we were
           immediately  involved  in  trying  to  solve  just  the  vaccine
           problem. How to administer the vaccine was the second problem.

      The problem was this. You have a vaccine which is a very, has a  vial,
           it's in a vial with about 0.25 milliliters  of  fluid.  That  is
           reconstituted. You have one vial that has dried  powder  of  the
           vaccine, another which has a quarter of a  milliliter  of  fluid
           which is a very small amount. To use a vaccine, you have to  put
           the liquid into the dry powder and mix it up. Then  you  had  to
           put it on the arm.  The  way  they  did  this  in  most  of  the
           developing countries was take like a glass rod, dip  it  in  and
           then put it on the - dip the rod against the arm, tip it against
           the arm and a little drop would be there. Then by and large what
           they did was scratch through the vaccine. They had a  number  of
           scratches through the vaccine, it was  an  old  technique  which
           goes back more than a 100 years.

      In the US we did  a  little  bit  differently  but  it  was  the  same
           principle but it was important that the US did it this way. They
           took and took a needle and they put the drop back on the arm and
           then they gently pushed the virus through the skin and the  idea
           was that if you got it just through the skin it  will  grow  and
           produce something. If you push too hard you will  get  bleeding.
           If the bleeding occurs then it washes out the virus.  You  don't
           push hard enough, it doesn't  go  into  the  skin,  and  so  the
           vaccination fails.


      Wyeth laboratories was developing a new device which I  visited  Wyeth
           laboratories because  it  was  the  question  of  improving  our
           vaccine production capabilities in the other countries and  they
           showed me this wonderful device which they developed.  A  little
           needle about - well, tube about so long. There  are  two  little
           prongs on the end. They called it a bifurcated or  sort  of  two
           fork needle. The idea was you put the needle  into  the  vaccine
           and you just withdrew it. Between those two  prong,  the  little
           bit of vaccine would be held and then they thought you press  it
           through the skin.

      In this way the amount of vaccine you could get from a  vial  was  100
           doses rather than 25 doses. Well, I looked at it and I know  how
           much trouble we had had in  trying  to  teach  them  to  medical
           students how to vaccinate because they were forever not  getting
           it quite - not enough pressure to break the skin. So  it  wasn't
           growing and then a number of them are getting a  little  bit  of
           drop of blood and that was thought to be bad. So  I  raised  the
           question of well, suppose that we take a needle and just hold it
           like this and poke it like this, we called it multiple puncture.
           Instead of  scratching  or  pressing  it  through,  do  multiple
           puncture. You are going to  get  bleeding.  So  let's  see  what
           happens.

      So we tried a few of these, they all got  very  successful  takes.  We
           took it to the field into Kenya and Egypt and  did  several  100
           children and we did it very vigorously. There was a little  drop
           of blood on everyone. Every single one of them  was  successful.
           So this was incredible. All of a sudden we were  going  to  have
           four times as much vaccine than we thought  we  had  or  we  are
           getting, with these wonderful needles. The needles cost  us,  we
           shortened them up a little bit and make  them  cheaper  than  we
           made them out of a stainless steel virtually.  We  could  get  a
           thousand of them for $5. You could boil them and reuse them  and
           we ran through about a 120 vaccinations perfectly  good.  So  we
           had needles very inexpensively.

      We had a vaccine and suddenly we had four times as much vaccine as  we
           thought we had. Then it was a matter of bringing those into play
           in the different countries and this went very rapidly. So it was
           another development, right at the beginning which  made  a  huge
           difference. It was a  crazy  little  thing.  Now  the  important
           thing, I think was is that the - the inventor of this, a man  by
           the name of Ben Rubin received a one time, to tell  you,  what's
           called the John Scott Medal of the City of Philadelphia for  the
           best, most important invention of a particular year. Here he was
           getting this and it had gone back - the award goes back  to  the
           1700s. Marconi has received it, Edison has received it so forth.
           He said, "This is the most insignificant patent or  invention  I
           have ever made," and he said, "And here I am receiving the  John
           Scott medal." And it was - it just was like inventing the safety
           pin. It was so incredible.

      So we began using that, we had - introduced the jet injector for  West
           Africa but very soon we said,  for  this  price  we  don't  have
           problems in mechanic to repair  or  what  have  you.  It's  very
           inexpensive, much less expensive than a bio - than jet injector.
           So pretty soon the bifurcated needles took over the whole of the
           world in terms of vaccination. Well, we had a couple of the very
           early problems that we had. There were many more.

Paul O'Grady:    So tell me how the smallpox program  moved  into  Asia  and
           East Africa?

D.A. Henderson:  Well, West Africa, I want to go back to  the  West  African
           program which began in '67 and they managed to record their last
           case in 1971. Well, ahead of schedule and under budget. Not  too
           many programs come through like that. Meanwhile, I had a man  in
           East Africa and he was working with the people in the  different
           countries and helping them  and  strengthening  what  they  were
           doing, a Russian, Ivan Ladnyi and they began to make  very  good
           progress. We, from WHO, began  supporting  Central  Africa,  not
           Central Africa, but Sudan  and  Zaire  are  two  huge  countries
           across the middle. This was frightfully  difficult  but  we  had
           some very good people, incredible people.  Some  national,  some
           internationals and they began to make a good deal of progress.

      Brazil, I got  back  to  say  Brazil  became  free  in  '71.  We  had,
           Indonesia was a bit of struggle but they became free by 1972. In
           fact the whole of  Africa,  was  free  of  smallpox  except  for
           Ethiopia. The whole of Africa was free of smallpox by the summer
           of 1973. We were only six years into the  program  and  here  we
           were with a good piece of the world free now of smallpox. So, in
           the summer of 1973, we were down to - just five  countries  that
           had  smallpox,  just  five.  It  was  India,  Pakistan,   Nepal,
           Bangladesh in Asia and Ethiopia.

      When you looked at India and that group - that bunch of  countries,  I
           think the population then was maybe about 700  million.  So  you
           look at it and you say, only four  countries  in  Asia  but  700
           million people is, at that time, almost three times the size  of
           United States. So it was not a small undertaking  to  deal  with
           that. Meanwhile in Ethiopia, they were doing a malaria  program.
           They did not want to see a smallpox program. So, the Minister of
           Health refused to even have  me  go  and  talk  with  him  about
           starting a program. So nothing had happened in Ethiopia  at  all
           on smallpox, up until late 1970 before I  managed  to  get  into
           Ethiopia and lay out a  plan  and  by  various  devices  working
           through the emperor to get approval to get started in Ethiopia.

      So we came in the summer of '73. We had programs in all the  countries
           and we were very optimistic that now we are on our way. The  big
           problem, frankly, at that time was India. Huge country, a number
           of people talked about India being like the native, like we talk
           about cholera being the home or India being the home of cholera.
           There are some who said, well, India with very dense population,
           particular climate  and  so  forth.  They  must  have  something
           special  here  that  maybe  is  the  home  for  smallpox.   Very
           difficult, you will never get rid of  it  there.  That  was  the
           general discussion that was going on.  We  weren't  making  much
           progress.

      India had started a program back in 1962, not so long after the  first
           World Health Assembly heads said, well, let's do an  eradication
           program. By the time they got to 1973  it  really,  they'd  made
           progress some of the southern states of India but most of India,
           they were still recording as much smallpox  as  they've  had  11
           years before. They were discouraged and really,  not  sure  they
           would continue. There was a lot of discussion about it. It was a
           problem saying we really have to keep going. They agreed  to  do
           so and this was the earlier 70s. They agreed to  keep  on  going
           but then we met and sort of the late spring of '73 and we  said,
           we have got to do something different.

Paul O'Grady:    Who's meeting?

D.A. Henderson:  In India, well  the  strategy  that  we  had  had  was  not
           working. They had done a lot of  vaccinating.  They  were  doing
           mass vaccination all the time, they were then  beginning  to  do
           what we called surveillance and containment. Really getting much
           better reporting and when a report came  from  a  village,  they
           would go out, send a team out. Try to vaccinate and control  the
           outbreak. It didn't seem to be working and there was a  still  a
           lot of cases and we were - they were  not  making  progress.  So
           that spring we decided what we needed to do was find  the  cases
           more quickly. Find them before they became outbreaks.

      So the decision was made  that  we  try  to  undertake  a  village  by
           village search throughout the whole of India in  10  days  time.
           Mobilize the health services for an  intensive  10  day  search.
           With this we were - would employ about a 120,000 people. And the
           idea initially was to go to selected parts of the village  in  a
           particular pattern to try and find cases and see what you  could
           turn up. There was a lot of planning. A lot of organization went
           on. We got Bill Foege from CDC, was sent over. I had  asked  for
           more help. They sent over a couple of people but India is a  big
           place and we have a very  cracked  team  of  international  from
           France, from Czechoslovakia, from Soviet Union, but not  a  lot,
           we were very few.

      So the first search was completed in October  in  this  one  state  of
           India. We were normally getting about 500  cases  a  week.  That
           first search was completed and they  recorded  10000  new  cases
           found, 10000 new cases. This wasn't even the high point  of  the
           season. This was really at the - almost the  beginning  of  when
           the seasonal increase occurred. Oh my gosh!  This  is  far,  far
           worse than we had ever imagined. Well, it was  even  worse  than
           that, because it wasn't several weeks later  I  found  that  the
           search teams had not done a great job and  they  really  reached
           only half of the villages. So it was probably twice  as  bad  as
           bad as I thought it was.

      They repeated the search in another two months and  they  got  better.
           By about the third search they got into  the  point  where  they
           would do house to house. We actually had a  team  following  and
           doing a sample number of the villages to make sure that they had
           really reached at least 80 percent of the houses.  So  we  began
           gradually to mobilize this tremendous force. It took 8  tons  of
           paper for one search. We began getting  more  cases.  The  cases
           were increasing. The problems were that of mobilizing the staff,
           of supervision, quality control. It was a really tough  job.  We
           went on and through the summer of 1974, when at  that  time  the
           smallpox goes down to its low as  points.  Some  of  -  smallpox
           transmits best like measles in the winter. Measles is  a  winter
           disease, smallpox is the same.

      Whatever it is, whether it's being dryer air and cooler air that  does
           it we don't really know  all  the  answers.  But  certainly  the
           summer months are where it gets to  the  lowest  point.  So  the
           summers and the states, northern states where  this  almost  all
           the smallpox was, the summers are terrible, 120  degrees.  There
           is not - limited amount of electricity and there is certainly no
           air conditioning. We were bringing in a lot of people who are on
           3-month volunteer stints  with  their  Indian  colleagues.  That
           summer it was murder. We brought them together,  once  a  month,
           looked at what they had done. Reports, we viewed all  of  these.
           We had no cell phones, we  had  no  telephones.  There  were  no
           computers. I mean, this was all done by hand. They'd come in for
           a weekend. We'd come in for work for a day and then they had one
           day of rest.

Paul O'Grady:    Can you identify a turning point in the Indian experience?

D.A. Henderson:  Yeah, I will come to that.  At  the  moment,  there  was  a
           turning point but a strange one. We worked through  '74  but  we
           got started going into late '74. The seasonal  pick  up,  picked
           up. There were more cases than ever, it was really a  going  and
           there were several longer term trends in the  disease  in  India
           and this was a little [1:03:18 inaudible]  with  a  longer  term
           trend. It was on its way up and we were not having that much  of
           an effect.

      However, by the time we got to around February, we realized  that  the
           search system was in place. That we had some  very  good  people
           supervising this and in fact I even remember  the  time  it  was
           with, Bill Foege, the  two  of  us  were  looking  at  this  and
           wondering now, where were we at this point in time  and  that  -
           but as Bill said, I am not sure I am going to put out a weekly -
           putting out, I guess a bi-weekly report and the curve was  going
           up and he said, the only thing I can  do  that's  optimistic  is
           turn it upside down. But we felt at that time, secretly that  we
           are on our way and they got worse.

      It got worse for the bad time in a way and  a  good  time  in  others.
           India detonated a nuclear device. They had people, press  coming
           from all over. The theme of all of the coverage,  news  coverage
           was India detonates nuclear  device,  smallpox  -  their  health
           system is so bad that they are the world's primary  country  for
           smallpox. So here is this advanced country with  such  primitive
           health facilities that it's epidemic for smallpox.  This  got  a
           lot of interest. The Indian government  was  not  pleased.  They
           were very upset and they began making more resources  available.
           Higher levels in government began paying  attention  to  it  and
           they assigned to the program, from  the  Indian  side,  four  of
           their very best people to work with four of our central  people.
           We call it the central appraisal team.

      Well, we got over that and for India at least, when  we  came  to  the
           end of the last cases in May of 1975, we thought we had the last
           case. There was a beggar woman out on a railway platform in  the
           far eastern part of India going into a whole area  and  she  had
           infected a bunch of people going after. We had no idea what  was
           going on.

      By that time  by  October,  the  Minister  of  Health  and  the  Prime
           Minister were very excited about this.  We  were  not  confident
           that we got rid of smallpox. October 5 - August 15th is  India's
           Independence Day. They were determined to announce that this was
           India's Independence Day and it's freedom from smallpox for  its
           first time in history. I would say we were chewing nails at that
           time, thinking, oh my gosh! If they have more cases,  you  know,
           the press coverage and these people don't  know  what  they  are
           doing, oh god. It would have been awful, that was the last case.

      Meanwhile, Bangladesh was  going  through  tragedy  after  tragedy  of
           flood and famine  and  we  had  an  exhausted  group  of  really
           fighting to get rid of it in Bangladesh which is  a  story  unto
           itself. So, on August 15th, the Director General and  I,  headed
           for Bangladesh. They only had I don't know, something like maybe
           80 villages infected at that point. It was  just  really  coming
           way down and we felt, my gosh! I think we are going to have - be
           rid of this bad disease for all the world. It was a very  severe
           time for smallpox. That would have been in.

      So we are on our way to the airport and got the word, all flights  are
           canceled. The President of the country, the really the  founding
           father of the country, Mujibur  Rahman,  had  been  assassinated
           along with his entire family. Martial  law  had  been  declared.
           Troops were moving  to  the  border.  Floods  of  refugees  were
           expected. We thought, oh my god, once more, but for some reason,
           the international group, was laid low. They worked locally, they
           kept out of the way and the expected civil war that was expected
           to erupt immediately did not. They went back to work and finally
           in October of '75 it was all done in Asia.

      Then we were left with Ethiopia  and  Somalia,  subsequently  Somalia.
           Well, if you like to hear the rest of the  story  I  can  go  on
           Ethiopia but Ethiopia is a huge country. People look at the  map
           and they say oh, it's about the same size as  Georgia,  but  not
           so. It's equivalent to all of the states on the eastern seaboard
           of the United States in area. It's  huge.  There  are  very  few
           roads or where there are roads or even roads you can  drive  on.
           It's estimated I think that, two-thirds of the population  lived
           more than one day's walk from any accessible road, at least  one
           day.

      We had just - the government had only, I think,  2000  health  workers
           in the whole country. For  a  while  we  were  working  with  20
           Ethiopian sanitarians, 14 US peace  corps,  about  six  Japanese
           peace corps and some Austrian peace corps  and  some  volunteers
           who kind of wandered in. Anybody who wanted to work, we put them
           to work and paid them the Ethiopian per diem which if you didn't
           [1:09:59 inaudible] high on the hog on that one, I can tell you.
           Then as they were making progress, slowly but it was  difficult.
           Some of the - first time we ran  into  a  huge  area  where  the
           people fought against vaccination. They didn't want it.

      Trying to solve that problem, took us  some  doing  but  finally  they
           wanted malaria drugs and we could give them  malaria  drugs.  We
           got malaria drugs to give them,  provided  they  got  vaccinated
           first. So they got vaccinated first and then got the drugs.  Not
           the way you like to run a program but that was the only  way  we
           were going to stop the disease. It was a  less  severe  decision
           than let's say in  Asia.  So  there  is  less  motivation,  less
           concern on the part of government.

      Well, we got all of a sudden the emperor Haile Selassie was in  charge
           and had been there you know, as emperor for a  long  time.  They
           had a coup, military coup. Marxist  military  group  took  over.
           Civil war broke out, so there was fighting in different parts of
           the country. The emperor was, I don't really know what  happened
           to him. I think he was killed. Then it was the  US  Peace  Corps
           had to pull out as did the other groups. A number of the embassy
           people pulled out and for a quite a  period  of  time  the  only
           people allowed by the military to go outside of Addis Ababa were
           the smallpox group.

      We had some pretty very good people, particularly our person  who  was
           the real leader of the program, he was a Brazilian fellow by the
           name of Ciro de Quadros. He  had  a  charm  and  an  ability  to
           persuade that was legendary. That's why we had permission to  go
           outside the country but that wasn't much fun because they were -
           we had to go to many  of  the  provinces  with  military  escort
           because it was too dangerous. So  they  fought  through  all  of
           that. It was really horrendous and then they came to a point.

      Finally we got additional people in,  and  then  finally  the  surgeon
           general of the United States came up with a  contribution  of  a
           million dollars for us to get  three  helicopters  to  transport
           people. It was so big. That made a huge difference. Well, one of
           them was shot down, one of them getting up there - I don't know,
           we don't know what reason went into like Kenya. Another one  was
           hit with - they threw a hand grenade at it. They were a pair  of
           those, of those and they took one for the - we had to get at one
           of them with a hostage and they were captured and we had  ransom
           notes which I've still got a copy of the request for ransom from
           the people dictated by the rebels,  written  by  the  helicopter
           pilot. While he was captured took the vaccine and  got  all  the
           rebels vaccinated, so took care of that, he was thinking all the
           time.

      Finally we got to this place in Dimo, a little  village  way  down  in
           the desert, last  case.  I  flew  down.  We  thought  we  got  a
           television crew down there, film this and we did and got  a  lot
           of footage of Dimo, crazy little village sitting in  the  middle
           of a desert. We had a hard time even finding it with  the  -  by
           helicopter, you couldn't spot at great distance.  We  went  back
           and we waited and they searched. Nothing, nothing.  It  went  on
           for eight weeks. We were about ready to make a statement at  the
           press, we are done. There was a report came in of two  cases  in
           Somalia right next door.

      Well to make a long story short, the Somali government, even  for  the
           all the discussions we had had with them, had been hiding cases.
           They knew they had smallpox.  They  were  admitting  them  to  a
           hospital in a sort of secret ward, nobody knew about. They  were
           trying to stop it but because they were  embarrassed,  the  only
           country with smallpox. They hated the Ethiopians and they  hated
           the thought that Ethiopia was free of smallpox. They refused  to
           believe that they were free.

      This went on and as they would let our people come in but  they  would
           let them go out beyond the main city  of  Mogadishu.  The  cases
           kept occurring but they are having  trouble  finding  out  where
           were they coming from, in other words, who was  infecting  them.
           Finally, there was a great discussion  about  this  and  one  of
           them, the turning points, I  think  it  was  that  a  couple  of
           turning points had happened. One being  they  captured  a  Dutch
           adviser who we had working with Ethiopians. He was kidnapped, if
           you will, with his team and vehicle and taken  to  Mogadishu.  I
           think we had eight or nine of these and then the UN commissioner
           would intervene and talk to president and minister.

      This fellow Bert van Ramshorst, finally they took him. He has  to  see
           the minister. So he spent, sat down with the minister and pretty
           well, persuaded him that Ethiopia was free of smallpox and  that
           there was a problem and that the - WHO would be willing to  help
           and so forth and so on. He made a quite a persuasive pitch here.
           Meanwhile, Assistant Director General, Ivon Lodney indicated  he
           would want to come down and visit the city of Mogadishu  at  the
           capital and meet with the Minister.  The  Director  General  was
           threatening to do the same and I think the pressure was on.

      Then they began to loosen up. So from then until this was about  March
           of '77 and the number of cases, I recall are  about  3000  cases
           finally that they had troubles because  they  had  nomad  groups
           moving all over the desert area, couldn't  find  them.  Smallpox
           kept spreading and you couldn't vaccinate them. It  wasn't  that
           they would resist vaccination, you couldn't find them. Then  the
           great problem was, come November, was the Hajj. Somalia is right
           near Saudi Arabia. Many people come from Somalia to  Mecca.  All
           we could imagine were people and they would  come  from  through
           Somalia from other countries, all we could imagine  was  can  we
           possibly have at this time, one of these groups  infected  going
           into Mecca and spreading  it  among  hundreds  of  thousands  of
           people and watching smallpox go like this.

      So there was a frantic effort in terms of - they flew in vehicles,  so
           we had more mobility and flew in all sorts  of  people  and  the
           government declared a national emergency and it went all out. On
           October 26, 1977, Ali Maow Maalin, a cook  23-year-old  was  the
           last case of smallpox. That was the end of the smallpox. We  had
           to spend two more years working in the countries to make sure it
           was really the last one.

Paul O'Grady:    How  did  you  find  out  about  that  last  case,  do  you
           remember?

D.A. Henderson:  Oh, yeah. They had brought in some people at this point  in
           time. They were moving people to an isolation camp to make  sure
           that they would be held. There was two kids who were brought  in
           by a vehicle from outside one of the program vehicles  and  they
           brought them in and they stopped  at  the  hospital  to  inquire
           about where the camp was. Ali Maalin was a cook at the hospital.
           He was supposed to have been vaccinated but he  wasn't.  He  had
           been a vaccinator, in fact but he hadn't been vaccinated. How we
           went wrong, - he got in the vehicle, rode for about  10  minutes
           till they got to the isolation camp. He got out and he came down
           with smallpox.

      Well, he came down with a rash, and as often the case the last is  the
           worst. He was admitted in a hospital and  diagnosed  as  chicken
           pox. Finally, they had  discharged  him  with  a  mild  case  of
           chicken pox and it was one of the other people, friends of  his,
           who said,  I  don't  think  this  is  chicken  pox.  It  wasn't,
           smallpox. He was a very popular guy and he had contact with  all
           sorts of people. So, there were everything  from  roadblocks  to
           all night searches throughout Mogadishu to goodness knows  what,
           trying to find possible other cases, but it was the last.

Paul O'Grady:    So do you have any final thoughts,  anything  you  want  to
           share about your experience with over the course of the years in
           the program?

D.A. Henderson:  Well, I think there were several things about  the  program
           that were very special and that is that we came together, people
           from across the world worked together very well. I  worked  very
           closely with the Russians. It was during the darkest days of the
           Cold War. Totally cooperative, we shared all  sort  of  problems
           and they had some things that needed to be corrected and I  flew
           to Moscow. We talked it over, they corrected them. We had people
           working across borders from one country to another. We  had  mix
           of nationalities out there. What was perfectly clear was that if
           we had a goal, we had leadership at all  these  levels  that  it
           became a very unique situation. Bridges were built such  as  you
           can't imagine. It formed the basis for going  on  from  smallpox
           and we really convened a meeting  and  before  the  program  was
           over, to say, the vaccination has been so  inexpensive.  We  can
           vaccinate  so  many  people  in  a  day,   so   effectively   so
           efficiently. We should be doing more of the smallpox vaccine.

      This  was  an  international  meeting  we  held  and  from  that  came
           recommendations for an expanded program for immunization,  which
           was finally accepted by the World Health Assembly in 1974,  even
           before the end of smallpox. The idea was to add other  vaccines,
           diphtheria, whooping cough, tetanus, the  DPT  vaccine,  measles
           and polio and add this to smallpox. That was  adopted  and  then
           UNICEF got behind it and rotary got behind the  polio  side  and
           the goal was at that time to reach 80  percent  of  the  world's
           children by 1990 with these six vaccines. At the  beginning,  we
           estimated that at best about 10  percent  were  receiving  these
           vaccines. So we had cases of  tetanus  and  diphtheria.  Totally
           preventable diseases, whole wards full of whooping cough and  so
           forth and good vaccines out there, well, made it. So by 1990, 80
           percent of the world's  children  had  been  vaccinated  against
           these  six  diseases.  So  this  was  the  expanded  program  in
           immunization which  is  going  on,  became  in  due  course  the
           eradication of polio. It served to eradicate measles  throughout
           the western hemisphere. Measles was gone.

      We had so few cases of tetanus and diphtheria that it was  a  amazing,
           they were  exceptionally,  just  throughout  the  whole  of  the
           Americas, they developed reporting system which I think, at  the
           beginning we had 500 hospitals reporting once a month. The  last
           count I looked at the reporting, they had weekly reporting  from
           42000  sites  in  Latin  America.  People  just  -  it's  better
           reporting for these diseases than it is in the United States  of
           America. This is going on to develop the group that has convened
           here, have done all sorts of marvelous things and  out  of  this
           came a feeling  of  we've  done  this,  why  can't  we  take  on
           something else. They have done that with great success.

      So, if there is a real need for  an  international  organization  WHO,
           even though there is some of those like our President  Bush  who
           have not felt the need to work with other countries, this  could
           never have been done in the United States, it could  never  have
           done by a  few  countries,  it  had  to  have  an  international
           organization. It showed also how much you  can  do  if  we  have
           preventive medicine and public health vaccines. We were  dealing
           with 10 to 15 million cases of smallpox a year, 2 million deaths
           a year and 10 years later we have zero cases, and  zero  deaths.
           This is pretty dramatic.

      Now you  are  seeing  similar  things  happening  with  measles.  Very
           dramatic changes and now we are talking  about  with  the  Gates
           Foundation supporting a lot of  things,  why  can't  we  go  and
           tackle malaria in a different way. Why aren't we doing  research
           to get better vaccine for tuberculosis,  why  don't  we  have  a
           vaccine against malaria? It's opened  up,  it's  begun  a  whole
           revolution in prevention which is really something to see. Today
           or last couple of days, we have been hearing  reports  of,  now,
           how many different fronts it's moving on very rapidly and really
           rethinking all of this.

      It has, I think, built bridges in the  international  field  that  you
           can't build in agriculture or education.  Those  are  political.
           Agriculture, for obvious reasons,  even  education,  it  becomes
           quite political. With the health side, you really just don't get
           into political issues. It's amazing, you don't and thus  it  has
           built relationships in ways that are really quite unique  across
           the Americas which I have spent more time with  recently.  There
           have been in other areas as well. They had days  of  tranquility
           in the  Americas,  where  in  the  fighting  in  Nicaragua.  The
           agreement was they would stop fighting for  two  days  and  they
           would and the vaccination team to go out. This has  happened  in
           Afghanistan, days of tranquility. So that even the rebel  groups
           could be approached and could be helpful.

      So we got to Peru in the end of polio in the Americas, the last  cases
           were in the area called the Shining Path, where the Shining Path
           was. They destroyed hospitals, they destroyed schools what  have
           you. What the people really behind the scenes, Ciro  de  Quadros
           who was the head of immunization for the Americas had  met  with
           the commanders of the Shining Path and talked it through and got
           commitments from them, not to harm  the  health  workers.  Well,
           they went through and this is what the health workers are doing.
           Guess  what,  they  searched  this  whole  area  which  was   so
           dangerous, it was a problem for the military to go into.

      So there, it's something that I think is unique about health here  and
           something which gives you great encouragement  for  the  future.
           Thus, I really feel  quite,  I  feel  like  we  have  a  made  a
           difference well  beyond  smallpox  eradication.  I  think,  well
           smallpox eradication, I think has been the first  step.  We  are
           now moving on well beyond that into many more exciting things.

Paul  O'Grady:     Great.  DA  Henderson,  thank  you  very  much  for  this
           interview.

D.A. Henderson:  Yeah, you are very welcome.

[End of audio 1:29:16]
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
INTERVIEW
Audio File: Carolyn Olsen Audio File
Transcribed: January 22, 2009


Interviewer:     This is an interview with Carolyn Olsen on July 11th two
      thousand and eight at the Centers for Disease Control and Prevention
      in Atlanta, Georgia about her role in the smallpox eradication
      campaign.  The interviewer is Melissa McSwegan.   With this interview
      we are hoping to capture for future generations the memories of
      participants and their families involved in eradicating smallpox.

      This is an incredibly important and historic achievement and we want
      to hear about your experience.  I have some questions to guide you but
      please feel free to recount any special stories or anecdotes that you
      remember about events or people.  The legal agreement you signed says
      that you are donating you're donating your oral history to the U.S.
      Federal government and it will be in the public domain.

      For the record could you please state your full name and that you know
      you are being recorded.

Interviewee:     My name is Carolyn Hardy Olsen and I know I am being
recorded.

Interviewer:     Okay, great.  Thank you.  Okay, so would you please
      briefly describe your childhood and you education and so on and what
      led you into work or participating in public health campaigns?

Interviewee:     I grew up in Wyoming and after doing all my schooling in
      Cheyenne Wyoming I went to the University of Wyoming where I graduated
      as civil engineer.  And so I was working in Los Angeles when I met
      Dennis and shortly after we were married.  We went to Africa and we
      enjoyed our three years in Liberia then we came back and again I
      worked as an engineer.  And we were in Springfield Illinois when he
      went to (Bagapur) for three months and during that time I was working
      for the environmental protection agency and also getting my masters
      degree in environmental engineering.

      So, when he went to India I said I can't go right now I have to finish
      my masters degree.  So, he sold the house out from under me and so I
      house sat that summer while I finished my degree but he knew I was
      coming to India cause I didn't have any place to live.  And so I
      finished my masters degree and then I arrived in India and he met me
      in Delhi and it was pretty bad.  And so after two days he put me on a
      train and we went off to Lucknow and he said, "I didn't decorate the
      apartment because I thought you could do it.  And I sat there and all
      the wire was on the outside, the refrigerator was in the living room.
      It was really basic and I thought, "Oh my goodness."  And so he said,
      "I've got to work now," and when he came back he said, "I've got to go
      the field tomorrow," and he wanted to go so we went off for a ten day
      field trip and when you go on a field trip you stay in very
      interesting places.

      Probably the best items that we took to India were our sleeping bags
      cause we were staying - they call them dock bungalows and they were
      usually about fifteen cents for a place to stay and breakfast and it
      wasn't worth it.

Interviewer:     Oh, right.

Interviewee:     They were really very basic and if we had water we would -
      if we had hot water we were very lucky but usually we had water.  Then
      when we came back from that first trip Lucknow looked great then about
      a couple weeks later I used to have to fly or take the train into
      Delhi to get supplies.  And like Dennis said it was like going to
      Europe.  I mean Delhi looked first class after being in the field.

Interviewer:     Your perspective changed quite a bit during that time.

Interviewee:     Yes.

Interviewer:     How did you - you mentioned that you went on a - on field
      visits with your husband when he was working with the smallpox
      campaign.  Did you play any particular role during these trips?

Interviewee:     Well, many of the villages were very rural and so I would
      usually walk along and because many times by having a woman with him
      the women were more comfortable but also I found that it's very
      interesting.  Sometimes they have [inaudible 04.23] these different
      things in the village.  I'll tell you one of the most interesting days
      though, in India women always have their legs covered and usually
      their arms.  So I used to wear Levis and a kurta and I had very long
      blonde hair at that time and often wore it in a pigtail or pulled
      back.  And on one occasion we came to this village way out in the
      middle of nowhere and I was reading a book that was really interesting
      so I said I'm not going into the village, I'll just stay here in the
      jeep.

      And so all the children come and they looked at me then they all ran
      away.  And then all the ladies came and they got in a nice little line
      and usually people will go 'Namaste' but if you're very important it's
      'Namaskar'.  And the ladies were all giving me the 'Namaskar' and then
      they would chat away in  Hindi.  Well, the driver was just howling.  I
      mean he was over by the - just holding his sides.  The children had
      told the women that Indira Gandhi had come to the village so they were
      all telling me - and all the men were in the field because they were
      farmers and so probably in some village in India there is the
      [inaudible 05.41] of the day Indira Gandhi came to visit.

      But in general we would always go to the different health units and
      many times the Indian doctor was somebody who was either trained in
      Delhi or Bombay, now called Mumbai, and they were so glad to see
      somebody who spoke English.  I mean they would get out their wedding
      pictures.  These poor young ladies had arranged marriages and now
      they're in a village and they were used to living in a big city and so
      often times we had dinner with them.  I mean it was a very - they were
      very hospitable and we just had a very interesting time in our field
      visits.  Again we would go to many different health units during a day
      tracking down things and making sure their records were right.

      The sanitary facilities, again being an environmental engineer were
      not always that great and so you always had to watch your intake
      during the day.  And so everybody wanted to give you tea and I didn't
      know at first how to say no and then I found out that, again it was
      Rujinder Singh our - Dennis' PMA who told me, "Tell them you're
      fasting."  So I would say, "Oh thank you but I'm fasting today,"  and
      they would say, "Why?"  And I say, "Oh I'm fasting for the health of
      my husband and the success of the smallpox program," and they would
      think I was just this wonderful person and then two health units
      further I would have a cup of tea again.  But again you were in an
      environment that was very different than what most people especially
      during the hot months it was like a hundred and twenty degrees and you
      couldn't roll down the windows in the jeep because the wind coming
      through.

      And one day our driver took a shortcut so we got lost and we ended up
      stopping in a village where they went in, took the straw out and got
      us a piece of ice out of the ground which we put in a bucket and
      bought about twenty four Coca Cola.  And we would get towels wet, put
      them on our head and it was just a interesting day, I mean very trying
      on us.

Interviewer:     And did you have the opportunity to apply your engineering
      and engineering training while you were living there?

Interviewee:     Not really.  Again sometime there would be water questions
      and - but it really didn't lend itself to get involved.  I was able to
      do that more when I was in Liberia.  I taught sanitation workers how
      to do mapping and different things but again we were - actually we
      were moving quite a bit when we were in India.

Interviewer:     Describe a bit your relationship with the host country
      counterparts or the people you were interacting with on a day to day
      basis.   How did that work?

Interviewee:     Being a woman in India is different.  Our living
      arrangement was quite nice in that we lived upstairs in what they
      called (vasadi) of the Dases.  And Mrs. Das was actually the president
      of the girls school next door, Isabel Thornbird College which is a
      prestigious college for Lucknow.  And Mr. Das had been the police
      chief for the whole state and so we were included in that part.  So
      there I felt very comfortable being a woman but when we were in the
      field it was - or when you were alone you always felt like, especially
      young boys between like fifteen and twenty three, they were very
      aggressive and so you would always like to make sure that you were -
      and as a result the PMA and the driver and everybody were always very
      protective of me.  And being a professional person I was not used to
      having to have to kind of being protected.

      And then later on when we moved to Delhi it was a matter of having the
      taxi driver watch you while you went into the market.  And it wasn't
      that you felt security, I mean it was just that they wanted to touch
      your hair or something.  One time - oh, I had - I was having a strange
      pain and my fingers were starting to go numb and so I went to a doctor
      in Delhi and they said that I have Hobo's Disease.  It was my arm from
      riding in the jeep I would have my arm up and it was pinching a nerve.
       And he says, "I think we should X-ray you."  So I went in and the
      doctor came in and he started laughing because the paramedic had put
      my hair, my blonde hair so it was like a halo while I was laying
      there.  But in general you just go with the flow of things.  It was
      quite interesting.

Interviewer:     What were some of the biggest challenges to living in
India?

Interviewee:     Food actually was kind of a challenge.  We were - when we
      were in the field we were usually vegetarians because you didn't know
      the last time somebody who may have come through and eaten meat so you
      didn't know how old the meat that was in the restaurant.  And we ate
      at the truck stops along the way and so we would always have to ask
      them to put the samosas back in or put new samosas into the hot oil so
      everything we ate was hot.  The embassy doctor used to just be amazed
      because we would not get ill but we didn't eat fresh vegetables unless
      we were home and they were peeled even if we went to a very nice hotel
      or a nice buffet and we had a lot of soup and a lot of things but also
      we had a cook.  He had a reputation.  He had worked for Dr. Francis
      and Dr. McGinnis and everybody knew that Iddu was just a wonderful
      cook and so Iddu was an old man, I mean now he is probably forty but
      he seemed like an old man to us at that time.

      And he became ill and they gave him streptomycin which caused inner
      ear damage and so he was having a hard time walking and so then I
      would pay for a rickshaw to bring him right up to the door and then I
      had him bring his daughter who had had smallpox so it was really quite
      appropriate.  She was blind in one eye and had pox - to help him so
      that he could his work.  And one day - she would marketing, he would
      do the cooking most of the time.  One day I am cooking, he is sitting
      there with his feet up, she is outside drinking tea and I'm thinking,
      "And I have servants,"  you know.  But during that same period of time
      Iddu got more sick and so about every six weeks or so we would have
      this regional meeting and all of the epidemiologists would come in and
      the international epidemiologists would come for lunch and then the
      Indian and the international ones would all come for dinner which
      would be about a hundred people.

      So, we would have usually about twelve to fifteen for lunch and I had
      Sabra who would help but Iddu was gone so it was up to me.  So I
      thought, "Well what," - so for lunch we had peanut butter and jelly
      sandwiches and Kool-Aid for the international group and then for the
      other people I did manage to find some things that were almost ready
      made, you add two vegetables and you became, you know.  And I thought
      okay this is adequate.  Well, the next month as we're going around to
      the different epidemiologists to see how things were going and
      everything, all the international ones says, "Boy I hope you have the
      same lunch next time we're here.  That was the best thing.  I go to
      bed at night dreaming of that peanut butter and jelly sandwich."  And
      then the Indian doctors, and Indian doctors actually had a harder time
      finding food because their wives had taken care of their food in their
      houses and rarely did they eat out.  And in India you have to sort
      your rice and you know all those different things.

      Well, a couple of them asked for my recipe for the different curries I
      had made that night and I didn't have the heart to tell them that I
      had gone to the store and bought a box of something that  I put in it.
       So I kept on like don't, [inaudible 15.21] the recipe you know, but I
      had an enjoyable time.  It was a challenge and you never quite knew
      what the day was going to bring.

Interviewer:     Were you able at some point to decorate your apartment?
      You had mentioned your apartment had all the wires on the outside and
      did it eventually become more...

Interviewee:     Well, it actually started looking pretty good.

Interviewer:     Okay.

Interviewee:     I mean, we had fluorescent lights and definitely - but
      during - well, electricity was not always available and so sometimes
      you would have company or somebody and all of a sudden all the power
      would go out.  And before the game Trivia Pursuit, we used to play a
      game that you would give the person the almanac and the flashlight and
      they would ask the other people questions.  So that was our
      entertainment on that but when we were in the field sometimes if you
      didn't have power we would go to the movie because the Hindi movies
      are four hours long, they usually have fans or if they are upscale
      they have air conditioning and they have their own generators.  So we
      used to go to a lot of Hindi movies when we were traveling and it was
      - like I said the heat was a challenge when you have a hundred and
      twenty degrees.

      Then the cold was a challenge because you had fifteen foot ceilings
      and no heat and so if you invited people over for dinner you would put
      the heater under the table and everybody would sit there in their
      coats and you would usually have soup or something hot.  But other
      than that I mean it was probably the most grueling experience I have.
      I mean if you look at going to school, going to college, going to
      India is just straight up.  I mean it's like they say you see the
      poorest, you see the richest.  You are the hottest, you are the
      coldest.  Everything is a dichotomy and the people there were just
      absolutely very hospitable and very, very nice.  They were you know
      again I would say kind of shy but some of the doctors that we met
      especially the Indian doctors that were in charge of different areas
      were very, very nice.  And this apartment that we had since they would
      come to visit us, they would see what we lived in so then they felt
      like they could invite us to their home so whenever we went to Delhi
      we would be invited to some of the doctors' houses.

      And probably one of the best invitations we ever had was Dr. Hakoli.
      While we were there they had the Kumbh Mela in Allahabad which happens
      I think every fifteen years and it's on the river banks of the River
      Ganges.  And on a busy day there's about probably ten to fifteen
      million people come and we were invited to come and stay in one of the
      tents for a minor bathing day so there was only about five million
      people there.  And so the Jumna, the Sangam and the Ganges all meet
      there and everybody goes to bathe and they have - they pray to the
      Sadhus.  And the first night we arrived there was this chanting so I
      asked Mrs. Hakoli, I said, "Do they pray all night?" cause it sounds
      like the Hare Krishna chant.  And she said, "Pray?"  And I said yes
      and she said, "Oh!  No they're listing hundreds of women who were lost
      today."  And it was a tradition that when you went back to your
      village you stopped at lost and found to see if anybody from your
      village had come and gotten lost to take them back.  And you would see
      these ladies with their saris tied together and some young son taking
      all their aunties to this festival.  So it was very, very interesting.

Interviewer:     What were some of the biggest differences between India in
      Liberia in comparing your two experiences?

Interviewee:     Well, I worked in Liberia so I was working as a school
      teacher there and teaching math and in India I felt like my role was
      more to support my husband and then there were a lot of social
      functions like when the international group came again we hosted at
      our house.  When we lived in Delhi and probably - well the type of
      people we met in India were very different even from the international
      side cause the Soviet Union was also - had provided quite a few
      epidemiologists and doctors for the program.  And so we not only had
      Russians but we also had people from Chezkslovakia and a lot of
      Eastern European countries.  And it was an education in social morays
      and also in how different countries looked at the Soviet Union and how
      when they socialized and when we socialized it was very different.
      Cause like if we were to go to a party it was put on by Dr. Codokevich
      or something as opposed to when we had a party we would look around
      and find out who else had a servant who would be the bartender and
      somebody else.  So we had all Indian staff working the party.

      When we went to a Soviet party it was people from the embassy.  I mean
      there were all kinds of ladies and other people that were Russian that
      were - you weren't uncomfortable but you knew it was very, very
      different.

Interviewer:     How did your time abroad particularly in India and Liberia
      with the smallpox program, how did that affect your career and your
      life afterwards?

Interviewee:     Well, on a I guess - India is such - I mean it's just
      there's so much energy and so much to do and so much to see that I
      just suddenly felt like I either had to write a book or do something
      and instead I started painting and in about six months I painted sixty
      some pictures all Indian.  And in India you can do anything so I had a
      one woman show and sold my paintings and it was really, it was quite
      interesting.  And one of the highlights was that Dr. Sensor actually
      purchased the first painting I ever painted which was of a train
      station and gave it to Dr. Fergie.  And so my claim to fame was that
      one of my paintings was in the Carter Center for a while but on a
      professional side it really brought home the need for clean water.
      And my profession as it moved forward I was commissioner of water and
      pollution control for the city of Atlanta and I was very involved in a
      lot of water and waste water activities.

      I also then became the president of a non profit which is called Water
      for People and it gives you a real empathy for how important clean
      water and drinking water is because when we were in the field in order
      to have clean water we used to carry - the old milk buckets there are
      kind of made of aluminum and about this tall.  And each night we would
      fill our jug up with water, put the immersion heater in, boil our
      water and put it in a - so we never had cold water but we had clean
      water.  And with all the disease and the different things you just
      realize that water is probably one of the most important parts of our
      existence.

Interviewer:     Well, do you have any other stories or anecdotes that you
      would like to share with us?  Any memorable moments from your time
      there?

Interviewee:     Oh, I must say that one of the - when we moved to Delhi I
      didn't get to go in the field anymore so I became a professional
      traveler and as a result anybody going anywhere I would go.  And I was
      able to go up to an area close to the Nepali border which was called
      Tiger Haven where they would bring tiger - small tigers back from
      London and get them back into the wild.  And they would put you up in
      a cage and let you watch the animals which was very interesting.
      Another time I went with some missionaries and we took a train ride on
      a no class train and it was a twenty four hour ride down to New Bombay
       and I was with some Swedish people and it was very, very interesting
      cause we used to travel by train but we used to travel at least first
      class something which wasn't that great.  But this was - I think it
      cost me ten dollars to take a twenty four hour trip one return.  And
      on one train we were in a car and the rest was freight and all of a
      sudden there was a band and it came through playing and it then got
      off the train.  We come to find out they were on top and that's where
      - also that's where they would make tea and they would lean down over
      and sell you tea into the compartment but they riding up on top.

      And the last trip that I took that was very interesting was some
      people from the embassy were going to go from Delhi to Kabul,
      Afghanistan.  So we went through Pakistan and through the Khyber Pass
      and into Afghanistan.  And that was all in the seventies so that was
      before the Russians came and I just feel very sad when I see what has
      happened to  Afghanistan.  I don't know if you've read it or not but
      Kite Runner when it described at the beginning is the kind of
      Afghanistan that I had seen and I also had empathy for Afghanistan
      cause when I went to University of Wyoming, University of Afghanistan,
      University of Wyoming were sister colleges so I had met Afghans then
      also.  But other than being a world traveler I think that was pretty
      much a very positive experience and again I'm sure it changed my life.
       I mean it just gave me a whole different way of looking at the world
      and from a South East Asian standpoint but also with all the different
      cultures that we met through the program.

Interviewer:     Well, thank you for sharing your story.

Interviewee:     Okay.
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dorothy F. Hicks. The interview is being
conducted at the Centers for Disease Control and Prevention in Atlanta,
Georgia, on July 14, 2006. It is a part of the 40th anniversary reunion of
the launching of the West Africa Smallpox Eradication Program. The
interviewer is Linda Harrar.
HARRAR:     There's no such thing as a wrong answer here. If you don't like
           the way you said something, just say, "Let me pick that up
           again," and you can start your thought again. So don't worry;
           it's not a high-pressure situation by any stretch of the
           imagination.
                 May I call you Dot? Is that okay?
Hicks:      Please do; all my friends do.
HARRAR:     Okay, great. How did you and your husband came to be involved
           with the smallpox eradication campaign?
Hicks:      My husband was here as an employee of the Centers for Disease
           Control but had been transferred to Raleigh, North Carolina. He
           was Chief of Venereal Disease Control as a federal assignee to
           the state of North Carolina.
                 We lived in the Raleigh area and didn't have children
           after being married for quite a few years and decided we would
           like to have a family. We progressed in adopting a little boy,
           and Jimmy came to live with us at 8 months. And we had our order
           in for a little girl, but Jimmy had to be 2 years of age before
           we could adopt again, under the law in North Carolina.
                 Jim didn't come home for lunch each day. He stayed at the
           office and went out with different people for lunch. And 1 day
           he came home, and he walked in the house at lunchtime and I
           said, "Are you feeling all right?"
                 And he said, "Yeah, I'm fine, but I think you'd better sit
           down."
                 I said, "Why? Are we being transferred to New York or
           Chicago?" because he knew those were 2 places where I had worked
           at 1 time and did not want to go back to live.
                 And he said, "No." He said, "I've been asked to take a job
           in West Africa."
                 And I said, "What are we going to do about the second
           child? When do you have to go?"
                 He said, "Yesterday they wanted me there."
                 And I said, "Let me call Josephine Kirk," who was the
           director, at that time, of the agency.
                 I said, "Josephine, we're supposed to get a little girl,
           and Jim's being sent over to West Africa."
                 And she said, "Well, Dot, if you would take a boy, we've
           got a precious little boy you could take."
                 And I said, "But we don't even have birth certificates yet
           for Jimmy because he's not 2 yet."
                 And she said, "Well, we'll work something out."
                 And I said, "Well, Jimmy has asthma, and I don't know how
           that's going to affect things."
                 And, of course, Jim told Dave Sencer [David J. Sencer],
           who at the time was the Director of CDC, and he said that CDC
           would get a waiver on it from Washington, which they did.
                 Jim left, and I was there until the house was sold, and
           then he came back to go over with us. So that was how we wound
           up in Lagos, Nigeria.
HARRAR:     Okay. And what were your first impressions when you arrived in
           Lagos with 2 children in . . .
Hicks:      In diapers. We came in from Switzerland, where it was snowing.
           When we arrived at the airport, they actually told us on the
           plane that it was very hot, and we, of course, had winter
           clothes on. When we deplaned, it wasn't like any airport here.
           It was like airports used to be in this country, where you had
           to deplane out on the tarmac and walk in. And as we walked in,
           there were guards with guns, and you had to walk through them to
           go into their security, and I wasn't used to that, of course. It
           wasn't 9/11 yet, so we weren't used to this kind of security.
                 And we got through security, and they had a car waiting to
           take us to a residence, which I had never seen. I had no idea
           where we would be going. And I was amazed, as we left the
           airport to head to Lagos. There were no streetlights, very few
           paved roads. But along the roads there were little stands that
           people obviously had made, and the only light was candlelight to
           sell their wares. So that was my first impression.
                 I was a bit apprehensive about where we were going to be
           living. What are we going to be living in? I didn't know whether
           it was a thatched hut or what it was going to be. But when we
           drove in, it was a compound. The housing had been provided by
           the government, and it turned out to be a very nice home.
                 Our only concern when we arrived is that we had been told
           by 1 of the physicians here who had been over there that they
           were concerned about having the 2 boys because the stairs were
           different than any stairs that we have here. They didn't have
           backing to the stairs, and with the children that small, they
           were concerned about when they started to crawl and get around.
           But we never worried, never had any problem with it. We were
           there when they were going up and down the stairs. And just
           things like that.
                 But it was a very nice compound, the housing that was
           provided, and the furniture was provided. By the guidelines, you
           had to hire locals to work for you while you were there. They
           had secured a nanny for us, a cook, and since cooks do not clean
           the house, we had a houseboy to clean.
                 And then, like dumb Americans going into that kind of an
           environment, we, in our sea freight, sent over a lawnmower. But
           we found out, when it arrived, that that's not what they use
           over there. They use machetes to cut the grass. It was little
           things like this.
                 But I thank God that we had a chance to see another
           culture.
HARRAR:     I imagine you learned some things and had some experiences that
           you will just never, ever forget.
                 How did you find the people of Nigeria? Were they
           welcoming to you?
Hicks:      Very friendly.
                 They had guards. You know, we were there during the
           Biafran War with the Eastern Region, the oil region of Nigeria,
           and the military capital was in Lagos. The American wives and
           children were given the opportunity to evacuate, but we could
           not come back. And we chose, as a family, to be together, even
           though Jim was traveling throughout the entire 19 countries, I
           believe it was. It may have been 20; I don't remember. And it
           was an experience then that I hadn't expected.
HARRAR:     What would you say the impact of this experience was on your
           family, on the boys growing up, and on your own view of the
           world?
Hicks:      My view of the world is that we don't know how fortunate we
           are. I wish I could convey that to people. And when people are
           poor in this country, I haven't seen anything in this country,
           as many places as we've lived, that would be anything like
           living in an environment like that. When you see children that
           are sold from 1 client to another to work, and they'd come to
           our backdoor in the morning carrying loaves of bread, little
           tiny loaves, to sell. Precious children. And children with
           swollen bellies, that you thought, "Boy, that child had too much
           to eat," and then you'd find out that it wasn't that they had
           too much to eat, they weren't getting enough to eat. It's hard
           to convey to somebody.
HARRAR:     It kind of breaks your heart, I'm sure.
Hicks:      It does.
HARRAR:     Especially when you're raising children of the same age.
Hicks:      Yes. But both of our sons now really don't remember anything
           because Jimmy became very ill with his asthma overseas, after we
           were there for 2 years, and had been hospitalized over there
           around 20 or 22 times. Jim was out of Nigeria, in 1 of the other
           countries, and they sent a cable and told him to come back
           because they didn't think Jimmy was going to make it, and they
           decided to send us home.
HARRAR:     It must have taken a lot of courage for you to be the mother
           and try to hold down the fort at home while this was happening
           and your husband was traveling.
Hicks:      So we were there about 2 years, going on 3 years, before we
           left. And we couldn't come straight home by plane. They wanted
           us to stop in major cities in case Jimmy had an attack.
                 He's now 42 years of age and is a chemical engineer with
           Solvay. And why he chose to take chemical engineering, I don't
           know, but he's in polymers. So he says, "Mom, we develop it on
           the computer, and if it explodes, we don't do it." But it's
           things like this.
HARRAR:     Do you remember how you felt when it was announced that
           smallpox had been eradicated?
Hicks:      Elated, absolutely! Jim continued to work in smallpox from here
           and would leave and go over for 6 weeks at a time and that sort
           of thing. But it was an experience that I'm thankful we were
           able to have.
HARRAR:     And did you see values in Nigeria maybe that you thought were
           powerful, whether it's family . . .
Hicks:      Absolutely family. The mothers, if they can afford to do it,
           keep their children, and they try to take care of them. They
           would feed the children before feeding themselves. You see
           little children laughing, and they don't realize what the
           situation is. They're not used to having a plate full of food.
           And I can remember my dad telling me, when I was growing up,
           that "you have to clean that plate now. There are a lot of poor
           people in the world." Well, we were poor, but I didn't know it
           until I grew up. You know, when you get to be in your 70s, you
           remember those days.
HARRAR:     And do you think that this experience really shaped your
           husband's career and his work that he did thereafter?
Hicks:      Oh, yes, absolutely. He'd been with CDC, was hired from Tampa
           Health Department after graduating from-am I allowed to say he's
           a Gator?
HARRAR:     Sure, go Gators!
                 And you yourself, did you ever work outside the home?
Hicks:      I was teaching the Nigerian police, equestrian arts. For years,
           I showed hunters and jumpers and 3- and 5-gaited saddle horses.
                 I was going to market 1 day with the boys, and I saw this
           Nigerian police officer-this is one of the things you may want
           to edit out-he had dismounted from his horse, had urinated, and
           couldn't get back on the horse again.
                 So I stopped the car and went over to him, and I said, "I
           could make that easy for you."
                 And he said, "How?"
                 And I said, "You lower the stirrup." And so I showed him
           how to lower the stirrup and how to put his foot in it, and gave
           him a boost up. I was a lot smaller than him, but he got up. And
           so the police asked me if I would help them with training, and I
           was doing that. They have a polo ground in Lagos.,
                 We actually lived on the island of Akoya, which is
           connected by a very small bridge. You don't even realize that
           it's an island until you go over the little bridge and wonder
           what it's doing there. You think it's a drainage ditch.
                 I was amazed at the fact that the sewage consists of open
           sewers. Before you could go into your own home, as a precaution,
           you would take your shoes off and wash your feet at the door.
           You just didn't go in and out when you were down in that area.
                 There was water there, and we wound up with a boat. We
           used to take the boys out to this little island that the embassy
           had. We'd take them to a hotel that they had, and it had a
           little pond. The children would push their little sailboats
           around that. And we'd have high tea in the afternoon on Sunday.
                 We were Christians, and we were fortunate enough, when we
           went over, to go to the First Baptist Church of Lagos with our
           sons. The first Sunday we were there, the service was in the
           Yorba tongue, and we knew the music, but it was sung in Yorba. I
           said to Jim as we were leaving, "Gosh, our sons will never
           understand the language, and we certainly don't understand it."
                 Having said that, a couple walked up to us. Quite
           honestly, I thought we were the only white people in there, but
           there was another couple, an older couple, who came over and
           introduced themselves. They had been sent over by the Southern
           Baptist Convention as missionaries and had been in Africa for
           many years. And we found out that their residence was just
           around the corner from our house. So they became grandparents to
           our children while they were there.
                 We mentioned to them that our children would never
           understand the sermon or the Bible. We read the Bible to them,
           but they needed to do something.
                 And she said, "Well, do you think you-all would be
           interested in trying to help to formulate an English-speaking
           church here?"
                 And we said, "Yes, of course."
                 And, to make a long story short, we were able to do that.
           We didn't have a preacher every Sunday, so Jim would take 1
           Sunday, and then there was another couple from Gulf Arabian
           American Oil who were Baptists, and they came, and he would
           preach 1 Sunday. And then there was a Nigerian man who was part
           of the Southern Baptist Convention but African, and he traveled
           in Nigeria from 1 place to another to do services, so he wasn't
           always there. Before we left, they had received enough money
           that we were in a school on Sunday mornings. A lot of the
           Nigerian young men who were in university chose to come to the
           English-speaking church because most of them had learned English
           when they were out of country, in the U.K. or in the United
           States, and they wanted to continue the language.
HARRAR:     Did you feel isolated when you were there? I mean, I know it
           was very tough in those years to-you couldn't call home easily.
Hicks:      No. You had to make an appointment to call home. As a matter of
           fact, when I was there, I received a wire through the embassy
           that my grandfather had passed away. It was during the Biafran
           situation. If I had left the country, I could not come back. And
           by the time I got the message, he was already buried, but I
           found that out only because I had made an appointment to make a
           long-distance call. And when I finally got through to my
           parents, he was already buried. So that was one of the factors.
                 The children reached the point that, when we came back to
           the States, they were speaking some of the Yorba tongue. The
           worst part of it was our help were not all of the same tribe,
           and there were 3 different dialects spoken in our house, not
           including English.
HARRAR:     Were you concerned that the children, aside from the asthma,
           would be affected by illnesses over there? Did your family, you
           or your husband, ever become ill?
Hicks:      No, not at all. We had a physician at the embassy. I couldn't
           find him at the time that Jimmy went code blue, but one of our
           own physicians, Dr. Stan Foster, I called his residence, and the
           help said that he was out playing tennis. And I said, "Can you
           get a message to him that I need help?" Jim was out of country
           at the time. And Stan was a lifesaver to us to get us over. He
           tried to work with Jimmy at home for a short time and saw that
           it wasn't going to work, so he drove. And, of course, because of
           the war, we were stopped by soldiers for security who wanted to
           go through the car and all that, and Stan was able to get
           through to them that this was an emergency and we had to get
           Jimmy to the hospital. So I'm thankful for that.
HARRAR:     Well, that was quite an experience.
                 I think we're all set. Thank you so much. It's really a
           great honor to meet you.
                                    # # #
&lt;/pre&gt;</text>
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Deane Hutchins about his activities in the West
Africa Smallpox Eradication Project. The interview is being conducted at
the Centers for Disease Control and Prevention in Atlanta, Georgia, on July
14, 2006, as a part of the 40th reunion of the West African Smallpox
Eradication Project, to mark the launch of the project. The interviewer is
Laura Harrar.

Harrar:     I noted in reading your bio that you were involved in private
           practice in Boothbay Harbor and then taught at the University of
           Maine. So how did you even begin to think about taking a leave
           of absence to join the Smallpox Eradication Program?
Hutchins:   While at the University of Maine, I was the Director of
           Clinical Services at the Student Health Center, and I what I
           thought was influenza. I knew D. A. Henderson [Donald A.
           Henderson] because he was my classmate in medical school, and I
           knew he'd been on the surveillance program for influenza. So I
           called him up and said, "D. A., are you interested in some
           throat washings of influenza?" And D. A. said, "No, not really,"
           he said, "but would you like to go to Africa?"
                 My wife and I had never talked about this. I went home
           that noon and talked with her and said I'd seen D. A. She said,
           "What did you talk about?" and I said, "Nothing in particular.
           He asked me if I wanted to go to Africa," and she said, "What
           did you tell him?"
                 I said, "I told him I would call him back."
                 My daughter was home from school, and she went to school
           and told her teacher we were going to Africa. Within 2 days, I
           had called D. A. back and said, "Yes, we'd like to go."
                 I got a leave of absence from the university for 2 years.
           Now, universities don't like to give a 2-year release, but the
           president of the university had been overseas himself and knew
           that it was a 2-year assignment. So I got the leave of absence,
           and we made up our mind and, in July, we came down to CDC and
           were on our way.
Harrar:     I noted that you had a major in zoology in your earlier years.
Hutchins:   Yes. Zoology was just part of the premedical course that we
           took.
Harrar:     And why do you think D. A. tapped you to do this? Had you ever
           imagined that you would be working abroad in public health?
Hutchins:   No. I'd done a few surveys at the university when they had
           their usual food outbreaks and tracked that down, but nothing
           really formal about epidemiology. As I mentioned, I worked with
           D.A. in the same room with the dissecting tables in medical
           school, so I knew him well.
Harrar:     Had you ever imagined that you would work abroad?
Hutchins:   Not in particular. I'd been overseas during World War II, but
           nothing beyond that.
Harrar:     Okay. So you can blame all of this on D.A.
Hutchins:   Blame it on D.A.
Harrar:     Okay, all right. Tell me a little bit about your family at the
           time. Were they excited about this? Was there just the one
           daughter?
Hutchins:   We'd never considered going overseas. My wife was excited about
           it; all 4 daughters were excited about it. And had there been
           one dissent, I'm sure we'd have thought that we shouldn't do it.
           But we decided to go and never regretted it at all.
Harrar:     Would you call your family adventurous and outgoing and
           curious?
Hutchins:   I guess the family probably was curious and was moderately
           outgoing. They had a good time.
Harrar:     What was the range of your daughters' ages at this point?
Hutchins:   The oldest one was 14; the youngest was probably 7.
Harrar:     So, start with the phone call from D. A. Henderson, and tell me
           what happened then, how you got yourself and your family to
           Africa.
Hutchins:   Well, we started preparing to go to Africa, and come June, we
           packed up our Volkswagen, packed up the car, and drove to
           Atlanta.
                 Ion the humorous side of things, we sent our Volkswagen
           bus in June to Nigeria, and we received it the next February,
           which was par for the course.
Harrar:     And so, did you need to send an enormous boatload of goods?
Hutchins:   Yes. We took a lot of things. We had 2 shipments. We had an air
           shipment of limited pounds, and then we had sea freight, in
           which you could take most anything you wanted. We read books to
           find out what we should take.
                 Air freight got there just before Christmas, and we left
           in October. Sea freight didn't get there until sometime in the
           spring.
Harrar:     Was it a pretty big culture shock for you and your family? Talk
           to me about the language issues and some of the cultural changes
           that they had to get used to.
Hutchins:   The cultural shock hit us, I think, the worst right in Lagos,
           which is a capital city. From the airport into the center of the
           city, it's pretty raw. The smells are terrible, as you may well
           remember. It wasn't unusual to see a dead body on the street,
           and it would stay there for a day or 2.
                 Most of the people we dealt with could speak English, so
           that wasn't a big problem. When we got up to Kaduna in northern
           Nigeria, we did try to pick up the local language, Hausa, enough
           so that we could say good morning, how are you, where's the
           bathroom, how do I get home, what time is it, and that type of
           thing.
Harrar:     Would you say that you were welcomed by the local people?
Hutchins:   Definitely. The local people were very nice. I never felt
           uncomfortable. And this was right before the Biafran War had
           started. But about 2 weeks before we went to Kaduna, they'd
           killed about 30,000 Ibo people who were living up there. So
           you'd go by these houses that were strictly empty and burned
           out, and we didn't realize the significance of it at the time,
           but, in retrospect, it was a little bit scary.
Harrar:     How did you and your wife feel about this once you got there
           and you realized what you had brought your family into?
Hutchins:   It was an adventure. I don't think we ever felt uncomfortable.
           There were problems like communications. We were there for 2
           years, and to call the United States, you had to book the call
           ahead of time. Then they would call London, London would call
           New York, then New York would call where you were calling. One
           time I did get through on the telephone. You were limited to 3
           minutes, but my 3 minutes were used up by the time they got
           through, and I could just barely hear my father say, "Hello."
           Then the operator said, "Your time is up." And I said, "Would
           you at least tell him that we're all right?" That was quite an
           experience.
                 We had a telephone in our house all the time we were
           there. It worked just 3 months. The military government took
           over the country. We lived right beside the military governor,
           and I know our telephone number was given to him. But that
           wasn't too bad because no one else had telephones either, so you
           couldn't call anybody.
Harrar:     So, did your family feel isolated at all, do you think?
Hutchins:   I don't think they felt isolated. All of my daughters went to
           school in Kaduna. The second semester, my oldest daughter went
           to an international school down in Ibadan, 400 miles from
           Kaduna. The problem there was that there was just one bridge
           across the Niger River, and this was after fighting had started;
           if they'd blown that bridge, it would have been difficult to get
           to my daughter.
                 Two other daughters went to a missionary school in Joss,
           which was an American school 150 miles from Kaduna. During the
           rainy season, you couldn't drive, so it was a mixed situation.
Harrar:     Transport, yes. And what was your exact role on the Smallpox
           Eradication Program?
Hutchins:   I was the Medical Officer in the Northern Region of Nigeria.
           Two Operations Officers worked with us.
Harrar:     So on a day-to-day basis, describe for me your activities and
           the range of challenges that you had.
Hutchins:   Well, let me tell you a little bit about our office. We lived
           in an ex-Minister of Finance house. This is a Muslim country,
           90% Muslims. So they had a long tunnel that went from the house
           out to the wives' quarters. There were 7 apartments out there, 4
           for wives and 3 for the concubines. Well, since the Minister had
           been kicked out of his house, the Ministry gave it to us to live
           in. We had our offices out in the old wives' quarters, which was
           crude but convenient. It wasn't very nice, but at least it was a
           place where we could sit down.
Harrar:     I thought you were going to say you installed your daughters.
Hutchins:   Well, I did have a kid come up to me and want to buy my
           daughter, but I told him she wasn't for sale. He was serious, I
           think.
Harrar:     On a day-to-day basis, what kinds of things were you involved
           in as a Medical Officer?
Hutchins:   I was concerned about the quality of the organization of the
           eradication program, smallpox reporting, and the vaccinating
           teams. As the reports of smallpox came in, we would investigate
           the outbreak and visit the various smallpox hospitals. That's
           about it, I guess.
Harrar:     Was there a strong sense of collegiality among the people
           working on the effort?
Hutchins:   Yes. We had 3 groups of teams, and each group had about 10
           teams; there were 7 people in each team. So we had well over 100
           Nigerians who were taught to give smallpox vaccinations. Now,
           most of them had not gone beyond 7th grade, but they were
           classified as health workers. We would teach them how to give
           smallpox vaccine with the jet injector and how to take care of
           the vaccine.
                 We stressed very strongly that the vaccine should be kept
           cold at all times. We told the drivers of the trucks to turn
           their refrigerators off-these were kerosene refrigerators-while
           moving along, and when they got to the destination, the first
           thing they should do is turn the refrigerator back on.
                 Well, I came across one truck one day, and it was probably
           100°F or so in the sun. He'd broken down. My first reaction was
           to put my hand down in the freezer to see if it was cold. It was
           hot. So I started giving him a bad time. "But, master," he says,
           "you said to turn it on when I got to my destination," and, of
           course, he was a long way from his destination.
                 But you could tell stories like this end on end.
Harrar:     What do you think were the biggest obstacles that you faced,
           that you had to find a way around?
Hutchins:   Communications, there's no question. For me to get in touch
           with my boss, Stan Foster [Stanley O. Foster], in Lagos was
           almost impossible. And to do it by courier took a long time,
           maybe another week or so, before you'd get an answer back. But
           communication, by all means, was difficult.
                 Transportation of vaccine-getting it from Lagos to Kaduna-
           was also difficult. I remember one time we were having problems
           with this, so we had one of the Americans put it on the plane in
           Lagos. We got to Kaduna, and the vaccine was not there.
           Unbelievable. To this day I don't know where it was. And we're
           talking about several thousand dollars' worth of vaccine.
Harrar:     When you were training the Nigerians, did you also learn things
           from them?
Hutchins:   Oh, yes.
Harrar:     Can you elaborate on that 2-way process?
Hutchins:   I guess, overall, the biggest thing you learn from all
           developing countries is that you're not going to change them a
           whole lot. They've been doing something one way, and they're
           going to continue doing it about the same way.
                 The first morning that we officially vaccinated, I had a
           schedule all made out. At 7:00, the driver is to be there; 8:00,
           we'd move out; at 9:00, we'd start vaccinating. Well, to begin
           with, the drivers didn't show up till after 9:00, and this was
           probably typical of where we worked.
Harrar:     Were there comical things that happened along the way?
Hutchins:   Oh, yes.
                 Well, thievery in developing countries is always a
           problem. We had these kerosene refrigerators, and kerosene was
           worth good money. So I went out one morning, and here's this
           fellow with a 5-gallon can of kerosene in his hand. "Oh," he
           says, "I'm not stealing, I'm putting it back."
                 I guess one of the funniest things that I remember
           concerned Dr. Foege [William H. Foege]. He had been in eastern
           Nigeria, and then the Biafran War broken out, and so they asked
           him to leave. He came up to northern Nigeria, where I was, and
           he said he would like to see some of my teams operating. So I
           gave him a truck and a driver, and he went out. About 3:00 in
           the afternoon, the Minister of Health called me and says,
           "Where's that Dr. Foege? You know, he came up from the east,"
           where, of course, there was fighting. And I said, "He's up-
           country."
                 And so they got the army out and picked him up that
           evening-they wouldn't let him break down his tent-and, under
           armed guard, brought him back to my house. Well, Dr. Foege is a
           very tall person to put in the back of a Land Rover, especially
           with an armed guard on both sides of him. And to hear Bill tell
           the story, he says, "I nudged one of these soldiers and said,
           'Would you mind moving that rifle over? It's hurting my leg.'"
Harrar:     Can't you just hear him saying that?
Hutchins:   Yeah.
Harrar:     Oh, boy. Okay.
                 I understand that you were involved in tracing monkeypox
           to humans in the 1970s.
Hutchins:   Yes. That was in Sierra Leone. I got a call about a case of
           smallpox in a small village. Well, this was after we thought
           smallpox had been eradicated from Sierra Leone. So I went out to
           this village and finally found the case. Clinically, it
           resembled smallpox; you couldn't tell that it wasn't smallpox.
           So I took a brief history and checked to see who had been
           vaccinated against smallpox, and this patient had not been
           vaccinated. I got some samples and sent them back to CDC. Well,
           again, communications. Two or 3 weeks later, I got a cable back
           saying, "This is smallpox. Look for other cases" because you
           can't have one case of smallpox without having another case.
                 So I started looking. After a few days, I got another
           cable from CDC saying, "This is not smallpox. It's monkeypox."
           If you grow it out on the allantoic membrane of chick embryos,
           you can differentiate the 2 viruses.
                 So I went back to the village again and took a better
           history, and, sure enough, this fellow had prepared a monkey to
           eat about 12 days before onset of his illness. This was a tribe
           that ate monkeys. He was the only one who had not been
           vaccinated against smallpox; the rest of the village had been
           vaccinated. This was good evidence that the smallpox vaccination
           also protected him against monkeypox.
Harrar:     Can you tell me a little bit more about the experience in
           Sierra Leone? How did it differ from the experience in Nigeria?
Hutchins:   Well, the day before we left the United States to go to Sierra
           Leone, WHO [World Health Organization] had reported cholera in
           West Africa for the first time, and so I called up CDC to get
           some information on it. I think I talked with Gene Gangarosa or
           one of the fellows in the enteric group, and they gave me what
           information they had on it off the top of their head.
                 I arrived at the airport in Freetown, and reporters were
           there asking how we were going to eradicate cholera; like we had
           eradicated smallpox? Of course, I didn't have any answers for
           them. It's a different disease, and you can't eradicate it like
           that. So I spent most of my time with the cholera program that
           we developed while we were there.
Harrar:     Were there things that you learned about public health in West
           Africa that you have been able to apply in your career since,
           either in some of these international places you worked or back
           in Maine?
Hutchins:   Well, if you see an outbreak of something, you take a different
           approach to it. Most practicing MDs aren't really interested in
           epidemiology, although you became interested in it once you'd
           seen how it can really help.
Harrar:     Is there anything that you wish you could have done differently
           in the way the program was run?
Hutchins:   Well, getting back to the communications, there wasn't too much
           that you could do to improve communications in those days.
           Today, of course, it's so much different.
Harrar:     And how would you say that this experience had an impact on
           your wife and children?
Hutchins:   Well, having lived with a different culture, especially a black
           culture, my kids have no racial bias at all. I don't know if I
           mentioned this before, but my oldest daughter went to school
           with 500 Nigerian schoolgirls, and I think there were 3 other
           expatriates in that school. My daughter has long blonde hair.
           The Nigerian girls were fascinated with this, and they'd come up
           and they'd feel her hair. She learned a lot. And the other kids
           went to various and sundry schools.
Harrar:     So your wife wasn't one who said, "How dare you make a decision
           like that?"
Hutchins:   Well, we had a good time the first 2 years in Nigeria. We went
           back to the States and swore we'd never go overseas again. We
           were back about 3 months, and we decided, "Well, gee, we really
           had a good time," so we went back to Sierra Leone. After Sierra
           Leone, I went with the State Department, taking care of the
           American Embassy personnel in these other countries.
Harrar:     So it turned you into adventurers for the rest of your life.
Hutchins:   Yes. And 2 of my daughters lived overseas after they were
           married.
Harrar:     Did any of them go into health?
Hutchins:   Two are nurses, and one married a doctor.
Harrar:     So, could you comment on the problems of health workers and how
           you could see that getting solved today, I mean from your
           experience seeing the need for trained health personnel?
Hutchins:   I realized that you could train uneducated people to do a
           health program. For example, these vaccinators that we had had
           very little education. Sterile technique was still unheard of,
           and we didn't really use much sterile technique. We did not
           clean off arms before people were vaccinated. We told the
           vaccinators that if they dropped the nozzle of the jet injector
           on the ground, clean it off with some alcohol or something. They
           would just brush it off and put it back on.
                 We did studies to see if there were any adverse effects,
           and there was no significant increase in infections from this
           lack of sterile technique.
Harrar:     And do you think that people can be trained who maybe haven't
           had an advanced education to do many of the tasks of public
           health?
Hutchins:   Yes. Especially something that's repetitive can be taught to
           most anyone. Matter of fact, there are places in West Africa now
           where they teach local people to do eye surgery. You know, it's
           one simple procedure, but they do it, and they have very good
           success with it.
Harrar:     I've heard it said, too, that if one wanted to really solve the
           problem of maternal mortality, if you could get some basic
           anesthesia capacity and some basic cesarean-section capacity,
           you could do an awful lot in field hospitals to save women's
           lives.
Hutchins:   Yes. I think there are places where they've taught the local
           technician to do cesarean sections. It's not that difficult.
           Now, if they run into problems, well, that is a problem, and
           they probably couldn't solve it. But 9 out of 10 go along as
           planned.
Harrar:     Better than obstructed labor?
Hutchins:   Yes.
Harrar:     Is there anything I can ask you that you haven't had a chance
           to speak about that you would like to?
Hutchins:   Well, it was a great experience. I would not recommend it to
           anyone if one member of the family didn't want to go overseas.
           As I said, I worked for the State Department Medical Program
           overseas afterwards. I saw some families that were sent over
           there and there'd be one dissenting family, and invariably that
           whole family was unhappy. They either had to be shipped out or
           would quit.
Harrar:     But, fortunately, you had a family full of adventurous people
           and curious people.
Hutchins:   Yes. Our kids were great, and my wife was great, and we had a
           good time.
Harrar:     Well, thank you so much. I really appreciate it.
                                    # # #
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
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&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with David Thompson about his activities in the West
Africa Smallpox Eradication Program. The interview is being conducted at
the Centers for Disease Control and Prevention, on July 14, 2006. This is
during the 40th anniversary celebration of the launching of the Smallpox
Eradication Program. The interviewer is Harrar.

Harrar:     Can you tell me where you received your early medical training?
Thompson:   I received my medical training at the University of Minnesota
           and graduated in 1965.
Harrar:     How did that prepare you for your experience with the Smallpox
           Eradication Program?
Thompson:   I had always been interested in international, global health.
           My parents were missionaries in South America. In my senior
           year, I received a Smith-Kline fellowship to work in a mission
           hospital in Cameroon for 3 months, and it was there that I
           became convinced that it was public health that needed the
           emphasis, not curative medicine; that was my primary goal from
           then on.
Harrar:     What was it specifically that led you to that conclusion?
Thompson:   I had the sense of a large population of people, a minority of
           whom ultimately came to the hospital, were treated, would go
           back home, and would keep coming back with the same problems. I
           realized that hospital-based care, as good and necessary as it
           is, didn't make much of a dent in things like mortality rates,
           etc. For me, it was confirmation that I wanted to go back to
           Africa, but I wanted to do public health. I had no idea that I
           would be involved in smallpox.
Harrar:     Can you be specific about the kinds of ailments that people
           might be better served by public health versus curative
           medicine?
Thompson:   Malaria is a big example; all the immunizable diseases;
           measles, whooping cough; malnutrition; TB, you name it. I
           realized then that I could have a much greater impact personally
           by multiplying my few gifts by working through physician
           extenders and by focusing on simple but effective community
           efforts of a preventive nature. Bill Foege [William H. Foege]
           impressed on me the other truth-that when you've got limited
           resources, you just prioritize and use those limited resources
           to serve the needs of an entire, clearly defined
           population/community.
Harrar:     Very interesting.
                 How did you come to be specifically involved with the
           Smallpox Eradication Program?
Thompson:   I was finishing a rotating internship at Hennepin County
           Medical Center in Minneapolis. It was the peak of the Vietnam
           War. I wasn't exactly a pacifist, but I was very, very
           uncomfortable with the war and didn't want to serve in it. So I
           applied to the Public Health Service (PHS). At that time I was
           planning on a medical missionary career, and I thought time as a
           PHS officer in the Indian Health Service would be good
           preparation.
                 I had a long application process. I was in the midst of a
           very busy internship. I had to have a physical exam that
           required going up to the Indian Health Service Hospital on the
           Cass Lake Indian Reservation. They discovered that I had a fair
           amount of dental work that had to be done before my application
           could be finalized. That took some time, and I thought I wasn't
           going to be accepted. I called all the various branches of the
           PHS, and everything seemed to be full. Then all of a sudden one
           day I got an airmail special delivery letter asking, "Would you
           be interested in going to Africa with CDC?" Nothing else. I
           said, "Absolutely," and that was the entree.
                 Dr. D.A. Henderson [Donald A. Henderson] came up to
           Minneapolis and interviewed us at the airport. When he found out
           that we were interested in medical missions, he proceeded to
           spend the rest of the interview talking about how poorly medical
           missions had done in the arena of public health. This was true.
           I left the interview very deflated, thinking, "Well, this won't
           go anywhere." And then, interestingly enough, we received the
           letter of acceptance.
Harrar:     What has been the contribution, do you think, of medical
           missions to the public health of Africa?
Thompson:   Historically, I think they've provided a lot of very good
           person-to-person medical care in terms of building hospitals,
           clinics, etc. Christian missions were pioneers in establishing
           medical and education institutions in the interior parts of many
           of these countries. A lot of these early missionaries died in
           the process of providing these services. But it was a system
           with fixed institutions. People came to these institutions. The
           philosophy was, "I'll take care of you if you cross my
           threshold," but then the people would go back out into the same
           situation, re-contract malaria and all the other diseases that
           you find in Africa, and then come back to the hospital. As time
           went on, studies showed clearly that most people died outside of
           the hospital. Historically Christian missions were slow to enter
           the field of public health.
                 I came at a time in medical mission work when there was
           beginning to be a shift towards thinking about a public health
           approach, and my involvement with CDC just confirmed that for me
           personally. Today, I think they're doing much more in terms of
           public health.
                 Later on I helped to start a totally community-owned and
           -oriented public health program in southern Chad, but I also
           provided regular medical care in the local government hospital
           and in our home.
Harrar:     What drew you, in your early life, to think that you might want
           to become a medical missionary?
Thompson:   I came from the rural Midwest, miniature Scandinavia. My
           parents were missionaries; they spent most of their lives in
           Bolivia and Ecuador. My father was a minister and a farmer, but
           he met all sorts of needs. I remember very well going with him
           up to the local village, taking care of people who had been
           severely burned. That instilled in me an interest in medicine
           that increased with time. I've always had an interest in issues
           of justice.
Harrar:     And what kinds of injustice have you seen that are most
           compelling to you that you wanted to fight?
Thompson:   Well, living in this time, injustice is such a huge issue. I
           have always been sensitive to the inequities, the imbalances,
           the increasing self-centeredness, and isolation that
           characterize our Western world, particularly the United States.
           My parents always allowed me to see and share in the suffering
           of others. They didn't hide this. As a matter of fact, they made
           me participate in it.
                 I remember very well when I was in early grade school. It
           was after the war, and my father insisted that we all sit up and
           listen to a radio program put on by the Lutheran World
           Federation, which then was focusing on the refugee situation in
           Germany. These were all very sad stories, and I remember wanting
           to go upstairs and hide.
Harrar:     And your parents wouldn't allow it?
Thompson:   No, no, they wouldn't.
Harrar:     I believe that Martin Luther King said that, of all the
           inequities there are in the world, the worst inequities are in
           health. Could you comment on health inequities?
Thompson:   Health inequities. I've spent 16 years of my life working in
           Africa, 12 of those in Chad, which is one of the poorest nations
           in the world. I had a child die on my dining room table from
           pneumonia. He'd been treated in the hospital, and he wasn't
           making it, so we took him into our house. My intervention with
           the limited resources we had did not work either. I watched so
           many children and adults die who didn't need to die.
                 And then we live in this very affluent country and culture
           with slums, a large homeless population, and millions of people
           without medical insurance let alone consider the utterly poor of
           the "two thirds world'. The United States is way down the list
           of industrial countries in terms of its giving to overcome
           global poverty. What our government does in this regard is
           pitiful.
                 These inequities can be overwhelming, but they don't need
           to be; we simply need to find a place where we can make a
           difference. And in my case, very fortunately, I had the
           marvelous opportunity to spend 4 years with CDC and the Smallpox
           Eradication Program. The 12 years in Chad were a wonderful time,
           when I was able to share and to learn, to participate. And,
           actually, I wanted to continue on in that work and spend the
           rest of my life working in Africa. But other things intervened
           and didn't make that possible.
                 So I struggle with the inequities even here right now. I
           work in an inner city, safety-net hospital, taking care of
           recent immigrant kids. So inequities are a part of my life.
Harrar:     Would you say that the inequities are greater in the developing
           world than they are here, or could you just comment on that?
Thompson:   They're of a different nature. It's interesting when you work
           in the inner city. There are certain strengths in African
           culture that aren't there in the inner city. There are ways in
           which a culture and the strengths that hold people together-the
           collective forces that make people help one another, that give
           people cohesiveness and commitment to a group-aren't as present
           in the inner city, but in Africa they're very strong. In Africa,
           excess of this commitment to community results in tribalism, but
           the very positive part of it is this tremendous allegiance to
           your clan, to your family, to your extended family. So the
           inequities are certainly bigger in Africa and in the
           underdeveloped world, but they are mitigated by the cohesiveness
           of the community and the concept of the extended family.
           Although the levels of poverty etc. in this country are
           certainly less, the inequities here are almost harsher and
           harder to tolerate because we could do something about it and we
           don't. So I think our failings or our guilt-if I can talk about
           guilt-is bigger here because it's our own country and our own
           people and we could do so much more. That does not take anything
           away from the responsibility we need to take to address global
           inequities and poverty.
Harrar:     I'm working on a series about health disparities right now in
           the United States so I'm just curious whether you see those as
           being directly involved with race or with socioeconomic status?
           Which is bigger in your own experience?
Thompson:   Our history of racism has had a very negative effect on our
           society. The result of that has contributed to a loss of
           identity and culture that has been very disruptive to family and
           community life. There are obvious and severe economic effects as
           well. There is a tendency to become callused towards this, to
           live in affluence with blinders on so we don't see the sadness
           and turmoil that are there. The solution-or at least an
           approach, if there is one-is to share, in some tangible way, the
           suffering of someone, somewhere (preferably close by) so that we
           don't lose sensitivity and become callused, isolated, thinking
           only about acquisition, protection, insurance against all
           suffering, and the need to live looking eternally young.
Harrar:     When you wake up in the morning and think, what's the meaning
           of my life, have you found some comfort that you . . .
Thompson:   Yes, I do. I wake up in the morning looking forward to the day.
           I come from a conservative religious community, Lutheran
           background, and right now I'm concerned about reawakening in the
           church a sense of biblical justice. The Bible is full of a
           prophetic kind of advice and wisdom that is concerned about
           taking care of the poor, the widow, the elderly, and the
           refugee. I wake up with hope, and I've got a good job that
           allows me to do this. We have a large extended family that
           reaches around the world. A wonderful part of this has been
           having a wife and a family who have been very supportive; they
           have been a very key part of this all along. I wouldn't have
           been able to do it without Joan.
Harrar:     Did you take your family abroad when you worked?
Thompson:   Oh, yes. When we went to Nigeria, the Biafran War was brewing,
           and our families were evacuated before the first year actually
           came to an end. Joan was 8 months' pregnant with our second
           child, who was born later in the United States. Then we were
           reassigned to Liberia, and our last child was born there. When
           we went back to Africa to work with the church, they were all in
           grade school; they all graduated from high school in Nigeria
           before returning to the United States for college. We raised our
           family in Africa. I'm very, very thankful for that.
Harrar:     How would you say that has changed their worldview?
Thompson:   Their worldview is such that they tend not to see color.
           They're similarly interested in living justly, if I can put it
           that way, in sharing.
                 Our daughter has 2 daughters; they live in Billings,
           Montana. One of the neatest things they did, when the girls were
           probably about 8 and 6 years old, was to get a list from United
           Way of families that needed specific things at Christmastime.
           They went out and the girls helped shop for all of these things.
           Then they actually delivered these things to United Way; that
           made a lasting impression.
Harrar:     So you have a sense that you were able to pass on to your
           children what your parents taught you.
Thompson:   Yes. I'm very thankful for what my parents gave me, and I'm
           thankful for the lessons we learned together as a family in
           Africa. One of the things we did was have our children
           participate in our life and activities, even though that
           involved interruptions, doing without things, and some degree of
           hardship. One night our children, who were in the latter grade
           school years at the time and home on vacation from their
           boarding school, were chatting. They were talking about parents
           who weren't available and weren't around. I kind of got the
           sense that they might be talking about me, so I said, "Well,
           look, I'm here every day; I'm here at night." And they replied,
           "But, Dad, you fall asleep." My work frequently took me out into
           the villages on motorbike and that sort of thing. I loved the
           work, but it was taxing and our children experienced a father
           who was often pulled in many directions and sometimes over-
           extended. But I think my children were able to accept and adjust
           to that and ultimately were able to share some of the sense of
           accomplishment that came from it.
            They're all doing similar things in very different arenas
           today. Our son and wife are actually going to Liberia to adopt 2
           Liberian girls this summer, we hope.
Harrar:     How exciting, that's great.
                 Can you tell me, on a day-to-day basis, what kinds of
           things did you do for the smallpox eradication effort? And tell
           me about Dr. Foege, too.
Thompson:   Yes, I had the good fortune of being assigned to the Eastern
           Region of Nigeria with Bill Foege and Paul Litchfield. I don't
           know why we were assigned together, but I suspect it might be
           the fact that Bill was a missionary at the time on contract to
           the smallpox program, and I was interested in medical missions.
           Paul Litchfield, our Operations Officer, had also been a Mormon
           missionary. I considered myself extremely fortunate to be part
           of this team!
                 We arrived in Enugu in the fall of that year, and very
           soon there was a major smallpox epidemic that produced over a
           thousand cases. The epidemic was centered in the area where Bill
           had worked before with the mission; consequently, he knew key
           people and understood the area. One of the missionaries was
           particularly helpful; he supplied us with motorbikes and we went
           hunting smallpox. For weeks, we (Paul Lichfield [Paul R.
           Lichfield], Bill, and I) spent most of the week out in the
           countryside trying to track down smallpox and organizing an
           official vaccination campaign. Then we'd come back on weekends
           and crash. It was tough on our families, specifically my wife
           and Paul's wife, who had never been overseas. For me, it was
           kind of a lark. I was having fun.


                 While the smallpox epidemic was raging in Ogoja Province,
           pressure was being applied to conduct a vaccination campaign in
           Enugu, the capital city. We temporarily moved our activities to
           Enugu. One day, Bill, Paul, and I were going around Enugu with a
           big map, looking for logical gathering sites to vaccinate
           people.
                 People started gathering around, and pretty soon policemen
           appeared; we were arrested and brought to the police station. In
           the context of all the fears and stories circulating about the
           atrocities etc. that preceded the war, our maps and activities
           looked suspicious. The police called the Ministry of Health, and
           Dr. Anazonwu, our counterpart, came down and said, "Fine, no
           problem." We were immediately released.
                 Towards the end of the Ogoja epidemic, we began hearing
           about hidden smallpox cases among people in a big town who
           belonged to a group called the Faith Tabernacle. This religious
           group refused immunization and vaccination. They were hiding
           these cases because they feared having vaccination forced on
           them and because the patients themselves would be sent to the
           huge isolation camp that the Ministry of Health had set up out
           in the bush. With the help of one of the health inspectors, I
           was able to investigate the epidemic and identified 4 distinct
           generations of smallpox that were being transmitted in this
           submerged and interrelated community without spreading to the
           rest of the community. Unfortunately, the conditions leading up
           to the Biafran War started heating up and we had to be
           evacuated. So, really, my memories of smallpox and the program
           in Nigeria are limited to the above
Harrar:     And your own faith, experience with faith, was that helpful to
           you in getting this group to open up to . . .
Thompson:   No.
Harrar:     No?
Thompson:   No, no, no.
Harrar:     That did not apply?
Thompson:   That didn't apply.
Harrar:     What other cultural obstacles did you encounter?
Thompson:   Fear of vaccination was the biggest thing along with the fear
           of being sent to the isolation camp if you were diagnosed with
           smallpox.
                 For the most part, the obstacles weren't all that great.
           The obstacles were more mechanical, just getting teams into the
           field, keeping them going, keeping them supplied. I think
           ultimately the people appreciated and cooperated.
                 The Ministries of Health weren't all that excited
           initially about smallpox eradication. They wanted measles
           immunization, and we had to combine measles immunization with
           smallpox to get to the smallpox program accepted.
                 I encountered a lot more cultural issues in my later work
           than I did in smallpox.
Harrar:     How about politics, either here in the United States or in the
           countries where you were working? Any comment on that?
Thompson:   I can't comment very much on politics.
                 Our time in Nigeria was so brief that our relationships
           were limited to one small sector of the Ministry of Health. Of
           course the fears of genocide and the tensions that led up to the
           Eastern Region's withdrawal from the federal government and the
           civil war were increasingly occupying people's attention and
           those did get in the way.
                 In Liberia the times were stable; the physician in charge
           of infectious disease and our immediate supervisor was a very
           wise and gracious ex-Haitian who did all the political
           interference. So we didn't have any political issues that I can
           recall.
Harrar:     Okay. You were starting to say that there were more cultural
           and political things when you worked in other places (in Chad
           more than in Liberia).
Thompson:   Generally speaking, working cross-culturally in Sub-Saharan
           Africa is difficult. There were often old historical distrusts
           and animosities. However, the area we were working in Chad had
           primarily one ethnic group; they had a long tradition of strong
           leadership and that was very helpful in organizing a community
           program. They had, in effect, a king; they were used to working
           together and that contributed significantly to the ultimate
           success of the program. In Chad, my work involved setting up a
           very simple healthcare system using lay volunteers, young
           farmers, whom we trained. They were able to treat malaria,
           prevent dehydration with oral rehydration, take care of simple
           wounds, and give a treatment for intestinal parasites as well as
           educate by example. An immunization program in participating
           villages was carried out with the cooperation of the local
           government hospital. We were there 12 years. After about 6
           years, I turned responsibility over to a Chadian nurse and
           worked as his advisor for an additional 6 years before leaving
           permanently. We chose the leadership carefully.That and the
           cultural cohesiveness helped them not only to continue on their
           own, but also to thrive.
                 There were relatively few cultural barriers with the Chad
           program. It was the cultural strengths of the community itself
           that made our work possible. I think we would have encountered a
           lot more barriers if we had started to expand this program
           beyond this limited population, to work interculturally.
Harrar:     How important do you think a primary healthcare system is to
           solving a global problem like smallpox or polio eradication?
Thompson:   It's part of the answer. The eradication of smallpox was a
           special case; it was basically achieved by applying massive,
           regional programs of a vertical nature. These regions of the
           world had minimal primary care resources, but that did not
           prevent them from mounting special mobile campaigns with the
           help of well-targeted and effective outside technical and
           financial assistance. The eradication of polio would prove to be
           much more difficult and more dependent on primary care
           resources. Even when I was with smallpox, I started thinking
           about how the eradication effort could be used to build primary
           healthcare at the local level. One thing the smallpox
           eradication effort did accomplish in respect to primary
           healthcare was the practical epidemiologic and managerial
           expertise it left behind in each country. The development of
           successful primary healthcare systems is highly dependent on
           operating from a firm public health/epidemiologic base! However,
           I didn't get a chance to apply what I learned in the smallpox
           program until I returned to Africa in 1975 under the auspices of
           our church. The goal then became to create a simple, self-
           sustaining, primary healthcare system with immunization as a
           core feature.
                 There are several unique healthcare systems operating in
           countries like Chad. The primary and most obvious is the
           government system, which is very centralized, poorly managed,
           and poorly supplied, for obvious reasons. Chad is one of the
           poorest countries in the world with very little infrastructure.
           (The main clinic building in Léré dated from the pre-World War I
           German colony era.) Another system, which I call the emerging or
           chaotic system, is the sale of almost anything in the
           marketplace. In addition, many families have a little box of
           medicines they received from their city relatives. And finally
           you've got the traditional healthcare system that includes
           herbalists, bonesetters, diviners, etc.
                 Unfortunately, with the passage of time and the
           availability of miracle medicines (antimalarials and
           antibiotics), an attitude arose in the popular mind that the
           individual is not really capable or responsible for his/her
           healthcare; an expert/outside agent provides that. The people
           lost their ability or confidence to care for themselves that
           they had, even though much of that care may have been
           problematic. So the long-term answer is to build a primary
           healthcare system that restores self-confidence along with local
           responsibility and control.
                 Large vertical programs have their place, and smallpox was
           probably the best example of a successful one. But I think as we
           move on from that, there has to be more emphasis on creating
           locally owned, locally driven, primary healthcare systems that
           nonetheless work within the system, subject to the local
           authorities. Good technical expertise and public health
           principles need to be coupled with local decision making as part
           of a more global national effort. This is what our program in
           Chad was all about, but we accomplished only the first step by
           establishing a program in a single cultural community. The next
           and harder step will be to grow related programs in other areas
           and cultures.
Harrar:     You mentioned that the local people you trained were
           volunteers, and I know there's a long history of community-based
           volunteers in many parts of Africa.
Thompson:   Right.
Harrar:     At the same time, I hear people like Jim Kim and Paul Farmer
           saying they think healthcare workers should be paid. You know,
           why should we ask the poorest people in the world to volunteer?
           Could you comment on that for a moment?
Thompson:   How are you going to pay for primary healthcare, and where do
           you start? One way is to pay them. Well, where are you going to
           get the money? These are subsistence farmers. The system that
           the villages agreed upon was that they would give each volunteer
           2 sacks of corn and I think 4 liters of cooking oil a year, plus
           some work in their fields. They didn't receive any money for the
           care they rendered. The medicines given to patients were sold at
           cost. This way they established a revolving fund that enabled
           them to buy new medicines. The reimbursement of the health
           workers, however, was always a problem, and it was tempting to
           dip into the health post funds. But how else are you going to
           start? In this case, most of the health workers were motivated
           by their Christian faith to be of service to their community
           without expecting anything in return. (The villagers, the great
           majority of whom were animist, selected the workers. There were
           absolutely no requirements as to church membership or religion.)
                 The other way is to pay for them from abroad, and then
           you're creating dependency. One of the rules we started out with
           was that we were going to use available technologies and
           available resources so that when I, as the white physician left,
           people couldn't say, "Well, I can't do this because he had
           this." So I limited my work resources. For instance, I rode a
           mobylette or a 100-cc motorbike, rather than a car. In similar
           ways I attempted to do my work in such a way so that the Chadian
           nurse who I trained and mentored could follow in my footsteps.
                 Ultimately, primary healthcare is linked to economic
           development. I always foresaw the next stage as not more
           healthcare, but economic development and local industry, doing
           something with agriculture so that people had more money. More
           resources would then be available to invest in the next stage of
           health development. Government is always a wasteful, albeit
           necessary, manager of resources. We need to foster development
           in a progressive, step-by-step manner with recurring cycles of
           very simple primary healthcare as we did in Léré, then economic
           development, then another level of healthcare, and so on, all
           based on developing sustainable local economies. The healthcare
           and economic cycles could of course go on simultaneously, but it
           is important that they be coordinated and go at a speed that is
           manageable by the local community. Unfortunately, we weren't
           able to see the next stage of economic development, but from
           reports, that seems to be happening currently. The program that
           I began is still going and actually expanding. But I wonder
           whether it can survive in the long term because of the economics
           and because they're just one local organization. They're limited
           to a sub-prefecture, 100,000 people. My dream was to take this
           model, build in adjacent areas, and then let it spread by
           itself. Hopefully, this may take place someday. I don't know.
Harrar:     What you said sounded very much like the Tau leadership. Have
           you read about that, that I go into the village and I talk to
           the people about what they need?
Thompson:   Yes.
Harrar:     I knew that I had succeeded if, when I left, the people said,
           "We can do this ourselves." It's a very powerful idea.
Thompson:   Yes. There's a story that I believe came out of Guatemala. A
           hospital in a rural area had difficulty in expanding their very
           good public health programs to villages in the near by
           mountains; the hospital wasn't having any effect on this group.
           Finally, in desperation, they sent someone up there with the
           question: "What are your problems?"
                 "Oh," they said, "our chickens are dying."
                 So they sent staff up to find out what the problem was
           with the chickens, solved it, and that was the entrée. If I had
           to do this all over again, I would have done a lot more of that.
                 I came in with good ideas and said, "This is the primary
           healthcare model we're going to start with," and as time would
           tell, the better way would have been to simply to come and say,
           "Okay, how do we do this, and what are your needs?" So I made
           mistakes.
Harrar:     But that's how you learn. Right?
Thompson:   That's how you learn. That's right.
Harrar:     So were you trained by the West Africans, or the East Africans?
Thompson:   West Africans.
Harrar:     Do you see lessons from the Smallpox Eradication Program that
           can be applied today to public health, other public health
           problems?
Thompson:   The model of the smallpox program was really simple, had very
           clear goals and objectives, and it used non-physicians
           extensively. I think the physicians were a necessary element,
           but the role of the Operations Officers was equally important.
           It was the people behind the scenes and the PHS Operations
           Officers who kept the vehicles running, who made sure there were
           adequate vaccine supplies, who kept the cold chains intact, who
           did a lot of the team teaching, supervision and mentoring. That
           was the real secret.
                 All of the countries were coming out of the colonial
           period with a certain legacy of hierarchy and beaurocracy. For
           instance, when it was proposed that I go to Liberia, there was a
           reluctance to accept me as an epidemiologist because I was just
           a recent graduate. I'd just finished an internship; I didn't
           have a public health degree at the time. There were a number of
           people like this. There was a tendency to believe you needed
           degrees and experience. One thing this program showed was that
           if you had professional staff with the basic medical background
           who were adaptable, teachable, creative, hardworking, and well
           supported, you could do almost anything. (The brief training
           provided by CDC before we left for Africa, that included the
           summer EIS course, was superb.) A good understanding of basic
           epidemiology was also critical. The proof of this is in the
           results of the program.
Harrar:     Can you elaborate on the epidemiology aspect of it? What were
           the challenges and the keys to that?
Thompson:   The epidemiologic keys pretty much came from Bill Foege and the
           principles behind his notion of eradication-escalation. First of
           all there are almost no cases of smallpox infection that are not
           quickly and easily recognizable. So the first step was to
           achieve a high level of herd immunity and a low incidence of
           smallpox by means of mass vaccination campaigns. Random sample
           vaccination scar surveys were then carried out to insure that
           the vaccination take-rates or immunity (as measured by a recent
           vaccination scar) were indeed adequate. The next step was to
           have a good surveillance system in place so that any suspected
           case of smallpox was reported and aggressively investigated.
           When cases were identified, the final tactic was to do ring
           immunization in the community around the case and look even more
           aggressively for other cases. It was simple and brilliant.
                 I think CDC did a marvelous job of putting resources
           behind this program so that we didn't run into mechanical
           roadblocks like lack of well-functioning equipment. One of the
           major problems was that the 4-wheel-drive vehicles were breaking
           down, but the needed axles were going to Vietnam, and so they
           had to scrounge and make do. But they always came up with
           solutions. The administrative backstopping by the Atlanta and
           Lagos staffs, and their ability to work things out with USAID
           [US Agency for International Development] and WHO [the World
           Health Organization], for instance, were extremely important.
           Finally the CDC staff on the ground in the individual countries
           and their partners were resourceful and became adept at finding
           local solutions.
Harrar:     So, how did you personally feel about being part of this
           program? In your own life and career, would you rate it right up
           there, or . . .
Thompson:   Oh, man. My involvement in the smallpox program was a mountain
           peak that I, in many respects, felt I didn't deserve; I consider
           myself extremely fortunate to have been a part of this. The
           opportunity to work with Bill Foege and to keep up that
           friendship down through the years has been stimulating and
           wonderful. All you have to do in public health circles is drop
           the word, "I was with smallpox," and you've got recognition.
Harrar:     Are there any funny, heartwarming, or terribly important
           stories to you that you'd like to lay down on tape?
Thompson:   Everybody knows Bill Foege; he's great! He has a fabulous
           memory and is one of the best story tellers around. He is
           extremely competitive, and once had a contest with an office
           mate as to how early they could get to work. Bill won that hands
           down!
            A secretary found him reading an airline schedule book and
           asked, "What are you doing?" Bill responded in all seriousness
           that he was memorizing the schedule. A bit suspicious, she asked
           him what the connections were between 2 specific cities. As luck
           would have it, he had been looking at exactly that specific
           connection and rapidly gave her the correct data. She was very
           impressed. Bill remained silent.
            Later Bill told a story of when he was in India with the
           smallpox program. He traveled frequently on the trains and made
           friends, as he was wont to do, with the conductors and staff. A
           staff member was leaving the country and Bill volunteered to
           take a large crate of personal effects with him to the coast. He
           got the train officials to agree to carry the crate without
           charge or papers. Arriving at the destination, the crate was
           unloaded, and Bill was heading out of the station. Some customs
           officials stopped him and asked for the papers on the crate.
           Realizing he was in a jam, he acted as if he couldn't understand
           and began talking in German. I believe he even began reciting
           the Lord's Prayer when his limited German ran out. His ruse was
           at the point of being discovered when the officials were
           interrupted by more serious problems and disappeared.
            Our counterpart in eastern Nigeria, Dr. Anazonwou, could never
           pronounce Dr. Foege's name, and he always called him Dr. Fog,
           which is kind of humorous considering who he is.
                 But I had other goals and after 4 years with smallpox, it
           was time to move on. We wanted to return to Africa as medical
           missionaries, but for some reason, those doors didn't open up
           right away. We went to Baltimore, where I received an MPH
           [Masters in Public Health] in international health. Since
           pediatrics seemed be the best clinical preparation, we returned
           to Minnesota, where I finished a residency in pediatrics at the
           University of Minnesota. By that time things were ready, and we
           returned to Africa.
Harrar:     And what do you see now as the biggest challenge in pediatric
           health for the children of the world and the children here in
           the United States?
Thompson:   It's interesting. The challenges for pediatrics in the United
           States are to provide access for all, to decrease the cost of
           medical care, to recognize the fact that a lot of the services
           we as physicians provide are not truly effective in terms of
           improving health and that a number of these services can be
           better provided by non-physicians. Our well-child checks (WCCs)
           are an example. There are good data to show that WCCs are a very
           ineffective use of resources. One of the things that I try to
           encourage our trainees to do is to think: how can we live and
           work in this environment in such a way that we use fewer
           resources so that we can devote more resources to kids in the
           underdeveloped part of the world?
Harrar:     And what do those children need?
Thompson:   Oh, boy. Well, the children in the rest of the world need
           peace, first of all, and that's a major failure on our part.
           They need local resources. They need training. They need
           opportunities for training. Probably one the hardest experiences
           for us was to see bright young kids who would have to take their
           exams multiple times or bribe an instructor in order to get
           their baccalaureate and graduate from the lycée. The corruption
           in the system was such that passing marks were frequently not
           enough to get a diploma. And then there was so little
           appropriate employment available once they did graduate. Not too
           surprisingly, we need education, job opportunities, and local
           development, so we don't have brain drain or brain loss (from
           lack of opportunity and use).
                 I always liked the bumper sticker that says, "Think
           globally; act locally." Right now, probably the biggest
           hindrance is our tremendous affluence and this political climate
           that we've created today, which is not only getting in the way
           today, but also will for decades.
Harrar:     What do you see to be the problems the way people are today?
 Thompson:  9/11 created an attitude of paranoia. As Americans, we weren't
           used to being attacked on our home ground. We've always been
           very cocky and self-assured. We could live in an isolated
           fashion without really suffering too much. But 9/11 kind of blew
           that all away. Unfortunately the reaction was to become even
           more insulated, self-protective, and defensive.
                 There is a glaring gap between the "haves" and the "have-
           nots" in the United States. An example from the healthcare field-
           and this has gotten a lot of press in Minnesota, the home of the
           whole HMO [health maintenance organization] idea-the CEO of
           United Health Group, a large HMO, received a total compensation
           of $124.8 million in 2004. Then look at the poverty rates and
           the rates of the uninsured! We live increasingly in an
           environment where we are repeatedly being invited to become more
           self-interested, self-protected, suspicious, and reactive to
           anything that looks contrary to our interests wherever that
           might be. Then we get involved in this war in Iraq. It is going
           to be very hard to recover from this and to move on.
Harrar:     Do you see some hope in other sorts of small things that are
           going on?
Thompson:   Oh, yes. There's lots of hope. The smallpox program created
           tremendous hope. And I think the program that we started in Chad
           does too. They've not only continued but have grown under total
           local leadership and financing. And we've seen our children grow
           up and do good things. Then you come back to a place like CDC
           and run into all these people and see what people are doing.
           Yes, there are a lot of good things going on.  There is plenty
           of hope
!Harrar:    Okay. Well, we thank you so much. That was really interesting.

                                    # # #
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. Stanley Foster about his activities in the
West Africa Smallpox Eradication Project. The interview is being conducted
at the Centers for Disease Control and Prevention as a part of the 40th
anniversary observance of the launching of the West Africa program. The
date is July 14, 2006, and the interviewer is Victoria Harden.

Harden:     Dr. Foster, would you begin by just briefly describing your
           childhood and your growing up, and who made you who you are.
Foster:          Okay. I grew up in Melrose, Massachusetts. My family was
           very religious. My father died when I was 9 years old, and one
           of the things that happened soon after that was I met Gordon
           Seagrave. He was the famous missionary surgeon whose Burmese
           nurses provided the medical care to Stillwell's troops during
           World War II. And he became my role model. From that stage on, I
           was going to be a doctor. I went to Williams College and then
           went on the University of Rochester.
                 I think the connection to CDC was through D.A. [Donald A.
           Henderson], who also graduated from Rochester, as did Deane
           Hutchins. At that time, in early '62, they were drafting
           doctors, so I decided I'd rather come to CDC than go to the
           Army, so I came here. One of the interesting things that sort of
           started it off was that with 2 "F" names, Bill Foege [William H.
           Foege] and I sat next to each other in the EIS class of '62. I
           was assigned to the Indian Health Service in Arizona and carried
           out 18 epidemiologic studies. My basic assignment was for
           trachoma. At that time, about 20% of the Indian children had
           trachoma.
Harden:     Had you specialized in infectious diseases or anything in your
           medical training?
Foster:     Internal medicine was my field. And, as was often the case,
           Alex [Alexander Langmuir] would try to seduce officers he wanted
           to stay. He sent me to Bolivia to investigate an outbreak of
           conjunctivitis in Peace Corps volunteers. I came back to my home
           in Phoenix, got to Atlanta at about 3:00 in the morning, and at
           6:00 in the morning I was on a plane back to Phoenix and on the
           way to the Truk Islands in the South Pacific to investigate an
           outbreak of diarrhea with Palmer Beasley.
                 The assignment was an epidemiologist's paradise because a
           boat would only go out to an island once a month. You would know
           the entry point, and there would be a health worker there who
           would write down the cases and the names. It was a great
           epidemic. And the pattern of transmission was that of influenza,
           but the disease was diarrhea. We brought back the specimens, and
           the lab tested them out. They couldn't come up with an agent. We
           tried to write up the article several times, but without an
           agent, we couldn't. Twelve years later, when I came back from
           Bangladesh in '76, the lab called me and said, "We just found
           out what your '64 outbreak was. It was a rotavirus."
Harden:     Rotavirus. Ah.
Foster:          So we pulled out the article, finished it, and got it
           published.
Harden:     So you were doing epidemiology up until 1966?
Foster:          Well, no, that's not quite true. I did my EIS training
           from '62 to '64. Then I left CDC and went back to Rochester for
           a year of residency. Then I went to the University of California
           in San Francisco and did a fellowship in pulmonary disease. I
           probably would have stayed on in San Francisco in pulmonary
           disease, but I got the call from D.A., saying, "Do you want to
           go to Africa and get rid of smallpox?" My wife and I thought
           about it, and we decided after 24 hours that was right. We had 3
           kids at the time, and I think one of the things we need to
           discuss is wives and kids.
Harden:     Yes.
Foster:          In terms of the impact of those experiences on the kids.
           Three or 4 of my kids' careers developed out of experiences with
           smallpox. My oldest son was interested in traditional medicines,
           and he now does Internet work in China. My second son, when he
           was in the 8th grade in Dhaka, Bangladesh, did a study of
           rickshaw drivers and how much of their income they spent on
           food. Now he's the chair of the Department of Economics at
           Brown. My third son got his start, really, in 1974 in
           Bangladesh, when we had tremendous floods and a famine. People
           were dying on the streets in front of our house. And he decided
           to go into medicine. I had no knowledge of the impact that the
           famine had on him until I read his Peace Corps application. And
           then I understood that that experience, back in '74, was the
           major event that sent him into medicine.
Harden:     This is very interesting. You said you came from a religious
           family. Were they missionaries or ministers?
Foster:          No, my wife's folks are missionaries. They went to
           Guatemala on their honeymoon. And her mother was interesting.
           She refused to go as a missionary wife. She said she'd only go
           as a missionary, and that was back in the '20s. They went down
           to Guatemala and learned Spanish. Then they learned Mayan and
           put the Mayan writing into a written language. And then they
           translated the New Testament. They had a school and a clinic.
           They stayed there for 45 years. Every year or 2, my wife and I
           go back to that same town. My wife is fluent in the Mam
           language. We have a nurse we work with, and she tells us what
           she wants us to teach.
Harden:     I'm interested in this streak of idealism.
Foster:          Oh, you should get a copy of my college caricature. I have
           a digitalized copy. It shows me sitting in a pot in Africa, with
           the pygmies standing around. "Bless this food to our use" and
           "Dr. Stanley, I presume" written at the bottom. I did have a
           missionary bent at that point in time.
Harden:     I'm seeing a different type of person who has been involved
           here at CDC with the smallpox program than what I have seen with
           investigators at NIH [the National Institutes of Health] in
           terms of the things that motivated them to go into research.
           Let's talk about once you were recruited into the program. They
           asked you apparently to recruit others, as well. And you
           mentioned that the recruitment of this 1 person.
Foster:          Andy Agle [Andrew N. Agle].
Harden:     . . .was interesting?
Foster:          Yes, it was very interesting. Andy was a public health
           advisor and a good mechanic. I remember, I met him at a building
           in San Francisco. He walked in, and he said, "I saw this
           advertisement that you wanted a public health person who spoke
           French and was a good mechanic, and I knew you needed me." That
           was it.
Harden:     Very confident.
Foster:          Yes, he was, there was no question about it. Andy turned
           out to be one of the best. He worked for a long time in West
           Africa; then he was working with smallpox in Afghanistan. He was
           getting bored with Afghanistan, and I brought him to Bangladesh.
           Then he worked for many years at the Carter Center and was very
           close to [President] Jimmy Carter. He did a lot of agricultural
           stuff and really worked incredibly well with the Carter Center.
           And then he took a job in Nigeria. He died about a year ago.
Harden:     Initially, you were the medical officer in Nigeria. Would you
           tell me which region you were in, and what you found?
Foster:          Well, I was responsible for the whole country. At that
           time, Nigeria had 4 regions. the West, the Midwest, the East,
           and the North. About half of the population was in the North and
           about half in the South. We had Margaret Grigsby and Jim Lewis
           in the western region; Warren Jones was in the Midwest; Bill
           Foege, Dave Thompson [David M. Thompson], and Paul Lichfield
           were in the East; and Deane Hutchins and Vicky Jones [Clara
           Jones] were in the North. And it was a very different program in
           the North than in the South.
Harden:     Would you tell me about that?
Foster:          In the North, the traditional leadership was incredibly
           strong. I remember the first village I went to, Gwadabaw, in
           '66.I got there at 6:00 in the morning, and there were 6,000 men
           in a line. We vaccinated the men, and then they went home, and
           then the women came out. Well, for the women to come out was a
           big social occasion. They really didn't want to go back in.
                 But I learned something that day, which was very
           interesting. It was a big district, and I told the district head
           that we should have 3 vaccination sites in his town because it
           would take us too long to do it at 1 site. He said, "I forbid
           you for doing that." He says, "Everybody has to be vaccinated in
           front of me. Nobody will tell me that they were vaccinated if it
           had to be in front of me, whereas if there were 3 sites, they
           could be tell me they were vaccinated when they weren't. The
           Emirs of Sokoto, Katsina, Kaduna, and Kano were very powerful
           people. The Emir of Sokoto would ride around in his Mercedes
           every night, and if there was no petrol, the Mercedes got pushed
           around town. But he was very powerful. So the only thing that
           you had to do in the North was to convince the Emir, and he
           would call in his district heads, and then everything would
           happen. It was easy to get 96%-98% coverage in that region. In
           the South, it was much more difficult. The people would not go
           200 or 300 yards for vaccination. People were much more
           independent in the South. There was not the structure, and it
           made it much more difficult to get people to come for
           vaccination.
Harden:     Why would they not want vaccinations?
Foster:          Well, I think if you go historically back, there was a
           demand for injections. We believe that occurred secondary to the
           yaws program, which gave shots of penicillin to treat yaws. But
           it cured venereal diseases and pneumonia and everything else. So
           injections were always sought after. In the North, the structure
           was such that people would be told to do it and they'd do it. In
           the South, you had to really convince them or use enough
           publicity to get people to come for vaccination. So it was a
           totally different thing.
                 And the epidemiology of measles was different. In the
           North, where the women are in purdah, or where the population
           density was relatively low, the median age of measles was about
           36 months. In Lagos, where you have mothers carrying their
           babies on their backs to market, the median age was around 14
           months, and then that was with a population of 600,000. When I
           went back in the '80s and '90s to Lagos, which now has a
           population of over 10 million and possibly 20 million, the
           median age of measles had dropped even further, to around 8
           months. Controlling measles was impossible.
Harden:     What was the toughest problem you encountered?
Foster:          Oh, the Biafran civil war. I had flown to Benin to see
           Warren Jones there. I got off the plane, and Biafran hijackers
           got on and hijacked the plane. And that plane later was used to
           bomb Lagos. It was very interesting: we believe that they were
           using the passenger plane as a bomber, defusing the bombs, and
           throwing them out the door. We felt that probably the reason
           that the plane exploded was because the bomb went off before it
           got out the door. Of course, they had to find somebody who was
           asleep at their gun to reward for shooting this plane down. That
           was tense, and a lot of people were evacuated.
                 I was talking with Deane Hutchins at lunch. I took the
           kids and my wife up to Kaduna because I thought it was safe. The
           next day, they bombed the Kaduna airport. But one of the
           interesting things at that time, we knew there was no smallpox
           in Biafra; but I was really afraid smallpox would get into
           Biafra. So I convinced the government that the safest thing for
           them to do was to vaccinate a large area around Biafra so that
           the smallpox wouldn't get out of Biafra into Nigeria. That way
           we kept it out. We also vaccinated a lot of children coming
           through the lines. The malnutrition in pockets of Biafra was
           just absolutely terrible. I think the war was really the
           toughest obstacle. The regional office was shattered by the
           bombings in Lagos, and it was not as safe a place as it had been
           before that.
Harden:     How did you get along with your counterparts?
Foster:          Oh, I had the most wonderful counterpart in the world, a
           fellow by the name of Yeme Ademola, who had gone to the Harvard
           School of Public Health. If you go back into the history of the
           smallpox/measles program, USAID [US Agency for International
           Development] wanted to do all the countries except Ghana and
           Nigeria. And Ademola was one of the ones who achieved its
           inclusion in the program He actually went and met with Senator
           Kennedy [John F. Kennedy] to push that.
                 Yeme was just so honest. He looked out for the poor. For
           example, he had a cooperative grain bank, where he would buy
           produce when the price was low, and then they would sell it when
           the price was high. He supported a clinic. He was just an
           absolutely wonderful guy, and he also was my neighbor. So he and
           my wife would often go out and have tea with Yemi and his
           British wife. He also is the subject of the most traumatic part
           of my time in Nigeria. I got a call one night about 3:00 in the
           morning, Rosa, his wife said that he had been attacked. When I
           arrived at the front door, the murderers went out the back door.
           He had been macheted across the neck. I went in and tried to
           save him, but I couldn't. And at that time, I wasn't thinking of
           my wife, who was pregnant. Panicked about me, she started to
           abort. It was a horrible day. And then the next day, the police
           came and wanted to put me under arrest for Yemi's murder. After
           a 6-hour standoff, the American Embassy got me off on account of
           my diplomatic status. So that was the single most traumatic
           event of my years in Nigeria.
                 We had an incredibly interesting team. We had Deane
           Hutchins and Vicki Jones. My favorite story of Vicki was when
           she went out in the field once for 4 or 5 weeks, and she'd
           either broken or forgotten her mirror. When she came back to
           Kaduna and looked at the mirror, she said, "Something's wrong."
           And then she realized it was that her face was white. In other
           words, she'd only seen black faces for 6 weeks. But she was
           wonderful.
                 The teams in the North were also just absolutely
           extraordinary people. They had a driver there. He would know,
           when he went into a village, who you needed to see first, who
           you see second, and who you should see third. He had driven for
           a political figure before that, and he was just good. The teams
           would go, and they could vaccinate with the jet injectors, 8,000-
           10,000 a day. The most I ever remember vaccinating in a day was
           once in the Midwest: with 4 lines we vaccinated 14,000.
Harden:     Wow.
Foster:          I think it's important to put in perspective what Henry
           Gelfand had learned about India. The Indians had vaccination
           numbers greater than the population, but they still had lots of
           smallpox. So Henry Gelfand went out there and did an assessment.
           And he found the vaccinators were vaccinating the schoolchildren
           regularly, so that they could get high numbers of vaccination,
           but coverage was very low. So when we went to West Africa, we
           were absolutely sure that with high coverage (Rafe [Ralph H.
           Henderson] and Don Eddins adapted coverage surveys from the US
           immunization survey to Africa) we would stop smallpox. There was
           no question about it. And that was our strategy, and we were
           absolutely sure that with high coverage with the jet injectors
           and coverage surveys-if we got above 90% coverage, or 95% or
           even better-we'd stop smallpox.
                 Four or 5 major events led to a change in that strategy.
           The first was that when we first arrived in Nigeria, there was a
           smallpox outbreak in eastern Nigeria, in Ogoja, where Bill Foege
           had been a missionary. They had a limited amount of vaccine. But
           by focusing the vaccine on the infected area, they stopped the
           outbreak. The second important thing was a series of spot maps
           that Bill Foege drew. Each year the smallpox would come from the
           North, and there'd be a few outbreaks on the northern border and
           in the East. Then the outbreaks would increase in number and
           frequency, so you could just see it spread southward. And
           although Bill doesn't remember this, I remember Bill sitting on
           the steps, looking at these monthly maps and seeing how the
           smallpox spread. And he raised the question, "If we stop these
           first few outbreaks, will we stop them all?" The third major
           event in the shift in strategy occurred in Abakaliki. (There's a
           nice paper about this by Dave Thompson and Bill.) They'd done a
           coverage survey, and Abakaliki had over 90% coverage. Then all
           of a sudden they had an outbreak of smallpox. The outbreak
           occurred in a religious group that had refused vaccination; I
           think it was called Faith Tabernacle. Smallpox even though the
           coverage in that area was 90%; the small group of unvaccinated
           people was able to sustain an outbreak. The fourth factor was
           the shape of the epidemic curve-a low in September-October and
           epidemic in the early spring. Bill figured it out that every
           chain of transmission in the fall caused 74 cases in the spring.
           He realized that the peak time for surveillance was when the
           chains of transmission were fewest. So, in my opinion, those
           were the major events that shifted the strategy from mass
           vaccination and surveys to surveillance/containment. And that
           was certainly a major shift.
                 And I think, although the disease eradication programs
           were different, when you compare smallpox to malaria, malaria
           was a centrally directed program, and they never really
           responded to the signs of drug resistance, and insect
           resistance, and the program failed. Smallpox was different. The
           program was driven by data collected in the field. We learned
           from our failures and changed strategies to address them.
                 When I teach on lessons learned from smallpox/measles, one
           of the major things is learning from our mistakes, being willing
           to learn from our mistakes. My favorite story on this is about
           Sabour. He was one of my team leaders in Bangladesh. At this
           time, India was free of smallpox, but we were still having
           trouble. And I went up to see Sabour in Mymensingh, near the
           Indian border. If we did everything right, once we found an
           affected village, there should be no cases after 14 days-after 1
           incubation period. So I asked Sabour, "How many outbreaks do you
           have?" And he said, "Sixteen." And I asked him, "How many had
           gone more than 14 days." And he said, "Eleven." Well, this was a
           disaster. The people could've walked those cases across to
           India, where the reward was big, and made a lot of money. And so
           I said to Sabour, "What are you doing?" His response was, "I'm
           doing everything the book says. I'm putting the patient in the
           house; I'm putting a guard at the front door and the back door.
           I have an extra guard at night to keep the guards awake. I am
           making a list of visitors, vaccinating them, and putting them
           under surveillance. I'm vaccinating everybody in the household.
           I'm vaccinating everybody in a half-mile. And I'm searching
           every place in 5 miles." And then, across a cup of tea, an
           incredible smile. And Sabour said, "And today I found out why.
           I'm going in, and I'm asking for a list of visitors. They are
           not giving me the names of relatives who came to visit because
           they don't consider relatives as visitors. And so we added a
           list of relatives to the procedure and solved the problem."
                 I think that this story illustrates one of the main points
           to get at, that a lot of us at CDC who are in leadership
           positions got a lot of credit for smallpox eradication, but it's
           these people who worked 28 days a month in the field, month in
           and month out for 5 years, some of them, who were the real
           heroes of smallpox.
                 The other lesson to get out of this story was the
           importance of giving workers at the field level the indicators
           to assess their own performance. When they didn't meet them,
           they asked why and come up with a solution.
                 There's 1 other similar story from India, which is really
           important. At a critical time in the program in India, things
           were going to hell in a basket in Bihar, and the numbers were
           going up. And the Minister said, "I'm sorry, no more
           surveillance/containment. We're going back to mass vaccination."
           Bill spent the whole weekend with the Minister, trying to
           convince him to continue surveillance/containment. But the
           Minister said he couldn't take the political pressure and he had
           decided that the only solution was to mass-vaccinate. At the
           Monday meeting, the Health Minister of Bihar got up and said,
           "I'm sorry, WHO [the World Health Organization] has recommended
           we continue to do this, but I can't stand the political heat any
           more, so we're going back to mass vaccination." In the back of
           the room, a hand raised. And a man got up and said, "Mister
           Minister, I am a poor country doctor. But when we have a house
           on fire in our village, we direct the water at that house and
           not the whole village." And the Minister said, "You have 1 more
           month." And fortunately over that month things got better, and
           so they continued surveillance/containment. Both of these
           examples illustrate the really major contributions that poorly
           paid and unrecognized field workers made. They really deserve a
           great deal of credit for what went on and the success achieved.
Harden:     But don't you think it was also remarkable that the bureaucracy
           and the people at headquarters were flexible enough to ask for
           and act on that kind of information? Many times you get
           bureaucracies that think they know best, no matter what's coming
           in. I think the synergy was quite remarkable.
      Foster:    Yes. Well, I think that's the main difference between
            smallpox and malaria. When we introduced the reward for
            reporting smallpox in Bangladesh, I introduced a single reward.
            But after about 6 months, only 35% of the public knew about the
            reward. And then all of a sudden, I discovered my mistake. None
            of the health workers were telling the public because they
            didn't want the public to claim the money. So we doubled the
            reward to pay both the health worker and the public, and within
            4 or 5 months, 80% of the country knew about the reward.
Harden:     So getting the word out, and knowing how the culture operates,
           also played a huge role.
Foster:          The Bangladeshi field staff used to say that working for
           the smallpox program was the best form of family planning (they
           were never home) because at least their wives didn't get
           pregnant. As you look at the evolution of
           surveillance/containment in West Africa to the rest of the
           world, it's a steady thing. .Probably the best place it was
           demonstrated was in Sierra Leone. Don Hopkins didn't have enough
           material to do the whole country. So on 1 side he did mass
           vaccination, the other he did surveillance/containment. Smallpox
           stopped in the southeastern area but continued on in the mass
           vaccination area. That proved surveillance/containment worked.
           Secondly, the legacy of surveillance/containment out of West
           Africa clearly was key to the success of global eradication of
           smallpox. Had it not been developed, it is unlikely that we
           would have ever stopped smallpox, in Asia especially.
Harden:     What about the role of the bifurcated needle? In my mind, West
           Africa was the jet injector and Asia was the bifurcated needle.
Foster:          This is not quite true. When we shifted from mass
           vaccination to surveillance/containment, the bifurcated needle
           became the preferred route of immunization. The bifurcated
           needle was developed to vaccinate chickens. It had 2 main
           advantages. It increased the amount of vaccine available 100-
           fold. It only took 1/100 the vaccine required by the multiple
           pressure method, where a drop was put on the skin and the site
           was scarified by pressing a needle parallel to the skin 15
           times. The bifurcated needle take rates were 99% effective
           versus the traditional method's effectivity of 90%-98%.
                 In Bangladesh, the bifurcated needle totally transformed
           containment. We could train a villager to use the bifurcated
           needle in 10-15 minutes. This brought ownership of containment
           to the village and quicker, more effective, control. It also
           solved the problem of getting health workers to spend nights in
           the infected villages, a major problem in the early stages in
           containment in Asia. Once you were hiring vaccinators to
           vaccinate their village, the barrier of the stranger was
           removed, and accommodations in the infected village were
           possible and acceptable.
                 I think we go should back just a little bit, to 1945.
           After World War II, smallpox was endemic in most countries of
           the world, especially in tropical areas, where the liquid
           vaccine was unstable in the heat. So the development of the
           freeze-dried vaccine (you could carry it in your pocket, it
           didn't require refrigeration, and you could mix it up for the
           day and it would be good) was a big thing.
New topic relevant to West African program but not to smallpox
                 And then the initial development of measles vaccine, the
           Edmonston B measles vaccine, it could only be given with gamma
           globulin. And the vaccine was not, at that time, licensed. It
           had been tested in about 20,000 kids. At just about that time, 4
           Ministers of Health visited the States and NIH. Harry Meyer
           happened to talk to them, and one of them got very excited. The
           Minister of Health of Upper Volta said measles was killing 20%
           of the children in Africa and Meyer should come to Upper Volta
           (now Burkino Faso) to test the vaccine there. So the first year,
           Harry went to Upper Volta and tested the vaccine. The vaccine
           proved its safety and efficacy without gamma globulin: that was
           a major step forward. The demand was such that the next year
           they vaccinated 700,000 in Burkina Faso. It was a tremendous
           success medically and politically.
                 Then the United States expanded to the other countries in
           OCCGE [Organization de Coordination et de Cooperation pour la
           Lutte Contre Grandes Endemies] and that was when CDC first
           became involved. Probably the best story about that concerns
           Larry Altman [Lawrence K. Altman]. Larry's now a science writer
           for the New York Times. He was sent out to Mali to address
           problems with the measles program there. One day he sent back a
           cable to Washington that said, "The trucks don't keep the
           vaccine cold." And a cable came back from Washington, "Park in
           the shade." And so Larry sent a cable back, "Send trees."
                 The measles program was a smashing success medically and
           politically. You had 3 parallel channels. You had the smallpox
           channel going on at CDC; you had Harry Meyer, who had proved the
           safety and effectiveness of given multiple vaccines at the same
           time. And then USAID and measles. USAID for some reason thought
           they could vaccinate a fourth of the children the first year, a
           fourth the second, a fourth the third, a fourth the last, and
           they would be done. That was totally wrong. I was talking to
           Dave Sencer about a phone call he got from A.C. Curtis from
           USAID, who called him and said, "What about a measles
           eradication program," and Dave said, "No, it can't be done.
           Measles is only control, Smallpox is eradication. Why don't we
           marry smallpox and measles?" Without measles, there would have
           been no West African Smallpox Eradication measles Control
           Program, no global program, and probably no eradication of
           smallpox. The WHO 1,000-page history of smallpox has several
           flaws, the major one being the order of chapters. They placed
           the West African chapter after India and Bangladesh. Bangladesh
           and India built on the lessons learned in West Africa and
           succeeded because of it
                 While the marriage of smallpox and measles was key to
           smallpox eradication, the effects on measles were short-lived
           because of the lack of infrastructure to maintain vaccination.
           Successful control of measles has only been achieved in the last
           5 years with a new strategy. It should be recognized that Jean
           Roy, the Operations Officer in Benin, has been a key player in
           this success in bringing the League of Red Cross Societies into
           play-resources from the wealthier countries and Red Cross
           volunteers on the ground to mobilize the public.
                 It should also be said that the marriage of smallpox and
           measles was a major barrier between USAID and CDC. USAID felt
           they had been been conned. This was really the basis of a lot of
           the angst between USAID and CDC because essentially USAID paid
           the whole bill.
                 And I was talking to D.A. last night on the phone, trying
           to clarify a few pieces of history, which is always difficult
           with D.A. When the United States first agreed to do smallpox,
           there was a briefing of the US delegation to the WHO Assembly.
           Even the secretary of HHS [Department of Health and Human
           Services; then, it was Health Education and Welfare] was not
           aware of the plan. So then the announcement went out at the
           assembly, from President Lyndon Johnson, that the United States
           would support a smallpox eradication program in West Africa.
           Later, the smallpox/measles marriage took place. Clearly, Dave
           Sencer was a key actor in this. D.A. told me last night-which I
           didn't know-that that press release about smallpox was written
           by Bill Moyers. That was the international Year of Cooperation,
           or something like that. And smallpox eradication and the US
           contribution fit this like a glove from 3 perspectives: science,
           development, and politics.
Harden:     You have mentioned the 2 women who were professionals the West
           African Program. Neither of them is here for the reunion, but
           could you talk about who they were and how exceptional they
           were?
Foster:          Yes. Two very different people. Vicki Jones, young, free
           spirit, guitar-playing, and Margaret Grigsby, an older, African-
           American woman professor at Howard, very prim and proper. I
           remember we had some issues insuring that there was a proper
           latrine arrangement for her when she went to the field. And it
           was difficult in the area that Margaret was in, in terms of
           getting cooperation. Margaret was great. She had her heart and
           soul in the program and bonded well with her African colleagues.
           I do remember the first outbreak I went to in the western
           region. They had isolated the smallpox patients in a cocoa farm,
           and the only people who were allowed to go there were those who
           had the scars of smallpox. This is very, very interesting. On
           the other hand, you have the smallpox cult, Shapona cult, where
           if you didn't want to get smallpox, you paid the priest. If you
           got smallpox and didn't want to die, you paid the priest. And if
           you died, the priest got all of your worldly possessions. So
           they couldn't lose.
                 There are historical accounts, in the 1800s, of priests
           actually infecting people who didn't pay up by putting smallpox
           scabs on sticks going into houses. Actually, I remember the last
           African outbreak I visited, in Togo. A couple of the traditional
           healers were there trying to pick scabs. Fortunately, the scars
           were from a vaccinial modified case, so it was not likely that
           there was much virus left.
Harden:     What did Africa teach you about yourself and about public
health?
Foster:          We were young; we were bright; but we were not bright
           enough to say we couldn't do it. I mean, that was really
           important. In other words, there was never a sense that we
           couldn't succeed. It was a totally different story in
           Bangladesh. But we learned as we went along. We had pretty good
           government response and fairly credible civil service. At least,
           we were paying per diems and that sort of thing, kept people
           working. It was a well-oiled machine. I mean, we had something
           like 80 Dodge trucks in Nigeria. We had lots of spare parts. I
           think the last one I saw running was in the late '80s.
Harden:     What kind of impact do you think the whole West African program
           had on the global eradication program?
Foster:          Had West Africa not succeeded, it's doubtful that the
           global program would have succeeded. I have no question in my
           mind that it laid the foundation, and one of the great
           injustices in the smallpox book is that the West Africa chapter
           is put after India and Bangladesh. This is extremely unfortunate
           and historically incorrect because a lot of the lessons learned
           out of West Africa laid the foundation for what went on in Asia,
           and Ethiopia, and Somalia.
Harden:     Indeed. Is there anything you would change if you were running
           the program all over again?
Foster:          What we did then, we couldn't do now.
Harden:     Say again?
Foster:          What we did then, we couldn't do now.
Harden:     Why?
Foster:          I mean, it was pretty much an expatriate-run operation-
           money-driven, technology-driven. We did not have the proper
           amount of deference to local culture and societies and
           governments.
Harden:     I wondered about that.
Foster:          It was pretty much a technology-driven program. It was
           marvelous in terms of the teams we had. Some of the Operations
           Officers, Dave Bassett for one, George Stroh for another. George
           was driving from Jos down to the South when his motor mounts
           broke, and his motor fell out of his engine. He put the motor
           back in and drove home. I mean, just that kind of ability, to
           react in the field. So that was important.
                 In Asia, several things were key. One was that the monthly
           meetings were incredibly important. People came in, they gave
           their reports, they shared the successes, they shared their
           failures, they got drunk, they sobered up, they got their money,
           they went back to the field. And most of them spent 25-28 days
           in the field. And as I look at CDC people going in the field
           now, they don't do that much any more.
Harden:     Are there any final things that you want to say?
Foster:          The challenges of West Africa were nothing compared to
           what it was in Bangladesh, especially in the floods of 1974,
           when the 2 remaining areas of infection were totally flooded out
           and people went into motion. We went from 89 infected villages
           in October of '74, to 1,500 the following May. We were all
           depressed. We lost it. A wonderful guy, Rangaraj, was my deputy;
           he was the first Indian physician parachutist. He had fought
           with Stillwell in Burma. And every morning, he would say, "It's
           going to be all right. Hang in there." Every day, he was like
           that. There was no rationale for that. Later on, when I was
           working in Somalia, I had a beer with Rangaraj 1 night, and I
           said, "Ranga, how could you have been so optimistic?" He said,
           "I didn't think you had a chance in hell in winning, but when I
           fought with Stillwell in World War II, I learned that if you
           ever thought you'd be dead the next day, you would be dead." So
           it was his military training and his optimism that enabled us to
           keep going, during incredibly difficult times. When I walk into
           an HIV/AIDS village today, I feel Ranga's hands on my shoulder.
           "Hang in there it will be all right."
Harden:     And eventually, to win.
Foster:          Yeah, and eventually to win. And Ranga was incredibly
           important. And there were lots of people like that. In
           Bangladesh, we had 22 nationalities on our staff, and they were
           they best. I mean, they were family. We were all 1 family. The
           monthly meetings were key. Then surveillance got incredibly
           better, and we were able to track things. And we used money. We
           paid $25,000 in rewards starting at $2.50 per report of an
           infected village and increasing to $50 as the number of infected
           villages in Bangladesh decreased. And we learned. For example,
           when we started in Bangladesh, we were having trouble with
           containment until we started hiring people from the village. The
           reason we were failing was because health workers had no place
           to stay in the villages. Once you started hiring villagers to do
           the work, you had a place for your health workers to stay. And
           so there was a tremendous lesson.
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                  <text>&lt;div class="landing"&gt;
&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. Ralph H. "Rafe" Henderson, about his role in
the West African Smallpox Eradication Project of the Centers for Disease
Control. Today is July 7, 2006, and this interview is being conducted as a
part of the 40th anniversary reunion of the launching of the Smallpox
Eradication Project. The interviewer is Victoria Harden.

Harden:     Dr. Henderson, I want to begin by setting the stage for who you
           were in the smallpox project, and I'd like to start at the
           beginning. If I am correct, you were born in New York City, on
           March 5, 1937. Would you give me a brief account of your
           childhood and education, who your parents were, and whether any
           of these early experiences nudged you towards medicine or public
           health?
Henderson:  Yes. My father was born in Burma, which is the explanation for
           my nickname, Rafe. The British soldiers in Burma, who were then
           in charge, used Rafe as a nickname for Ralph. My father's name
           was also Ralph, and when he named me Ralph, then they called me
           Rafe as a nickname. So that explains that. But it also explains
           my orientation for international health. My grandparents were
           medical missionaries; their grandparents were also medical
           missionaries in Jamaica. My uncle was a medical missionary in
           China. My father was the black sheep of the family: he went into
           publishing with the Reader's Digest.
                 But my brother and I became physicians. When I was doing
           my internship at Boston City Hospital, I was contacted by
           somebody from CDC, who told me about the Epidemic Intelligence
           Service (EIS). And that, combined with a lot of my other
           interests in the international sphere and missionary work-
           although my father was not religious and I'm not particularly
           either-seemed to be a very good next step for my career in
           public health.
Harden:     Let's drop back a little bit and ask you to talk about your
           years at Harvard. You were at Harvard for both your
           undergraduate education and medical school. Was there anybody on
           the faculty who was particularly important to your career?
Henderson:  Yes, obviously in college, one always has heroes. Mine was a
           psychologist named Jerry Bruner [Jerome S. Bruner], who was
           dealing with cognitive psychology, and I found that very
           interesting. I won't tell you the funny things we did, but in
           any case, it was an interesting time at Harvard. I was there
           only 3 years because I had spent the year before going to
           Harvard as an exchange student for the English-Speaking Union.
           So I was in the U.K. for a year, in what was a public school,
           before coming to Harvard, so I was only at Harvard for 3 years.
           Then I went on to medical school.
                 In medical school, many of us were very, very influenced
           by Professor Thomas Weller, who had worked with Enders [John
           Franklin Enders] and Robbins [Frederick C. Robbins] in
           developing the polio vaccine and later on the measles vaccine.
           Weller was very eloquent about tropical public health and the
           challenges and the needs that were going on. As I say, a whole
           bunch of us came out from under his tutelage very interested
           (well, let's say interested because we were too young to be
           career-committed at that point). I think he was a strong
           influence.
Harden:     You joined CDC immediately after your internship and residency
           in Boston City Hospital. Were you one of the folks joining
           initially to avoid-pardon me, to discharge-your military
           obligation?
Henderson:  Well, I think "avoid" is a very good term because I think for
           many of us, that was 1965, '64, '65, when the Vietnam War, was
           just starting. And how does one want to spend one's military
           career? Well, it was certainly a very easy choicevivid  one for
           us. I would like to think that my own reflexes-both seeing the
           difficulties of practicing in a city hospital, where you're
           seeing end-stage disease and not being able to do very much
           about it, and my interest in international health-made CDC a
           choice whether or not there had been a military draft. But it
           was clear that that served the best of all purposes as far as I
           was concerned. I was not interested in serving in other areas of
           the military. I was very interested in serving in what I knew,
           at that point, CDC was doing.
Harden:     In public health service.
Henderson:  Right.
Harden:     So in 1965 and '66, you were an EIS Officer. Would you talk a
           little bit about your EIS training and assignments?
Henderson:  Well, it was incredible. In those days, they used to call the
           interns "the iron men" because we didn't get salaries, we ate at
           the hospital, we often slept at the hospital, we had 1 set of
           clothes. But we came to Atlanta and we're presented with a slide
           rule; we got a salary; we were treated like important
           individuals. It was incredible. Absolutely incredible. And we
           had a very exciting 6-week EIS course, training us in shoe-
           leather epidemiology. Because of my interest in international
           health, I applied to the smallpox unit. I was lucky enough to be
           selected. And then, lo and behold, I was sent off, very shortly
           after the training, to West Africa as a technical advisor to the
           French public health organization in the western part of West
           Africa, called the OCCGE [Organization de Coordination et de
           Cooperation pour la Lutte contre Grandes Endemies]. That's a
           very long name, but part of it, the Grands Endemies, translates
           into the "great endemic diseases."
                 I have to back up a couple of steps to explain why I was
           going over there. In about 1963, roughly, the NIH [National
           Institutes of Health] conducted a major field trial of measles
           vaccine in West Africa, beginning in Upper Volta, as it was
           called. And it was an astounding success. They covered most of
           Upper Volta in a few months, with mobile teams, and did it very
           well. They had high vaccination coverage, and measles pretty
           well disappeared.
                 Now, that was a self-serving exercise, in that we, the
           United States, wanted to test the measles vaccine on a large
           scale. Here was an area where this could be done, where it was
           desperately needed, where kids were dying of this disease, and
           you would have had to have a very, very bad vaccine indeed, not
           to be ethically justified in doing a combined trial of the
           immunization and of the vaccine itself and seeing what impact
           you would have on public health. Well, the impact was absolutely
           astounding.
                 One of the reasons that USAID [US Agency for International
           Development] was willing to go along with D.A. Henderson [Donald
           A. Henderson] and others at CDC in joining a smallpox
           eradication program, which USAID wasn't interested in, with the
           measles program, which USAID was interested in, was that they
           knew that they couldn't do much with the measles program unless
           they had some good technical support. USAID had some disastrous
           experiences without technical support, before they funded the
           full program in '66.
                 Because the United States had the measles vaccine and no
           other nation did, it was perceived that a measles immunization
           program allowed the United States an entryway into West Africa,
           where the French culture was dominant, one that did not compete
           with the French either on educational or economic grounds. But
           here was a neutral health ground-very popular concept. All the
           countries desperately wanted the measles vaccine because measles
           was such a bad disease.
                 And so I went over as one of the people to help out in the
           stages before the full program got going. I was advising OCCGE
           in running these mass immunization campaigns with measles
           vaccines.
                 Now, the French were very good at doing mass campaigns;
           there was no problem with that. The problem was that they were
           not very good at dealing with this funny, electrical jet
           injector, which we were using to administer the vaccine. And
           they were not very good at dealing with the many, many
           difficulties in supply and logistics posed by our USAID and U.S.
           Government contributions to the programs. And so, when I
           arrived, or at least one of my interviews was with the Ministry
           of Health in Upper Volta and with the Chef des Grands Endemies,
           the French advisor who was running the Grands Endemies. The
           Minister was furious because our 5 Dodge trucks that had been
           given to help administer the vaccines were consuming his entire
           budget of gasoline for his entire Grands Endemies. And the USAID
           deal was, "We give you the trucks, but you run them. You pay for
           the gasoline." And of course, that just wiped out the budget for
           the Ministry of Health for gas. All of these enormous trucks
           were consuming all the gasoline. And so he was not a happy
           person.
Harden:     Was there any solution to this problem?
Henderson:  They did the best they could. They were unhappy, but they did
           not do  a bad job with the things.  One of my problems as
           advisor was firing off cables about getting spare parts for the
           jet injectors. They kept running out of some tiny points-I
           didn't know what they were, but I think that on a regular engine
           they'd be called the points. They relate to the electrical
           system. Forget it. But that's all I knew. And I knew that they
           were burning out, and they couldn't get spare parts. So one of
           my jobs as a technical advisor, very technical, was to send
           cables back saying, "Send more of these things because they
           can't run the injectors." Nor did CDC send enough diluent, so we
           were often using Evian, one of the French bottled waters, as
           diluent for the measles vaccine.
                 I was overseas for about 6 months, traveled widely in
           those countries. I was treated extremely well by the French
           advisors, even though they knew I didn't speak very good French
           and they knew a lot more than I did about anything they cared to
           ask me about. But they were very gracious, very good about
           teaching me and helping me learn about things. I think I saw in
           those 6 months enough problems to last me the rest of my life
           about what can go wrong with an immunization program and with
           other kinds of public health programs that you're running. It
           was extremely valuable.
Harden:     One of the points that has been made over and over here is that
           medical knowledge about smallpox was really only the first step
           to eradicating it. The logistical problems, and the personnel
           problems, and the diplomatic problems, all of these things were
           key to eradicating the disease. So you were seeing this in
           advance of the project.
Henderson:  Yes, I think that's very true. I think the CDC tradition,
           though, is an important one to emphasize. We medical people went
           over with public health advisors, who joined us as nonmedical
           people, who were there exactly for the management issues. CDC
           had had a long tradition of this in the venereal disease control
           program, as it was called in the old days, and the advisors then
           branched out into tuberculosis and many other programs. There
           were always public health advisors who were trying to get the
           logistics and the management right. And so I think the CDC
           position was, "We've got to have some medical expertise to be
           credible, but we really need the management to be sure that we
           can be effective." And I think that was really the key to the
           success of much of what we did.
                 We didn't have such great medical knowledge of smallpox,
           if I can say that. The program was designed to immunize
           everybody in West Africa against smallpox, sort of a 100%
           vaccination coverage. And we didn't find out until a couple of
           years into the program that we didn't need to do that. That was
           one of the really startling breakthroughs in the program-the
           ring vaccination strategy of simply immunizing around active
           smallpox cases, breaking the cycle of transmission, and not
           going all-out to maintain high levels of immunity in all sectors
           of the population. We learned that relatively rapidly, I must
           say, within a year or so of the program. But it was a major
           conceptual breakthrough for us.
Harden:     Would you walk me through setting up the regional office in
           Lagos? You were the Deputy Director and the epidemiologist. I
           know that the Director, Dr. Lythcott [George I. Lythcott], is no
           longer alive. So will you tell me about how it was formed and
           how it functioned?
Henderson:  Well, it's a funny thing. I have very little idea about that. I
           knew that there was to be a regional office and that George was
           the Director. When I was in West Africa, and the full program
           came into being, I was then recruited from my role as an EIS
           Officer to join as the Deputy Chief of the regional office.
           George had worked in Ghana, and was a senior person, very well
           respected. It was perceived that if we were going to have a
           regional office, we should have a good regional office. And in
           the early days, as I understand it, the idea was that this would
           be the first regional office. Then, as the program expanded
           worldwide, as we got rid of smallpox in West Africa and then
           moved to other regions, there would be other regional offices in
           other regions, which were similarly constituted. In any event,
           we never did that. Ours turned out to be the only regional
           office.
                 I was there as an epidemiologist, but I was one of the few
           people who spoke French. So even though I didn't speak French
           very well, my responsibilities were mainly for looking after the
           francophone countries. My role as deputy was sort of doing all-
           hands work. We had an equipment specialist with us, a very good
           health educator, a statistician, and a secretary who was
           knowledgeable about local and embassy issues having worked  in
           West Africa before. And we also had Jim Hicks [James W. Hicks],
           our Senior Administrative Officer, who was very effective.
                 George, as the Director, dealt with all the terrible,
           terrible political problems that were really insolvable, and he
           managed to solve most of them. Jim Hicks dealt with equally
           difficult administrative problems, like who had furniture in
           their houses just in Lagos; could we get transport from the
           embassy in the early days; what was going on with the financing
           of things. He had all sorts of fights  with the embassy and the
           USAID mission, who didn't really have the resources to give the
           support that they were supposed to to our group in the regional
           office.
Harden:     Now you, as I understand, wrote most of the E-1s, the programs
           for each of the countries, in the francophone countries. Is this
           correct?
Henderson:  I don't remember that. At my age, I'm finding that happens more
           and more often. I do know that I spent some time going around
           with George Lythcott and Henry Gelfand trying to finalize and
           write what we called pro-ags, project agreements.
Harden:     Yes, that's what I meant.
Henderson:  That's right. I recently got a communication from a colleague
           who was working with us in West Africa. He sent me some of the
           letters he had sent me then. And he quoted me asking if we could
           give some of the cars that had been assigned to us, as advisors,
           to our national counterparts? And he said in the letter to me,
           "Rafe, you had already anticipated this and put the request in
           for these cars. You knew that they would be needed by the
           ministry, and that you couldn't justify it just for the
           ministry, but you would justify it by giving it to the advisors
           who were there, anticipating that they would then be shifted
           back." I have no recollection of that at all.
Harden:     There was, at this point, however, some tension between CDC
           personnel and USAID as to whom the CDC reported to-whether they
           reported to USAID, or reported to CDC through the regional
           office .  And I think it fell on you to clear the air about
           this, if my reading is correct.
Henderson:  Boy, I don't remember that either, very much. I do remember
           going to a couple of countries; my wife and I were talking about
           that. I remember being in Chad, and I was trying to recall, 40
           years later, why was I in Chad? And then it occurred to me,
           there was something going on with USAID and our staff there that
           I apparently was trying to mediate. Again, I don't remember the
           details of that. I do remember that there was a general problem
           when we from CDC came into the West African countries, and we
           felt we were masters of the universe, and there was nobody about
           to tell us what to do, certainly neither USAID nor the embassy.
            We had a mission. We were going to get our stuff done. And so
           that was a general tension that I do recall. I don't remember my
           role exactly, and what I did about it.
Harden:     You started to tell me about developing the cluster sampling
           system and the instruments we adhered to, to do the sampling.
           Would you explain, for the record, what cluster sampling is, and
           how you developed it?
Henderson:  I can, but I would also like to go back at some stage, to lead
           up as to why I ever got into that.
Harden:     Okay, let's go back. Tell me how you got into cluster sampling.
Henderson:  I had come back from India in the spring of 1967, when there
           was a smallpox outbreak. We had been expected to eradicate
           smallpox in India in a very short period of time. We did not
           succeed in doing that. My wife and I came back to CDC, and found
           that, in the interim, the Biafran War had broken out. She was
           then not allowed to go back to Lagos as a dependent. I would not
           go back to Lagos without her, and we arranged a compromise, as
           my range of responsibilities was the francophone countries
           anyhow. I did a whole series, 6 months or so, of continuous
           consultancies, firefighting, and all sorts of stuff in West
           Africa.
                 And then the Biafran War settled down, and we were able to
           go back to Lagos. I got back to my regular job, as Deputy Chief
           of the regional office. And I promptly got myself into trouble
           with headquarters because I kept feeling that the policies that
           we were being asked to follow by headquarters were not the best
           ones for us in the field and that there was not a very good
           understanding of what was needed in the field.
Harden:     And when you say headquarters, you mean here in Atlanta?
Henderson:  In Atlanta. So I became a very shrill voice, I'm afraid,
           demanding and troublesome. And I don't remember whether I was
           called back, or whether I had to come back on for another
           occasion, but when I did get back here at CDC, I was pretty well
           told, "Enough of this nonsense. We need some assessments done.
           Go do them." Again, my memory is foggy, and it may be that there
           was a lot of help, but I don't remember. What I remember was
           going off and saying, "Oh yeah. Okay. We need to do
           assessments." And it turned out to be 3 major assessments, one
           in northern Nigeria, one in western Nigeria, one in Niger. And I
           brought some reports that I'd been looking at recently, and
           trying to scratch my head, and yeah, the cluster sample survey
           was part of that assessment or evaluation. There were also
           aspects of the assessments where we reviewed records,
           interviewed people, looked at the health centers, inspected
           vaccination teams, and the rest of it. So it was a very
           extensive project.
                 Now on cluster sampling: if you do a random sample, if it
           was the Gallup polls that we do in the United States, you can
           get away with sampling a relatively tiny fraction of the
           population. But you have to do it in a very meticulous, random
           manner, so that the individual that you select is not selected
           with any bias that you can imagine. This is very intensive, very
           expensive, and very difficult to do. A compromise that was
           developed by CDC staff, Serfling and Sherman (Robert Serfling
           and Ida Sherman of CDC), here in the United States, was a
           cluster technique. And that meant that, rather than taking a
           single individual and asking questions, you could take a group
           of individuals. But if you did that, you had to compensate for
           the fact that they were a group and no longer independent. So
           one of the group had more similarities to the other members of
           the group than if you'd taken a totally different person from a
           different area because the cluster was a geographic cluster. So
           you would get households that were all together, or members of a
           household that were all together-that was the "cluster" part of
           the cluster . Rather than sampling as individual people, you
           sampled them in groups. I had learned the Serfling-Sherman
           technique as an EIS Officer. We had done a sample in Atlanta.
           Bill Foege [William H. Foege] did a modification of that in The
           Gambia early on. I knew about that.
                 So when I was asked to run these surveys, run these
           evaluations, and do a cluster survey as part of that, I further
           adapted that survey. To look back on that, it was incredible.
           How am I going to do a survey in a huge area of the country?
           What kind of a sample do I select? How do I get the records
           done? How do I collate them? I taught myself to type; I didn't
           know how to. I realized I was going to have to write these long
           reports, so I was going to have to type.
                 I realized I was going to need some way of recording the
           data. So I had worked on my own files with McBee cards-strange
           animals. I'm just going to hold up one. It's a strange card with
           a lot of holes on the sides of it. And you punch a notch in a
           hole. Each hole corresponds to something you've written on the
           card. So, for example, is this person who you're sampling a male
           or a female? Male, 1; female, 2. If they check 1, I punch 1,
           which is numbered on the edge of the card. At the end of the
           day, I get a hundred cards together, and with a sort of
           knitting needle, I run through the hundred cards, at the number
           1. And lo and behold, all the cards that have this number
           punched fall out, if I shake them vigorously enough. These cards
           were fascinating to use-difficult to use, but a godsend because
           I could then train teams, who would go out with these cards and
           then, while they were in the field, simply mark a number for
           each of the data points I had. Then at the end of the day at
           their leisure, they would take a paper punch and punch out the
           holes that corresponded to what they had found during the
           survey. Then I collected all the cards from all the teams at the
           end of the survey, went home, and spent a long time shaking
           knitting needles and having the cards fall out. And I'm sure
           there were a lot of errors involved with the things. But it was
           absolutely an incredible exercise, and I can't believe, even to
           this day, that I was able to do that, with very short notice, to
           go in, to design the cards, to decide on the sample surveys.
                 But I want to talk a little bit about the actual sample
           survey design because that was fascinating. What are you going
           to do with a population that is as varied as you have in West
           Africa? Yes, you've got some people in cities, but you've got
           people in villages. You've got people that don't particularly go
           to a village; they're nomads; they're all over the place. And,
           again, I'm just impressed with ourselves, myself, in that time.
           We designed the sample surveys to try to get if not a valid
           sample, at least an idea of these various groups.
                 So, for example, we could have a sample survey that said,
           let's take a valid statistical survey of all the villages in a
           catchment area, or a state, or a country, that are under 5,000
           population. Perhaps we thought under 5,000 would be a high-risk
           group for smallpox. We'd get all the villages. So you select,
           say, 30 villages out of those. And then we said, "You get your
           sample from that village but then leaving the village, for the
           next 10 kilometers, you stop every person you see, and you
           interview them-no matter who they are, or what they're doing."
           And then we said, "In addition to that, you go to some of the
           local markets, and you do a market survey and find out who's
           there. And within the market, sometimes you can select
           individual groups." We knew there were nomadic tribes, and we
           could recognize them because they wore distinctive things. So we
           could say, "Survey 10 of the nomads from this area, and 10 from
           that area."
                 In western Nigeria, we had an area of the state that was
           very heavily influenced by fetisheurs, by the traditional
           healers. And we knew that they had a cult, the Shapona or
           smallpox cult, that did not appreciate being vaccinated against
           smallpox. They were against vaccination. And we knew that
           vaccination coverage was lower in that area than in other areas.
           So we did a separate sample of the fetish area and the nonfetish
           area.
                 We did all sorts of tricks to try to probe where we were
           weak. It wasn't so much that the sample was going to give us a
           wonderful average of what was going on in the country, but my
           idea was, let's point the finger at where we think we're doing
           least well. Let's find out what's going on there; that's where
           we need to make the changes. It was just a fascinating
           experience. As I said earlier, the survey was only part of the
           full assessments we did.  We also looked at records, we
           interviewed people, we inspected vaccination teams.
                 We found faults everywhere. There were problems
           everywhere. And that was one of the great lessons that I learned
           in my life-despite all the problems that you find every day, and
           despite the fact that you think nothing's going well, that isn't
           always the case. You can have some success despite it.
                 The other thing that was impressive looking back now on
           this, is that there was no stopping us. I mean, getting a sample
           survey, doing these assessments, that's no problem. We'll just
           do it. And I think it was the attitude of the entire program. We
           had a goal; we were going to do it; nothing was going to stop
           us.
                 I'll tell you 1 other anecdote that illustrates that. We
           got stuck in western Nigeria during one of these assessments. We
           got often stuck in western Nigeria. It was during the rainy
           season, and we spent more times pulling ourselves out of mud
           holes than anything else. But we were in a rubber plantation,
           for reasons I don't understand, but we were doing a survey
           there. And it turned out that the vehicle was running down on
           hydraulic brake fluid. The brake pedal kept getting weaker and
           weaker. And we knew when we left in the morning that we needed
           some extra fluid. We had some, but by the middle of the day, it
           was getting low, and we were running out. And we finally looked
           under the hood and found that the brake line was rubbing against
           the engine, and it had cut a little hole in the hydraulic line.
           And I said, "Right, okay. I know how to do that from an intern
           in Boston City Hospital. Give me some tape, and I'll tape it
           up." I taped it up. But each time I did it, because the brake
           line has a lot of pressure it just blew the tape away. It didn't
           work at all. We were down to our very last little bit of
           hydraulic fluid, and I said, "Right. What am I going to do?" And
           we got some cotton that we had for first aid. I took some sap
           out of a rubber tree, chewed the sap into the cotton to make it
           a solid compress, and tied a whole series of very tight suture
           knots around the hydraulic line. Amazingly, the thing held 'til
           we got back at the end of the day. But that was the attitude:
           "This isn't going to stop us. We can fix this. Nothing is going
           to stop us." And that happened over and over and over again, to
           everybody in the program. It was incredible. And I think it was
           one of the things that made the program just such a success.
           People would not be stopped.
Harden:     Now, do a little analysis here. Was it just because these
           particular people were so special? Was it an American thing? Was
           it inspiration from above? What do you think made this group?
           Obviously, it's a very special group. Do you have any opinions
           on this?
Henderson:  I hesitate to say it, but I'll say it anyhow. It's not a very
           special group. And I think that's the magic of it. Special in
           that the challenge was there, yes. Good leadership. Good
           support. A strong image of what needed to be done. But by God,
           when you do that, and you give people responsibility and things
           that they've never met before, most times, most people will rise
           to that challenge. And I say that because I then had experiences
           later in life, in the World Health Organization (WHO), or other
           programs, where we had the same sort of thing. We had specific
           goals to achieve and people from many cultures, many different
           backgrounds, still rising to that challenge in an extraordinary
           way.
                 And don't forget, as I'm sure that nobody will, that we
           were a tiny fraction of those who did the work. Most were the
           nationals -  the vaccination teams, the staff, the people living
           in the endemic villages. So let's be clear that we were helpers
           in a project that was done largely by national staff.
Harden:     Were there any particular problems in dealing with the national
           staff that you recall or were there good relations from start to
           finish?
Henderson:  I would have to say mixed. I think the relationship got better
           as we all got more familiar with the environment and the
           cultures with which we were dealing. When we arrived, we, the
           CDC people, fresh out of the U.S., were impatient. We didn't
           understand why something couldn't be done yesterday; what was
           the problem? And of course, the folks we were dealing with-
           whether it were the national ministries of health, the French or
           English advisors who were there, the other expatriates-they
           thought we were nuts when we first arrived. They couldn't
           understand why we were having these expectations. Many of the
           French thought that the word "eradication" should be eradicated.
           They had very little little time for this eradication concept.
                 And so, yes, there were a lot of tensions with that. But I
           would have to say, again, that the experience of the public
           health advisors-who had dealt with those kinds of issues in the
           United States with state and local health departments and
           recalcitrant public officials at all levels and learned to find
           ways of getting things done so that everybody went along with it-
           these types of situations are where they really shone. We in the
           medical officer field were often not so good at that, and I
           think we were very well served by having the public health
           advisors with us.
Harden:     In December 1969, there was an observance of the hundred
           millionth vaccination in Niger. Were you involved in that at
           all, and do you have any special memories of that event?
Henderson:  That was in Ghana, and I have some memories of it. I wasn't
           involved with the organization of the event, thank goodness,
           because it was a massive affair. But I do remember going and
           giving an interview to the Ghanaian newspaper about things. The
           report of the interview in the press talked about our work in
           eradicating rabies or malaria, or something totally not having
           anything to do with what I had said or what the program was
           about. One of the reasons I was doing that interview was that, I
           think the Minister of Health and George, the Director of the
           program, were off doing the hundred millionth observance, and
           they needed somebody to satisfy the local news media who could
           speak about the program. So my role was a very minor one. But it
           was a grand affair.
Harden:     If you were going to do the program all over again, would you
           change anything about the way it was run?
Henderson:  Given that it worked, I think not.
Harden:     How did the smallpox eradication program change your life and
           career, or did it?
Henderson:  Oh, very much. When I came to CDC, my idea was to work in
           public health for a while, go back to internal medicine, and
           maybe get a joint accreditation in public health and internal
           medicine, as many of my colleagues were doing. But when I got to
           West Africa and had a little bit of experience there, 2 things
           happened. One, I was addicted to public health. Two, I knew I
           had to go back and get some management training. So I applied to
           the Director of CDC, Dave Sencer, and asked him for a career
           development extension to go back and get a degree in public
           health at Harvard Medical School. And I said, "I know Harvard. I
           will look during that first year at the School of Public Health
           and I will find some management training I can do during the
           second year."   I was sitting in Lagos, so I couldn't tell
           Sencer exactly what that second year was about, but I said it
           would be management. And, in fact, I tried to get into the
           Harvard business school, but they had a very rigid program that
           I thought was very unhelpful. The Kennedy School was just
           starting a program of Master of Public Policy. They wouldn't let
           me into it because they said I was too old. I think I was 28 or
           29. I insisted that I was just the right person and talked my
           way into it. So that was my second year of training.  So it did
           change my life in a radical way.
Harden:     What impact do you think the program had? What impression did
           it leave in Africa about the United States, about CDC? Do you
           think it had an impact on the end?
Henderson:  I think it was good. I mean, it may have been astounding. When
           you're working down in the guts of an organization, one doesn't
           see the perspective of what others have about the whole range of
           things. I don't think we left a bad impression, by any means.
           But that was nothing I was aware of, or got feedback on.
Harden:     You said your wife was traveling with you. What impact did the
           smallpox eradication effort have on your marriage, in terms of
           anything? Traveling?
Henderson:  Well, we were unusual. We had just gotten married. My wife is a
           pharmacist, and we didn't have kids. And I thought that she
           could be extremely helpful in what I was doing. Sample surveys
           are not difficult to do. Keeping the records, drawing maps,
           things of that sort, she does very well, and so we worked as a
           team. And we continued to travel wherever we could as a team,
           together. Now, she wasn't paid by anybody. I paid for whatever
           travel was going on, but we worked together all the time. And in
           fact, when I think about it now, it set an unusual precedent. We
           kept running into problems later in life, when she would sit in
           on staff meetings, or go to meetings with other organizations,
           and they would say, "What's your wife doing here?" Well, there
           would be administrative assistants, other people who would not
           be contributing from a professional perspective but would be
           sitting and listening in.  But the fact that she was a wife
           alienated a lot of people. Eventually, she began introducing
           herself as my personal assistant. That seemed to work a lot
           better. But it had a very strong bonding affect on our marriage
           and lasted throughout our professional lives and through the
           present..
Harden:     Before we stop, is there anything else about the Smallpox
           Eradication Program that you think of, that we should discuss?
Henderson:  I think that one of the extraordinarily important legacies was
           the group of people. Now, I have just told you that the group of
           people was not extraordinary, that they were ordinary people.
           But having gone through that experience, many of them continued
           on working together as colleagues throughout their careers. And
           the smallpox program in West Africa morphed into the larger
           global program, with many of our staff from West Africa joining
           the global smallpox eradication program and having major roles
           in that.
                 After spending some time at Harvard and back at CDC, I
           went back to WHO in 1977. I had left West Africa in '69. So
           almost a decade later, I came back to international health at
           the recommendation of Dave Sencer, to go and replace D.A.
           Henderson at WHO and to run what was then a new program, the
           Expanded Program on Immunization, which was a child of the
           smallpox program.
            Even in the smallpox days, we were looking at how to use other
           vaccines with smallpox vaccine, how to do combined
           immunizations. So a lot of the science had already been done by
           us in West Africa, plus other colleagues elsewhere that were
           working on the same issue. When smallpox success seemed assured
           in 1974, the Expanded Program on Immunization was adopted by
           WHO. The idea was to take what we knew about the smallpox
           experience, providing immunizations for a disease, and do a
           childhood immunization program. The program faltered for a
           couple of years, and I was called in  both because the program
           was faltering and D.A. who everyone assumed would take over the
           program decided to leave WHO.  There was a desire on the part of
           the U.S. to have a CDC US person replace D.A. and I went back to
           do that.
                 Now, when I went back, a lot of the "mafia" I worked with
           were the smallpox mafia-both the smallpox mafia that we had in
           West Africa and the larger mafia that was then created when the
           global program was created because the global smallpox program
           was just phasing out. So suddenly I had a whole large staff of
           people who had that same motivation, who had that same
           perspective, coming into my program now, into the Expanded
           Program on Immunization. They continued on to do polio
           eradication, the diarrheal disease program, a whole slew of
           very, very important public health initiatives. And that came, I
           think, directly from this initiative in West Africa, the
           smallpox group, then going to the larger, international group,
           and then the international group coalescing around several
           extremely important public health programs.
Harden:     Do you think there will be another disease we can eradicate?
Henderson:  Well, we're certainly trying with polio.
Harden:     And having some very difficult problems, I think, and
           discussions about whether it will be done.
Henderson:  Yes. It's a very interesting quandary in public health because
           you don't know, when you're beginning, if you're going to
           succeed. If you knew that, it wouldn't be a problem. You'd just
           get it done. We didn't know when we did smallpox in the
           beginning that we would succeed. In fact, we had to change the
           program radically in order to succeed. The same is happening
           with polio-major, major technical breakthroughs, change your
           philosophy, change of the way we approach things-learning as we
           go, and having a lot of problems on the way. But that's the way
           you make progress in science. That's the way you get better.
           Now, there may come a day when we say, "Okay, enough is enough.
           We've got to call it quits." But until that very end, I think
           it's absolutely well worth giving it the best shot that we can.
            Malaria was a situation where we tried and tried, and then it
           became increasingly apparent that this was not going to work. We
           didn't have the science. We didn't have the technical skills or
           the technical equipment to do the job. We had to change the goal
           of the program. That's not happened with polio, yet. We have a
           lot of good irons in the fire, and I don't think we should be
           anywhere near giving up at this time.
            But there will also be interest in eradicating measles; there
           will be interest in eradicating other diseases. When I did the
           Expanded Program on Immunization, coming in in '77, people in
           WHO said, "OK Rafe, we know who you are. You're one of these
           eradication people. You are just interested in the short term."
           And I said, "Not on your life. I'm not interested in
           eradication. I'm interested in long-term childhood
           immunization."
            But I was interested in eradication. And I came back to that in
           the late 1980s, when our routine immunization had more or less
           done what it could do. It was reaching levels that were not too
           bad but were also not too good. And at that point, we adopted
           polio eradication, not only because we thought we were ready for
           it but also because the polio eradication effort was 1 thing
           that stiffened us up in the other efforts. Because we were
           dealing with a specific disease, that helped us do the rest of
           the things, gave us more enthusiasm for doing those other
           things, as well. And I do think that the occasional disease-
           specific initiative, whether it's eradication or radical control
           of a disease, can help strengthen a larger health initiative, or
           set of initiatives, and will remain a useful public health
           strategy as long as we have both the combination of large,
           integrated services that we're doing and some specific things
           that are within those integrated services. I think that
           combination remains extraordinarily important in public health
           and probably in other enterprises as well.
Harden:     Thank you so much for speaking with me. I think we've got some
           fine footage here. I am delighted about the details on the
           cluster sampling system. Nobody else has provided anything on
           that for me, so I'm very pleased to have that.
Henderson:  Good.
###
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                <text>Dr. Henderson was Deputy Director of the West African Smallpox Program, stationed in Lagos in the Regional Office.  He was responsible for the on the ground epidemiologic aspects of the program and developed methods of evaluation that have served in a multitude of other programs.  He was subsequently assigned to WHO to initiate and direct the Expanded Immunization Program, and was an Assistant Director General of WHO.</text>
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&lt;p&gt;Smallpox disease was declared eradicated in 1980, the result of a collaborative global campaign. To date, it is the only disease affecting humans to be eradicated from the world. Global eradication of smallpox ranks among the great achievements of humankind. Gone, through determined human effort, is a disease which has brought death to millions, frequently altering the course of history, and traveling through the centuries to every part of the world.  &lt;/p&gt;
&lt;p&gt;The vital contributions made by the Centers for Disease Control and Prevention are highlighted. Official government correspondence, meeting transcripts, policy statements, surveillance reports and mortality statistics tell a part of that story. Adding depth to these traditional archives are the personal stories of the public health pioneers who worked tirelessly on the frontlines of the smallpox eradication campaign.&lt;/p&gt;
&lt;p&gt;The links above connect you to a database of oral histories, photographs, documents, and other media.&lt;/p&gt;
&lt;p&gt;Use of this information is free, but please see &lt;strong&gt;“About this Site”&lt;/strong&gt; for guidance on how to acknowledge the sources of the information used&lt;/p&gt;
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              <text>&lt;pre&gt;&lt;strong&gt;
 Interview Transcript
&lt;/strong&gt;
This is an interview with Dr. David J. Sencer, former Director of CDC,
about the West Africa Smallpox Eradication Program in the 1960s. The
interview was conducted on July 7, 2006, at CDC during the 40th anniversary
of the launch of the program. The interviewer was Victoria Harden.

Harden:     Dr. Sencer, before we get to smallpox, I'd like to establish
           that in 1966 you were the Director of CDC and managed the
           overall direction of the West African Smallpox Eradication
           Program.
                 You were born in Grand Rapids, Michigan, on November 10,
           1924. Would you describe your childhood and your pre-college
           education?
Sencer:          I don't remember very much about the early years. My
           father died when I was 4, in 1929, just at the beginning of the
           Depression, and my mother had to go to work. I was an only child
           in an empty house and had to fend for myself. I went to
           elementary school in Grand Rapids and started high school there
           as well. My mother felt that I needed to be in an environment
           where there were more men, however, rather than living just with
           a lonely widow. So she encouraged me to apply for a scholarship
           to Cranbrook School, a boarding school outside Detroit, and I
           was awarded one. My mother had to pay $32 a month, which in 1936
           was quite a burden on her, but between that money and the
           scholarship, I was able to attend Cranbrook School for 5 years.
           I think I received a very good basic education in an environment
           which was much more masculine than being home with my mother.
Harden:     At that time, did you have any notion of what you wanted to do
           for a career?
Sencer:          When I was in high school, the things that really
           interested me were the sciences: biology, chemistry, geology. I
           was more interested in the sciences than I was in the "softer"
           things.
Harden:     You went to Wesleyan for your college education in the middle
           of the war, in 1942. Tell me about going to college at this
           time, and how this prepared you for medical school.
Sencer:          Actually, that's the beginning of the war, 1942, not the
           middle.
Harden:     Yes, the beginning, you're correct.
Sencer:          My first year was a normal undergraduate year. There was
           no pressure to speed up my education, and the draft was not
           threatening. I took normal liberal arts courses-English, German,
           history, and 1 course in biology.
                 The next year, however, the pressure began to build. The
           military had a variety of programs-the Naval V-12 Program and
           the ASTP[Army Specialized Training Program]-through which
           college students could actually enroll in the military, be paid
           a small stipend as able-bodied seamen or privates, and continue
           their college educations with a commitment to become military
           officers after graduation. I was in the Naval V-12 Program at
           Wesleyan.
                 By that time, assessing my various interests, I had also
           decided that medical school would be the best career route for
           me, and I was thinking of getting into biomedical research. We
           didn't call it biomedical research at that time, but doing
           research in medicine was my goal. Suddenly, however, I found
           that I had to accelerate my program. I took organic chemistry
           first thing in the morning, followed by inorganic chemistry,
           which actually provided the introductory material for organic
           chemistry, plus physics. The only things that I could find to
           fill out my schedule were 2 courses in German literature. That
           year I struggled with a very heavy classroom load and completed
           all of my pre-med credits. Although I had not expected it, the
           Navy officials at Wesleyan informed me that I had to leave the
           undergraduate program because I had completed my pre-med
           credits. There were no openings in medical school, however, so I
           was sent to naval boot camp.
Harden:     Let me interrupt you, just for 1 moment before we go forward.
           You said you had determined that you would go into medicine.
           Would you explain how you came to that decision? Did anybody
           push you in that direction?
Sencer:          No, no. There was no role model. That was the way my own
           thinking just evolved, considering my various interests.
                 I went to boot camp and learned close-order drill, how to
           evacuate a lifeboat, how to climb a rope, and other things like
           that. I became a hospital corpsman, which at that time was known
           as a "pharmacist medic." I was at Mare Island Naval Hospital and
           then at the Naval Hospital, Camp Pendleton, the Marine Corps
           base. My name was on a list to be transferred to the Marine
           Corps. During this period, someone asked me if I wanted to go to
           medical school. I said, "I have a choice between the Marines and
           medical school? I'm a coward. I'll go to medical school."
                 Initially, I went to a 2-year medical school at the
           University of Mississippi, in Oxford. I was in a class of 27
           people. After I finished my 2 years there, I transferred to the
           University of Michigan for the final 2 years of medical school.
           Soon after I got to Ann Arbor, a routine chest x-ray showed that
           I had minimal tuberculosis. For a year, I was hospitalized at
           the university hospital because effective drugs had not yet been
           discovered and so tuberculosis was treated with bed rest. In Ann
           Arbor, when they said bed rest, that is what they meant:
           bedpans, meals in bed, etc. Once a month they would weigh you.
           You would roll out of bed onto a stretcher, and they would weigh
           the stretcher and you. After a year of bed rest, you collapsed
           on the floor when you tried to stand up because your knees
           weren't used to carrying your weight.
Harden:     What did you do all that year? Did you read?
Sencer:          I read and listened to the radio. I read the New York
           Times, Harper's, the Atlantic Monthly, and the Saturday Review
           of Literature. The hospital's 1 rule was that you could read
           anything you wished as long as it had nothing to do with your
           job. I read no medicine, no journals. This was good because it
           opened up a whole new variety of things to me. When you have
           been in the grind of pre-med and medical school, you don't have
           time to think about a world outside of science. I also listened
           to the radio. I had an FM radio, and in those days, that was
           unusual. I could get the political broadcasts, the Town Meeting
           of the Air, and similar things that got me interested in
           politics. That year was a life-changing interlude. I won't say I
           enjoyed it, but it was probably the best thing that happened to
           me. I also learned to knit.
Harden:     And would you say this had a lot to do with your later interest
           in worldwide public health?
Sencer:          I think it planted seeds. I did not immediately become an
           advocate of anything, but the reading, listening, and thinking
           planted seeds and gave me a background in things other than
           science and medicine. I went back to medical school and finished
           on a part-time basis because they were very cautious in those
           days about not over-stressing patients with tuberculosis. I
           finished in January 1952 or December 1951. I have the
           distinction of being both the first and last in my class. I was
           a class of 1, so if I want to brag, I can do it. If I want to
           poor-mouth, I can do that, too. I'd met my wife before I went
           into the hospital, and after I got out, we got engaged and got
           married.
                 I started my internship in Ann Arbor, a rotating
           internship in medicine. I continued with what we called a
           residency in those days and call a fellowship nowadays. I had a
           residency in internal medicine for about a year and a half. One
           day on grand rounds, the Chief of Medicine said to me, "Sencer,
           you know the military's looking for you?" I said, "Well, no. I'm
           4F." He said, "Not anymore. They say you're 1A, and they want
           you. They wrote and asked if you were essential, and I told them
           the department would fall apart for exactly 2 minutes if you
           left." By this time, we were also expecting a baby, and we were
           preparing to move out of our apartment before the baby arrived
           because no pets or children were allowed. Here I was, then,
           faced with 2 decisions: what to do and where to stay. I
           contacted the navy to see if I could re-enlist, but they turned
           me down because of my medical history with tuberculosis. The
           navy did say that if I were drafted, it would be happy to take
           me into its quota. I thought that was a terrible way to do
           business.
                 One night, I was at a concert in Ann Arbor and saw a
           friend who was a professor of public health, Cy Axelrod [S.J.
           Axelrod]. I told him my problems, and he said, "Join the Public
           Health Service (PHS)." I said, "What's that?" He explained and
           said that the PHS had a tuberculosis research program that I
           might be able to join. I wrote the Public Health Service and
           said that I want to join their tuberculosis program. They
           responded with the question "Why?" and I answered, "I know why,
           what I want to know is when." Finally, in January 1955, I became
           a Public Health Service officer in the tuberculosis program.
Harden:     Do you think you would have stayed in internal medicine and
           gone into private practice had you not come into the PHS to
           satisfy your military?
Sencer:          We liked Ann Arbor, and I thought that I might just stay
           on at the university.
Harden:     But instead, you joined the Public Health Service and began to
           work in tuberculosis and migrant health.
Sencer:          At first, I just sat around in Washington. They did not
           seem to know what to do with me. I worked as a code clerk on
           some research projects in tuberculosis. Eventually, I was sent
           to Idaho to run a survey of the health status of migrant
           laborers. When I arrived, I found a little caravan of 2 house
           trailers used as examining rooms, a mobile x-ray truck, and a
           mobile laboratory. To gather data, we had to drive to labor
           camps around the Snake River Valley, so I learned how to drive a
           car with a trailer attached. We would go into a labor camp, hook
           up the water, and talk with them about coming in for
           examinations.
                 Several things about this assignment changed my whole
           attitude about medicine. I began really seeing people who were
           disenfranchised. These were people who claimed to be from Eagle
           Pass or Farr, Texas, but you knew very well they were from the
           other side of the border. They had come to Idaho for 6 months,
           but they could not get citizenship during those 6 months, so
           they had no rights in Idaho. The farmers weren't interested in
           paying them anything more than the minimum wage, and there was
           no health insurance. We didn't see much disease in these camps,
           actually, because the migrants were a fairly healthy group. They
           had to be in order to work in the fields 12 hours a day.
                 One case we did encounter was that of a young man who had
           a tuberculosis of the knee. Idaho had agreed to accept people in
           the hospital if they had infectious tuberculosis, but he didn't
           have infectious tuberculosis. We were faced with the question,
           "How do we get him treatment?" Finally, we decided that the only
           way was to bend the rules a bit. We convinced the young man that
           he was under 18-he was actually 20-because if he was under 18,
           he qualified for Crippled Children's Services, a federally
           funded service. By this subterfuge, we were able to get him
           treated.
                 A few days later, we found a 12-year-old girl who had far-
           advanced tuberculosis in the hospital in a town we visited. The
           hospital administrator called us and said, "Get her out of
           here." He obviously did not want to have to treat her any
           longer. I went to see her parents, and I said, "Don't visit your
           daughter, because if you do, they'll make you take her home."
           Instead, we made arrangements to have her transferred to the
           tuberculosis hospital about 100 miles away.
                 To go to the hospital, however, she had to possess 2 pairs
           of pajamas and a toothbrush. Well, pajamas, what are they?
           Migrant workers did not own them. I said, "Let's see what we can
           do." I went to the TB Association, but they would not provide
           the money to buy the pajamas. Their attitude seemed to be, "She
           doesn't buy Christmas Seals, so we won't help her." I went to
           the Latter-Day Saints, as this was a big Mormon area. "She's not
           one of ours," they said. I went to the Catholic church, and the
           priest said, "They never baptize 'em down there in the valley,"
           but he gave me $10 anyway. I gave it back to him. There was a
           small community of Quakers outside of town, and I went out and
           met with their elders, and they said, come back at 6:00 PM. I
           went back at 6:00, and there was a whole pile of clothes. I
           thought, "Oh boy, this is an opportunity to talk to them about
           problems with the migrants." But they wanted to talk about the
           fact they were playing baseball on Sunday in Boise, not the
           thorny and politically volatile problem of migrant people.
           People were willing to help a little on an individual basis, but
           no one wanted to address the larger problems.
                 Those problems, however, got me interested in public
           health because public health measures provided a way in which
           you could do more for large groups of people than what you could
           do trying to help 1 individual at a time. I had begun thinking
           of a career change into public health when I got a letter
           saying, "You're being transferred to Columbus, Georgia, to run
           the tuberculosis research station there." This seemed like a
           great opportunity to me, so we moved, but it was my wife's first
           experience in the South, and Columbus, Georgia, was really
           "South" at that time. She was not a bit happy. I, on the other
           hand, had a wonderful job.
                 And the PHS then sent me to the School of Public Health at
           Harvard. Getting a Harvard MPH [Master's in Public Health] was
           in my view a necessary "union card" for moving forward in a
           public health career. I learned very little at Harvard, except
           from the other students. What they taught me was much more
           important than many of the courses that I took.
                 After finishing my MPH, I returned to Columbus for a year
           and then transferred to Washington, to a job that I thought was
           just terrible. Finally, however, I realized that it provided an
           excellent opportunity to learn how things really happen in
           Washington. I worked in the Bureau Chief's office essentially as
           a "gofer," but I learned about the budget process, about
           interagency problems, and about how things really transpired at
           this level. Then, in 1960, I was transferred to CDC as the
           Assistant Chief, and I fell in love with an agency.
Harden:     That is what I understand. Elizabeth Etheridge stated in her
           history of CDC that you always thought the best job in the world
           was to be Director of the CDC.
Sencer:          Absolutely.
Harden:     So, obviously, your mind had shifted. Your Washington training
           served you well in learning how the bureaucracy functioned. Now
           walk me through your rise through CDC until we come to the
           beginning of the smallpox program.
Sencer:          For the first 2 years, I was the Assistant Director. Larry
           Smith [Clarence A. Smith] was the Director. To become familiar
           with all of the activities of CDC, I obtained copies of all
           articles published by the print shop at CDC and scanned them.
                 During those 2 years, I was intimately involved with
           decisions relating to how polio vaccine would be licensed. In
           1955, when the Public Health Service licensed the inactivated
           vaccine [Salk vaccine], the PHS bought all of the existing
           vaccine and distributed it to the states but did not give the
           states any money to help organize distribution programs. For the
           states, the easiest way to reach children was to give it through
           the public schools. The result was a shift in polio cases back
           towards what was known as "infantile paralysis." By the 1950s,
           polio had become a disease more of older children and young
           adults, but after school-aged children began receiving routine
           vaccinations, it was the preschool-aged children who became
           vulnerable to infection with polio. These tended to be the
           children of people living in the inner cities with low incomes,
           who could not afford to have pediatricians vaccinate their
           children. There were outbreaks of polio in the late '50s and
           early '60s in Kansas City, Chicago, and other cities, all
           concentrated in the inner cities.
                 When oral polio vaccine came on the horizon, the Surgeon
           General's Public Affairs Officer J. Stuart Hunter suggested
           following the same distribution procedure. We at CDC opposed
           this. We wrote legislation stipulating that the Public Health
           Service would provide vaccines, not just against polio, but also
           against all childhood vaccines, to state and local health
           departments and that this vaccine could be used for children
           under 5 years of age. The legislation also included money for
           the states to organize immunization programs. This shifted
           federal law from a focus solely on polio to a broader emphasis
           on general immunization against childhood diseases, including
           diphtheria, tetanus, and whooping cough. This law stood as basic
           immunization legislation for a long time. Vaccines against
           measles, German measles, and chickenpox were subsequently added
           to the law's coverage.
                 Between 1963 and 1966, I was CDC Deputy Director; Jim
           Goddard [James Goddard] was Director. Jim was a wonderful guy.
           He was gung-ho, do everything. After about 6 months, however,
           Jim decided that he was in the wrong job. He thought he was
           better suited to run a small agency that needed to grow or an
           agency that was in trouble and needed to be fixed. CDC was
           neither. So Jim began looking for another job, and, basically, I
           did the day-to-day management of CDC during those years. In
           1966, Jim was appointed Commissioner of the Food and Drug
           Administration, which was an agency that was in great trouble at
           that time and still is.
                 I became CDC Director in 1966. At the same time, USAID [US
           Agency for International Development] transferred the Malaria
           Eradication Program, which was in great trouble, to CDC. Malaria
           eradication was failing because it was based on premises that
           did not work. Suddenly, CDC had the responsibility for a program
           that was failing. We also inherited staff in 16 different
           countries, and we had to fund them out of the CDC budget. It was
           a huge problem. CDC became the biggest employer of people in
           Haiti through the program. The whole Malaria Eradication Program
           became a direct CDC hire, and we could imagine the staff of the
           Malaria Eradication Program 1 day marching down the streets as
           part of a political uproar in Haiti. But over time-not in 1966,
           but over time-we brought about major changes in the way malaria
           was approached around the world. We worked with WHO [the World
           Health Organization] to get away from the concept of eradication
           and to begin emphasizing control and prevention of deaths in
           children.
                 Later, in 1966, the smallpox program started. Actually, it
           goes back before that. Let me reconstruct the history as well as
           I can remember it. I will talk about CDC's involvement in
           smallpox, not the whole smallpox eradication effort around the
           world. During World War II, Alex Langmuir [Alexander Langmuir],
           the Director of Epidemiology at CDC, had been very interested in
           biological warfare. The Epidemic Intelligence Service (EIS) was
           created, in fact, because of the threat of biological warfare
           during the Korean War. During Congressional testimony, Dr.
           Justin Andrews, who was the Director of CDC at that time, was
           asked about how we planned to address biological warfare. Justin
           thought real quickly on his feet, and said that since military
           draft obligations could be fulfilled through service in the
           Public Health Service, CDC would establish an epidemiology
           service of young people who would be trained to recognize
           abnormal occurrences and thus be able to provide early warning
           against biological warfare. That is how the EIS began.
                 Alex, of course, had been plotting for such a program, and
           he happily seized the opportunity posed by biological warfare to
           implement it. For a long time, he had been interested in
           smallpox, and he got D.A. Henderson [Donald A. Henderson]
           interested as well. In 1962, Don Millar [J. Donald Millar] was
           sent to Indonesia as an EIS Officer as part of a malaria
           assessment program, and while there, he saw smallpox for the
           first time. He became very interested in the disease, and when
           he came back, surreptitiously carrying some scabs of smallpox
           for the lab, he was put in charge of what was called "smallpox
           surveillance" in the Epidemiology Program. He was it. No one
           else was involved.
                 Henderson and Millar began discussing whether smallpox was
           a disease that could be eradicated. In contrast to malaria,
           which has a mosquito vector and animal hosts as well as human
           hosts, smallpox is directly transmitted from person to person
           and has no animal reservoir, which makes it possible to
           eradicate. We had a good vaccine, which made the disease
           susceptible to eradication. The military had invented a jet
           injector, which could be used to give rapid vaccinations to
           large numbers of people. CDC helped the military modify the jet
           injector so that it was possible to give intradermal injections,
           since smallpox injections had to be given intradermally.
                 The intradermal jet injector was tested with smallpox
           vaccine in the friendly islands of Tonga. Everybody made cynical
           jokes about why they picked Tonga-why not choose a lovely
           Pacific island with gorgeous beaches? Our audiovisual group here
           at CDC made a beautiful movie of this, called Miracle at Tonga,
           with the waves crashing up on the scene. But the actual reason
           it was chosen was that Tonga had never had smallpox, and there
           had never been any vaccinations, so it was a virgin territory in
           which to try out vaccinating people with a jet injector, and it
           worked very well.
                 In 1965, after a couple of years in Geneva, the World
           Health Assembly of WHO passed a resolution calling for the
           worldwide eradication of smallpox. President Lyndon Johnson also
           issued a statement saying the United States would support this
           initiative and contribute to the effort.
Harden:     Was CDC involved with getting President Johnson to issue that
           statement?
Sencer:          Yes, but I had nothing to do with it. Alex and D.A.
           Henderson worked with Jim Watt [James Watt], who was the
           Director of International Health for the Public Health Service.
           They also worked the streets of Geneva to get the resolution
           passed, and they deserve a lot of credit for this. It involved a
           lot of hard, political horse-trading. The Indians were against
           it, and representatives from countries that had been burned by
           the failed malaria eradication said, "Oh, no, no, no." But D.A.
           Henderson had become quite familiar with WHO, and WHO had become
           quite familiar with D.A., which I think becomes important as we
           go on.
                 One day in 1965, Jim Goddard was out of town, so I took a
           phone from Dr. A.C. Curtis [Arthur Clayton Curtis], who was in
           the African Bureau of USAID. He asked if CDC would like to take
           on a measles eradication program in West Africa. This call came
           at a propitious time. Dr. Harry Meyer at NIH [National
           Institutes of Health], in the old Division of Biologic
           Standards, was testing out different strains of measles vaccine
           in large populations. Measles was a terrible disease in Africa,
           with high mortality in children. It was a real killer. Many of
           the field trials in which Dr. Meyer was involved were done in
           West Africa, and the measles vaccine proved to be a tremendous
           success. USAID looked at the results of Meyer's efforts and
           decided that it might be a good time for CDC and USAID to expand
           the measles vaccine program in West Africa. I told Dr. Curtis
           that we were not interested in measles eradication, because
           measles eradication was not feasible, but that measles control
           might be feasible if we could couple it with smallpox
           eradication. If we could do that, CDC would be interested. And
           he said, "Sure." It was as simple as that.
                 Then began the hard work of negotiating agreements with
           USAID, writing what they call pro-ags [program agreements or E-
           1s], and all sorts of documents that had to be written about
           each country, and getting each country's agreement with the
           documents. Dr. Henry Gelfand, on CDC staff, spent lots of time
           going from country to country, getting country agreements,
           getting things signed, trying to recruit people to become part
           of the program. All of this was happening in late 1965 and early
           1966. Finally, all of the paperwork was done. USAID had agreed
           to fund the program. We had a 5-year agreement with USAID for a
           program to start on July 1, 1966.
                 D.A. was a good friend of mine, and of the family, and his
           daughter and our oldest daughter were also very close friends.
           They were in the same grade in school. His daughter often told
           my daughter that they were moving to Geneva in November, but
           when I would ask D.A. about this, he would reply, "Oh, no, I'm
           not going. I want to stay here and run the CDC program." His
           daughter Leigh, however, continued to say, "We're getting ready
           to leave in November," and D.A. continued to insist, "Oh, no,
           no." But finally, he said that he was moving to the WHO in
           Geneva, arguing "I was ordered to do it." Well, you know his
           mouth was drooling to take on the WHO program all the time.
                 When D.A. was transferred to Geneva, Don Millar was
           appointed head of the Smallpox Eradication Program. Don had been
           studying at the London School of Tropical Medicine for a year.
           He had gone there because there were people in England who were
           very much interested in smallpox and could provide him with
           additional experience and training. You will be interviewing Dr.
           Millar, I'm sure, and you might want to ask him about his
           dissertation at the London School. I'll let him tell the story.
           By the fall of 1966, Don had come back from England. He was the
           logical one to head up the Smallpox Eradication Program (SEP).
                 In the early part of 1966, the SEP had been run out of
           D.A.'s Epidemiology Program. The people in the Epidemiology
           Program were provincial in some ways. They thought that
           epidemiologists were the only professionals needed to craft a
           solution to any infectious disease problem. A big program like
           this, however, requires logistical experts as well as
           epidemiologists, so I pressed the Epidemiology Program to add
           Public Health Advisors to the staff of the SEP... I pushed hard
           to have Billy Griggs appointed as a deputy to D.A. Henderson, to
           deal with the nitty-gritty of organizing and paperwork and so
           on. As the SEP began staffing up for the West African program,
           Billy made sure that there was a person called an "Operations
           Officer" with each of the epidemiologist "Medical Officers." The
           Operations Officer took care of the logistical things that had
           to be done. You'll be talking to many of those.
Harden:     As CDC Director, what made you buy into that idea? Did the time
           that you had spent with the migrants influence your realization
           of how many "operations" details were involved in such a public
           health effort?
Sencer:          Yes. When I first came to CDC, there was an older man
           (he's 9 days older than I am) by the name of Bill Watson
           [William C. Watson Jr.]. He had been in the Venereal Disease
           (VD) Program for a good number of years, and it had been
           transferred to CDC. Larry Smith was the Director of CDC at that
           time, and he had previously been the Director of the VD Program.
           He knew Bill's capabilities. He had moved Bill out of the VD
           Program and appointed him Assistant Executive Officer at CDC.
                 I got to know Bill very well-he was a close personal
           friend as well as a professional colleague. He often told
           stories about how the VD investigators worked, and through
           listening to him, I began to understand that the logistical
           effort was a key part of disease control programs. People who
           could get out in the field, knock on doors, talk to people, and
           understand how people behaved were essential. The first
           assignments given to VD Public Health Advisors usually were in
           local health departments. They tracked down contacts of cases of
           syphilis and gonorrhea and tried to bring them in for treatment.
           After a couple of years of this work, they would become
           supervisors, with responsibility for several other people.
Harden:     And they weren't physicians.
Sencer:          Oh no. They were a group of people who were recruited at
           the baccalaureate level. They were not disappointed pre-meds,
           but rather people who were interested in people. There were
           certain schools at which the PHS traditionally recruited because
           the PHS knew that these schools would turn out the sorts of
           people that they wanted. The recruits would move up in a
           supervisory managerial chain that stood behind the physician in
           charge. In a state health department, there would always be a
           senior Public Health Advisor behind the physician who was the
           state VD Control Officer. The Public Health Advisor pushed,
           pushed, pushed. He or she never made a medical decision but
           pushed the physician to make the necessary decision and assume
           the leadership role. And they learned quickly that this was how
           you get things done. You don't have to make the decisions
           yourself if you can get somebody else to make the right
           decisions.
Harden:     That's very interesting.
Sencer:          Yes. A history of the Public Health Advisors is being
           written. I think they're looking for a publisher.
Harden:     You were explaining how the SEP was organized-what types of
           people were needed. What did you look for in your staff? What
           did they need to be able to run this program successfully?
Sencer:          I looked for Billy Griggs to make good personnel
           decisions. The physicians had already been pretty much recruited
           by D.A. We lost a few real misfits the first year in training.
           Many of the physicians who were recruited were EIS Officers.
           Stan Foster [Stanley O. Foster], for example, had been an EIS
           Officer. He had left CDC and was back in residency training.
           D.A. called him and said, "You want to go to Africa?" And Stan
           said, "Sure," and he came back to CDC. Rafe Henderson [Ralph H.
           Henderson], who had been appointed to be the regional
           epidemiologist on the ground in West Africa, had been at CDC for
           quite some time. He had been on some of the early trips to West
           Africa. Rafe had very good sense about people, too.
                 I put my trust in the people who were running the program.
           I knew Billy Griggs made good decisions; I knew Don Millar made
           good decisions; I knew D.A. was charismatic and a great
           stimulator. He was not the best manager, but while he was here,
           he developed some excellent management techniques. I knew what
           was going on, but I did not micromanage. My philosophy is to
           hire good people to run something, and then you let them run it.
Harden:     When did you make your first trip to Africa?
Sencer:          In the smallpox program? I think my first trip was for the
           25 millionth vaccination event. They had a big celebration in
           Ghana, in 1968, to mark the 25 millionth vaccination that was
           given. This was a great public relations opportunity for the
           Smallpox Eradication Program. USAID thought it was wonderful.
           Many ambassadors were there. Jim Lewis, who you'll be
           interviewing later, was the Operations Officer in Ghana. He made
           most of the arrangements for this great to-do. It was out in the
           country, about 90 miles north of Accra. There were tribal chiefs
           in uniform, with umbrellas and gold robes and dancing, and so
           on. Events like this were called durbars. I remember that the
           American Ambassador shook his head, saying, "I've been to a 12-
           chief durbar, but this is the first time I've ever been to an 18-
           chief durbar." The Surgeon General was there, and he gave the 25
           millionth vaccination to a screaming little girl.
                 After the event, while we were there, we had more
           meetings. USAID had also recruited a reporter from the New York
           Times,. Fred Friendly's son. They had the military attaché's DC3
           from the embassy in Dakar. The next day we flew for breakfast
           from Dakar to Abidjan, had breakfast at the airport with the
           Minister of Health and the ambassador; flew to Monrovia,
           Liberia, for lunch with the Minister of Health and the
           ambassador; and to Freetown, Sierra Leone, for dinner. We refer
           to that as "breakfast in Abidjan." All of this was good public
           relations. It showed that the Surgeon General of the Public
           Health Service was with us-that is, that we had support from the
           top. It reinforced at USAID, too, the importance that we gave to
           the program because we were able to get the Surgeon General to
           participate.
                 From Sierra Leone, we flew to Bamako, in Mali. The pilot
           had never been there. He flew east until he found the Niger
           River, and then he followed the river up to Bamako. Mali, at
           that time, was a Marxist country, with mostly Chinese activity
           there. It was Chinese construction, Chinese this, Chinese that,
           Chinese all over the place. We spent some time in Bamako, then
           flew out to a market town, and then took the Dodge trucks out to
           the Dogon Territory. This was located at the "end of nowhere,"
           out with cliffs that fall off into the sub-Saharan plateau. The
           Dogons are the people who had the big, big masks. They had
           dancing and thousands and thousands of people getting
           vaccinated. It was very colorful. There was a missionary there,
           with whom we stayed. He had been in the mission field for 40
           years. Ten years out, 2 years back, 10 years out, 2 years back.
           We slept under the stars, where there were no artificial lights.
           It was a wonderful experience. The next day we flew to Timbuktu
           and then went on through Niger, Togo, Dahomey, and back to
           Lagos, and home. That was my first major trip to Africa during
           the Smallpox Eradication Program.
Harden:     Tell me more about how you ran CDC as Director at this time.
Sencer:          Even in those days, I was known for "walking around." I
           wanted to know what was happening, so I walked around to see
           things. I would ask questions, and it scared people sometimes.
           There was 1 person I recall, into whose office I seemed to walk
           every time he was reading his paperback instead of working.
           Finally, he didn't even put it in his desk drawer when I came
           in.
Harden:     Could you say a little more about the bureaucratic relationship
           of the Smallpox Eradication Program to the Department of Health
           and Human Services, to the Public Health Service, to the
           National Institute of Allergy and Infectious Diseases at NIH,
           and any other federal agencies?
Sencer:          The West African program was self-contained as far as
           budget and management were concerned. We had our money from
           USAID. Billy Griggs handled most of the dealings with USAID
           concerning paperwork. At the front office level, we did not have
           too many problems with USAID. The collaboration was something
           that we knew about on a day-to-day basis, but it was not
           something that gave us problems. We had good leadership, and our
           philosophy was to get good people and let them do the work.
Harden:     What was the toughest problem that you faced?
Sencer:          During the African program? You know, most of the
           problems, Billy handled. Ask him about that because the toughest
           problems were paperwork and things like that. Our real problems
           with smallpox began after the African program. The 1 thing that
           the African program did was to demonstrate that mass vaccination
           was not the way to go in smallpox eradication. You'll get Bill
           [William H. Foege] to tell this story himself, but early in the
           program, Bill was working as a medical missionary in eastern
           Nigeria. He was volunteering as the smallpox epidemiologist for
           that area. He did not have enough money to buy enough vaccine
           for the mass vaccination program, so he began looking at spot-
           maps of how smallpox was moving from village to village and how
           long it took to move from village to village. He said, "If we
           could prevent smallpox from moving from 1 village to the next,
           maybe we could break the chain of transmission." He developed a
           scheme of getting village leaders to tell them when there was a
           smallpox case. He and his team would then go in and vaccinate
           the people in that village and around it-the contacts of those
           with smallpox-to contain the disease. And suddenly, smallpox in
           his area began disappearing. He hit it at the low point in
           transmission, so he was able to get to all of the foci of
           smallpox, and smallpox disappeared from his area.
                 This strategy was presented in a variety of ways to others
           in the program. Finally, it became possible to see if it would
           work on a large scale. In Sierra Leone, Don Hopkins [Donald R.
           Hopkins] was the Medical Officer and Jim Thornton was the
           Operations Officer. Sierra Leone had the highest rates of
           smallpox in Africa and was as backward as they come. Don and Jim
           knocked out smallpox in months. This impressive demonstration
           caused Foege's strategy to be adopted for the whole West African
           program.
Harden:     What mechanism did you use to tell everybody, "We're changing
           the way we're doing the Smallpox Eradication Program?" And what
           convinced you that Dr. Foege's approach was the way to go?
Sencer:          This was a scientific study. They needed to show
           convincing data that the strategy worked, and they did. I didn't
           have anything to do with it other than to say, "Yes, you've got
           the data to support your argument. We will do it that way."
Harden:     But I understand the World Health Organization's approach to
           smallpox eradication did not change so rapidly, even in light of
           these data.
Sencer:          Yes. WHO was reluctant to accept this. They had been
           selling the concept of mass vaccination, and they were reluctant
           to begin talking about a new approach. They had sold countries
           on mass vaccination, and to change strategies would require that
           they go back and re-educate them. After the West African Program
           was completed, D.A. finally accepted that this was the way to
           go, and it was after the African program that the hard work in
           smallpox eradication began. That is another story, of India and
           Bangladesh and so on.
Harden:     Once you had achieved zero pox in West Africa and had finished
           the program, CDC no longer received funding from USAID. You did
           not want to let the program completely die, however, because you
           wanted to continue surveillance activities, as I recall. At that
           point, you appointed Bill Foege to be head of the Smallpox
           Eradication Program. Would you talk about the follow-up from CDC
           to the West African program?
Sencer:          When we reached zero pox in West Africa, Bill came back to
           CDC. Don was still in charge of the CDC smallpox program for a
           while. Then the International Red Cross called and said that
           they were concerned about the famine in West Africa, which
           occurred as a result of the Nigerian War. The Red Cross asked if
           Bill Foege-they asked for him by name-would come and do
           surveillance of how bad the famine was. Bill went, even though
           his wife was very reluctant to have him go because she knew if
           he went, he might not come back soon because he would want to
           stay and see things through. He went out and developed a
           surveillance technique for the famine, and we began feeding CDC
           people in, to maintain the surveillance activities and to
           identify where the famine was at its worst, so that relief
           activities could get to those places. This was being done with
           CDC money at this point, but we had little authority to pay for
           famine management in African countries. We were able to do it
           under the guise of protecting the United States from the
           possibility of the recrudescence of smallpox. Some of the travel
           was being paid for by USAID, but CDC was paying all the
           salaries.
                 Then the State Department began getting worried about what
           was happening in Biafra, the secessionist state. State asked if
           we would send somebody in to do a rapid assessment. Karl Western
           [Karl A. Western], who had been at CDC for a good number of
           years, agreed to go. He was taken out to 1 of the islands off of
           Nigeria and flown in at night to Biafra. We had no official
           presence in Biafra. Karl did a magnificent job of showing that
           the famine in Biafra was the worst famine that had occurred
           since the potato famine in Holland after the war, but that it
           was localized. He also showed that 1 organization's relief
           activity would set up in a village, and then other
           organizations' relief activities would come in in competition.
           You'd get the Lutherans, you'd get the Catholics, you'd get the
           Worldfam, Oxfam, and so on. This meant that some villages were
           getting all of the aid, but the major part of the country was
           not getting any. Aid was flowing to places where it was easy to
           get to but not out in the bush.
                 As a result of Western's work, I got a call 1 night from
           Jesse Steinfeld, the Surgeon General. He said, "You and Western
           get to town, right now." On a snowy January night, we went to
           Washington, to the White House. We went into the Situation Room,
           and who should show up but Henry Kissinger. Suddenly, we were
           briefing Henry Kissinger on famine in Biafra. At that time,
           Kissinger was the National Security Advisor. In typical
           Kissinger fashion, he was playing USAID, which was arguing that
           there was no problem in Biafra, against the State Department,
           which was arguing that there was a serious problem in Biafra. He
           was enjoying the bureaucratic struggle. He didn't give a hoot
           about famine. It was the bureaucratic struggle. Kissinger later
           became Secretary of State.
                 We also briefed the State Department person who was going
           to Congress the next day. One of the major signs of malnutrition
           is edema of the legs, which is caused by protein deficiency.
           Assessing edema in a population was a quick way of determining
           how bad the famine was. This Assistant Secretary of State kept
           calling it "endema," and we kept saying, "No sir, it's 'edema.'"
           "Oh, yes," he would say. He got to Congress, however, and in his
           testimony, it was "Endema, endema, endema."
Harden:     I want to drop back into the smallpox program and ask if there
           is any other event of significance that springs to your mind
           like the 25 millionth vaccination event you described?
Sencer:          We went to a village, Ede, in Nigeria, for the observance
           of the 10 millionth vaccination in Nigeria. When we got there,
           there was the Timi, who was the chief of the village. He was
           wearing a leopard-skin cap and robes, and when he went out into
           the town square, everybody gathered around. He stood up and gave
           the most erudite history of smallpox in Nigeria, back into the
           early days of colonialism. It was beautiful.
                 Afterwards, we went in to his house and saw a plaque on the
           wall that said, "Honorary Kentucky Colonel," and another plaque
           that said, "Honorary Alumnus of Western Michigan University."
           Surprised, I asked him to tell me about those plaques. He said,
           "I'm an expert in the talking drums, and the State Department
           takes me to the United States to give lectures on the talking
           drums. In return, Kentucky made me an honorary colonel, and
           Western Michigan made me an honorary alumnus."
                 We asked, "What are talking drums?" He said, "The drums
           talk. They don't talk in code, they talk in Yoruba. Would you
           like a demonstration? I always keep a drummer out in the
           courtyard across from my house in the morning, so he can tell me
           what's going on in the village on the drums." He then asked his
           drummer to demonstrate the drums. One of the USAID people said,
           "Have that man across the way come in and bow to the Timi and
           throw the cat out." So the drummer pounded away, and this guy
           came running across, bowed to the Timi, picked the cat up, and
           threw it out.
                 I said, "Hmm, put-up job." He said, "All right, you tell
           him what to say with the drums." I was smoking in those days. I
           said, "Tell the man to come and take a cigarette out of my
           pocket and light it. He pounded the drums, and this guy came in,
           counted 1, 2, 3, 4, to me, reached into my pocket, took out a
           cigarette, put it in my mouth, reached into his robes, and
           pulled out a lighter. He said, "You know, it's true. We speak in
           syllables. The drum has a head that you can squeeze the side of,
           and it changes the sound, the tone, but it has trouble with
           English words.
                 Don Millar said, "How would it say 'Dr. Millar?'" He said,
           "Oh, that's Yoruba. Do-ki-tar-mil-lar." And that drum began
           going, "Do-ki-tar-mil-lar, do-ki-tar-mil-lar." You could hear
           it. Bill Foege-he was known as the tallest man in Africa-said
           that when he was coming to a village, the drums would pound out,
           "The tallest man in Africa is coming." Learning about the
           talking drums was a wonderful experience.
Harden:     What else did you learn about Africa in the program?
Sencer:          What did I learn about Africa? Oh, my goodness. In those
           days, it was a wonderful, wonderful part of the world. There was
           a lot of concern about improvement, but they were not as highly
           politicized as they are now. You would get outside the capital
           city and find wonderful people who were shaking off colonialism.


                 One of the things about the West African program is that
           there were 2 very distinct parts of Africa in which we worked:
           francophone Africa and anglophone Africa. Each had a very
           different medical system. The French were much better organized
           than the English. When colonial government ended, the English
           just picked up and left. The French left things behind and left
           some Frenchmen behind, too. They pretty much controlled the
           currency, and communications, and so on.
Harden:     Let me change the question slightly. What did Africa learn
           about the United States and CDC?
Sencer:          Thank you for asking. One day in 1969 in the World Health
           Assembly, the Minister of Health of Mali, which had been a
           Chinese-Marxist country, made a speech. This man said, "I want
           to thank the United States for giving us assistance in our
           smallpox eradication program, but not so much for the vaccine or
           the machinery or the Jeeps but for the people that the United
           States sent to help us." That, to me, was the crowning glory of
           the program. The Africans recognized that it was people rather
           than things that the United States gave to Africa. We had sent
           to Africa young guys and gals who had had no experience in
           diplomacy, who had no experience with politics and so on, and
           they went out, altruistic and wanting to get a job done. "We've
           got a job, let's go do it, we can't do it ourselves, and we've
           got to get the people in Africa to do it. We'll be there to
           stand behind them and push. We'll give them the tools, we'll
           give them the know-how, but they've got to do it." And they did
           it.
Harden:     I have just a few more questions. In the middle of the West
           African project, some people recommended that smallpox
           vaccinations be stopped in the United States, and this became a
           hot topic of discussion at CDC. Would you comment on that?
Sencer:          Actually, it was a little after the West African program,
           because it was in 1972 that we really came to the belief that we
           could safely stop smallpox vaccinations. By then, enough
           eradication had been achieved, not only in Africa but in other
           parts of the world, to minimize the threat to the United States.
           The risk of importation was so slight that the risks of
           continuing vaccination with the predictable adverse reactions
           that occur with smallpox vaccine far exceeded it. As usual, we
           had a meeting of our immunization advisory committee to go over
           all of this.
                 We met on a Saturday morning. I had invited the Medical
           Officer of Health of Great Britain, George Godber, with whom I
           had seen recently, to come to our meeting. George was a
           fascinating person. He was the architect of the National Health
           Service in England. Ruddy-faced, white hair, monocle. He had
           lost this eye, and he said, "Why spend money on 2 lenses? I only
           need one." He kept a handkerchief up in his sleeve to pull out
           and wipe his eye. He was a real character but highly articulate.
           He wrote and spoke beautifully. At that meeting, we struggled
           mightily with the wording of our recommendation on smallpox
           vaccination. George finally said, "Dave, excuse me, this is your
           country. But it is my language." He clarified the wording for
           us.
Harden:     If you were going to start the program over again, would you
           change anything about how it was run?
Sencer:          No.
Harden:     Not a thing?
Sencer:          Not a thing-as long as I could have the same people.
Harden:     How did the program change your career at CDC? What impact did
           it have?
Sencer:          It changed CDC, and since I was part of CDC, it changed my
           career. What it did was push CDC into international health, into
           global health. It was the first time that we had responsibility
           for a large international program from its inception. We had
           inherited the malaria program, but the West African Smallpox
           Eradication Program was totally a CDC operation. This was the
           beginning of CDC's global involvement that continues to this
           day, not just of ideas and equipment, but of people. In Dakka,
           at the old cholera lab; we started the field epidemiology
           training programs in different countries. It just goes on and on
           and on. I think that individuals grow with the organization. You
           don't pull the organization. The organization pulls you.
Harden:     Since your role in the smallpox program was here at
           headquarters in Atlanta, did it have any impact on your family?
Sencer:          Not as much as it might have, although I did a lot more
           traveling after the program began. I was not a traveling
           salesman, just home on the weekends, but I did have to travel a
           lot. It became worse with traveling to Washington, but I think
           my family were envious of my going to Geneva for 2 or 3 weeks
           every year for the World Health Assembly meeting, and things
           like that. But I don't think it had any great impact on the
           family.
Harden:     But all 3 of your children are in the field of health in 1 way
           or another. Am I right?
Sencer:          Yes. Our oldest daughter, Susan, is a pediatric
           oncologist. Our middle daughter, Ann, is a nurse practitioner in
           oncology, and our son, Stephen, is Deputy General Council at
           Emory, but he handles a lot of the research and intellectual
           property sorts of things there.
Harden:     Before we stop, is there anything else that you would like to
           add?
Sencer:          I'm tired.
Harden:     Thank you very much for speaking with me. I think this gets us
           off to a wonderful start for these recollections.
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